Recent progress in neuroactive marine natural products

Translocation of PKC by Yessotoxin in an in Vitro Model of Alzheimer’s Disease with Improvement of Tau and β-Amyloid Pathology

(2013) Eva Alonso et al.   ACS Chemical Neuroscience

Systemic Kappa Opioid Receptor Agonists in the Treatment of Chronic Pruritus: A Literature Review

(2013) N Phan et al.   ACTA DERMATO-VENEREOLOGICA

Manzamine A, a marine-derived alkaloid, inhibits accumulation of cholesterol ester in macrophages and suppresses hyperlipidemia and atherosclerosis in vivo

(2013) Keisuke Eguchi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Australian marine sponge alkaloids as a new class of glycine-gated chloride channel receptor modulator

(2013) Walter Balansa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Kinase Inhibitors of Marine Origin

(2013) Sandip B. Bharate et al.   CHEMICAL REVIEWS

The ladder-shaped polyether toxin gambierol anchors the gating machinery of Kv3.1 channels in the resting state

(2013) Ivan Kopljar et al.   JOURNAL OF GENERAL PHYSIOLOGY

Studies on an (S)-2-Amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic Acid (AMPA) Receptor Antagonist IKM-159: Asymmetric Synthesis, Neuroactivity, and Structural Characterization

(2013) Lina Juknaitė et al.   JOURNAL OF MEDICINAL CHEMISTRY

An Overview on the Marine Neurotoxin, Saxitoxin: Genetics, Molecular Targets, Methods of Detection and Ecological Functions

(2013) Kathleen Cusick et al.   Marine Drugs

Identification of a  -  opioid receptor heteromer-biased agonist with antinociceptive activity

(2013) I. Gomes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Total Synthesis and Biological Evaluation of Phidianidines A and B Uncovers Unique Pharmacological Profiles at CNS Targets

(2012) John T. Brogan et al.   ACS Chemical Neuroscience

Structure of a tetrameric galectin fromCinachyrellasp. (ball sponge)

(2012) Douglas M. Freymann et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Manzamines

(2012) Mona Radwan et al.   CELL CYCLE

Marine Cyanobacterial Fatty Acid Amides Acting on Cannabinoid Receptors

(2012) Rana Montaser et al.   CHEMBIOCHEM

Effect of Gambierol and Its Tetracyclic and Heptacyclic Analogues in Cultured Cerebellar Neurons: A Structure–Activity Relationships Study

(2012) Sheila Pérez et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Differential Effects of Crambescins and Crambescidin 816 in Voltage-Gated Sodium, Potassium and Calcium Channels in Neurons

(2012) Víctor Martín et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Fluorescent Saxitoxins for Live Cell Imaging of Single Voltage-Gated Sodium Ion Channels beyond the Optical Diffraction Limit

(2012) Alison E. Ondrus et al.   CHEMISTRY & BIOLOGY

The Chemistry and Biology of the Bryostatins: Potential PKC Inhibitors in Clinical Development

(2012) B.-F. Ruan et al.   CURRENT MEDICINAL CHEMISTRY

Evidence for a new binding mode to GSK-3: Allosteric regulation by the marine compound palinurin

(2012) Axel Bidon-Chanal et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Total Syntheses of (-)-α-Kainic Acid

(2012) Christos I. Stathakis et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The action site of the synthetic kainoid (2S,3R,4R)-3-carboxymethyl-4-(4-methylphenylthio)pyrrolidine-2-carboxylic acid (PSPA-4), an analogue of Japanese mushroom poison acromelic acid, for allodynia (tactile pain)

(2012) Shinichiro Miyazaki et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Isolation of novel prototype galectins from the marine ball sponge Cinachyrella sp. guided by their modulatory activity on mammalian glutamate-gated ion channels

(2012) T. Ueda et al.   GLYCOBIOLOGY

Cyanobacterial Peptides as a Prototype for the Design of Potent β-Secretase Inhibitors and the Development of Selective Chemical Probes for Other Aspartic Proteases

(2012) Yanxia Liu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selectivity, Cocrystal Structures, and Neuroprotective Properties of Leucettines, a Family of Protein Kinase Inhibitors Derived from the Marine Sponge Alkaloid Leucettamine B

(2012) Tania Tahtouh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Biosynthetically Intriguing Chlorinated Lipophilic Metabolites from Geographically Distant Tropical Marine Cyanobacteria

