Enhancing immunogenicity and cross-reactivity of HIV-1 antigens by in vivo targeting to dendritic cells

Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells

(2012) Thomas Vollbrecht et al.   AIDS

The Thai Phase III Trial (RV144) Vaccine Regimen Induces T Cell Responses That Preferentially Target Epitopes within the V2 Region of HIV-1 Envelope

(2012) M. S. de Souza et al.   JOURNAL OF IMMUNOLOGY

Severe Immune Dysregulation Affects CD4+CD25hiFoxP3+ Regulatory T Cells in HIV-Infected Patients With Low-level CD4 T-Cell Repopulation Despite Suppressive Highly Active Antiretroviral Therapy

(2012) Gema Méndez-Lagares et al.   JOURNAL OF INFECTIOUS DISEASES

Preserved Function of Regulatory T Cells in Chronic HIV-1 Infection Despite Decreased Numbers in Blood and Tissue

(2012) Mathieu Angin et al.   JOURNAL OF INFECTIOUS DISEASES

Magnitude and Breadth of the Neutralizing Antibody Response in the RV144 and Vax003 HIV-1 Vaccine Efficacy Trials

(2012) D. C. Montefiori et al.   JOURNAL OF INFECTIOUS DISEASES

Longitudinal Changes of Peripheral Blood DC Subsets and Regulatory T Cells in Chinese Chronic HIV-1-Infected Patients during Antiretroviral Therapy

(2012) Mei Zhang et al.   PLoS One

Quantitative proteomic analysis of exosomes from HIV-1-infected lymphocytic cells

(2012) Ming Li et al.   PROTEOMICS

Memory and naive-like regulatory CD4+ T cells expand during HIV-2 infection in direct association with CD4+ T-cell depletion irrespectively of viremia

(2011) Russell B. Foxall et al.   AIDS

Myeloid dendritic cells isolated from tissues of SIV-infected Rhesus macaques promote the induction of regulatory T cells

(2011) Pietro Presicce et al.   AIDS

mRNA-based dendritic cell vaccination induces potent antiviral T-cell responses in HIV-1-infected patients

(2011) Ellen Van Gulck et al.   AIDS

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity

(2011) P. J. Tacken et al.   BLOOD

Mechanism of T cell exhaustion in a chronic environment

(2011) Hyun-Tak Jin et al.   BMB Reports

A phase I/IIa immunotherapy trial of HIV-1-infected patients with Tat, Rev and Nef expressing dendritic cells followed by treatment interruption

(2011) Sabine D. Allard et al.   CLINICAL IMMUNOLOGY

Advances in Dendritic Cell-Based Vaccines for HIV

(2011) B. Patham et al.   CURRENT MEDICINAL CHEMISTRY

Immunogenicity of DNA vaccines in humans: It takes two to tango

(2011) Shan Lu   Human vaccines & immunotherapeutics

DC-SIGN mediated antigen-targeting using glycan-modified liposomes: Formulation considerations

(2011) Medha D. Joshi et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Human immunodeficiency virus type 1 Nef in human monocyte-like cell line THP-1 expands treg cells via toll-like receptor 2

(2011) Xiaolin Qin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Therapeutic Dendritic Cell-Based Vaccine for HIV-1 Infection

(2011) Felipe García et al.   JOURNAL OF INFECTIOUS DISEASES

The combination of 4-1BBL and CD40L strongly enhances the capacity of dendritic cells to stimulate HIV-specific T cell responses

(2011) Brenda De Keersmaecker et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Gold Nanoparticles Coated with Oligomannosides of HIV-1 Glycoprotein gp120 Mimic the Carbohydrate Epitope of Antibody 2G12

(2011) Marco Marradi et al.   JOURNAL OF MOLECULAR BIOLOGY

Immunotherapy of Murine Retrovirus-Induced Acquired Immunodeficiency by CD4 T Regulatory Cell Depletion and PD-1 Blockade

(2011) W. Li et al.   JOURNAL OF VIROLOGY

On the Role of the SP1 Domain in HIV-1 Particle Assembly: a Molecular Switch?

