Article
Multidisciplinary Sciences
Jian Wang, Peirong Xu, Yeyong Zhang, Shuai Han, Gongteng Wang, Hangxiang Wang, Haihan Song, Shufeng Li
Summary: The study develops injectable anticancer nanoassemblies through self-assembly technique, which exhibit tumor-restricted pharmacology and can be self-activated without exogenous stimuli. The anticancer agent cabazitaxel is covalently dimerized to form the prodrug diCTX, which is further coassembled with an ROS generator diDHA. The refined nanoparticles show durable antitumor efficacy in a preclinical model and lower toxicity compared to free drug combinations, suggesting great potential for clinical translation.
Review
Chemistry, Multidisciplinary
Sena Karaosmanoglu, Mengjiao Zhou, Bingyang Shi, Xiujuan Zhang, Gareth R. Williams, Xianfeng Chen
Summary: The clinical applications of many anti-cancer drugs are limited by their hydrophobic nature, leading to the development of carrier-based nanoparticles. However, these strategies often fail to efficiently encapsulate drugs and may cause toxicity problems in the long term. Therefore, elegantly designed strategies for carrier-free nanodrugs, including simple self-assembly and chemical modifications, are desired for high quality, stability, and performance.
JOURNAL OF CONTROLLED RELEASE
(2021)
Correction
Chemistry, Multidisciplinary
Celia Arib, Nadia Bouchemal, Maria Barile, Didier Paleni, Nadia Djaker, Nathalie Dupont, Jolanda Spadavecchia
Summary: This study presents a novel design of gold nanoparticles by using flavin-adenine-dinucleotide as a coupling reagent, and evaluates their physico-chemical properties, as well as discusses their potential applications in nanomedicine.
NANOSCALE ADVANCES
(2023)
Article
Materials Science, Biomaterials
Hongsen Wang, Yu Wang, Zhaohui Zheng, Fang Yang, Xiaobin Ding, Aiguo Wu
Summary: In this study, four donor-acceptor compounds were synthesized to develop a multifunctional single molecule phototherapeutic agent with excellent fluorescence imaging, photothermal therapy, and photodynamic therapy. The compounds exhibited aggregation-induced emission characteristics and had long emission wavelengths, photostability, biocompatibility, photothermal stability, and singlet oxygen generation performance. The photothermal conversion efficiency of one of the compounds reached 84.5%. Cellular internalization and therapy demonstrated the compounds' good biocompatibility, excellent cell bioimaging, and cancer phototherapy capabilities in vitro.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Chemistry, Multidisciplinary
Guillermo Moreno-Alcantar, Pierre Picchetti, Angela Casini
Summary: The discovery of medicinal properties of gold complexes has led to the development of new anticancer drugs, which are unique in their modes of action. Current research focuses on designing drug leads with enhanced pharmacological activities and improving physicochemical properties of gold compounds. Encapsulation of gold compounds in nanocarriers or their grafting onto targeted delivery vectors may lead to new nanomedicines for clinical applications. This article provides an overview of gold anticancer compounds and a detailed review of nanoparticle-based delivery systems for gold chemotherapeutics.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Chemistry, Multidisciplinary
Nienke Ruijter, Lya G. Soeteman-Hernandez, Marie Carriere, Matthew Boyles, Polly McLean, Julia Catalan, Alberto Katsumiti, Joan Cabellos, Camilla Delpivo, Araceli Sanchez Jimenez, Ana Candalija, Isabel Rodriguez-Llopis, Socorro Vazquez-Campos, Flemming R. Cassee, Hedwig Braakhuis
Summary: The Safe-by-Design (SbD) concept aims to enhance the development of safer materials/products by reducing hazards and exposures through timely interventions. This review evaluates commonly used in vitro assays for their suitability in SbD hazard testing of nanomaterials (NMs). It also discusses the effects of various factors on predictivity and the compatibility of assays with advanced materials and NMs released during the lifecycle.
Article
Chemistry, Multidisciplinary
Catia T. Perciani, Lewis Y. Liu, Lawrence Wood, Sonya A. MacParland
Summary: The use of engineered nanoparticles has shown promise in enhancing vaccine efficacy and host immune responses to viral and tumor antigens. By harnessing the properties of nanoparticles, it may be possible to overcome current obstacles in vaccinology and oncology.