(2012) Joshawna K. Nunnery et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and Synthesis of Skeletal Analogues of Gambierol: Attenuation of Amyloid-β and Tau Pathology with Voltage-Gated Potassium Channel and N-Methyl-d-aspartate Receptor Implications

(2012) Eva Alonso et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isolation and Structural Determination of the First 8-epi-type Tetrodotoxin Analogs from the Newt, Cynops ensicauda popei, and Comparison of Tetrodotoxin Analogs Profiles of This Newt and the Puffer Fish, Fugu poecilonotus

(2012) Yuta Kudo et al.   Marine Drugs

Tetrodotoxin (TTX) as a Therapeutic Agent for Pain

(2012) Francisco Rafael Nieto et al.   Marine Drugs

Sea Anemone (Cnidaria, Anthozoa, Actiniaria) Toxins: An Overview

(2012) Bárbara Frazão et al.   Marine Drugs

The chemistry and biology of organic guanidine derivatives

(2012) Roberto G. S. Berlinck et al.   NATURAL PRODUCT REPORTS

Comparison of acetylcholine receptor interactions of the marine toxins, 13-desmethylspirolide C and gymnodimine

(2012) Terry A. Hauser et al.   NEUROPHARMACOLOGY

A search for BACE inhibitors reveals new biosynthetically related pyrrolidones, furanones and pyrroles from a southern Australian marine sponge, Ianthella sp.

(2012) Hua Zhang et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Methodology for the preparation of olive oil open ring secoiridoids

(2012) K Vougogiannopoulou et al.   PLANTA MEDICA

GABA-A Channel Subunit Expression in Human Glioma Correlates with Tumor Histology and Clinical Outcome

(2012) Anja Smits et al.   PLoS One

Marked difference in saxitoxin and tetrodotoxin affinity for the human nociceptive voltage-gated sodium channel (Nav1.7)

(2012) J. R. Walker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synthesis of saxitoxins

(2012) Osamu Iwamoto et al.   PURE AND APPLIED CHEMISTRY

The molecular mystique of tetrodotoxin

(2012) Edward G. Moczydlowski   TOXICON

Additional bioactive guanidine alkaloids from the Mediterranean sponge Crambe crambe

(2012) Stéphanie Bondu et al.   RSC Advances

Total Synthesis of (+)-7-Bromotrypargine and Unnatural Analogues: Biological Evaluation Uncovers Activity at CNS Targets of Therapeutic Relevance

(2011) John T. Brogan et al.   ACS Chemical Neuroscience

Detailed LC-MS/MS Analysis of Ciguatoxins Revealing Distinct Regional and Species Characteristics in Fish and Causative Alga from the Pacific

(2011) Kentaro Yogi et al.   ANALYTICAL CHEMISTRY

A Synthetic Route to the Saxitoxin Skeleton: Synthesis of Decarbamoyl α-Saxitoxinol, an Analogue of Saxitoxin Produced by the Cyanobacterium Lyngbya wollei

(2011) Yusuke Sawayama et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

On the origins and biosynthesis of tetrodotoxin

(2011) Rocky Chau et al.   AQUATIC TOXICOLOGY

Marilones A–C, phthalides from the sponge-derived fungusStachylidiumsp.

(2011) Celso Almeida et al.   Beilstein Journal of Organic Chemistry

Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers

(2011) Eliseu O. De Oliveira et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antillatoxin is a sodium channel activator that displays unique efficacy in heterologously expressed rNav1.2, rNav1.4 and rNav1.5 alpha subunits

(2011) Zhengyu Cao et al.   BMC NEUROSCIENCE

Cyclic Imines: Chemistry and Mechanism of Action: A Review

(2011) Alberto Otero et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Total Synthesis of (−)-Brevenal: A Streamlined Strategy for Practical Synthesis of Polycyclic Ethers

(2011) Makoto Ebine et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Skeletal Analogues of Saxitoxin Derivatives and Evaluation of Their Inhibitory Activity on Sodium Ion Channels NaV1.4 and NaV1.5

(2011) Ryoko Shinohara et al.   CHEMISTRY-A EUROPEAN JOURNAL

A review of pharmacological and toxicological potentials of marine cyanobacterial metabolites

(2011) M. Nagarajan et al.   JOURNAL OF APPLIED TOXICOLOGY

Deconstruction of the α4β2 Nicotinic Acetylcholine Receptor Positive Allosteric Modulator Desformylflustrabromine

