Untying a nanoscale knotted polymer structure to linear chains for efficient gene delivery in vitro and to the brain

GDNF Gene Delivery via a 2-(Dimethylamino)ethyl Methacrylate Based Cyclized Knot Polymer for Neuronal Cell Applications

(2013) B. Newland et al.   ACS Chemical Neuroscience

Controlled multi-vinyl monomer homopolymerization through vinyl oligomer combination as a universal approach to hyperbranched architectures

(2013) Tianyu Zhao et al.   Nature Communications

Biomaterial approaches to gene therapies for neurodegenerative disorders of the CNS

(2013) Ben Newland et al.   Biomaterials Science

Application of Living Free Radical Polymerization for Nucleic Acid Delivery

(2012) David S. H. Chu et al.   ACCOUNTS OF CHEMICAL RESEARCH

The neurotoxicity of gene vectors and its amelioration by packaging with collagen hollow spheres

(2012) Ben Newland et al.   BIOMATERIALS

Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D “Knot” Polymer Structure for Nonviral Gene Delivery

(2012) Ben Newland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

An antibody fragment functionalized dendritic PEGylated poly(2-(dimethylamino)ethyl diacrylate) as a vehicle of exogenous microRNA

(2012) M. Monaghan et al.   Drug Delivery and Translational Research

Non-viral gene delivery nanoparticles based on Poly(β-amino esters) for treatment of glioblastoma

(2011) Stephany Y. Tzeng et al.   BIOMATERIALS

3D Single Cyclized Polymer Chain Structure from Controlled Polymerization of Multi-Vinyl Monomers: Beyond Flory–Stockmayer Theory

(2011) Yu Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial

(2011) Peter A LeWitt et al.   LANCET NEUROLOGY

Gold nanorod–siRNA induces efficientin vivogene silencing in the rat hippocampus

(2011) Adela C Bonoiu et al.   Nanomedicine

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing

(2011) K. T. Al-Jamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

(2010) Ben Newland et al.   CHEMICAL COMMUNICATIONS

Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells

(2010) José L. Santos et al.   JOURNAL OF CONTROLLED RELEASE

Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial

(2010) William J Marks et al.   LANCET NEUROLOGY

Amine-modified hyperbranched polyesters as non-toxic, biodegradable gene delivery systems

(2009) Regina Reul et al.   BIOMATERIALS

Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone

(2009) Ester J. Kwon et al.   BIOMATERIALS

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

(2009) A.L.C. Cardoso et al.   JOURNAL OF CONTROLLED RELEASE

Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles

(2009) David M Yurek et al.   MOLECULAR THERAPY

Performance of three PDMAEMA-based polycation architectures as gene delivery agents in comparison to linear and branched PEI

(2009) Anja Schallon et al.   REACTIVE & FUNCTIONAL POLYMERS

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology