Structure and noncanonical chemistry of nonribosomal peptide biosynthetic machinery

Ribosome-independent biosynthesis of biologically active peptides: Application of synthetic biology to generate structural diversity

(2012) Tobias W. Giessen et al.   FEBS LETTERS

Biosynthesis of Himastatin: Assembly Line and Characterization of Three Cytochrome P450 Enzymes Involved in the Post-tailoring Oxidative Steps

(2011) Junying Ma et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Four-Enzyme Pathway for 3,5-Dihydroxy-4-methylanthranilic Acid Formation and Incorporation into the Antitumor Antibiotic Sibiromycin

(2011) Tobias W. Giessen et al.   BIOCHEMISTRY

Unraveling Terminal C-Domain-Mediated Condensation in Fungal Biosynthesis of Imidazoindolone Metabolites

(2011) Stuart W. Haynes et al.   BIOCHEMISTRY

Streptomyces clavuligerusHlmI Is an Intramolecular Disulfide-Forming Dithiol Oxidase in Holomycin Biosynthesis

(2011) Bo Li et al.   BIOCHEMISTRY

Structural Basis for Phosphopantetheinyl Carrier Domain Interactions in the Terminal Module of Nonribosomal Peptide Synthetases

(2011) Ye Liu et al.   CHEMISTRY & BIOLOGY

Insights into the Biosynthesis of Hormaomycin, An Exceptionally Complex Bacterial Signaling Metabolite

(2011) Ivonne Höfer et al.   CHEMISTRY & BIOLOGY

Chemoenzymatic Synthesis of Cryptophycin Anticancer Agents by an Ester Bond-Forming Non-ribosomal Peptide Synthetase Module

(2011) Yousong Ding et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Fungal Nonribosomal Peptide Synthetase Module that can Synthesize Thiopyrazines

(2011) Kangjian Qiao et al.   ORGANIC LETTERS

Metabolic Engineering for the Production of Natural Products

(2011) Lauren B. Pickens et al.   Annual Review of Chemical and Biomolecular Engineering

Biochemical and Structural Characterization of Bisubstrate Inhibitors of BasE, the Self-Standing Nonribosomal Peptide Synthetase Adenylate-Forming Enzyme of Acinetobactin Synthesis,

(2010) Eric J. Drake et al.   BIOCHEMISTRY

Trichoderins, novel aminolipopeptides from a marine sponge-derived Trichoderma sp., are active against dormant mycobacteria

(2010) Patamaporn Pruksakorn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Acylation during Glidobactin Biosynthesis by the Tridomain Nonribosomal Peptide Synthetase Module GlbF

(2010) Heidi J. Imker et al.   CHEMISTRY & BIOLOGY

Insights into an Unusual Nonribosomal Peptide Synthetase Biosynthesis

(2010) Tina M. Binz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Characterization of the Cyclomarin/Cyclomarazine Prenyltransferase CymD Directs the Biosynthesis of Unnatural Cyclic Peptides⊥

(2010) Andrew W. Schultz et al.   JOURNAL OF NATURAL PRODUCTS

The Nonribosomal Peptide Synthetase Enzyme DdaD TethersNβ-Fumaramoyl-l-2,3-diaminopropionate for Fe(II)/α-Ketoglutarate-Dependent Epoxidation by DdaC during Dapdiamide Antibiotic Biosynthesis

(2010) Marie A. Hollenhorst et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analysis of Intact and Dissected Fungal Polyketide Synthase-Nonribosomal Peptide Synthetase in Vitro and inSaccharomyces cerevisiae

(2010) Wei Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Biosynthesis of HSAF, a Tetramic Acid-Containing Macrolactam from Lysobacter enzymogenes

(2010) Lili Lou et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reconstruction of the saframycin core scaffold defines dual Pictet-Spengler mechanisms

(2010) Kento Koketsu et al.   Nature Chemical Biology

Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus

(2010) B. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics

(2010) W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and heterologous expression of the biosynthetic gene cluster for holomycin produced by Streptomyces clavuligerus

(2010) Sheng Huang et al.   PROCESS BIOCHEMISTRY

Relationship between sequence conservation and three-dimensional structure in a large family of esterases, lipases, and related proteins

(2010) Miroslaw Cygler et al.   PROTEIN SCIENCE

The Biosynthetic Logic of Polyketide Diversity

(2009) Christian Hertweck   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of Sibiromycin, a Potent Antitumor Antibiotic

(2009) W. Li et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Cyclopiazonic Acid Biosynthesis inAspergillussp.: Characterization of a Reductase-like R* Domain in Cyclopiazonate Synthetase That Forms and Releasescyclo-Acetoacetyl-l-tryptophan

(2009) Xinyu Liu et al.   BIOCHEMISTRY

Synthesis and Structure-Activity Correlation of a Brunsvicamide-Inspired Cyclopeptide Collection

(2009) Thilo Walther  et al.   CHEMBIOCHEM

Biosynthesis of the cyclooligomer depsipeptide bassianolide, an insecticidal virulence factor of Beauveria bassiana

(2009) Yuquan Xu et al.   FUNGAL GENETICS AND BIOLOGY

Structure of a Eukaryotic Nonribosomal Peptide Synthetase Adenylation Domain That Activates a Large Hydroxamate Amino Acid in Siderophore Biosynthesis

(2009) T. Verne Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SylC Catalyzes Ureido-Bond Formation During Biosynthesis of the Proteasome Inhibitor Syringolin A

(2009) Heidi J. Imker et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Development of Yondelis® (trabectedin, ET-743). A semisynthetic process solves the supply problem

(2009) Carmen Cuevas et al.   NATURAL PRODUCT REPORTS

Structural insights into nonribosomal peptide enzymatic assembly lines

(2009) Alexander Koglin et al.   NATURAL PRODUCT REPORTS

PKS and NRPS release mechanisms

(2009) Liangcheng Du et al.   NATURAL PRODUCT REPORTS

Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin

(2009) Laura C. Wieland Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Production of the Antifungal Isochromanone Ajudazols A and B inChondromyces crocatus Cm c5: Biosynthetic Machinery and Cytochrome P450 Modifications

(2008) Kathrin Buntin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biosynthesis of the Cyclooligomer Depsipeptide Beauvericin, a Virulence Factor of the Entomopathogenic Fungus Beauveria bassiana

(2008) Yuquan Xu et al.   CHEMISTRY & BIOLOGY

The multienzyme architecture of eukaryotic fatty acid synthases

(2008) Marc Leibundgut et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Substrate Promiscuity of the Cyclic Dipeptide Prenyltransferases fromAspergillus fumigatus§

(2008) Huixi Zou et al.   JOURNAL OF NATURAL PRODUCTS

How to tailor non-ribosomal peptide products—new clues about the structures and mechanisms of modifying enzymes

(2008) Stefan A. Samel et al.   Molecular BioSystems

The biosyntheticgene cluster of zorbamycin, a member of the bleomycin family of antitumor antibiotics, from Streptomyces flavoviridis ATCC 21892

(2008) Ute Galm et al.   Molecular BioSystems

Dynamic thiolation–thioesterase structure of a non-ribosomal peptide synthetase

(2008) Dominique P. Frueh et al.   NATURE

Structure elucidation and biosynthesis of fuscachelins, peptide siderophores from the moderate thermophile Thermobifida fusca

(2008) E. J. Dimise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE

The Chemical Versatility of Natural-Product Assembly Lines

(2007) Christopher T. Walsh   ACCOUNTS OF CHEMICAL RESEARCH