Anticonvulsant neuropeptides as drug leads for neurological diseases

Analgesic Neuropeptide W Suppresses Seizures in the Brain Revealed by Rational Repositioning and Peptide Engineering

(2010) Brad R. Green et al.   ACS Chemical Neuroscience

Anticonvulsant effects and behavioural outcomes of rAAV serotype 1 vector-mediated neuropeptide Y overexpression in rat hippocampus

(2010) F Noe et al.   GENE THERAPY

Somatostatin analogues in the treatment of gastroenteropancreatic neuroendocrine tumours, current aspects and new perspectives

(2010) Marialuisa Appetecchia et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Identification and Functional Characterization of a Stable, Centrally Active Derivative of the Neurotensin (8−13) Fragment as a Potential First-in-Class Analgesic

(2010) Francis M. Hughes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Engineering Galanin Analogues That Discriminate between GalR1 and GalR2 Receptor Subtypes and Exhibit Anticonvulsant Activity following Systemic Delivery

(2010) Charles R. Robertson et al.   JOURNAL OF MEDICINAL CHEMISTRY

GalR2-positive allosteric modulator exhibits anticonvulsant effects in animal models

(2010) X. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutagenesis of human neuropeptide Y/peptide YY receptor Y2 reveals additional differences to Y1 in interactions with highly conserved ligand positions

(2010) Helena Åkerberg et al.   REGULATORY PEPTIDES

Peptide drugs to target G protein-coupled receptors

(2010) Kathrin Bellmann-Sickert et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Anticonvulsant Met-Enkephalin Analogues Containing Backbone Spacers Reveal Alternative Non-Opioid Signaling in the Brain

(2009) Hee-Kyoung Lee et al.   ACS Chemical Biology

Cancer, Chemistry, and the Cell: Molecules that Interact with the Neurotensin Receptors

(2009) Rebecca M. Myers et al.   ACS Chemical Biology

Lanreotide for the treatment of acromegaly

(2009) F. Castinetti et al.   ADVANCES IN THERAPY

Which Carbonic Anhydrases are Targeted by the Antiepileptic Sulfonamides and Sulfamates?

(2009) Giuseppina De Simone et al.   Chemical Biology & Drug Design

Glycosylated Neurotensin Analogues Exhibit Sub-picomolar Anticonvulsant Potency in a Pharmacoresistant Model of Epilepsy

(2009) Hee-Kyoung Lee et al.   ChemMedChem

Antiepileptic Drugs in Non-Epilepsy Disorders

(2009) Cecilie Johannessen Landmark   CNS DRUGS

Synthetic therapeutic peptides: science and market

(2009) Patrick Vlieghe et al.   DRUG DISCOVERY TODAY

Delivering multiple gene products in the brain from a single adeno-associated virus vector

(2009) S B Foti et al.   GENE THERAPY

Acromegaly pathogenesis and treatment

(2009) Shlomo Melmed   JOURNAL OF CLINICAL INVESTIGATION

Synthesis and Applications of Polyamine Amino Acid Residues: Improving the Bioactivity of an Analgesic Neuropeptide, Neurotensin

(2009) Liuyin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Comparison of N-Terminal Modifications on Neurotensin(8−13) Analogues Correlates Peptide Stability but Not Binding Affinity with in Vivo Efficacy

(2009) Kevin S. Orwig et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel, Potent, and Radio-Iodinatable Somatostatin Receptor 1 (sst1) Selective Analogues

(2009) Judit Erchegyi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Requirements for a Lipoamino Acid in Modulating the Anticonvulsant Activities of Systemically Active Galanin Analogues

(2009) Liuyin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective and Brain Penetrant Neuropeptide Y Y2 Receptor Antagonists Discovered by Whole-Cell High-Throughput Screening

(2009) S. P. Brothers et al.   MOLECULAR PHARMACOLOGY

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Temporal lobe epilepsy causes selective changes in mu opioid and nociceptin receptor binding and functional coupling to G-proteins in human temporal neocortex