(2011) S. A. K. Datta et al.   JOURNAL OF VIROLOGY

Programming the magnitude and persistence of antibody responses with innate immunity

(2011) Sudhir Pai Kasturi et al.   NATURE

Protective HIV-specific CD8+ T cells evade Treg cell suppression

(2011) Shokrollah Elahi et al.   NATURE MEDICINE

Frequency of Circulating Regulatory T Cells Increases during Chronic HIV Infection and Is Largely Controlled by Highly Active Antiretroviral Therapy

(2011) Pietro Presicce et al.   PLoS One

Comparable T helper 1 (Th1) and CD8 T-cell immunity by targeting HIV gag p24 to CD8 dendritic cells within antibodies to Langerin, DEC205, and Clec9A

(2011) J. Idoyaga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeted antigen delivery and activation of dendritic cells in vivo: Steps towards cost effective vaccines

(2011) Paul J. Tacken et al.   SEMINARS IN IMMUNOLOGY

GP120-specific exosome-targeted T cell-based vaccine capable of stimulating DC- and CD4+ T-independent CTL responses

(2011) Roopa Hebbandi Nanjundappa et al.   VACCINE

Challenges in dendritic cells-based therapeutic vaccination in HIV-1 infection

(2011) Felipe García et al.   VACCINE

A novel self-assembled nanoparticle vaccine with HIV-1 Tat49-57/HPV16 E749-57 fusion peptide and GM-CSF DNA elicits potent and prolonged CD8+ T cell-dependent anti-tumor immunity in mice

(2011) Jun Tang et al.   VACCINE

Immunogenicity and safety of an HIV-1 lipopeptide vaccine in healthy adults: a phase 2 placebo-controlled ANRS trial

(2010) Dominique Salmon-Céron et al.   AIDS

Vaccine-induced IgG2 anti-HIV p24 is associated with control of HIV in patients with a ‘high-affinity’ FcγRIIa genotype

(2010) Martyn A French et al.   AIDS

Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A

(2010) Olivier P. Joffre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Targeted PLGA nano- but not microparticles specifically deliver antigen to human dendritic cells via DC-SIGN in vitro

(2010) Luis J. Cruz et al.   JOURNAL OF CONTROLLED RELEASE

Characterization of human DNGR-1+BDCA3+leukocytes as putative equivalents of mouse CD8α+dendritic cells

(2010) Lionel Franz Poulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Increased B7-H1 Expression on Dendritic Cells Correlates with Programmed Death 1 Expression on T Cells in Simian Immunodeficiency Virus-Infected Macaques and May Contribute to T Cell Dysfunction and Disease Progression

(2010) H. Xu et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Analysis of Frequency and Phenotype of T Regulatory Cells in HIV Infection: CD39 Expression of FoxP3+ T Regulatory Cells Correlates with Progressive Disease

(2010) J. Schulze zur Wiesch et al.   JOURNAL OF VIROLOGY

HIV-1 Lentiviral Vector Immunogenicity Is Mediated by Toll-Like Receptor 3 (TLR3) and TLR7

(2010) K. Breckpot et al.   JOURNAL OF VIROLOGY

Polyelectrolyte Capsules-containing HIV-1 p24 and Poly I:C Modulate Dendritic Cells to Stimulate HIV-1-specific Immune Responses

(2010) Winni De Haes et al.   MOLECULAR THERAPY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Mosaic HIV-1 vaccines expand the breadth and depth of cellular immune responses in rhesus monkeys

(2010) Dan H Barouch et al.   NATURE MEDICINE

Safety and Immunogenicity of Therapeutic DNA Vaccination in Individuals Treated with Antiretroviral Therapy during Acute/Early HIV-1 Infection

(2010) Eric S. Rosenberg et al.   PLoS One

Uridine Metabolism in HIV-1-Infected Patients: Effect of Infection, of Antiretroviral Therapy and of HIV-1/ART-Associated Lipodystrophy Syndrome

(2010) Pere Domingo et al.   PLoS One

In vivo expansion of naive and activated CD4+CD25+FOXP3+ regulatory T cell populations in interleukin-2-treated HIV patients

(2010) L. Weiss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

B cell responses to HIV-1 infection and vaccination: pathways to preventing infection

(2010) Barton F. Haynes et al.   TRENDS IN MOLECULAR MEDICINE

HIV gag protein is efficiently cross-presented when targeted with an antibody towards the DEC-205 receptor in Flt3 ligand-mobilized murine DC

(2009) Leonia Bozzacco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Assembly and intracellular trafficking of HLA-B*3501 and HLA-B*3503

