Article
Environmental Sciences
Hosny Abd El Fadil, Amany Behairy, Lamiaa L. M. Ebraheim, Yasmina M. Abd-Elhakim, Heba Hussein Fathy
Summary: This study investigated the protective effects of mulberry leaf and olive leaf ethanolic extracts against paracetamol-induced liver injury in rats. The results showed that olive leaf extract had superior antioxidant and antiapoptotic capabilities compared to mulberry leaf extract in protecting against paracetamol-induced liver injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Infectious Diseases
Anchalee Rawangkan, Pattama Wongsirisin, Grissana Pook-In, Achiraya Siriphap, Atchariya Yosboonruang, Anong Kiddee, Jureeporn Chuerduangphui, Nanthawan Reukngam, Acharaporn Duangjai, Surasak Saokaew, Ratsada Praphasawat
Summary: Lung cancer, especially non-small cell lung cancer (NSCLC), is a complex disease. The study aimed to evaluate the new function of dinactin in anti-NSCLC proliferation. The results showed that dinactin suppressed cell growth and reduced cancer stemness properties in NSCLC cells, suggesting its potential as a promising strategy for NSCLC therapy targeting cancer stem cells.
Review
Oncology
Lei Wang, Xiaowei Qin, Jianmin Liang, Pengfei Ge
Summary: Pyroptosis is a lytic pro-inflammatory type of programmed cell death that has a complex relationship with cancer. It can provide a comfortable environment for tumor proliferation as inflammatory cell death, but excessive activation can also inhibit the development of tumor cells.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Ovarian cancer, a heterogeneous disease, is commonly treated with surgery and chemotherapy, but natural products like resveratrol may offer a safe alternative therapy with anticancer effects. Resveratrol, commonly found in human diet, has shown promising results in fighting ovarian cancer cells.
Article
Biochemistry & Molecular Biology
Xiaoxiao Xu, Yanbing Xue, Qin Fang, Zhen Qiao, Shuo Liu, Xin Wang, Rupei Tang
Summary: pH-sensitive nanoparticles with MDR-reversal ability were prepared for efficient doxorubicin delivery in cancer therapy. Both in vitro and in vivo experiments demonstrated the potential of these dual-functional nanoparticles in inhibiting tumor growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Oncology
Hai-Qun Dong, Shi-Jing Liang, Yu-Ling Xu, Yi Dai, Na Sun, Dong-Hong Deng, Peng Cheng
Summary: The study found that Liproxstatin-1 inhibited the proliferation of K562 leukemia cells and exerted anticancer effects by affecting the cell cycle and apoptotic signaling pathways. Liproxstatin-1 induced cell cycle arrest, apoptosis, and pyroptosis, providing new hope for leukemia treatment.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Atala B. Jena, Umesh C. Dash, Asim K. Duttaroy
Summary: This study investigated the interaction between curcumin and EGCG, plant-derived compounds, with NLRP3 complex using in silico approach. The results showed that curcumin and EGCG had higher binding affinity for NLRP3 protein compared to other complex proteins, suggesting their potential impact on the complex's function. Protein-protein interaction studies further confirmed the efficacy of these compounds in hindering the formation of NLRP3 complex. The therapeutic effect of curcumin and EGCG may be mediated by preventing the development of the NLRP3 complex.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Fisheries
Han-Se Kim, Sehee Jo, Kwan-Sik Yun, Kyeong-Jun Lee
Summary: The study found that adding 0.05-0.1% of micelle silymarin to the feed significantly improved the growth performance, feed utilization, immune response, and antioxidant capacity of olive flounder. It also promoted the development of intestine and liver tissues. Compared to regular silymarin, micelle silymarin showed similar or higher effects even at low supplementation levels. Therefore, dietary micelle silymarin is expected to be a more effective and economical supplement for olive flounder.
