Article
Physics, Applied
Hariharan Nhalil, Moty Schultz, Shai Amrusi, Asaf Grosz, Lior Klein
Summary: We present a planar Hall effect magnetometer consisting of a parallel array of permalloy-based elliptical sensors. The array configuration and fabrication parameters are optimized using numerical simulations. The magnetometer achieves equivalent magnetic noise (EMN) of 16 pT/(sic) Hz at 100 Hz, 25 pT/(sic) Hz at 10 Hz, 98 pT/(sic) Hz at 1 Hz, and 470 pT/(sic) Hz at 0.1 Hz. The absence of magnetic flux concentrators in this design highlights its advantages. This straightforward, cost-effective magnetometer shows potential for applications requiring pT resolution at room temperature.
JOURNAL OF APPLIED PHYSICS
(2023)
Review
Chemistry, Analytical
Songrui Wei, Xiaoqi Liao, Han Zhang, Jianhua Pang, Yan Zhou
Summary: Fluxgate magnetic sensors, based on Faraday's law of electromagnetic induction, have a structure similar to a transformer and have been widely used in geophysics, astro-observations, wearable electronic devices, and non-destructive testing. Recent research has focused on reducing noise, improving calibration methods, and increasing sensitivity.
Article
Multidisciplinary Sciences
Qitao Hu, Si Chen, Paul Solomon, Zhen Zhang
Summary: In this study, sub-10-nm electrical double layer-gated silicon nanowire field-effect transistors (SiNWFETs) are used to directly detect the events of capturing and emitting a single hydrogen ion (H+) at the solid/liquid interface. The ability to achieve ion detection with single charge resolution is demonstrated, along with a systematic investigation of the kinetics of single H+-DB interactions. The SiNWFETs show unprecedented capability for electrical sensing applications, especially in studying the physics of solid/liquid interfacial interactions at the single charge level.
Article
Multidisciplinary Sciences
Laura Benhaim-Sitbon, Maria Lev, Uri Polat
Summary: Heterophoria is a common disorder that affects binocular fusion and can lead to misalignment of the eyes and reading difficulties. Recent studies have found abnormal patterns of low-level visual processing in individuals with heterophoria, resulting in larger perceptive fields (PF). The size of the PF is closely related to masking and crowding. This study explored the impact of heterophoria on PF size, foveal crowding, and letter identification. The results showed that heterophoric individuals had larger horizontal PF size, stronger crowding, and an extended crowding zone, which required more processing effort. The study also found a correlation between the crowding zone, PF size, and the severity of heterophoria. These findings could explain the variability in masking literature and reading difficulties in individuals with high heterophoria.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Mikael Hoffmann, Henrik Stovring
Summary: Defining new cases is a crucial step in epidemiology and pharmacoepidemiology, and there are two types of new cases for drug use: first-ever and recurrent. The length of run-in period is associated with misclassifications, which can be expressed using the positive predictive value (PPV). A study in Sweden examined the incidence proportion of statins for different run-in periods and found variations in the incidence rate. At least five different misclassifications can be introduced based on how incidence is defined.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2022)
Article
Optics
Giuseppe Ortolano, Alberto Paniate, Pauline Boucher, Carmine Napoli, Sarika Soman, Silvania F. Pereira, Ivano Ruo-Berchera, Marco Genovese
Summary: Quantum entanglement and squeezing have improved phase estimation and imaging beyond the classical limits in interferometric settings. However, the advantage of quantum in non-interferometric phase imaging methods commonly used in the classical domain, such as ptychography and diffractive imaging, is still lacking. In this study, we demonstrate the enhancement of imaging a pure phase object in a non-interferometric setting by exploiting entanglement, measuring only the phase effect on the free-propagating field.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Acoustics
Truls Gjestland, Makoto Morinaga
Summary: ISO published a technical specification aiming to facilitate the comparison of survey results on noise annoyance. An analysis of survey results suggests the use of a weighting procedure to achieve greater similarity between two annoyance questions. Additionally, it is important to use a definition of high annoyance that aligns with relevant noise regulations.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wingchi E. Kwok
Summary: RF coils are crucial for MRI, playing a vital role in image quality. Selecting suitable coils, proper usage, and quality control are essential for optimal image quality and patient safety.
Article
Optics
M. Was, E. Polini
Summary: In this paper, we present an experimental method to directly and quantitatively measure backscatter interference, as well as the relation between backscatter interference, beam radius, and the scattering sample bidirectional reflectance distribution function. The experimental results demonstrate that our method is capable of measuring backscatter from high-quality optics at angles as low as 500 mu rad with an angular resolution of 160 mu rad.
Article
Engineering, Electrical & Electronic
Louise Springer, Frank Ludwig, Uros Mavric, Volodymyr Vasylyuk, Heinrich Pryschelski, Matthias Hoffmann, Holger Schlarb, Alexander Koelpin, Arne F. Jacob
Summary: This article summarizes the theoretical and technical limitations of applying carrier-suppression interferometer (CSI) methods for precision phase-noise measurements. The reported CSI setup outperforms conventional down-mixing methods by more than two orders of magnitude. The research achieved a detection floor of -205 dBc/Hz and a time resolution of 10.76 as at a 13 GHz operation frequency, without the use of cross correlation or power recycling techniques.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Optics
Sandro Heuke, Xavier Audier, Herve Rigneault
Summary: A double modulation scheme is proposed for stimulated Raman microscopy, where both the pump and Stokes beams are modulated at fm and 2fm. By exploiting aliasing and reduction of repetition rate, the proposed scheme amplifies the signal amplitude by a factor of 1.5, 2, and 4 for different modulation frequencies and experimental realizations at the same average power. The derived noise power for different sources shows that the double modulation scheme can achieve up to 16-fold speed improvement in stimulated Raman scattering imaging compared to single beam modulation.
Article
Optics
Farid Ya Khalili, Emil Zeuthen
Summary: State-of-the-art linear sensors for force, motion, and magnetic fields have achieved high sensitivity levels where quantum noise plays a significant role. The best optomechanical devices have reached the standard quantum limit (SQL), with proposed methods for overcoming it. There are two more fundamental quantum sensitivity constraints known as the energetic quantum limit and the dissipative quantum limit.
Article
Physics, Applied
M. Petrenko, A. S. Pazgalev, A. K. Vershovskii
Summary: A new method for measuring magnetic fields using a single laser beam with time-modulated ellipticity is introduced, allowing for hyperfine and Zeeman optical pumping, excitation and detection of magnetic resonance. This method simplifies the Bell-Bloom magnetometric scheme while maintaining sensitivity and eliminating the need for radio-frequency fields, making it ideal for creating sensor arrays. Experimental studies show the efficiency of the method for challenging magnetoencephalographic tasks.
PHYSICAL REVIEW APPLIED
(2021)
Article
Instruments & Instrumentation
V. Jaberian Hamedan, J. Winterflood, C. Blair, L. Ju, C. Zhao
Summary: Thermal noise is a significant contribution to gravitational wave detectors, and silicon with its low thermal expansion and high thermal conductivity shows promise as a candidate material for test masses. Optimizing design and measuring mechanical Q-factors can improve performance.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2022)
Article
Public, Environmental & Occupational Health
Sha Li, Daniel Yee Tak Fong, Janet Yuen Ha Wong, Bradley McPherson, Esther Yuet Ying Lau, Lixi Huang, Mary Sau Man Ip
Summary: Nonrestorative sleep was found to be associated with noise sensitivity in addition to family income, season, exercise, social support, somatic symptoms, stress, and depression. Nocturnal noise negatively impacted time in bed, total sleep time, and awakenings, but was not directly related to nonrestorative sleep.
Review
Chemistry, Analytical
Gabriele Magna, Manuela Stefanelli, Giuseppe Pomarico, Mario Luigi Naitana, Donato Monti, Corrado Di Natale, Roberto Paolesse
Summary: The detection and discrimination of chiral analytes is crucial in various industries. The use of sensor arrays as an alternative method is gaining more attention. This strategy mimics the functioning of natural olfactory systems to achieve the identification and quantification of chiral compounds.