Article
Pharmacology & Pharmacy
Kaushik Sarkar, Manish Kumar, Abhishek Jha, Kanchan Bharti, Mohan Das, Brahmeshwar Mishra
Summary: Tuberculosis (TB) is a global infectious disease with many challenges in treatment, and nanomedicine may help overcome these challenges.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Environmental Sciences
Vrishali Subramanian, Willie J. G. M. Peijnenburg, Martina G. Vijver, Carlos F. Blanco, Stefano Cucurachi, Jeroen B. Guinee
Summary: The concept of Safe by Design (SbD) aims to ensure the safety of materials and products throughout their life cycle. However, there is a lack of methodological approaches and practical guidelines for implementing SbD. The combined use of Life Cycle Assessment (LCA) and Risk Assessment (RA) is considered suitable for implementing SbD at different stages of product design. Critical gaps need to be addressed for wider application of SbD. Rating: 8 out of 10.
Review
Chemistry, Multidisciplinary
Eman Jaradat, Edward Weaver, Adam Meziane, Dimitrios A. Lamprou
Summary: In conventional drug administration, drug molecules may not effectively reach the pathological site, so nanoparticles (NPs) as drug carriers have potential. NPs have a large surface area and quantum properties. Traditional methods for manufacturing NPs have limitations and new methods need to be investigated.
Review
Chemistry, Multidisciplinary
Hannah C. Geisler, Hannah C. Safford, Michael J. Mitchell
Summary: The placenta, a temporary organ during pregnancy, plays a vital role in regulating exchange between maternal and fetal circulation. Placental disorders such as preeclampsia, fetal growth restriction, placenta accreta spectrum, and gestational trophoblastic disease arise from abnormal placental development and can lead to severe complications. Nanomedicine offers potential solutions to these disorders by selectively delivering therapeutics to the placenta while protecting the fetus. This review discusses nanomedicine strategies to diagnose and treat placental disorders and highlights novel disease targets for the rational design of precision nanocarriers.
Article
Chemistry, Multidisciplinary
Riccardo Rampado, Dan Peer
Summary: Design of experiment (DoE) is a powerful statistical technique that aims to optimize output variables by varying multiple factors simultaneously, using the minimum number of experimental runs. Although DoE has great potential for innovation and process optimization, it is not widely applied in nanomedicine and is often not well understood.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Nanoscience & Nanotechnology
Rene Rebollo, Feras Oyoun, Yohann Corvis, Mazen M. El-Hammadi, Bruno Saubamea, Karine Andrieux, Nathalie Mignet, Khair Alhareth
Summary: This study utilized a microfluidic system to fabricate liposomes with different molar ratios, and optimized the process and conditions using design of experiments (DoE) principles. An artificial neural network (ANN) model was constructed to predict the size and polydispersity index (PDI) of the liposomes. The results demonstrated the feasibility of producing optimized liposomes with high reproducibility using microfluidic manufacturing processes, DoE, and Artificial Intelligence (AI), enabling faster development and clinical transfer of nanobased medications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Irini Furxhi, Rossella Bengalli, Giulia Motta, Paride Mantecca, Ozge Kose, Marie Carriere, Ehtsham Ul Haq, Charlie O'Mahony, Magda Blosi, Davide Gardini, Anna Costa
Summary: In this study, we developed quantitative structure-activity relationship models based on nanoscale features and biological attributes to predict hazard classes. We also obtained interpretable rules using a Bayesian network structure to consider safety aspects during the synthesis stage. This study reveals the importance of quantitative intrinsic hazard criteria and discusses the challenges and future directions for their generation and implementation.
ACS APPLIED NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jaeseong Jeong, Su-Yong Bae, Jinho Lee, Suh-young Kwon, Ju Han Lee, Jinhee Choi
Summary: This study investigates the toxicity of two nano-sized MAX phases (Ti2AlC and Ti3AlC2) and finds that they exhibit certain cytotoxicity and genotoxicity, highlighting the importance of evaluating the potential hazards of nano-sized MAX phases and providing valuable insights for safe design.
