Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds

Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non-Native Aromatic Products

(2013) Anna L. Vagstad et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Embellicines A and B: Absolute Configuration and NF-κB Transcriptional Inhibitory Activity

(2013) Weaam Ebrahim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Case Study of Empirical and Computational Chemical Shift Analyses: Reassignment of the Relative Configuration of Phomopsichalasin to That of Diaporthichalasin

(2012) Susan G. Brown et al.   JOURNAL OF NATURAL PRODUCTS

Navigating the Fungal Polyketide Chemical Space: From Genes to Molecules

(2012) Yit-Heng Chooi et al.   JOURNAL OF ORGANIC CHEMISTRY

Strained cyclophane natural products: Macrocyclization at its limits

(2012) Tanja Gulder et al.   NATURAL PRODUCT REPORTS

Explorations of catalytic domains in non-ribosomal peptide synthetase enzymology

(2012) Gene H. Hur et al.   NATURAL PRODUCT REPORTS

The structures of type I polyketide synthases

(2012) Adrian T. Keatinge-Clay   NATURAL PRODUCT REPORTS

A fungal ketoreductase domain that displays substrate-dependent stereospecificity

(2012) Hui Zhou et al.   Nature Chemical Biology

Phorone A and Isophorbasone A, Sesterterpenoids Isolated from the Marine Sponge Phorbas sp.

(2012) Weihong Wang et al.   ORGANIC LETTERS

A “Diels-Alderase” at Last

(2011) Craig A. Townsend   CHEMBIOCHEM

Synthesis of Naturally Occurring Cyclohexene Rings Using Stereodirected Intramolecular Diels-Alder Reactions Through Asymmetric 1,3-Dioxane Tethering

(2011) Hajer Abdelkafi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

GKK1032A2, a secondary metabolite from Penicillium sp. IBWF-029-96, inhibits conidial germination in the rice blast fungus Magnaporthe oryzae

(2011) Jens Becker et al.   JOURNAL OF ANTIBIOTICS

Rational Domain Swaps Decipher Programming in Fungal Highly Reducing Polyketide Synthases and Resurrect an Extinct Metabolite

(2011) Katja M. Fisch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioinspired Synthesis of Hirsutellones A, B, and C

(2011) K. C. Nicolaou et al.   ORGANIC LETTERS

Total Synthesis of Hirsutellone B via Ullmann-Type Direct 13-Membered Macrocyclization

(2011) Hiromi Uchiro et al.   ORGANIC LETTERS

A dimeric pyrrocidine from Neonectria ramulariae is an inhibitor of prolyl oligopeptidase

(2011) Yoshihito Shiono et al.   Phytochemistry Letters

Synthetic studies of GKK1032s: the asymmetric synthesis of the decahydrofluorene skeleton via a novel cyclization of silyl enol ether and sequential retro Diels–Alder and intramolecular Diels–Alder reactions

(2011) Hiromi Uchiro et al.   TETRAHEDRON LETTERS

Occurrence of pyrrocidine and dihydroresorcylide production amongAcremonium zeaepopulations from maize grown in different regions

(2010) Donald T. Wicklow et al.   CANADIAN JOURNAL OF PLANT PATHOLOGY

Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in Vitro and inSaccharomyces cerevisiae

(2010) Wei Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

New insights into the formation of fungal aromatic polyketides

(2010) Jason M. Crawford et al.   NATURE REVIEWS MICROBIOLOGY

Construction of the Cyclophane Core of the Hirsutellones via a RCM Strategy§

(2010) Mingzheng Huang et al.   ORGANIC LETTERS

Stereoselective synthesis of the decahydrofluorene core of the hirsutellones

(2010) Geoff T. Halvorsen et al.   TETRAHEDRON LETTERS

Total Synthesis of Hirsutellone B

(2009) K. C. Nicolaou et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chemistry and biology of non-tetramic γ-hydroxy-γ-lactams and γ-alkylidene-γ-lactams from natural sources

(2009) Bastien Nay et al.   NATURAL PRODUCT REPORTS

Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization

(2009) Jason M. Crawford et al.   NATURE

A Rapid, Asymmetric Synthesis of the Decahydrofluorene Core of the Hirsutellones

(2009) S. David Tilley et al.   ORGANIC LETTERS

Studies toward the total synthesis of the hirsutellones

(2009) Mingzheng Huang et al.   TETRAHEDRON LETTERS

Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246

(2008) Yoshihito Shiono et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Authentic Heterologous Expression of the Tenellin Iterative Polyketide Synthase Nonribosomal Peptide Synthetase Requires Coexpression with an Enoyl Reductase

(2008) Laura M. Halo et al.   CHEMBIOCHEM

Thioesterase-Like Role for Fungal PKS-NRPS Hybrid Reductive Domains

(2008) James W. Sims et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Late Stage Oxidations during the Biosynthesis of the 2-Pyridone Tenellin in the Entomopathogenic FungusBeauveria bassiana

(2008) Laura M. Halo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Modification of culture conditions for production of the anti-tubercular hirsutellones by the insect pathogenic fungusHirsutella niveaBCC 2594

(2008) S. Madla et al.   LETTERS IN APPLIED MICROBIOLOGY

Intramolecular cyclizations of polyketide biosynthesis: mining for a “Diels–Alderase”?

(2008) Wendy L. Kelly   ORGANIC & BIOMOLECULAR CHEMISTRY

Antimicrobial Activity of Pyrrocidines fromAcremonium zeaeAgainst Endophytes and Pathogens of Maize

(2008) Donald T. Wicklow et al.   PHYTOPATHOLOGY

The Crystal Structure of a Mammalian Fatty Acid Synthase

(2008) T. Maier et al.   SCIENCE

Deconstruction of Iterative Multidomain Polyketide Synthase Function

(2008) J. M. Crawford et al.   SCIENCE