Article
Chemistry, Analytical
Mauro Tomassetti, Riccardo Pezzilli, Giuseppe Prestopino, Corrado Di Natale, Pier Gianni Medaglia
Summary: This paper presents a novel non-enzymatic modified glassy carbon (GC) sensor for hydrogen peroxide (H2O2) determination in healthy and diabetic human urine. The sensor is based on the (GC-Ag-paste)-catalytic proline-assisted LDH system, where LDH is attached to the glassy carbon using silver paste and proline is utilized to enhance the catalytic properties of LDH. The sensor exhibits high sensitivity and the proline-assisted LDH system effectively detects H2O2 in the urine samples.
Article
Crystallography
Mauro Tomassetti, Claudio Leonardi, Riccardo Pezzilli, Giuseppe Prestopino, Corrado Di Natale, Pier Gianni Medaglia
Summary: We have developed a simple, fast, and inexpensive voltammetric system for determining proline concentration. The system uses a non-enzymatic sensor and can accurately measure the concentration of proline in standard solutions and real samples. The method has been successfully applied to commercial wine samples.
Review
Biochemistry & Molecular Biology
Manuela Stefanelli, Gabriele Magna, Corrado Di Natale, Roberto Paolesse, Donato Monti
Summary: Conjugating the porphyrin ring with an amino acid via amide linkage allows for the creation of both amphiphilicity and chirality in the macrocycle. The use of proline residue is advantageous due to its conformational rigidity, which allows for efficient transfer and amplification of molecular chirality in aqueous environments. This article describes the evolution of studies conducted by the authors to achieve chiral systems from porphyrin-proline derivatives, both in solution and in the solid state. The discussion focuses on fundamental aspects that influence the resulting molecular architectures, including the nature of the appended group, the presence of coordinated metal ions, and the properties of the solvent. The fine-tuning of these parameters enables the creation of stereospecific structures with distinct chiroptical and morphological features. Solid films based on these chiral systems are also obtained and their recognition abilities in gaseous and liquid phases are discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Rosamaria Capuano, Antonella Mansi, Emilia Paba, Anna Maria Marcelloni, Alessandra Chiominto, Anna Rita Proietto, Andrea Gordiani, Alexandro Catini, Roberto Paolesse, Giovanna Tranfo, Corrado Di Natale
Summary: This paper characterizes the volatile organic compounds (VOCs) pattern emitted in vitro by Legionella pneumophila cultures and compares it with those produced by other Legionella species and by Pseudomonas aeruginosa. The results show that the VOCs can differentiate Legionella pneumophila from other waterborne microorganisms.
Article
Chemistry, Analytical
Gabriele Magna, Eugenio Martinelli, Roberto Paolesse, Corrado Di Natale
Summary: The standard model of artificial olfaction, which includes sensor arrays and pattern recognition algorithms, fails to achieve most of the natural olfaction features. This study bridges this gap by using a biologically derived processing algorithm on a highly redundant sensor array, and creating an over-segmented reference space using a Self-Organizing Map (SOM) to enable odor identification.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Multidisciplinary
Lai Van Duy, To Thi Nguyet, Dang Thi Thanh Le, Nguyen Van Duy, Hugo Nguyen, Franco Biasioli, Matteo Tonezzer, Corrado Di Natale, Nguyen Duc Hoa
Summary: Gas sensors are crucial for various aspects of human life, including production processes, occupational safety, food quality assessment, and air pollution monitoring. The development of gas sensors that are efficient, small, and inexpensive is a challenge but important for environmental and human health protection. In this paper, a resistive sensor based on thin V2O5 nanosheets for ammonia detection at room temperature was reported, with good performance and selectivity.
Review
Green & Sustainable Science & Technology
Angelo Milone, Anna Grazia Monteduro, Silvia Rizzato, Angelo Leo, Corrado Di Natale, Sang Sub Kim, Giuseppe Maruccio
Summary: Gas sensing research has experienced a worldwide revival in recent years. The emergence of novel sensing materials and increasing opportunities for applications have greatly contributed to the progress in this field. This review focuses on emerging approaches, recent breakthroughs, and applications in various sectors such as environmental monitoring, food aroma identification, and healthcare.
