The structural biology of enzymes involved in natural product glycosylation

Structural Studies of AntD: An N-Acyltransferase Involved in the Biosynthesis of d-Anthrose

(2012) Rachel L. Kubiak et al.   BIOCHEMISTRY

UDP-N-acetylglucosamine enolpyruvyl transferase as a potential target for antibacterial chemotherapy: recent developments

(2011) Ankur Gautam et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Biochemical and Structural Characterization of WlbA fromBordetella pertussisandChromobacterium violaceum: Enzymes Required for the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy-d-mannuronic Acid

(2011) James B. Thoden et al.   BIOCHEMISTRY

Combined Structural and Functional Investigation of a C-3′′-Ketoreductase Involved in the Biosynthesis of dTDP-l-Digitoxose

(2011) Rachel L. Kubiak et al.   BIOCHEMISTRY

Mechanisms and structures of vitamin B6-dependent enzymes involved in deoxy sugar biosynthesis

(2011) Anthony J. Romo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The crystal structure of ADP-L-glycero-D-manno-heptose-6-epimerase (HP0859) from Helicobacter pylori

(2011) Md Munan Shaik et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Glycosyltransferase structural biology and its role in the design of catalysts for glycosylation

(2011) Aram Chang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Glycosyltransferases as biocatalysts

(2011) Monica M Palcic   CURRENT OPINION IN CHEMICAL BIOLOGY

Nucleophilic Participation of Reduced Flavin Coenzyme in Mechanism of UDP-galactopyranose Mutase

(2011) He G. Sun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expanding the Nucleotide and Sugar 1-Phosphate Promiscuity of Nucleotidyltransferase RmlA via Directed Evolution

(2011) Rocco Moretti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Structural Form in the SAM/Metal-Dependent O‑Methyltransferase Family: MycE from the Mycinamicin Biosynthetic Pathway

(2011) David L. Akey et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules

(2011) Richard W. Gantt et al.   NATURAL PRODUCT REPORTS

Altered architecture of substrate binding region defines the unique specificity of UDP-GalNAc 4-epimerases

(2011) Veer S. Bhatt et al.   PROTEIN SCIENCE

Dynamics of glucosamine-6-phosphate synthase catalysis

(2010) Stéphane Mouilleron et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Molecular Architecture of aC-3′-Methyltransferase Involved in the Biosynthesis ofd-Tetronitrose

(2010) Nathan A. Bruender et al.   BIOCHEMISTRY

X-ray Structure of KijD3, a Key Enzyme Involved in the Biosynthesis ofd-Kijanose

(2010) Nathan A. Bruender et al.   BIOCHEMISTRY

Molecular Structure of WlbB, a BacterialN-Acetyltransferase Involved in the Biosynthesis of 2,3-Diacetamido-2,3-dideoxy-d-mannuronic Acid,

(2010) James B. Thoden et al.   BIOCHEMISTRY

Structure and Mechanism of ORF36, an Amino Sugar Oxidizing Enzyme in Everninomicin Biosynthesis,

(2010) Jessica L. Vey et al.   BIOCHEMISTRY

Structural Analysis of WbpE fromPseudomonas aeruginosaPAO1: A Nucleotide Sugar Aminotransferase Involved in O-Antigen Assembly,

(2010) Angelyn Larkin et al.   BIOCHEMISTRY

Molecular Architecture of TylM1 fromStreptomyces fradiae: AnN,N-Dimethyltransferase Involved in the Production of dTDP-d-mycaminose,

(2010) Amanda E. Carney et al.   BIOCHEMISTRY

Glycosyltransferases and their Assays

(2010) Gerd K. Wagner et al.   CHEMBIOCHEM

Redesign of Polyene Macrolide Glycosylation: Engineered Biosynthesis of 19-(O)-Perosaminyl- Amphoteronolide B

(2010) Eve Hutchinson et al.   CHEMISTRY & BIOLOGY

Biosynthetic enzymes of unusual microbial sugars

(2010) Hazel M Holden et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Discovery and design of carbohydrate-based therapeutics

(2010) Laura Cipolla et al.   Expert Opinion on Drug Discovery

Carbohydrate mimetics and scaffolds: sweet spots in medicinal chemistry

(2010) Laura Cipolla et al.   Future Medicinal Chemistry

Molecular mechanisms of fosfomycin resistance in clinical isolates of Escherichia coli

(2010) Sho Takahata et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Structural Insights into the Catalytic Mechanism of Bacterial Guanosine-diphospho-d-mannose Pyrophosphorylase and Its Regulation by Divalent Ions

(2010) Marie-Cécile Pelissier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemoenzymatic Synthesis, Inhibition Studies, and X-ray Crystallographic Analysis of the Phosphono Analog of UDP-Galp as an Inhibitor and Mechanistic Probe for UDP-Galactopyranose Mutase

(2010) Sarathy Karunan Partha et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural basis for the reaction mechanism of UDP-glucose pyrophosphorylase

(2010) Hun Kim et al.   MOLECULES AND CELLS

Structural and mechanistic basis for a new mode of glycosyltransferase inhibition

(2010) Thomas Pesnot et al.   Nature Chemical Biology

The crystal structure of the Y140F mutant of ADP-L-glycero-D-manno-heptose 6-epimerase bound to ADP-β-D-mannose suggests a one base mechanism

(2010) Thomas Kowatz et al.   PROTEIN SCIENCE

Structure and function of GlmU fromMycobacterium tuberculosis

(2009) Zhening Zhang et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Structure ofN-acetylglucosamine-1-phosphate uridyltransferase (GlmU) fromMycobacterium tuberculosisin a cubic space group

(2009) Sunil Kumar Verma et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Characterization of CalS9 in the biosynthesis of UDP-xylose and the production of xylosyl-attached hybrid compound

(2009) Dinesh Simkhada et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Structural and Functional Studies of QdtC: AnN-Acetyltransferase Required for the Biosynthesis of dTDP-3-Acetamido-3,6-dideoxy-α-d-glucose†‡

(2009) James B. Thoden et al.   BIOCHEMISTRY

Structural Analysis of QdtB, an Aminotransferase Required for the Biosynthesis of dTDP-3-acetamido-3,6-dideoxy-α-d-glucose†‡

(2009) James B. Thoden et al.   BIOCHEMISTRY

Evidence of Kinetic Control of Ligand Binding and Staged Product Release in MurA (Enolpyruvyl UDP-GlcNAc Synthase)-Catalyzed Reactions,

(2009) Sean G. Jackson et al.   BIOCHEMISTRY

Two Site-Directed Mutations Are Required for the Conversion of a Sugar Dehydratase into an Aminotransferase§

(2009) Paul D. Cook et al.   BIOCHEMISTRY

X-ray Crystallography Reveals a Reduced Substrate Complex of UDP-Galactopyranose Mutase Poised for Covalent Catalysis by Flavin,

(2009) Todd D. Gruber et al.   BIOCHEMISTRY

Chemistry and Biology of Galactofuranose-Containing Polysaccharides

(2009) Michele R. Richards et al.   CHEMBIOCHEM

Structure, mechanism and engineering of plant natural product glycosyltransferases

(2009) Xiaoqiang Wang   FEBS LETTERS

Carbohydrate scaffolds in chemical genetic studies

(2009) Francesco Nicotra et al.   JOURNAL OF BIOTECHNOLOGY

Structural Basis of Substrate Binding to UDP-galactopyranose Mutase: Crystal Structures in the Reduced and Oxidized State Complexed with UDP-galactopyranose and UDP