(2009) Luisa Rocha et al.   NEUROBIOLOGY OF DISEASE

Neuropeptide Y: Its multiple effects in the CNS and potential clinical significance

(2009) E. E. Benarroch   NEUROLOGY

A novel GalR2-specific peptide agonist

(2009) Johan Runesson et al.   NEUROPEPTIDES

Developing novel antiepileptic drugs: Characterization of NAX 5055, a systemically-active galanin analog, in epilepsy models

(2009) H. Steve White et al.   Neurotherapeutics

Endogenous opiates and behavior: 2008

(2009) Richard J. Bodnar   PEPTIDES

Behavioral effects of neuropeptides in rodent models of depression and anxiety

(2009) Susan Rotzinger et al.   PEPTIDES

30 years of dynorphins — New insights on their functions in neuropsychiatric diseases

(2009) Christoph Schwarzer   PHARMACOLOGY & THERAPEUTICS

GPC Receptors and Not Ligands Decide the Binding Mode in Neuropeptide Y Multireceptor/Multiligand System†

(2008) Diana Lindner et al.   BIOCHEMISTRY

Peptide backbone modifications on the C-terminal hexapeptide of neurotensin

(2008) Jürgen Einsiedel et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Delivery of peptides to the brain: Emphasis on therapeutic development

(2008) William A. Banks   BIOPOLYMERS

Neuropeptide Y gene therapy decreases chronic spontaneous seizures in a rat model of temporal lobe epilepsy

(2008) Francesco Noè et al.   BRAIN

Galanin – 25 years with a multitalented neuropeptide

(2008) S. E. Counts et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Galanin – 25 years with a multitalented neuropeptide

(2008) M. R. Picciotto   CELLULAR AND MOLECULAR LIFE SCIENCES

Galanin – 25 years with a multitalented neuropeptide

(2008) X.-J. Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Galanin – 25 years with a multitalented neuropeptide

(2008) J. N. Crawley   CELLULAR AND MOLECULAR LIFE SCIENCES

Galanin – 25 years with a multitalented neuropeptide

(2008) K. Mitsukawa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Galanin – 25 years with a multitalented neuropeptide

(2008) J. T. Lerner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Conus Venoms - A Rich Source of Peptide-Based Therapeutics

(2008) Tiffany Han et al.   CURRENT PHARMACEUTICAL DESIGN

Design, Synthesis, and Characterization of High-Affinity, Systemically-Active Galanin Analogues with Potent Anticonvulsant Activities

(2008) Grzegorz Bulaj et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a New Analogue of Neurotensin that Crosses the Blood−Brain Barrier

(2008) Pierre Bredeloux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neurotensin Enhances GABAergic Activity in Rat Hippocampus CA1 Region by Modulating L-Type Calcium Channels

(2008) Shanshan Li et al.   JOURNAL OF NEUROPHYSIOLOGY

Somatostatin Receptor Subtype 4 Couples to the M-Current to Regulate Seizures

(2008) C. Qiu et al.   JOURNAL OF NEUROSCIENCE

Somatostatin: An endogenous antiepileptic

(2008) Melanie K. Tallent et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Heightened Amygdala Long-Term Potentiation in Neurotensin Receptor Type-1 Knockout Mice

(2008) Taiju Amano et al.   NEUROPSYCHOPHARMACOLOGY

IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels

(2008) Anthony J. Harmar et al.   NUCLEIC ACIDS RESEARCH

Molecular recognition of the NPY hormone family by their receptors

(2008) Diana Lindner et al.   NUTRITION

Endogenous opiates and behavior: 2007

(2008) Richard J. Bodnar   PEPTIDES

Neuropeptide Y Y2 receptor in health and disease

(2007) S L Parker et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibitory effects of synthetic somatostatin receptor subtype 4 agonists on acute and chronic airway inflammation and hyperreactivity in the mouse

(2007) Krisztián Elekes et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Somatostatinergic systems in brain: Networks and functions

(2007) Cécile Viollet et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY