Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms
出版年份 2012 全文链接
标题
Triptolide: structural modifications, structure–activity relationships, bioactivities, clinical development and mechanisms
作者
关键词
-
出版物
NATURAL PRODUCT REPORTS
Volume 29, Issue 4, Pages 457
出版商
Royal Society of Chemistry (RSC)
发表日期
2012-01-24
DOI
10.1039/c2np00088a
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Derivatization of (5R)-hydroxytriptolide from benzylamine to enhance mass spectrometric detection: Application to a Phase I pharmacokinetic study in humans
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- Triptolide augments the effects of 5-lipoxygenase RNA interference in suppressing pancreatic tumor growth in a xenograft mouse model
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- Triptolide Directly Inhibits dCTP Pyrophosphatase
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- Complexity of dendritic cell subsets and their function in the host immune system
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- Triptolide and its expanding multiple pharmacological functions
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- MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML
- (2011) B Z Carter et al. LEUKEMIA
- XPB, a subunit of TFIIH, is a target of the natural product triptolide
- (2011) Denis V Titov et al. Nature Chemical Biology
- Total synthesis of novel D-ring-modified triptolide analogues: structure–cytotoxic activity relationship studies on the D-ring of triptolide
- (2011) Bing Zhou et al. ORGANIC & BIOMOLECULAR CHEMISTRY
- Triptolide (TPL) Inhibits Global Transcription by Inducing Proteasome-Dependent Degradation of RNA Polymerase II (Pol II)
- (2011) Ying Wang et al. PLoS One
- Effects of triptolide on RIZ1 expression, proliferation and apoptosis in multiple myeloma U266 cells
- (2010) Fei Zhao et al. ACTA PHARMACOLOGICA SINICA
- Design, synthesis, and biological evaluation of novel water-soluble triptolide derivatives: Antineoplastic activity against imatinib-resistant CML cells bearing T315I mutant Bcr-Abl
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- Synthesis and biological evaluation of novel triptolide analogues for anticancer activity
- (2010) Bing Zhou et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells
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- RETRACTED: Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells
- (2010) Haili Li et al. CANCER LETTERS
- RNA polymerase – An important molecular target of triptolide in cancer cells
- (2010) Jingxuan Pan CANCER LETTERS
- Diastereoselective formal total synthesis of (±)-triptolide via a novel cationic cyclization of 2-alkenyl-1,3-dithiolane
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- Report of 12 cases of ankylosing spondylitis patients treated with Tripterygium wilfordii
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- Role of triptolide in cell proliferation, cell cycle arrest, apoptosis and histone methylation in multiple myeloma U266 cells
- (2010) Fei Zhao et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways
- (2010) Nameeta Mujumdar et al. GASTROENTEROLOGY
- Triptolide promotes spinal cord repair by inhibiting astrogliosis and inflammation
- (2010) Zhida Su et al. GLIA
- Meta-Analysis of Tripterygium Wilfordii Hook F in the Immunosuppressive Treatment of IgA Nephropathy
- (2010) Yi-Zhi Chen et al. INTERNAL MEDICINE
- Triptolide and TRAIL Combination Enhances Apoptosis in Cholangiocarcinoma
- (2010) Kimberly A. Clawson et al. JOURNAL OF SURGICAL RESEARCH
- Triptolide reduces proteinuria in experimental membranous nephropathy and protects against C5b-9-induced podocyte injury in vitro
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- Increased accumulation of hypoxia-inducible factor-1α with reduced transcriptional activity mediates the antitumor effect of triptolide
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- Triptolide ameliorates IL-10-deficient mice colitis by mechanisms involving suppression of IL-6/STAT3 signaling pathway and down-regulation of IL-17
- (2010) Yi Li et al. MOLECULAR IMMUNOLOGY
- Triptolide reduces cyst formation in a neonatal to adult transition Pkd1 model of ADPKD
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- Efficient synthesis of the key intermediate triptophenolide methyl ether for the synthesis of (−)-triptolide
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- Triptolide inhibits Jak2 transcription and induces apoptosis in human myeloproliferative disorder cells bearing Jak2V617F through caspase-3-mediated cleavage of Mcl-1