(2009) Sarathy Karunan Partha et al.   JOURNAL OF MOLECULAR BIOLOGY

Ligand Binding and Substrate Discrimination by UDP-Galactopyranose Mutase

(2009) Todd D. Gruber et al.   JOURNAL OF MOLECULAR BIOLOGY

The Crystal Structure of the Novobiocin Biosynthetic Enzyme NovP: The First Representative Structure for the TylF O-Methyltransferase Superfamily

(2009) Inmaculada Gómez García et al.   JOURNAL OF MOLECULAR BIOLOGY

A bacterial glycosyltransferase gene toolbox: Generation and applications

(2009) Annette Erb et al.   PHYTOCHEMISTRY

Structure-Based Phylogeny as a Diagnostic for Functional Characterization of Proteins with a Cupin Fold

(2009) Garima Agarwal et al.   PLoS One

Natural-Product Sugar Biosynthesis and Enzymatic Glycodiversification

(2008) Christopher J. Thibodeaux et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Accommodation of GDP-Linked Sugars in the Active Site of GDP-Perosamine Synthase†,‡

(2008) Paul D. Cook et al.   BIOCHEMISTRY

Structure and Mutagenic Conversion of E1Dehydrase: At the Crossroads of Dehydration, Amino Transfer, and Epimerization†‡

(2008) Peter Smith et al.   BIOCHEMISTRY

Structure and Active Site Residues of PglD, anN-Acetyltransferase from the Bacillosamine Synthetic Pathway Required forN-Glycan Synthesis inCampylobacter jejuni†,‡

(2008) Erumbi S. Rangarajan et al.   BIOCHEMISTRY

Three-Dimensional Structure of DesVI fromStreptomyces venezuelae: A SugarN,N-Dimethyltransferase Required for dTDP-Desosamine Biosynthesis†‡

(2008) E. Sethe Burgie et al.   BIOCHEMISTRY

Structural Analysis of ADP-Glucose Pyrophosphorylase from the BacteriumAgrobacterium tumefaciens†,‡

(2008) Jill R. Cupp-Vickery et al.   BIOCHEMISTRY

GDP-Perosamine Synthase: Structural Analysis and Production of a Novel Trideoxysugar†,‡

(2008) Paul D. Cook et al.   BIOCHEMISTRY

Recent knowledge and innovations related to hexofuranosides: structure, synthesis and applications

(2008) Pauline Peltier et al.   CARBOHYDRATE RESEARCH

The impact of enzyme engineering upon natural product glycodiversification

(2008) Gavin J Williams et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteria

(2008) Shannon C Timmons et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Glycosyltransferases, Important Tools for Drug Design

(2008) Andriy Luzhetskyy et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A structural basis for the allosteric regulation of non-hydrolysing UDP-GlcNAc 2-epimerases

(2008) Lucas M Velloso et al.   EMBO REPORTS

Crystal Structure and Catalytic Mechanism of PglD fromCampylobacter jejuni

(2008) Nelson B. Olivier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and Mechanism of the Rebeccamycin Sugar 4′-O-Methyltransferase RebM

(2008) Shanteri Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Unifying Nitrososynthase Involved in Nitrosugar Biosynthesis

(2008) Yunfeng Hu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Characterization of CalE10, theN-Oxidase Involved in Calicheamicin Hydroxyaminosugar Formation

(2008) Heather D. Johnson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Investigation of Binding of UDP-Galfand UDP-[3-F]Galfto UDP-galactopyranose Mutase by STD-NMR Spectroscopy, Molecular Dynamics, and CORCEMA-ST Calculations†

(2008) Yue Yuan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Crystal structure of UDP-N-acetylglucosamine enolpyruvyl transferase fromHaemophilus influenzae in complex with UDP-N-acetylglucosamine and fosfomycin

(2008) Hye-Jin Yoon et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Evolutionarily conserved regions and hydrophobic contacts at the superfamily level: The case of the fold-type I, pyridoxal-5′-phosphate-dependent enzymes

(2004) Alessandro Paiardini et al.   PROTEIN SCIENCE