ENVIRONMENTAL SCIENCE-NANO
(2023)
Article
Biochemical Research Methods
Daniel Ehrsam, Sandro Sieber, Mouhssin Oufir, Fabiola Porta, Matthias Hamburger, Joerg Huwyler, Henriette E. Meyer Zu Schwabedissen
BIOCONJUGATE CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Claudia Suenderhauf, Benjamin Berger, Maxim Puchkov, Yasmin Schmid, Sabine Mueller, Joerg Huwyler, Manuel Haschke, Stephan Kraehenbuehl, Urs Duthaler
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Review
Pharmacology & Pharmacy
Andreas Schittny, Jorg Huwyler, Maxim Puchkov
Article
Pharmacology & Pharmacy
Tim Dreckmann, Julien Boeuf, Imke-Sonja Ludwig, Joerg Luemkemann, Joerg Huwyler
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Article
Pharmacology & Pharmacy
Christina Haeuser, Pierre Goldbach, Joerg Huwyler, Wolfgang Friess, Andrea Allmendinger
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2020)
Review
Chemistry, Multidisciplinary
Joachim Schuster, Atanas Koulov, Hanns-Christian Mahler, Pascal Detampel, Joerg Huwyler, Satish Singh, Roman Mathaes
PHARMACEUTICAL RESEARCH
(2020)
Article
Chemistry, Multidisciplinary
A. Schittny, S. Philipp-Bauer, P. Detampel, J. Huwyler, M. Puchkov
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Chemistry, Medicinal
Christoph Grapentin, Claudia Mueller, Ravuri S. K. Kishore, Michael Adler, Inas ElBialy, Wolfgang Friess, Jorg Huwyler, Tarik A. Khan
JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Correction
Chemistry, Multidisciplinary
Joachim Schuster, Atanas Koulov, Hanns-Christian Mahler, Pascal Detampel, Joerg Huwyler, Satish Singh, Roman Mathaes
PHARMACEUTICAL RESEARCH
(2020)
Article
Pathology
Christophe A. C. Freyre, Stephan Spiegel, Caroline Gubser Keller, Marc Vandemeulebroecke, Holger Hoefling, Valerie Dubost, Emre Corek, Pierre Moulin, Imtiaz Hossain
Summary: Various deep learning approaches have been proposed to tackle challenges in computational pathology by learning structural details in an unbiased way. The study emphasizes the significance of histology-specific models in solving a wide range of computational pathology tasks such as biomarker classification, localization, and feature prediction.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Pediatrics
Leonie Wagner-Hattler, Klara Kiene, Julia Bielicki, Marc Pfister, Maxim Puchkov, Joerg Huwyler
Summary: The study evaluated the acceptability of a novel child-appropriate oral dispersible tablet formulation. The results showed high acceptability among parents and children, with smooth administration process and no distress observed in any of the children. The proposed child-friendly dosage form is expected to improve drug adherence in pediatric patients.
Article
Biochemistry & Molecular Biology
Laura Nicolle, Jens Casper, Melanie Willimann, Celine M. A. Journot, Pascal Detampel, Tomaz Einfalt, Hiu Man Grisch-Chan, Beat Thony, Sandrine Gerber-Lemaire, Jorg Huwyler
Summary: The study developed a novel chitosan-derivative, dCS-Suc-LPEI-14, showing promising biocompatibility, cytotoxicity, and transfection efficiency. Through in vitro and in vivo experiments, its potential for non-viral gene therapy was confirmed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Virology
Patrick Hauswirth, Philipp Graber, Katarzyna Buczak, Riccardo Vincenzo Mancuso, Susanne Heidi Schenk, Juerg P. F. Nueesch, Jorg Huwyler
Summary: Mutated NS1 variants, particularly the NS1-T585E single-amino acid mutant, showed potential oncotoxic effects in human hepatocellular carcinoma cell lines. Proteomics analysis revealed new interaction partners and signaling pathways of NS1, providing mechanistic explanations for its oncolytic effects.
Article
Environmental Sciences
Verena N. Schreier, Emre corek, Christian Appenzeller-Herzog, Beat J. Bruschweiler, Birgit Geueke, Martin F. Wilks, Benoit Schilter, Jane Muncke, Thomas J. Simat, Martin Smiesko, Nicolas Roth, Alex Odermatt
Summary: This study aims to identify and organize existing knowledge and associated gaps in hazard and exposure information on 34 PET oligomers through a systematic evidence map (SEM) to support regulatory decision-making. The study found substantial deficiencies in the available evidence on ADME/TK/PK, hydrolysis, and health/bioactivity effects of PET oligomers, currently preventing appropriate risk assessment. It is essential to develop more systematic and tiered approaches to address the identified research needs and assess the risks of PET oligomers.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Pharmacology & Pharmacy
Klervi Golhen, Michael Buettcher, Jonas Kost, Joerg Huwyler, Marc Pfister
Summary: The majority of therapeutics currently available are not suitable for pediatric patients, thus there is a need to develop child-friendly dosage forms. This review discusses the challenges and opportunities in the development of such dosage forms, including taste masking, tablet size, dose flexibility, excipient safety, and acceptability. It also explores the example of orally dispersible tablets (ODTs) as a child-friendly drug delivery strategy, utilizing inorganic particulate drug carriers as multifunctional excipients to address unique medical needs in infants and children while maintaining a favorable excipient safety and acceptability profile in these vulnerable patient populations.