(2011) Nadezhda German et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leucettines, a Class of Potent Inhibitors of cdc2-Like Kinases and Dual Specificity, Tyrosine Phosphorylation Regulated Kinases Derived from the Marine Sponge Leucettamine B: Modulation of Alternative Pre-RNA Splicing

(2011) Mansour Debdab et al.   JOURNAL OF MEDICINAL CHEMISTRY

Binding and Selectivity of the Marine Toxin Neodysiherbaine A and Its Synthetic Analogues to GluK1 and GluK2 Kainate Receptors

(2011) Masaki Unno et al.   JOURNAL OF MOLECULAR BIOLOGY

Allosteric Modulator Desformylflustrabromine Relieves the Inhibition of α2β2 and α4β2 Nicotinic Acetylcholine Receptors by β-Amyloid1–42 Peptide

(2011) Anshul Pandya et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Two Brominated Cyclic Dipeptides Released by the Coldwater Marine SpongeGeodia barrettiAct in Synergy As Chemical Defense

(2011) Martin Sjögren et al.   JOURNAL OF NATURAL PRODUCTS

Bunodosine 391: An Analgesic Acylamino Acid from the Venom of the Sea AnemoneBunodosoma cangicum

(2011) André J. Zaharenko et al.   JOURNAL OF NATURAL PRODUCTS

Cannabinomimetic Lipid from a Marine Cyanobacterium

(2011) Marcelino Gutiérrez et al.   JOURNAL OF NATURAL PRODUCTS

Synthesis and Biological Activity of Kalkitoxin and its Analogues

(2011) Taiki Umezawa et al.   JOURNAL OF ORGANIC CHEMISTRY

A Stereocontrolled Synthesis of (+)-Saxitoxin

(2011) Vasudev R. Bhonde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of Brevenal

(2011) Yuan Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Total Synthesis of the Spirocyclic Imine Marine Toxin (−)-Gymnodimine and an Unnatural C4-Epimer

(2011) Ke Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Tetrodotoxin as a Tool to Elucidate Sensory Transduction Mechanisms: The Case for the Arterial Chemoreceptors of the Carotid Body

(2011) Asuncion Rocher et al.   Marine Drugs

Gustatory Detection of Tetrodotoxin and Saxitoxin, and Its Competitive Inhibition by Quinine and Strychnine in Freshwater Fishes

(2011) Toshiaki J. Hara   Marine Drugs

Analytical Challenges: Determination of Tetrodotoxin in Human Urine and Plasma by LC-MS/MS

(2011) Kelvin Sze-Yin Leung et al.   Marine Drugs

The Chemical Synthesis of Tetrodoxin: An Ongoing Quest

(2011) Jaclyn Chau et al.   Marine Drugs

Neuroprotection by marine-derived compound, 11-dehydrosinulariolide, in an in vitro Parkinson’s model: a promising candidate for the treatment of Parkinson’s disease

(2011) Wu-Fu Chen et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

(2011) Eva Alonso et al.   NEUROCHEMISTRY INTERNATIONAL

3,4′-Linked bis(piperidines) related to the haliclonacyclamine class of marine alkaloids: synthesis using crossed-aldol chemistry and preliminary biological evaluations

(2011) Martin G. Banwell et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structure and Cytotoxicity of Phidianidines A and B: First Finding of 1,2,4-Oxadiazole System in a Marine Natural Product

(2011) Marianna Carbone et al.   ORGANIC LETTERS

Antinociceptive effects of MSVIII-19, a functional antagonist of the GluK1 kainate receptor

(2011) Chang-Shen Qiu et al.   PAIN

Synthesis and biological evaluation of triazole analogues of antillatoxin

(2011) Ryosuke Goto et al.   TETRAHEDRON

Immunoregulatory potential of marine algal toxins yessotoxin and okadaic acid in mouse T lymphocyte cell line EL-4

(2011) Alicia Martín López et al.   TOXICOLOGY LETTERS

Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases

(2011) Victor Chi et al.   TOXICON

Cdk5: a multifaceted kinase in neurodegenerative diseases

(2011) Zelda H. Cheung et al.   TRENDS IN CELL BIOLOGY

Effects of Spider Venom Toxin PWTX-I (6-Hydroxytrypargine) on the Central Nervous System of Rats

(2011) Lilian M. M. Cesar-Tognoli et al.   Toxins

Investigations into the Toxicology of Spirolides, a Group of Marine Phycotoxins

(2011) Rex Munday et al.   Toxins

Neurotoxins and Their Binding Areas on Voltage-Gated Sodium Channels

(2011) Marijke Stevens et al.   Frontiers in Pharmacology

Synthesis and structure–affinity relationships of novel small molecule natural product derivatives capable of discriminating between serotonin 5-HT1A, 5-HT2A, 5-HT2C receptor subtypes

