Article
Biophysics
Luisa Ribeiro Nicoleti, Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Marcela Tavares Luiz, Rafael Miguel Sabio, Marlus Chorilli
Summary: Glioblastoma multiforme is a common and aggressive brain cancer, and current treatments face challenges. Kaempferol, a flavonoid, shows anti-tumor activity but has limited bioavailability. The use of nanostructured lipid carriers (NLC) can improve the delivery of lipophilic drugs, enhancing their therapeutic efficacy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Gustavo Henrique Rodrigues da Silva, Ludmilla David de Moura, Fabiola Vieira de Carvalho, Gabriela Geronimo, Talita Cesarim Mendonca, Fernando Freitas de Lima, Eneida de Paula
Summary: This study focused on NLC formulations for encapsulation of antineoplastic agents, with special emphasis on in vivo studies. NLC has emerged as a powerful DDS to improve the bioavailability, targeting, and efficacy of antineoplastics, while decreasing their toxic effects.
Article
Biochemical Research Methods
Eman Gomaa, Heba A. Fathi, Noura G. Eissa, Mahmoud Elsabahy
Summary: Construction of nanocarriers, such as NLCs, has great potential in drug delivery systems. NLCs, as a new generation of solid lipid nanoparticles, have higher drug loading efficiency compared to SLNs and offer advantages in terms of preparation and scalability.
Article
Nanoscience & Nanotechnology
Mustafa K. Shehata, Assem A. Ismail, Maher A. Kamel
Summary: This study aimed to prepare and evaluate AST-loaded nanostructured lipid carriers (NLCs) for nose-to-brain drug delivery in rat model of AD. The optimized AST-NLCs showed improved therapeutic properties and significantly reduced oxidative stress, amyloidogenic pathway, neuroinflammation, and apoptosis in AD-like rats.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Pharmacology & Pharmacy
Mohammed A. S. Abourehab, Ahmed Khames, Samar Genedy, Shahin Mostafa, Mohammad A. Khaleel, Mahmoud M. Omar, Amani M. El Sisi
Summary: Sesame oil-based NIC-NLC was successfully formulated and optimized for intranasal delivery, showing promising synergy in neuroprotection. The optimized formula exhibited excellent bioavailability and brain targeting efficiency, indicating its potential for treating dementia.
Review
Pharmacology & Pharmacy
Thi-Thao-Linh Nguyen, Han-Joo Maeng
Summary: This article reviews the latest research progress in nose-to-brain drug delivery and focuses on the use of SLN and NLC formulations for the treatment of central nervous system diseases. These formulations can overcome the challenges of limited drug absorption and small nasal cavity volume, thereby improving drug bioavailability.
Article
Biochemistry & Molecular Biology
Xavier Llorente, Gerard Esteruelas, Lorena Bonilla, Mariana Garnica Agudelo, Ingrid Filgaira, Daniel Lopez-Ramajo, Ruoyi C. Gong, Concepcio Soler, Marta Espina, Maria Luisa Garcia, Joan Manils, Montserrat Pujol, Elena Sanchez-Lopez
Summary: Nanocarriers, including nanostructured lipid carriers (NLC), are highly effective for topical drug administration. Optimized NLCs loaded with the drug Riluzole (RLZ-NLCs) were developed as a potential treatment, featuring biodegradability, biocompatibility, and sustained drug release. RLZ-NLCs showed successful delivery of RLZ in a sustained manner, inhibition of keratinocyte cell proliferation, and non-angiogenic properties, making them a promising strategy for treating keratinocyte hyperproliferative conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Claudia Pina Costa, Joao Nuno Moreira, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: The management of CNS disorders is challenging due to the need for drugs to cross the BBB and reach the brain. Using the intranasal route combined with lipid-based nanocarriers has shown promising results in targeting drugs to the brain. Although the exact mechanism remains unclear, these systems are more effective than other routes and are expected to be approved by regulatory authorities in the future.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Nanoscience & Nanotechnology
Sara Cunha, Ben Forbes, Jose Manuel Sousa Lobo, Ana Catarina Silva
Summary: Treatment for Alzheimer's disease focuses on slowing symptom progression and enhancing quality of life. Nasal delivery offers a potential alternative route to directly deliver drugs to the brain, but clearance mechanisms in the nasal cavity hinder drug delivery efficiency. Formulations of lipid-based nanosystems show promise in optimizing nose-to-brain drug delivery, minimizing side effects, and maximizing therapeutic benefits.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sharifah Nurfadhlin Afifah Syed Azhar, Siti Efliza Ashari, Norhazlin Zainuddin, Masriana Hassan
Summary: Advanced hybrid component development in nanotechnology plays a crucial role in the drug delivery industry. This paper reviews important perspectives on nanohybrids in drug delivery, focusing on nanostructured lipid carriers (NLC) and hydrogel systems. The hybrid system enhances the synergistic properties of the hydrogel and reduces aggregation of the NLC, leading to superior functionality. The significant progress in NLC-hydrogel systems, including preparation, applications, advantages, and underlying issues, is discussed.
