Biomaterial approaches to gene therapies for neurodegenerative disorders of the CNS

GDNF Gene Delivery via a 2-(Dimethylamino)ethyl Methacrylate Based Cyclized Knot Polymer for Neuronal Cell Applications

(2013) B. Newland et al.   ACS Chemical Neuroscience

pH-Triggered Nanoparticle Mediated Delivery of siRNA to Liver Cells in Vitro and in Vivo

(2013) Soumia Kolli et al.   BIOCONJUGATE CHEMISTRY

A Natural Vanishing Act: The Enzyme-Catalyzed Degradation of Carbon Nanomaterials

(2012) Gregg P. Kotchey et al.   ACCOUNTS OF CHEMICAL RESEARCH

Click-Modified Cyclodextrins as Nonviral Vectors for Neuronal siRNA Delivery

(2012) A. M. O’Mahony et al.   ACS Chemical Neuroscience

Transfection of macrophages by collagen hollow spheres loaded with polyplexes: A step towards modulating inflammation

(2012) Christophe Helary et al.   Acta Biomaterialia

Chemistry for peptide and protein PEGylation

(2012) M.J. Roberts et al.   ADVANCED DRUG DELIVERY REVIEWS

The effect of intraluminal contact mediated guidance signals on axonal mismatch during peripheral nerve repair

(2012) William T. Daly et al.   BIOMATERIALS

Sustained local delivery of bioactive nerve growth factor in the central nervous system via tunable diblock copolypeptide hydrogel depots

(2012) Bingbing Song et al.   BIOMATERIALS

PEGylated poly(2-(dimethylamino) ethyl methacrylate)/DNA polyplex micelles decorated with phage-displayed TGN peptide for brain-targeted gene delivery

(2012) Yong Qian et al.   BIOMATERIALS

The neurotoxicity of gene vectors and its amelioration by packaging with collagen hollow spheres

(2012) Ben Newland et al.   BIOMATERIALS

Melittin-grafted HPMA-oligolysine based copolymers for gene delivery

(2012) Joan G. Schellinger et al.   BIOMATERIALS

Injectable hydrogels for central nervous system therapy

(2012) Malgosia M Pakulska et al.   Biomedical Materials

Further characterisation of the LPS model of Parkinson’s disease: A comparison of intra-nigral and intra-striatal lipopolysaccharide administration on motor function, microgliosis and nigrostriatal neurodegeneration in the rat

(2012) Deirdre B. Hoban et al.   BRAIN BEHAVIOR AND IMMUNITY

Cell Type-Associated Differences in Migration, Survival, and Immunogenicity following Grafting in CNS Tissue

(2012) Jelle Praet et al.   CELL TRANSPLANTATION

Localized and Sustained Delivery of Fibroblast Growth Factor-2 from a Nanoparticle-Hydrogel Composite for Treatment of Spinal Cord Injury

(2012) Catherine E. Kang et al.   CELLS TISSUES ORGANS

Single cyclized molecule structures from RAFT homopolymerization of multi-vinyl monomers

(2012) Yu Zheng et al.   CHEMICAL COMMUNICATIONS

Functional recovery after spinal cord injury in dogs treated with a combination of Matrigel and neural-induced adipose-derived mesenchymal Stem cells

(2012) Sung-Su Park et al.   CYTOTHERAPY

Encapsulated Cell Biodelivery of Nerve Growth Factor to the Basal Forebrain in Patients with Alzheimer’s Disease

(2012) Maria Eriksdotter-Jönhagen et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Non-viral gene therapy for spinal cord regeneration

(2012) Li Yao et al.   DRUG DISCOVERY TODAY

Survival, migration and differentiation of mouse tau-GFP embryonic stem cells transplanted into the rat auditory nerve

(2012) Björn Palmgren et al.   EXPERIMENTAL NEUROLOGY

Long-term expansion of human foetal neural progenitors leads to reduced graft viability in the neonatal rat brain

(2012) Rike Zietlow et al.   EXPERIMENTAL NEUROLOGY

Channeled scaffolds implanted in adult rat brain

(2012) Cristina Martínez-Ramos et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Therapeutics, imaging and toxicity of nanomaterials in the central nervous system

(2012) Antonio Nunes et al.   JOURNAL OF CONTROLLED RELEASE

Lipid peptide nanocomplexes for gene delivery and magnetic resonance imaging in the brain

(2012) Michele J. Writer et al.   JOURNAL OF CONTROLLED RELEASE

Insight into the role of N,N-dimethylaminoethyl methacrylate (DMAEMA) conjugation onto poly(ethylenimine): cell viability and gene transfection studies

(2012) Alireza Nouri et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Neuron-Targeted Copolymers with Sheddable Shielding Blocks Synthesized Using a Reducible, RAFT-ATRP Double-Head Agent

(2012) Hua Wei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Single Cyclized Molecule Versus Single Branched Molecule: A Simple and Efficient 3D “Knot” Polymer Structure for Nonviral Gene Delivery

(2012) Ben Newland et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Protective Extracellular Matrix-Based Gene Delivery Reservoir Fabricated by Electrostatic Charge Manipulation

(2012) Shane Browne et al.   MOLECULAR PHARMACEUTICS

Intranasal Delivery of HMGB1 siRNA Confers Target Gene Knockdown and Robust Neuroprotection in the Postischemic Brain

(2012) Il-Doo Kim et al.   MOLECULAR THERAPY

In vivo degradation of functionalized carbon nanotubes after stereotactic administration in the brain cortex

(2012) Antonio Nunes et al.   Nanomedicine

NTS-Polyplex: a potential nanocarrier for neurotrophic therapy of Parkinson's disease

(2012) Daniel Martinez-Fong et al.   Nanomedicine-Nanotechnology Biology and Medicine

Progressive multiple sclerosis: The treatment gap

(2012) Courtney Humphries   NATURE

Advances in natural biomaterials for nerve tissue repair

(2012) Zin Z. Khaing et al.   NEUROSCIENCE LETTERS

Cationic long-chain hyperbranched poly(ethylene glycol)s with low charge density for gene delivery

(2012) Chunlai Tu et al.   Polymer Chemistry

Peptide functionalized nanoparticles for nonviral gene delivery

(2012) Rachel M. Levine et al.   Soft Matter

Gene Therapy for Parkinson's Disease

(2012) Rachel Denyer et al.   Parkinsons Disease

Physically Associated Synthetic Hydrogels with Long-Term Covalent Stabilization for Cell Culture and Stem Cell Transplantation

(2011) Jianjun Zhang et al.   ADVANCED MATERIALS

Gene Delivery into Mesenchymal Stem Cells: A Biomimetic Approach Using RGD Nanoclusters Based on Poly(amidoamine) Dendrimers

(2011) Deepti Pandita et al.   BIOMACROMOLECULES

Influence of Polymer Architecture and Molecular Weight of Poly(2-(dimethylamino)ethyl methacrylate) Polycations on Transfection Efficiency and Cell Viability in Gene Delivery

(2011) Christopher V. Synatschke et al.   BIOMACROMOLECULES

The fate of ultrafast degrading polymeric implants in the brain

(2011) Dan Y. Lewitus et al.   BIOMATERIALS

The reverse of polymer degradation: in situ crosslinked gel formation through disulfide cleavage

(2011) Aram O. Saeed et al.   CHEMICAL COMMUNICATIONS

Clinical translation of cell transplantation in the brain

(2011) Stephen B. Dunnett et al.   Current Opinion in Organ Transplantation

Tunable elastin-like polypeptide hollow sphere as a high payload and controlled delivery gene depot

(2011) Biraja C. Dash et al.   JOURNAL OF CONTROLLED RELEASE

3D Single Cyclized Polymer Chain Structure from Controlled Polymerization of Multi-Vinyl Monomers: Beyond Flory–Stockmayer Theory

(2011) Yu Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Gold nanorod–siRNA induces efficientin vivogene silencing in the rat hippocampus

(2011) Adela C Bonoiu et al.   Nanomedicine

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Getting RNAi therapies to the brain

(2011) Louisa Flintoft   NATURE REVIEWS GENETICS

Transgene expression in the striatum following intracerebral injections of DNA nanoparticles encoding for human glial cell line-derived neurotrophic factor

(2011) A.M. Fletcher et al.   NEUROSCIENCE

Development and characterisation of a novel rat model of Parkinson's disease induced by sequential intranigral administration of AAV-α-synuclein and the pesticide, rotenone

(2011) P. Mulcahy et al.   NEUROSCIENCE

Functional motor recovery from brain ischemic insult by carbon nanotube-mediated siRNA silencing

(2011) K. T. Al-Jamal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nano-textured self-assembled aligned collagen hydrogels promote directional neurite guidance and overcome inhibition by myelin associated glycoprotein

(2011) Mohammad T. Abu-Rub et al.   Soft Matter

Current Challenges for the Advancement of Neural Stem Cell Biology and Transplantation Research

(2011) Kristien Reekmans et al.   Stem Cell Reviews and Reports

Improving Viability of Stem Cells During Syringe Needle Flow Through the Design of Hydrogel Cell Carriers

(2011) Brian A. Aguado et al.   TISSUE ENGINEERING PART A

Controlled Release of Plasmid DNA from Hyaluronan Nanoparticles

(2011) Sunil Mahor et al.   Current Drug Delivery

Patterned transgene expression in multiple-channel bridges after spinal cord injury

(2010) Laura De Laporte et al.   Acta Biomaterialia

The formation of protein concentration gradients mediated by density differences of poly(ethylene glycol) microspheres

(2010) Jacob L. Roam et al.   BIOMATERIALS

The therapeutic potential of human multipotent mesenchymal stromal cells combined with pharmacologically active microcarriers transplanted in hemi-parkinsonian rats

(2010) Gaëtan J.-R. Delcroix et al.   BIOMATERIALS

Potential of rat bone marrow-derived mesenchymal stem cells as vehicles for delivery of neurotrophins to the Parkinsonian rat brain

(2010) Teresa C. Moloney et al.   BRAIN RESEARCH

Compacted DNA Nanoparticle Gene Transfer of GDNF to the Rat Striatum Enhances the Survival of Grafted Fetal Dopamine Neurons

(2010) David M. Yurek et al.   CELL TRANSPLANTATION

A highly effective gene delivery vector – hyperbranched poly(2-(dimethylamino)ethyl methacrylate) from in situ deactivation enhanced ATRP

(2010) Ben Newland et al.   CHEMICAL COMMUNICATIONS

Gene delivery by lipoplexes and polyplexes

(2010) Conchita Tros de Ilarduya et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Postacute Ischemia Vascular Endothelial Growth Factor Transfer by Transferrin-Targeted Liposomes Attenuates Ischemic Brain Injury After Experimental Stroke in Rats

(2010) Hao Zhao et al.   HUMAN GENE THERAPY

NGF release from thermo-responsive collagen-polyNIPAam polymer networks supports neuronal cell growth and differentiation

(2010) Susanne Doleski et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Biocompatibility of poly(ethylene glycol)-based hydrogels in the brain: An analysis of the glial response across space and time

(2010) K. B. Bjugstad et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Functionalization of poly(amidoamine) dendrimers with hydrophobic chains for improved gene delivery in mesenchymal stem cells

(2010) José L. Santos et al.   JOURNAL OF CONTROLLED RELEASE

Receptor-Mediated Gene Delivery Using PAMAM Dendrimers Conjugated with Peptides Recognized by Mesenchymal Stem Cells

(2010) José L. Santos et al.   MOLECULAR PHARMACEUTICS

A Temporal Gene Delivery System Based on Fibrin Microspheres

(2010) Mangesh M. Kulkarni et al.   MOLECULAR PHARMACEUTICS

Long-term Delivery of Nerve Growth Factor by Encapsulated Cell Biodelivery in the Göttingen Minipig Basal Forebrain

(2010) Lone Fjord-Larsen et al.   MOLECULAR THERAPY

Chitosan/siRNA Nanoparticles Biofunctionalize Nerve Implants and Enable Neurite Outgrowth

(2010) Ursula Mittnacht et al.   NANO LETTERS

A reliable method for detecting complexed DNA in vitro

(2010) C. Holladay et al.   Nanoscale

Dual stimuli responsive PEG based hyperbranched polymers

(2010) Yixiao Dong et al.   Polymer Chemistry

Dual-stimuli sensitive nanogels fabricated by self-association of thiolated hydroxypropyl cellulose

(2010) Junjun Tan et al.   Polymer Chemistry

Design of biomaterials to enhance stem cell survival when transplanted into the damaged central nervous system

(2010) M. J. Cooke et al.   Soft Matter

Nonviral Gene Delivery: Principle, Limitations, and Recent Progress

(2009) Mohammed S. Al-Dosari et al.   AAPS Journal

Cell death: protein misfolding and neurodegenerative diseases

(2009) Tomohiro Nakamura et al.   APOPTOSIS

A star-PEG–heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases

(2009) Uwe Freudenberg et al.   BIOMATERIALS

Local gene delivery from ECM-coated poly(lactide-co-glycolide) multiple channel bridges after spinal cord injury

(2009) Laura De Laporte et al.   BIOMATERIALS

Hyaluronic acid hydrogel loaded with genetically-engineered brain-derived neurotrophic factor as a neural cell carrier

(2009) Tadashi Nakaji-Hirabayashi et al.   BIOMATERIALS

The support of neural stem cells transplanted into stroke-induced brain cavities by PLGA particles

(2009) Ellen Bible et al.   BIOMATERIALS

Brain-targeting gene delivery and cellular internalization mechanisms for modified rabies virus glycoprotein RVG29 nanoparticles

(2009) Yang Liu et al.   BIOMATERIALS

Gene delivery targeted to the brain using an Angiopep-conjugated polyethyleneglycol-modified polyamidoamine dendrimer

(2009) Weilun Ke et al.   BIOMATERIALS

Thermosensitive injectable hyaluronic acid hydrogel for adipose tissue engineering