(2010) David F. Cummings et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Improved synthesis and in vitro/in vivo activities of natural product-inspired, artificial glutamate analogs

(2010) Masato Oikawa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ircinialactams: Subunit-selective glycine receptor modulators from Australian sponges of the family Irciniidae

(2010) Walter Balansa et al.   BIOORGANIC & MEDICINAL CHEMISTRY

9.3 KDa components of the injected venom of Conus purpurascens define a new five-disulfide conotoxin framework

(2010) Carolina Möller et al.   BIOPOLYMERS

A series of structurally novel heterotricyclic α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate receptor-selective antagonists

(2010) MB Gill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Marine Indole Alkaloids: Potential New Drug Leads for the Control of Depression and Anxiety

(2010) Anna J. Kochanowska-Karamyan et al.   CHEMICAL REVIEWS

New Methods to Explore Marine Resources for Alzheimers Therapeutics

(2010) P. Williams et al.   Current Alzheimer Research

NovelN-Methylated 8-Oxoisoguanines from Pacific Sponges with Diverse Neuroactivities

(2010) Tsuyoshi Sakurada et al.   JOURNAL OF MEDICINAL CHEMISTRY

A Bastadin with Potent and Selective δ-Opioid Receptor Binding Affinity from the Australian SpongeIanthella flabelliformis

(2010) Anthony R. Carroll et al.   JOURNAL OF NATURAL PRODUCTS

Xestosaprols from the Indonesian Marine SpongeXestospongiasp.

(2010) Jingqiu Dai et al.   JOURNAL OF NATURAL PRODUCTS

The Hoiamides, Structurally Intriguing Neurotoxic Lipopeptides from Papua New Guinea Marine Cyanobacteria

(2010) Hyukjae Choi et al.   JOURNAL OF NATURAL PRODUCTS

Pharmacological Characterization of the Allosteric Modulator Desformylflustrabromine and Its Interaction with  4 2 Neuronal Nicotinic Acetylcholine Receptor Orthosteric Ligands

(2010) M. M. Weltzin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Tetrodotoxin Receptor of Voltage-Gated Sodium Channels—Perspectives from Interactions with μ-Conotoxins

(2010) Robert J. French et al.   Marine Drugs

The Chemical and Evolutionary Ecology of Tetrodotoxin (TTX) Toxicity in Terrestrial Vertebrates

(2010) Charles T. Hanifin   Marine Drugs

LC/MS Analysis of Tetrodotoxin and Its Deoxy Analogs in the Marine Puffer Fish Fugu niphobles from the Southern Coast of Korea, and in the Brackishwater Puffer Fishes Tetraodon nigroviridis and Tetraodon biocellatus from Southeast Asia

(2010) Jun-Ho Jang et al.   Marine Drugs

On the Chemistry, Toxicology and Genetics of the Cyanobacterial Toxins, Microcystin, Nodularin, Saxitoxin and Cylindrospermopsin

(2010) Leanne Pearson et al.   Marine Drugs

Neurotoxic Alkaloids: Saxitoxin and Its Analogs

(2010) Maria Wiese et al.   Marine Drugs

The Tetrodotoxin Binding Site Is within the Outer Vestibule of the Sodium Channel

(2010) Harry A. Fozzard et al.   Marine Drugs

Bryostatin 1 Inhibits Phorbol Ester-Induced Apoptosis in Prostate Cancer Cells by Differentially Modulating Protein Kinase C (PKC)   Translocation and Preventing PKC -Mediated Release of Tumor Necrosis Factor- 

(2010) V. A. von Burstin et al.   MOLECULAR PHARMACOLOGY

Ciguatoxin: developing the methodology for total synthesis

(2010) Minoru Isobe et al.   NATURAL PRODUCT REPORTS

The chemistry and biology of organic guanidine derivatives

(2010) Roberto G. S. Berlinck et al.   NATURAL PRODUCT REPORTS

Spiroimine shellfish poisoning (SSP) and the spirolide family of shellfish toxins: Isolation, structure, biological activity and synthesis