Article
Pharmacology & Pharmacy
Mengyu Chen, Yuexin Cui, Wenyan Hao, Yueyue Fan, Jingqiu Zhang, Qianqian Liu, Mingrui Jiang, Yang Yang, Yingzi Wang, Chunsheng Gao
Summary: Chemotherapy is currently the main treatment measure for glioma, but the low solubility of chemotherapeutic drugs and the biological barrier of solid tumors hinder the efficacy of anticancer therapy. The study developed a bionanostructured lipid carrier with tumor targeting abilities using nanostructured lipid carriers and the glioma C6 cancer cell membrane to encapsulate dihydroartemisinin, showing promising anti-tumor effects both in vitro and in vivo.
Article
Chemistry, Physical
Jessica Otarola, Patricia G. Molina, Mariano Garrido, N. Mariano Correa
Summary: A detailed spectroscopic study was conducted to analyze the interaction between an active principle and a lipid-based drug delivery system. The study found that not all PX molecules were fully incorporated into the carrier system, with some molecules located inside the lipid core and others outside the nanocarrier. Spectroscopic techniques revealed the structural behavior of PX species, indicating that the enolic structure was predominant both inside and outside the NLCs.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Pharmacology & Pharmacy
K. M. Noorulla, Mohd Yasir, Faizi Muzaffar, Roshan, Mohammed M. Ghoneim, Alanood S. Almurshedi, Abdurazak J. Tura, Sultan Alshehri, Teshome Gebissa, Shimelis Mekit, Mohammed Muqtader Ahmed, Ameeduzzafar Zafar
Summary: The study aimed to design and optimize Buspirone-loaded nano structured lipid carriers coated with Chitosan for nose to brain delivery. The optimized formulation exhibited acceptable performance with higher bioavailability and targeting efficiency.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
C. P. Costa, S. Cunha, J. N. Moreira, R. Silva, E. Gil-Martins, V. Silva, L. Azevedo, A. F. Peixoto, J. M. Sousa Lobo, A. C. Silva
Summary: Optimized diazepam-loaded NLC formulation with negative surface charge showed smaller particle size, higher encapsulation efficiency, and better biocompatibility for targeting the brain compared to the formulation with positive surface charge. The sustained drug release effect was observed in both formulations, with the negative surface charge formulation exhibiting greater cytotoxicity than the positive surface charge formulation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Agricultural Engineering
Sharifah Nurfadhlin Afifah Syed Azhar, Siti Efliza Ashari, Jen Kit Tan, Nur Kartinee Kassim, Masriana Hassan, Norhazlin Zainuddin, Rosfarizan Mohamad, Intan Diana Mat Azmi
Summary: Nanostructured lipid carriers (NLC) are effective vehicles for improving the bioavailability of poorly water-soluble drugs. This study investigated the impact of preformulation on different liquid lipids and solid lipids for the quality attributes of Mitragyna speciosa leaves extract-based NLC suitable for drug delivery system.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Cell Biology
Hong-Fang Mei, Neha Poonit, Yi-Chun Zhang, Chu-Yuan Ye, Hui-Lin Cai, Chen-Yi Yu, Yong-Hai Zhou, Bei-bei Wu, Jun Cai, Xiao-Hong Cai
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2018)
Article
Biochemistry & Molecular Biology
Shanshan Zhou, Jiqun Wang, Xia Yin, Ying Xin, Zhiguo Zhang, Taixing Cui, Jun Cai, Yang Zheng, Quan Liu, Lu Cai
Article
Cell Biology
Xingyu Lin, Rekha Jagadapillai, Jun Cai, Lu Cai, Guoguang Shao, Evelyne Gozal
INFLAMMATION RESEARCH
(2020)
Article
Immunology
Tianci Chu, Yi Ping Zhang, Zhisen Tian, Chuyuan Ye, Mingming Zhu, Lisa B. E. Shields, Maiying Kong, Gregory N. Barnes, Christopher B. Shields, Jun Cai
JOURNAL OF NEUROINFLAMMATION
(2019)
Article
Cardiac & Cardiovascular Systems
Yin Kang, Guangyan Zhang, Emma C. Huang, Jiapeng Huang, Jun Cai, Lu Cai, Sheng Wang, Bradley B. Keller
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Qi Liu, Yunhuan Liu, Fengyuan Li, Zelin Gu, Min Liu, Tuo Shao, Lihua Zhang, Guangyao Zhou, Chengwei Pan, Liqing He, Jun Cai, Xiang Zhang, Shirish Barve, Craig J. McClain, Yiping Chen, Wenke Feng
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2020)
Article
Cell Biology
Jiqun Wang, Jian Zhang, Liping Chen, Jun Cai, Zhijie Li, Zhiguo Zhang, Qi Zheng, Yonggang Wang, Shanshan Zhou, Quan Liu, Lu Cai
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Neurosciences
Zhisen Tian, Tianci Chu, Lisa B. E. Shields, Qingsan Zhu, Yi Ping Zhang, Maiying Kong, Gregory N. Barnes, Yuanyi Wang, Christopher B. Shields, Jun Cai
MOLECULAR NEUROBIOLOGY
(2020)
Article
Neurosciences
Yichun Zhang, Hongchao Cao, Xuehao Qiu, Danfen Xu, Yifeng Chen, Gregory N. Barnes, Yunjia Tu, Adwoa Takyiwaa Gyabaah, Abdulla Husain Abdulla Ahmed Gharbal, Chenlei Peng, Jun Cai, Xiaohong Cai
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)
Article
Cardiac & Cardiovascular Systems
Guangyan Zhang, Yin Kang, Dakotah Cathey, Amanda J. LeBlanc, Jun Cai, Lu Cai, Sheng Wang, Jiapeng Huang, Bradley B. Keller
Summary: This study demonstrates the crucial role of Nrf2 in the prevention of RV dysfunction and PAH by sulforaphane. Sulforaphane cannot reverse the RV dysfunction and increased RV systolic pressure induced by SuHx in Nrf2 knockout mice. Therefore, increasing Nrf2 activity in patients with PAH may have therapeutic potential.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Review
Cell Biology
Tianci Chu, Lisa E. Shields, Wenxin Zeng, Yi Zhang, Yuanyi Wang, Gregory Barnes, Christopher Shields, Jun Cai
Summary: Multiple sclerosis is an autoimmune disease that affects the central nervous system by attacking the myelin sheath. Glial cells play a crucial role in neuroinflammation and neurodegeneration associated with multiple sclerosis. Maintaining a balanced glial response is important for efficient remyelination and neuroregeneration.
NEURAL REGENERATION RESEARCH
(2021)
Article
Neurosciences
Rahul Oberoin, Tianci Chu, Nicholas Mellen, Rekha Jagadapillai, Hezhong Ouyang, Lori A. Devlin, Jun Cai
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2019)
Meeting Abstract
Medicine, General & Internal
R. Oberoi, N. Mellen, T. Chu, R. Jagadapillai, H. Ouyang, L. Devlin, R. Wu, J. Cai
JOURNAL OF INVESTIGATIVE MEDICINE
(2018)
Article
Cell Biology
Guoxiang Wang, Yi Ping Zhang, Zhongwen Gao, Lisa B. E. Shields, Fang Li, Tianci Chu, Huayi Lv, Thomas Moriarty, Xiao-Ming Xu, Xiaoyu Yang, Christopher B. Shields, Jun Cai
DISEASE MODELS & MECHANISMS
(2018)
Article
Biochemistry & Molecular Biology
Hui Xu, Jiqun Wang, Jun Cai, Wenke Feng, Yonggang Wang, Quan Liu, Lu Cai
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Nanoscience & Nanotechnology
Daniela Rubanova, Svitlana Skoroplyas, Alena Libanska, Eva Randarova, Josef Bryja, Michaela Chorvatova, Tomas Etrych, Lukas Kubala
Summary: This study explored the use of nanocarriers to deliver dexamethasone for treating rheumatoid arthritis. The results showed that this method increased the accumulation of dexamethasone in the arthritic area, had a dose-dependent healing effect, and reduced the accumulation of the RA mediator RANKL. This study provides a feasible strategy for improving rheumatoid arthritis therapy.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Article
Nanoscience & Nanotechnology
Thanpisit Lomphithak, Apiwit Sae-Fung, Simone Sprio, Anna Tampieri, Siriporn Jitkaew, Bengt Fadeel
Summary: In this study, iron-doped hydroxyapatite (FeHA) was evaluated as a potential nanomedicine approach for treating PDAC. The results showed that FeHA, in combination with a sublethal dose of the GPX4 inhibitor RSL3, could trigger ferroptosis in KRAS mutant PANC-1 cells while sparing normal human cells. The induction of ferroptosis by FeHA plus RSL3 was found to be dependent on the metalloreductase STEAP3 in PDAC cells.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)
Review
Nanoscience & Nanotechnology
Marco Felipe Salas-Orozco, Ana Cecilia Lorenzo-Leal, Idania de Alba Montero, Nuria Patino Marin, Miguel Angel Casillas Santana, Horacio Bach
Summary: The emergence of antibiotic-resistant bacteria in severe infections is a growing concern, particularly in hospital environments. Metal-based nanomaterials have shown potential as an alternative to combat these bacteria, but there is a risk of bacterial resistance and environmental accumulation.
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2024)