AQUACULTURE INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Jongbeom Chae, Jin Soo Kim, Seok Tae Choi, Seul Gi Lee, Oyindamola Vivian Ojulari, Young Jin Kang, Taeg Kyu Kwon, Ju-Ock Nam
Summary: The study found that Farrerol can inhibit the survival of SKOV3 cells and induce cell cycle arrest and apoptosis. Additionally, Farrerol can induce cell apoptosis through the ERK/MAPK pathway. Moreover, Farrerol can attenuate TNF-alpha-induced lipolysis and increase adipogenic differentiation in 3T3-L1 cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ernawati Sinaga, Ami Fitrayadi, Asrori Asrori, Sri Endarti Rahayu, Suprihatin Suprihatin, Vivitri Dewi Prasasty
Summary: The study found that Pandanus odoratissimus extract significantly reduced hepatic enzyme activities and protein levels in paracetamol-induced rat serum, indicating its potential hepatoprotective effect.
PHARMACEUTICAL BIOLOGY
(2021)
Article
Environmental Sciences
Mabrouk Attia Abd Eldaim, Eman Ragab Barakat, Mohamed Alkafafy, Samy Ahmed Abd Elaziz
Summary: The study assessed the preventive potential of silymarin against lead-induced hepatorenal toxicity in rats by modulating oxidative stress, lipid oxidation, pathological changes in liver and kidney tissues, improving the antioxidant defense system of the liver and kidneys, and reducing pro-apoptotic gene expression in liver tissue.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Magda M. F. Ismail, Taghreed Z. Shawer, Rabab S. Ibrahim, Mostafa S. Abusaif, Mona M. Kamal, Rasha M. Allam, Yousry A. Ammar
Summary: This study discovered seventeen novel quinoxaline-3-propanamides that exhibited strong cytotoxic activity against colon cancer and breast cancer cells by targeting vascular endothelial growth factor receptor-2. These compounds showed higher selectivity and cytotoxicity compared to reference drugs, and they effectively inhibited angiogenesis and induced apoptosis through various pathways.
Article
Biochemistry & Molecular Biology
Mourad A. M. Aboul-Soud, Hanane Ennaji, Ashok Kumar, Mohammad A. Alfhili, Ahmed Bari, Maqusood Ahamed, Mohamed Chebaibi, Mohammed Bourhia, Farid Khallouki, Khalid M. Alghamdi, John P. Giesy
Summary: The study found that EECC exhibits significant antioxidant and anticancer activities, particularly against breast cancer cells. The cytotoxicity of EECC is mediated by the generation of ROS, leading to apoptosis and necrosis, possibly through binding to the caspase-3 receptor.
Article
Biochemical Research Methods
Seong-Bin Yang, Dong-Nyeong Lee, Minho Seo, Dong Wook Shin, Seokwoo Lee, Jun-Hyuck Lee, Young-Ho Lee, Jooho Park
Summary: A carrier-free nanomedicine was developed in this study to effectively deliver drugs to tumor tissues through self-assembly. It overcomes the manufacturing complexity, toxicity, and low loading capacity associated with typical polymer-based nanocarriers, exhibiting outstanding drug delivery performance. This carrier-free nanomedicine shows great potential for targeted anticancer therapy, demonstrating significant therapeutic effects for solid tumors.