(2009) Huaping Tan et al.   BIOMATERIALS

Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone

(2009) Ester J. Kwon et al.   BIOMATERIALS

Delivery of small-interfering RNA (siRNA) to the brain

(2009) Saroj P Mathupala   EXPERT OPINION ON THERAPEUTIC PATENTS

Targeting novel integrative nuclear FGFR1 signaling by nanoparticle-mediated gene transfer stimulates neurogenesis in the adult brain

(2009) Ewa K. Stachowiak et al.   Integrative Biology

Tf-lipoplex-mediated c-Jun silencing improves neuronal survival following excitotoxic damage in vivo

(2009) A.L.C. Cardoso et al.   JOURNAL OF CONTROLLED RELEASE

Neuroprotection by biodegradable PAMAM ester (e-PAM-R)-mediated HMGB1 siRNA delivery in primary cortical cultures and in the postischemic brain

(2009) Il-Doo Kim et al.   JOURNAL OF CONTROLLED RELEASE

Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles

(2009) Rongqin Huang et al.   JOURNAL OF GENE MEDICINE

Gene therapy using lactoferrin-modified nanoparticles in a rotenone-induced chronic Parkinson model

(2009) Rongqin Huang et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Long-term Transgene Expression in the Central Nervous System Using DNA Nanoparticles

(2009) David M Yurek et al.   MOLECULAR THERAPY

Rapid pH/temperature-responsive cationic hydrogels with dual stimuli-sensitive grafted side chains

(2009) Jie Zhang et al.   POLYMER

Performance of three PDMAEMA-based polycation architectures as gene delivery agents in comparison to linear and branched PEI

(2009) Anja Schallon et al.   REACTIVE & FUNCTIONAL POLYMERS

Current tissue engineering and novel therapeutic approaches to axonal regeneration following spinal cord injury using polymer scaffolds

(2009) Nicolas N. Madigan et al.   RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY

Directed Growth of Adult Human White Matter Stem Cell–Derived Neurons on Aligned Fibrillar Collagen

(2009) Babette Lanfer et al.   TISSUE ENGINEERING PART A

Preparation of Chitosan/Polyglutamic Acid Spheres Based on the Use of Polystyrene Template as a Nonviral Gene Carrier

(2009) Gildas Réthoré et al.   TISSUE ENGINEERING PART C-METHODS

A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

(2008) Jordan J. Green et al.   ACCOUNTS OF CHEMICAL RESEARCH

Affinity-based release of glial-derived neurotrophic factor from fibrin matrices enhances sciatic nerve regeneration

(2008) Matthew D. Wood et al.   Acta Biomaterialia

Biodegradable and pH-Sensitive Hydrogels for Cell Encapsulation and Controlled Drug Release

(2008) De-Qun Wu et al.   BIOMACROMOLECULES

Injectable hydrogels as unique biomedical materials

(2008) Lin Yu et al.   CHEMICAL SOCIETY REVIEWS

Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel

(2008) C GONG et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Tf-lipoplexes for neuronal siRNA delivery: A promising system to mediate gene silencing in the CNS

(2008) A.L.C. Cardoso et al.   JOURNAL OF CONTROLLED RELEASE

Liposome encapsulated polyethylenimine/ODN polyplexes for brain targeting

(2008) Young Tag Ko et al.   JOURNAL OF CONTROLLED RELEASE

Epidemiology of Parkinson’s disease

(2008) Guido Alves et al.   JOURNAL OF NEUROLOGY

Self-Assembling Nanofibers Inhibit Glial Scar Formation and Promote Axon Elongation after Spinal Cord Injury

(2008) V. M. Tysseling-Mattiace et al.   JOURNAL OF NEUROSCIENCE

Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson's disease: an open-label, phase I trial

(2008) William J Marks et al.   LANCET NEUROLOGY

Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease

(2008) Alim Louis Benabid et al.   LANCET NEUROLOGY

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

An injectable enzymatically crosslinked hyaluronic acid–tyramine hydrogel system with independent tuning of mechanical strength and gelation rate

(2008) Fan Lee et al.   Soft Matter

Advanced nanogel engineering for drug delivery

(2008) Koen Raemdonck et al.   Soft Matter

Dynamic Imaging of Functionalized Multi-Walled Carbon Nanotube Systemic Circulation and Urinary Excretion

(2007) L. Lacerda et al.   ADVANCED MATERIALS

The use of lactoferrin as a ligand for targeting the polyamidoamine-based gene delivery system to the brain

(2007) Rongqin Huang et al.   BIOMATERIALS

Thermoresponsive hydrogels in biomedical applications

(2007) Leda Klouda et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Neural tissue engineering of the CNS using hydrogels

(2007) David R. Nisbet et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Intravenous glial-derived neurotrophic factor gene therapy of experimental Parkinson's disease with Trojan horse liposomes and a tyrosine hydroxylase promoter

(2007) Chun-Fang Xia et al.   JOURNAL OF GENE MEDICINE