ADVANCED SUSTAINABLE SYSTEMS
(2023)
Article
Chemistry, Analytical
Leonardo Papale, Alexandro Catini, Rosamaria Capuano, Valerio Allegra, Eugenio Martinelli, Massimo Palmacci, Giovanna Tranfo, Corrado Di Natale
Summary: Indoor locations with limited air exchange can easily be contaminated by harmful volatile compounds. Thus, it is important to monitor the distribution of chemicals indoors to reduce associated risks. In this study, a monitoring system based on a Machine Learning approach is introduced, which utilizes a low-cost wearable VOC sensor in a Wireless Sensor Network (WSN) to process information and localize mobile sensor units.
Article
Chemistry, Analytical
Mauro Tomassetti, Riccardo Pezzilli, Claudio Leonardi, Giuseppe Prestopino, Corrado Di Natale, Luigi Campanella, Pier Gianni Medaglia
Summary: This study demonstrates that introducing nanostructured layered double hydroxides (LDHs) into the anode compartment can enhance the kinetic performance of a direct catalytic ethanol fuel cell (DCEFC). The calibration sensitivity of the method increases by 1.3-fold with the introduction of LDHs and even further in the presence of hydrogen peroxide. By modifying the fuel cell with enzyme catalase crosslinked on LDHs and in the presence of hydrogen peroxide, the calibration sensitivity increases by 8-times. This modification shows positive results in ethanol detection for analytical applications and can also improve the energy performance of a DCEFC.
Article
Chemistry, Analytical
Yolande Christelle Ketchanji Mougang, Laurent-Mireille Endale Mangamba, Rosamaria Capuano, Fausto Ciccacci, Alexandro Catini, Roberto Paolesse, Hugo Bertrand Mbatchou Ngahane, Leonardo Palombi, Corrado Di Natale
Summary: Tuberculosis is a common cause of death in many countries, and the current diagnostic method of smear microscopy has a low true positive rate. Analyzing exhaled VOCs using sensors has been proposed as a promising alternative for disease diagnosis. Testing an electronic nose based on sensor technology in a Cameroon hospital showed promising results for the diagnosis of pulmonary TB.
Article
Engineering, Electrical & Electronic
Guru Prasad Kuppuswamy, Mallikarjuna Swamy Shabanur Matada, Gobinath Marappan, Mohammed Yusuf Mulla, Surya Velappa Jayaraman, Corrado Di Natale, Yuvaraj Sivalingam
Summary: This study focuses on the development of a nickel-metal organic framework (Ni-MOF) with sheetlike morphology on a carbon paper (CP) electrode for the noninvasive detection of glucose. The Ni-MOF/CP electrode serves as an extended gate for the measurement of glucose concentrations ranging from 20 μM to 1.47 mM. The sensor demonstrates good sensitivity, selectivity, and sensitivity preservation in human saliva, making it a potential alternative device for the noninvasive diagnosis of diabetes mellitus.
ACS APPLIED ELECTRONIC MATERIALS
(2023)
Article
Chemistry, Analytical
Lorena Di Zazzo, Sujithkumar Ganesh Moorthy, Rita Meunier-Prest, Eric Lesniewska, Corrado Di Natale, Roberto Paolesse, Marcel Bouvet
Summary: The versatility of metal complexes of corroles has raised interest in the use of these molecules as elements of chemical sensors. To compensate for the scarce conductivity, corroles are often used to functionalize the surface of conductive materials or incorporated into heterojunction devices. These heterostructure sensors can detect ammonia and relative humidity with high sensitivity.
Article
Chemistry, Multidisciplinary
Giacomo Picci, Sara Farotto, Jessica Milia, Claudia Caltagirone, Vito Lippolis, Maria Carla Aragoni, Corrado Di Natale, Roberto Paolesse, Larisa Lvova
Summary: We have developed a new type of acyclicsquaramidereceptors (L1-L5) that can selectively detect ketoprofen and naproxen anions (KF- and NS-, respectively) in water. The receptors form hydrogen bonds with the anions, and compounds L1-L5 have been tested as ionophores for the detection of KF- and NS- in polymeric membranes. The developed sensors show high precision detection capabilities with low relative errors and high sensitivity and selectivity towards NS-.
Proceedings Paper
Chemistry, Analytical
Rosamaria Capuano, Khasim Cali, Alexandro Catini, Roberto Paolesse, Krishna Persaud, Corrado Di Natale
Summary: A hybrid array of biosensors and chemical sensors is introduced as a functional electronic nose. The results indicate that both sensor technologies play complementary roles in the complete identification of a set of similar volatile organic compounds, independent of their concentrations.
2022 IEEE INTERNATIONAL SYMPOSIUM ON OLFACTION AND ELECTRONIC NOSE (ISOEN 2022)
(2022)
Article
Chemistry, Analytical
Mengmeng Guo, Na Luo, Yueling Bai, Zhenggang Xue, Qingmin Hu, Jiaqiang Xu
Summary: A porous heterostructure WO3-C/In2O3 was designed and prepared for a miniature H2 sensor, which showed higher response value, lower operating temperature, fast response-recovery speed, and low limit of detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Feng Hu, Hui Hu, Yuting Li, Xiaohui Wang, Xiaowen Shi
Summary: Arsenic contamination in water bodies is a significant health risk. This study developed a chitosan-catechol modified electrode for rapid and accurate detection of trace amounts of arsenic. The modified electrode demonstrated good detection capability and resistance to ionic interference, making it suitable for in situ detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Yantao Zhang, Qian Liu, Tao Tian, Chunhua Xu, Pengli Yang, Lianju Ma, Yi Hou, Hui Zhou, Yongjun Gan
Summary: In this study, a lysosome-targeting buffering fluorogenic probe (Lyso-BFP) was designed and synthesized, demonstrating excellent photostability, pH specificity, and responsiveness to lysosomal acidification in living cells. The performance of Lyso-BFP in pH sensing was attributed to the inhibition of the photo-induced electron transfer process. Lyso-BFP allowed for wash-free imaging and long-term real-time monitoring of lysosome pH changes based on its off-on fluorescence behavior and buffer strategy.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Wei Cai, Wenbo Sun, Jiayue Wang, Xiaokui Huo, Xudong Cao, Xiangge Tian, Xiaochi Ma, Lei Feng
Summary: In this study, a near-infrared fluorescent probe HCBG was developed for imaging of alpha-GLC. HCBG exhibited excellent selectivity and sensitivity towards alpha-GLC in complex bio-samples, and showed good cell permeability for in situ real-time imaging. Through the high-throughput screening system established by HCBG, a natural alpha-GLC inhibitor was successfully isolated and identified. This study provides a novel fluorescence visualization tool for discovering and exploring the biological functions of diabetes-related gut microbiota, and a high-throughput screening approach for alpha-GLC inhibitor.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Trey W. Pittman, Xi Zhang, Chamindie Punyadeera, Charles S. Henry
Summary: Heart failure is a growing epidemic and a significant clinical and public health problem. Researchers have developed a portable and affordable diagnostic device for heart failure that can be used at the point-of-care, providing a valid alternative to current diagnostics approaches.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Anders O. Tjell, Barbara Jud, Roland Schaller-Ammann, Torsten Mayr
Summary: An optical hydrogen peroxide sensor based on catalytic degradation and the detection of produced oxygen is presented. The sensor offers higher resolution and better sensitivity at lower H2O2 concentrations. By removing O2 from the sample solution, a more sensitive O2 sensor can be used for measurement. The sensor has been successfully applied in a flow-through cell to measure H2O2 concentration in different flow rates.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Seong Jae Kim, Ji-hun Jeong, Gaabhin Ryu, Yoon Sick Eom, Sanha Kim
Summary: Surface-enhanced Raman spectroscopy (SERS) is a high-sensitivity, label-free detection method with various analytical applications. Researchers have developed a hydrophobic SERS substrate based on engineered carbon nanotube arrays (CNT-SERS) and studied the role of structural design at both micro and nanoscales. The substrate demonstrated controlled self-enrichment capability and enhanced sensitivity, with a significant increase in the SERS signal. The study also proposed a theoretical model and a concentration strategy inspired by plants for analyte deposition on microarrays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Dan Zhao, Renjun Jiang, Xiaoqiang Liu, Subbiah Alwarappan
Summary: In this study, a novel ternary composite material was constructed by assembling cerium vanadate nanorods on reduced graphene oxide-microcrystalline cellulose nanosheets, and it was used for real-time monitoring of the concentration of superoxide anions in vivo. The ternary composite showed excellent conductivity, large surface area, and abundant active sites, leading to a wider linear range, high sensitivity, low detection limit, and fast response time for superoxide anion detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Tengfei Wang, Liwen Wang, Guang Wu, Dating Tian
Summary: In this study, a covalent organic framework material TaTp-COF with porous and uniform spheres was successfully prepared via hydrothermal reaction, and it was found to significantly enhance the aggregation-induced emission (AIE) of berberine. The unique emission properties of berberine on TaTp-COF were studied and utilized for the sensitive detection of berberine.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Lin Li, Yilei Ding, Lei Xu, Shuoran Chen, Guoliang Dai, Pengju Han, Lixin Lu, Changqing Ye, Yanlin Song
Summary: In this study, a novel TTI based on a ratiometric fluorescent nanosensor is designed, which has the advantages of high accuracy and low cost. Experimental and theoretical investigations confirm its pH responsiveness and demonstrate its good sensitivity and reliability. By monitoring the total volatile basic nitrogen, this TTI can accurately predict food spoilage and can be adaptively modified for different types of food. The TTI based on this nanosensor enables visual monitoring of food quality.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Fangju Chen, Xueting Wang, Wei Chen, Chenwen Shao, Yong Qian
Summary: Lung cancer is the second most common malignant tumor worldwide. Drug resistance in lung cancer leads to treatment failure and recurrence in majority of patients. This study developed a fluorescent prodrug that can be activated in cancer cells to release drugs, and its signal can be tracked by imaging. It shows a unique autophagy-driven ferroptosis effect, indicating its potential for targeting drug-resistant cancer cells.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Weichao Li, Qiming Yuan, Zhangcheng Xia, Xiaoxue Ma, Lifang He, Ling Jin, Xiangfeng Chu, Kui Zhang
Summary: This study developed a high-performance gas sensor for formaldehyde detection by modifying ZnSnO3 with ZnO QDs and SnO2 QDs. The modified sensor showed improved sensing response and lower working temperature. The presence of ZnO QDs formed rich heterojunctions, increased surface area, and provided oxygen deficiency for formaldehyde sensing reaction, thus enhancing the sensor performance. This research provides an alternative method to enhance the sensing properties of MOS by QDs modification.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Joung-Il Moon, Eun Jung Choi, Younju Joung, Jin-Woo Oh, Sang-Woo Joo, Jaebum Choo
Summary: A novel nanoplasmonic substrate was developed for biomedical applications, which showed strong hot spots for detecting biomarkers at low concentrations. The substrate, called AuNPs@M13, was made by immobilizing 60 nm gold nanoparticles onto the surface of an M13 bacteriophage scaffold. It demonstrated higher sensitivity and lower limit of detection compared to commercially available assays.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Ning Li, Ya Zhang, Ying Xu, Xiaofang Liu, Jian Chen, Mei Yang, Changjun Hou, Danqun Huo
Summary: The molecular subtype of breast cancer guides treatment and drug selection. Invasive tests can promote cancer cell metastasis, so the development of high-performance, low-cost diagnostic tools for cancer prognosis is crucial. Liquid biopsy techniques enable noninvasive, real-time, dynamic, multicomponent, quantitative, and long-term observations at the cellular, genetic, and molecular levels. A Cu-Zr metal-organic framework (MOF) nanoenzyme with monatomic Cu attachment has been synthesized and proven to have high catalytic performance. The sensor constructed using this nanoenzyme shows potential for accurate classification of breast cancer serum samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Analytical
Jeongmin Kim, Hyemin Kim, Seunghyun Park, Hyeonaug Hong, Yong Jae Kim, Jiyong Lee, Jaeho Kim, Seung-Woo Cho, Wonhyoung Ryu
Summary: This study presents a method to fabricate independently functioning microneedle (MN) electrodes with narrow intervals for high precision electrochemical sensing. The optimized mixture of photocurable polymer and single-wall carbon nanotubes was used to mold single composite MNs, which were then attached to pre-patterned electrodes. Plasma etching and electropolymerization were performed to enhance the electrochemical activity, and Prussian blue and glucose oxidase were electrodeposited on the MNs for glucose detection. The MN electrodes showed good sensitivity and linearity, and the feasibility of glucose detection was demonstrated in an in vivo mouse study.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