- (2009) Qi Chen et al. CANCER LETTERS
- Triptolide Inhibits Bcr-Abl Transcription and Induces Apoptosis in STI571-resistant Chronic Myelogenous Leukemia Cells Harboring T315I Mutation
- (2009) X. Shi et al. CLINICAL CANCER RESEARCH
- Phase I dose-escalation study of F60008, a novel apoptosis inducer, in patients with advanced solid tumours
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- Alternative activation of macrophages: Immune function and cellular biology
- (2009) Audrey Varin et al. IMMUNOBIOLOGY
- Design and Synthesis of Novel C14-Hydroxyl Substituted Triptolide Derivatives as Potential Selective Antitumor Agents
- (2009) Zheng Li et al. JOURNAL OF MEDICINAL CHEMISTRY
- Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex
- (2009) Pablo Kizelsztein et al. JOURNAL OF NEUROIMMUNOLOGY
- Triptolide is an inhibitor of RNA polymerase I and II-dependent transcription leading predominantly to down-regulation of short-lived mRNA
- (2009) S. Vispe et al. MOLECULAR CANCER THERAPEUTICS
- A Small-Molecule Triptolide Suppresses Angiogenesis and Invasion of Human Anaplastic Thyroid Carcinoma Cells via Down-Regulation of the Nuclear Factor- B Pathway
- (2009) W. Zhu et al. MOLECULAR PHARMACOLOGY
- Triptolide exerts anti-tumor effect on oral cancer and KB cells in vitro and in vivo
- (2009) Yuan-Wu Chen et al. ORAL ONCOLOGY
- Effects of triptolide from Tripterygium wilfordii on ERα and p53 expression in two human breast cancer cell lines
- (2009) Jing Liu et al. PHYTOMEDICINE
- Triptolide therapy for neuroblastoma decreases cell viability in vitro and inhibits tumor growth in vivo
- (2009) Mara B. Antonoff et al. SURGERY
- Triptolide alters histone H3K9 and H3K27 methylation state and induces G0/G1 arrest and caspase-dependent apoptosis in multiple myeloma in vitro
- (2009) Fei Zhao et al. TOXICOLOGY
- Anti-angiogenic activity of triptolide in anaplastic thyroid carcinoma is mediated by targeting vascular endothelial and tumor cells
- (2009) Wenbo Zhu et al. VASCULAR PHARMACOLOGY
- Effects of triptolide from Radix Tripterygium wilfordii (Leigongteng) on cartilage cytokines and transcription factor NF-κB: a study on induced arthritis in rats
- (2009) Cheng Xiao et al. Chinese Medicine
- Effective therapy for nephritis in (NZB × NZW)F1 mice with triptolide and tripdiolide, the principal active components of the Chinese herbal remedyTripterygium wilfordii Hook F
- (2008) Xuelian Tao et al. ARTHRITIS AND RHEUMATISM
- Fluorination of triptolide and its analogues and their cytotoxicity
- (2008) Yutaka Aoyagi et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Triptolide sensitizes AML cells to TRAIL-induced apoptosis via decrease of XIAP and p53-mediated increase of DR5
- (2008) B. Z. Carter et al. BLOOD
- Triptolide-Induced Transcriptional Arrest Is Associated with Changes in Nuclear Substructure
- (2008) S. J. Leuenroth et al. CANCER RESEARCH
- Formal total synthesis of triptolide
- (2008) Natalie A. Miller et al. CHEMICAL COMMUNICATIONS
- The suppressive effect of triptolide on chronic colitis and TNF-α/TNFR2 signal pathway in interleukin-10 deficient mice
- (2008) Xiaowei Wei et al. CLINICAL IMMUNOLOGY
- Differential effects of triptolide and tetrandrine on activation of COX-2, NF-κB, and AP-1 and virus production in dengue virus-infected human lung cells
- (2008) Jun-Ting Liou et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Inhibitory effect of triptolide on interleukin-18 and its receptor in rheumatoid arthritis synovial fibroblasts
- (2008) Y. Lu et al. INFLAMMATION RESEARCH
- Antiangiogenic activity of Tripterygium wilfordii and its terpenoids
- (2008) Ming-Fang He et al. JOURNAL OF ETHNOPHARMACOLOGY
- Triptolide modulates T-cell inflammatory responses and ameliorates experimental autoimmune encephalomyelitis
- (2008) Ying Wang et al. JOURNAL OF NEUROSCIENCE RESEARCH
- Triptolide Reduces Cystogenesis in a Model of ADPKD
- (2008) S. J. Leuenroth et al. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
- Triptolide Inhibits the Differentiation of Th17 cells and Suppresses Collagen-induced Arthritis
- (2008) Y. Wang et al. SCANDINAVIAN JOURNAL OF IMMUNOLOGY
- Prolongation of Rat Intestinal Allograft Survival by Administration of Triptolide-Modified Donor Bone Marrow-Derived Dendritic Cells
- (2008) T. Chen et al. TRANSPLANTATION PROCEEDINGS
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