BIOCONJUGATE CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Moamen Elsafty, Ahmed Abdeen, Mohamed Aboubakr
Summary: The study found that allicin (ALC) and/or omega-3 fatty acids (O3FA) may have a protective impact against acetaminophen-induced kidney damage through their anti-inflammatory, anti-apoptotic, and antioxidant defense systems.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Sahar A. Helmy, Saif El-Mofty, Amal M. El Gayar, Ibrahim M. El-Sherbiny, Yousra M. El-Far
Summary: The study aimed to enhance the efficacy of trans-ferulic acid (TFA) by loading it into folate-receptor-targeted poly lactic-co-glycolic acid nanoparticles (FA-PLGA-TFA NPs) and evaluating the antitumor efficacy of Doxorubicin (Dox)/FA-PLGA-TFA NPs combination against DMBA-induced breast cancer, as well as its safety profile. The combination not only inhibited Notch signaling but also suppressed synergy with other pathways, reduced P-gp levels, and maintained organ health and white blood cell count. This approach could potentially reduce side effects and improve antitumor activity compared to the standard AC regimen.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alaa M. Mansour, Sarah Yahia, Hassan Reda Hassan Elsayed, Saied A. E. El-Attar, Mohammed E. Grawish, Youssry M. El-Hawary, Ibrahim M. El-Sherbiny
Summary: The newly developed PCL-based nanofibrous composite scaffold showed enhanced periodontal wound healing/regeneration of class II furcation defects. Moreover, the combination of ADSCs seeded onto the scaffold further enhanced the periodontal tissues regeneration, demonstrating significant improvements in defect dimensions and tissue quality compared to the control group.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Pharmacology & Pharmacy
Alaa M. Ali, Ahmed S. Abo Dena, Magdi H. Yacoub, Ibrahim M. El-Sherbiny
Summary: The aim of this work is to build a computational model to study the flowability of fungal spores and pollen grains in order to predict their ability to reach the deep lung and relate it to allergies. The results show that the drag force exerted on the spores and pollen grains can affect their ability to cause disease. Additionally, certain shapes of spores and pollen grains have low drag and can be used for drug delivery to the deep lung.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shaimaa A. Khalid, Rabeay Y. A. Hassan, Rasha Mohamed El Nashar, Ibrahim M. El-Sherbiny
Summary: In this study, a bacterial imprinted polymer-based biosensor was developed for rapid and selective detection of Salmonella typhimurium. The biosensor exhibited high sensitivity and specificity towards the target pathogen and showed no interference signals when tested with other non-targeted pathogens. The biosensor also demonstrated the capability to directly detect the pathogen in minced beef meat samples, eliminating the need for bacterial enrichment steps.
Article
Chemistry, Medicinal
Yasmine Radwan, Kholoud K. Arafa, Monira G. Ghoniem, Eida S. Al-Farraj, Ibrahim M. El-Sherbiny
Summary: This study aimed to investigate the synergistic therapeutic effect of the novel combination of capsaicin and 5-fluorouracil encapsulated in lipid nanocapsules. The results showed that the developed nanoformulations had good physical stability and exhibited superior antiproliferative effect compared to the free drugs.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2023)
Article
Pharmacology & Pharmacy
Mohamed El -Far, Alaa Essam, Fardous F. El-Senduny, Amira O. Abd El-Azim, Sarah Yahia, Ibrahim M. El-Sherbiny
Summary: In this study, the anticancer effect of a novel drug combination using nanoformulations of Quercetin and Ascorbyl palmitate was investigated in Ehrlich ascites carcinoma (EAC)-bearing mice. The combination treatment significantly reduced tumor growth, increased antioxidant status, and reduced lipid peroxidation. The combination also downregulated the expression of p-STAT3 and HIF-1 alpha, induced cell cycle arrest and apoptosis in EAC cells, and caused DNA damage. The combination was also superior in the destruction of the mitochondrial membrane.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mohamed Fawzi Kabil, Osama A. Badary, Frank Bier, Shaker A. Mousa, Ibrahim M. El-Sherbiny
Summary: Cancer is a major cause of death worldwide, and chemotherapy is the most commonly used treatment. However, current chemotherapeutic treatments have limitations, including lack of specificity and adverse effects. Lipid nanoparticles (LNPs) offer a promising nanocarrier system to improve drug delivery and reduce side effects, potentially leading to better therapeutic outcomes.
JOURNAL OF LIPOSOME RESEARCH
(2023)
Correction
Pharmacology & Pharmacy
Amira Mansour, Mohamed Y. Mahmoud, Alaa F. Bakr, Monira G. Ghoniem, Fatima A. Adam, Ibrahim M. El-Sherbiny
Article
Chemistry, Multidisciplinary
Mostafa Fytory, Amira Mansour, Waleed M. A. El Rouby, Ahmed A. Farghali, Xiaorong Zhang, Frank Bier, Mahmoud Abdel-Hafiez, Ibrahim M. El-Sherbiny
Summary: By grafting glycyrrhetinic acid to polyethyleneimine, a biocompatible Zr-based metal-organic framework was designed for efficient controlled drug release and selective targeting against hepatic cancer cells. The improved core-shell structure enhanced the drug loading capacity and selectivity towards tumor cells, while exhibiting minimal toxicity to normal cells. This study provides a new approach for active drug delivery and efficient cancer therapy applications.
Article
Chemistry, Multidisciplinary
Sarah Yahia, Islam A. Khalil, Monira G. Ghoniem, Ibrahim M. El-Sherbiny
Summary: This work aimed to develop a functional spine unit (FSU) replacement using different technologies to mimic the structure and function of the vertebral body (VB) and intervertebral disc (IVD) and treat spinal tuberculosis (TB). 3D-printed scaffolds with different porous patterns were fabricated to replace damaged VB and IVD. The results showed excellent mechanical strength and biocompatibility of the custom-designed replacements, along with the expected prolonged release of antibiotics. These findings suggest that this drug-eluting scaffold system could be used for treating various spinal problems.
Article
Pharmacology & Pharmacy
Amira Mansour, Mostafa Fytory, Osama M. Ahmed, Fatema El-Zahraa S. Abdel Rahman, Ibrahim M. El-Sherbiny
Summary: This study developed a novel nanostructure for breast cancer treatment by loading Methotrexate (MTX) and 5-fluorouracil (Fu) into a core-shell nanocarrier. The nanostructure showed high drugs' entrapment efficiency and a pH-responsive drug release pattern. In vitro and in vivo experiments demonstrated the enhanced anticancer effect of the developed nanostructure and its ability to maintain the normal functions of vital organs.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Chemistry, Multidisciplinary
Ahmed S. Abo Dena, Mariam Dhaou, Ibrahim M. El-Sherbiny
Summary: In this study, a fluorescent molecularly imprinted polymer (FMIP) was developed for the solid-phase extraction (SPE) and fluorimetric determination of hydrochlorothiazide (HCTZ) in water. The FMIP exhibited high adsorption capacity and selectivity for HCTZ, making it suitable for easy and fast SPE of HCTZ.
Article
Nanoscience & Nanotechnology
Amany A. Aboomeirah, Wessam A. Sarhan, Eman A. Khalil, Ahmed Abdellatif, Ahmed S. Abo Dena, Ibrahim M. El-Sherbiny
Summary: We developed a well-designed single-dose extracellular matrix (ECM)-mimicking nanofibers (NFs)-reinforced hydrogel (HG)-based skin substitute for wound healing. The skin substitute exhibited adjustable mechanical characteristics, outstanding physical properties, and an excellent porous microstructure. In vivo application of the skin substitute demonstrated excellent wound-healing activity and improvement in the quality of the regenerated skin.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Biomaterials
Sarah Yahia, Ahmed S. Abo Dena, Rasha M. El Nashar, Ibrahim M. El-Sherbiny
Summary: This study reports the fabrication of a new transdermal patch for delivering varenicline tartrate, a smoking cessation drug. The patch is composed of nanomicelles-in-coaxial nanofibers structure, which exhibits good release properties and low cytotoxicity.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Multidisciplinary
Said F. Hamed, Ayat F. Hashim, Hoda Abdel Hay, Kamel A. Abd-Elsalam, Ibrahim M. El-Sherbiny
Summary: Omega-3 fatty acids are potential therapeutic agents with antioxidant, nutritional, and health benefits. However, their unsaturated nature makes them susceptible to oxidation, requiring protection in food products. This review discusses the chemistry, natural sources, health benefits, and antimicrobial activity of omega-3 fatty acids. It also highlights the challenges of incorporating omega-3 fatty acids into foods, particularly regarding oxidation, and explores the use of natural polyphenols and different wall materials for microencapsulation. Various encapsulation techniques are also discussed.
EGYPTIAN JOURNAL OF CHEMISTRY
(2022)