(2009) Vilasack Thammavongsa et al.   IMMUNOGENETICS

Enhanced immunogenicity and cross-reactivity of HIV-1 V3-peptide and multiple antigen peptides conjugated to distinct carrier proteins

(2009) Luis J. Cruz et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Utilization of Immunoglobulin G Fc Receptors by Human Immunodeficiency Virus Type 1: a Specific Role for Antibodies against the Membrane-Proximal External Region of gp41

(2009) L. G. Perez et al.   JOURNAL OF VIROLOGY

Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori

(2009) Sonja I Gringhuis et al.   NATURE IMMUNOLOGY

S04-04 OA. HIV-specific responses induced by anti-CD40 targeting antibodies

(2009) N Loof et al.   Retrovirology

P19-26. Directing macaque immune responses with an anti-dendritic cell HIV Gag p24 fusion protein vaccine

(2009) F Martinon et al.   Retrovirology

P17-04. Targeting HIV peptides to human dendritic cells via CD40 elicits expansion of multi-epitope polyfunctional CD4+ and CD8+ T cells in HIV patients

(2009) A Flamar et al.   Retrovirology

HIV Nef is Secreted in Exosomes and Triggers Apoptosis in Bystander CD4+ T Cells

(2009) Metka Lenassi et al.   TRAFFIC

Mechanism for increased immunogenicity of vaccines that form in vivo immune complexes with the natural anti-Gal antibody

(2009) Ussama M. Abdel-Motal et al.   VACCINE

A novel HIV T helper epitope-based vaccine elicits cytokine-secreting HIV-specific CD4+ T cells in a Phase I clinical trial in HIV-uninfected adults

(2009) Xia Jin et al.   VACCINE

A universal anti-HIV-1 Tat epitope vaccine that is fully synthetic and self-adjuvanting

(2009) Gideon Goldstein et al.   VACCINE

Production of a Dendritic Cell-Based Vaccine Containing Inactivated Autologous Virus for Therapy of Patients with Chronic Human Immunodeficiency Virus Type 1 Infection

(2008) T. L. Whiteside et al.   Clinical and Vaccine Immunology

B7-H1 up-regulation impairs myeloid DC and correlates with disease progression in chronic HIV-1 infection

(2008) Xicheng Wang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Induction of HIV-specific T and B cell responses with a replicating and conditionally infectious lentiviral vaccine

(2008) Jeremy B. Wingard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dendritic cell-based human immunodeficiency virus vaccine

(2008) C. R. Rinaldo   JOURNAL OF INTERNAL MEDICINE

Cross-Reactive Human Immunodeficiency Virus Type 1-Neutralizing Human Monoclonal Antibody That Recognizes a Novel Conformational Epitope on gp41 and Lacks Reactivity against Self-Antigens

(2008) M.-Y. Zhang et al.   JOURNAL OF VIROLOGY

A Bispecific Antibody Composed of a Nonneutralizing Antibody to the gp41 Immunodominant Region and an Anti-CD89 Antibody Directs Broad Human Immunodeficiency Virus Destruction by Neutrophils

(2008) M. Duval et al.   JOURNAL OF VIROLOGY

Engineered lentivector targeting of dendritic cells for in vivo immunization

(2008) Lili Yang et al.   NATURE BIOTECHNOLOGY

TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses

(2008) Eva Schlosser et al.   VACCINE

Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial

(2008) Paul Spearman et al.   VACCINE

Combining DNA technologies and different modes of immunization for induction of humoral and cellular anti-HIV-1 immune responses

(2008) Andreas Bråve et al.   VACCINE

Co-Immunization of Mice with a Retroviral DNA Vaccine and GITRL-Encoding Plasmid Augments Vaccine-Induced Protection Against Retrovirus Infection

(2008) Ulf Dittmer et al.   VIRAL IMMUNOLOGY

Neutralizing activity of antibodies to the V3 loop region of HIV-1 gp120 relative to their epitope fine specificity

(2008) Ralph Pantophlet et al.   VIROLOGY

HIV-1 Infection of Bone Marrow Hematopoietic Progenitor Cells and Their Role in Trafficking and Viral Dissemination

(2008) Aikaterini Alexaki et al.   PLoS Pathogens

V3 CTL epitope density in a single recombinant molecule antigen differentially affects the number and activity of primary and memory CD8+ T cells

(2007) Lu Lu et al.   VACCINE