(2010) Stéphanie M. Guéret et al.   NATURAL PRODUCT REPORTS

Total Synthesis of (+)-Decarbamoylsaxitoxin and (+)-Gonyautoxin 3

(2010) Osamu Iwamoto et al.   ORGANIC LETTERS

Palmyrolide A, an Unusually Stabilized Neuroactive Macrolide from Palmyra Atoll Cyanobacteria

(2010) Alban R. Pereira et al.   ORGANIC LETTERS

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

(2010) Y. Bourne et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycine and glycine receptor signaling in hippocampal neurons: Diversity, function and regulation

(2010) Tian-Le Xu et al.   PROGRESS IN NEUROBIOLOGY

Synthesis and bioactivity of (±)-tetrahydrohaliclonacyclamine A

(2010) Brian J. Smith et al.   TETRAHEDRON

Enantioselective Total Synthesis of the Marine Toxin (−)-Gymnodimine Employing a Barbier-Type Macrocyclization

(2009) Ke Kong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Twisted Side Chain of Antillatoxin is Important for Potent Toxicity: Total Synthesis and Biological Evaluation of Antillatoxin and Analogues

(2009) Ken Okura et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

(−)-Dibromophakellin: An α2B adrenoceptor agonist isolated from the Australian marine sponge, Acanthella costata

(2009) Rohan A. Davis et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A novel class of H3 antagonists derived from the natural product guided synthesis of unnatural analogs of the marine bromopyrrole alkaloid dispyrin

(2009) J. Phillip Kennedy et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Drugs from slugs—Past, present and future perspectives of ω-conotoxin research

(2009) Jon-Paul Bingham et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Hoiamide A, a Sodium Channel Activator of Unusual Architecture from a Consortium of Two Papua New Guinea Cyanobacteria

(2009) Alban Pereira et al.   CHEMISTRY & BIOLOGY

A Novel Conus Snail Polypeptide Causes Excitotoxicity by Blocking Desensitization of AMPA Receptors

(2009) Craig S. Walker et al.   CURRENT BIOLOGY

Regioselective Domino Metathesis of Unsymmetrical 7-Oxanorbornenes with Electron-Rich Vinyl Acetate toward Biologically Active Glutamate Analogues

(2009) Masato Oikawa et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Halichlorine is a novel L-type Ca2+ channel inhibitor isolated from the marine sponge Halichondria okadai Kadota

(2009) Yoshiki Tsubosaka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Full Domain Closure of the Ligand-binding Core of the Ionotropic Glutamate Receptor iGluR5 Induced by the High Affinity Agonist Dysiherbaine and the Functional Antagonist 8,9-Dideoxyneodysiherbaine

(2009) Karla Frydenvang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure−Activity Relationship and Mechanism of Action Studies of Manzamine Analogues for the Control of Neuroinflammation and Cerebral Infections

(2009) Jiangnan Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Carteriosulfonic Acids A−C, GSK-3β Inhibitors from aCarteriospongiasp.

(2009) Malcolm W. B. McCulloch et al.   JOURNAL OF NATURAL PRODUCTS

Palmyramide A, a Cyclic Depsipeptide from a Palmyra Atoll Collection of the Marine CyanobacteriumLyngbya majuscula†

(2009) Masatoshi Taniguchi et al.   JOURNAL OF NATURAL PRODUCTS

Aplysinopsins - Marine Indole Alkaloids: Chemistry, Bioactivity and Ecological Significance

(2009) Dobroslawa Bialonska et al.   Marine Drugs

Conotoxins: natural product drug leads

(2009) Reena Halai et al.   NATURAL PRODUCT REPORTS

A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo

(2009) L. Serenó et al.   NEUROBIOLOGY OF DISEASE

Pharmacological activity of C10-substituted analogs of the high-affinity kainate receptor agonist dysiherbaine

(2009) L. Leanne Lash-Van Wyhe et al.   NEUROPHARMACOLOGY

Exploring kainate receptor pharmacology using molecular dynamics simulations

(2009) Pekka A. Postila et al.   NEUROPHARMACOLOGY

Potentiation of Local Anesthetic Activity of Neosaxitoxin with Bupivacaine or Epinephrine: Development of a Long-Acting Pain Blocker

(2009) Alberto J. Rodriguez-Navarro et al.   NEUROTOXICITY RESEARCH

Total Synthesis of Brevenal

(2009) Hiroyoshi Takamura et al.   ORGANIC LETTERS

A polyether biotoxin binding site on the lipid-exposed face of the pore domain of Kv channels revealed by the marine toxin gambierol

(2009) I. Kopljar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

(+)-7-Bromotrypargine: an antimalarial β-carboline from the Australian marine sponge Ancorina sp.

(2009) Rohan A. Davis et al.   TETRAHEDRON LETTERS

Synthesis of bifunctional saxitoxin analogues by biotinylation

(2009) Cedric Robillot et al.   TOXICON

Actions of octocoral and tobacco cembranoids on nicotinic receptors

(2009) P.A. Ferchmin et al.   TOXICON

Ciguatera: A public health perspective

(2009) Robert W. Dickey et al.   TOXICON

Paralytic shellfish poisoning: Seafood safety and human health perspectives

(2009) Stacey M. Etheridge   TOXICON

Dinoflagellate polyether within the yessotoxin, pectenotoxin and okadaic acid toxin groups: Characterization, analysis and human health implications

(2009) Humberto J. Dominguez et al.   TOXICON

Neurotoxic cyanobacterial toxins

(2009) Rómulo Aráoz et al.   TOXICON

The Continuing Saga of the Marine Polyether Biotoxins

(2008) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The histamine H3receptor: an attractive target for the treatment of cognitive disorders

(2008) T A Esbenshade et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cellular Origin of Dysiherbaine, an Excitatory Amino Acid Derived from a Marine Sponge

(2008) Ryuichi Sakai et al.   CHEMBIOCHEM

Total Synthesis of (−)- and (+)-Decarbamoyloxysaxitoxin and (+)-Saxitoxin

(2008) Osamu Iwamoto et al.   Chemistry-An Asian Journal

Regioselective Domino Metathesis of 7-Oxanorbornenes and Its Application to the Synthesis of Biologically Active Glutamate Analogues

(2008) Minoru Ikoma et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Total Synthesis and Biological Evaluation of the Marine Bromopyrrole Alkaloid Dispyrin: Elucidation of Discrete Molecular Targets with Therapeutic Potential

(2008) J. Phillip Kennedy et al.   JOURNAL OF NATURAL PRODUCTS

Secondary Metabolites from Three Florida Sponges with Antidepressant Activity

(2008) Anna J. Kochanowska et al.   JOURNAL OF NATURAL PRODUCTS

Tetrodotoxin for Moderate to Severe Cancer Pain: A Randomized, Double Blind, Parallel Design Multicenter Study

(2008) Neil A. Hagen et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Lorcaserin, a Novel Selective Human 5-Hydroxytryptamine2C Agonist: in Vitro and in Vivo Pharmacological Characterization

(2008) W. J. Thomsen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Design and Synthesis of Ladder-Shaped Tetracyclic, Heptacyclic, and Decacyclic Ethers and Evaluation of the Interaction with Transmembrane Proteins

(2008) Kohei Torikai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Neurotoxic Shellfish Poisoning

(2008) Sharon Watkins et al.   Marine Drugs

Neurotoxins from Marine Dinoflagellates: A Brief Review

(2008) Da-Zhi Wang   Marine Drugs

Ciguatera Fish Poisoning: Treatment, Prevention and Management

(2008) Melissa Friedman et al.   Marine Drugs

Anticancer Alkaloid Lamellarins Inhibit Protein Kinases

(2008) Dianne Baunbæk et al.   Marine Drugs

Tetrodotoxin – Distribution and Accumulation in Aquatic Organisms, and Cases of Human Intoxication

(2008) Tamao Noguchi   Marine Drugs

Native glycine receptor subtypes and their physiological roles

(2008) Joseph W. Lynch   NEUROPHARMACOLOGY

Total Synthesis of (−)-Brevenal: A Concise Synthetic Entry to the Pentacyclic Polyether Core

(2008) Makoto Ebine et al.   ORGANIC LETTERS

Tetrodotoxin

(2008) Toshio NARAHASHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Gambierol, a toxin produced by the dinoflagellate Gambierdiscus toxicus, is a potent blocker of voltage-gated potassium channels

(2008) Eva Cuypers et al.   TOXICON

Mechanisms of potentiation of the mammalian GABAAreceptor by the marine cembranoid eupalmerin acetate

(2007) P Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rapid and Efficient Synthesis of Dysiherbaine and Analogues to Explore Structure−Activity Relationships

(2007) Makoto Sasaki et al.   JOURNAL OF ORGANIC CHEMISTRY

Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice

(2007) Francisco Rafael Nieto et al.   PAIN

Identification of antidepressant drug leads through the evaluation of marine natural products with neuropsychiatric pharmacophores

(2007) Jeffrey A. Diers et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR