Article
Oncology
Wenfeng Gou, Xiaojun Yu, Shaohua Wu, Hongying Wu, Huajie Chang, Leyuan Chen, Huiqiang Wei, Changfen Bi, Hongxin Ning, Yingliang Wu, Wenbin Hou, Daiying Zuo, Yiliang Li
Summary: This study investigated the impact of AND-1 on the radiosensitivity of non-small cell lung cancer (NSCLC) and found that AND-1 inhibition significantly increased the radiosensitivity of NSCLC cells, likely by regulating the cell cycle and enhancing DNA damage.
Review
Biochemistry & Molecular Biology
Chibin Cheng, Daniel Seen, Chunwen Zheng, Ruijie Zeng, Enmin Li
Summary: RhoA plays a crucial role in DNA damage response by interacting with key components of DNA repair and cell cycle control. Understanding the role of RhoA in DDR can provide insights into DDR mechanisms and aid in the development of cancer therapies in the future.
Article
Biochemistry & Molecular Biology
Jia-feng Tang, Guo-li Li, Tao Zhang, Yu-mei Du, Shi-ying Huang, Jian-hua Ran, Jing Li, Di-long Chen
Summary: In this study, it was found that HHT effectively inhibits the proliferation of melanoma cells by inducing DNA damage, apoptosis, and cell cycle arrest. Both in vitro and in vivo experiments confirmed the inhibitory effect of HHT on melanoma, providing evidence for its potential as an anti-melanoma agent.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Cell Biology
Navin Gupta, Takuya Matsumoto, Ken Hiratsuka, Edgar Garcia Saiz, Pierre Galichon, Tomoya Miyoshi, Koichiro Susa, Narihito Tatsumoto, Michifumi Yamashita, Ryuji Morizane
Summary: Kidneys have the capacity for intrinsic repair, but when overwhelmed, incomplete repair can lead to chronic kidney disease. Limited treatments exist due to the limited predictivity of animal studies. This study used kidney organoids to identify genes and pathways involved in intrinsic repair and discovered a potential therapeutic candidate that can prevent the progression of chronic kidney disease.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Editorial Material
Microbiology
Jacob L. Steenwyk
Summary: Cell cycle checkpoints and DNA repair pathways are crucial for maintaining genome integrity, but recent studies have revealed evolutionary diversity in eukaryotic DNA damage responses, with some fungi showing reduced activation of key kinases and downregulation of genome maintenance genes in response to DNA damage.
Article
Food Science & Technology
Silu Hou, Yuqiang Cheng, Zhaofei Wang, Luming Xia, Jian Wang, Hengan Wang, Jianhe Sun, Jingjiao Ma, Yaxian Yan
Summary: This study investigated the toxic effects of deoxynivalenol (DON) on gastric mucosal epithelial cells and found that DON can inhibit cell activity, induce DNA damage, apoptosis, and cell cycle arrest. These findings are important for understanding the cytotoxicity and gastric diseases caused by DON.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Oncology
Jiajing Niu, Jiamei Wang, Qi Zhang, Zhihua Zou, Yushuang Ding
Summary: The study revealed that sublethal doses of cinobufagin suppressed the viability of cancer cells by inducing oxidative stress, leading to DNA damage and cell cycle regulation that ultimately resulted in the induction of apoptosis.
CANCER CELL INTERNATIONAL
(2021)
Review
Genetics & Heredity
Yongxin Li, Yan Tong, Jiaqi Liu, Jianlin Lou
Summary: DNA is crucial for organism development and function. MiRNA, a type of non-coding RNA, may play an important role in the DNA damage response by influencing processes like cell cycle, DNA repair, and apoptosis, thereby impacting genomic stability and tumorigenesis.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Ireneusz Litwin, Seweryn Mucha, Ewa Pilarczyk, Robert Wysocki, Ewa Maciaszczyk-Dziubinska
Summary: In this study, it was found that trivalent antimony can cause various forms of DNA damage, including replication and oxidative DNA damage, and affect the activation of DNA damage checkpoints and formation of recombination repair centers in the model organism Saccharomyces cerevisiae.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Amina Jamal Laham, Maha Saber-Ayad, Raafat El-Awady
Summary: DYRK1A is a dual kinase involved in Down syndrome and plays a critical role in tumorigenesis. It can phosphorylate itself and substrates, having dual effects on tumor development.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Cell Biology
Miaowen Liu, Huimin Chen, Xinyue Chen, Jianping Xiong, Zhiwang Song
Summary: UCHL3 is significantly up-regulated in NSCLC tissues and cell lines, associated with poor prognosis in patients. Knockdown of UCHL3 enhances radio-sensitivity of NSCLC cells, increases IR-induced DNA damage through impairing HR repair.
Article
Medicine, Research & Experimental
Ya-jun Hou, Dawei Li, Weiqi Wang, Leilei Mao, Xiaoyan Fu, Baoliang Sun, Cundong Fan
Summary: This study evaluated the anticancer effects and mechanism of NT157 against human glioma growth, and found that NT157 alone inhibited glioma cell growth by regulating cell cycle, promoting apoptosis, and inducing DNA damage and dysfunction of signaling pathways. Combined treatment with TRAIL further enhanced apoptosis by upregulating DR5 and inducing DNA damage.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biotechnology & Applied Microbiology
Daniel O 'Reilly, Jillian Belgrad, Chantal Ferguson, Ashley Summers, Ellen Sapp, Cassandra McHugh, Ella Mathews, Adel Boudi, Julianna Buchwald, Socheata Ly, Dimas Moreno, Raymond Furgal, Eric Luu, Zachary Kennedy, Vignesh Hariharan, Kathryn Monopoli, William Yang, Jeffery Carroll, Marian DiFiglia, Neil Aronin, Anastasia Khvorova
Summary: Huntington's disease is caused by expansion of the CAG trinucleotide repeat tract in the huntingtin gene. Somatic repeat expansion, mediated by the mismatch repair pathway, accelerates disease onset in non-dividing cells. Silencing the MutS homolog 3 (MSH3) gene using chemically modified siRNA effectively blocks CAG-repeat expansion in the striatum of HD mouse models without affecting other MMR genes. This finding provides a promising treatment approach for HD and other repeat expansion diseases.
Article
Genetics & Heredity
Delisa E. Clay, Donald T. Fox
Summary: Genome damage is a common threat to all organisms, and DNA damage responses (DDRs) play a crucial role in initiating cell cycle arrest, repair, and cell death. While many DDR components are conserved across different organisms, there are also adaptations to specific needs. Research on model genetic organisms has greatly advanced our understanding of DDR mechanisms and how they are influenced by the cell cycle stage. Future studies expanding beyond traditional model organisms will further enhance our knowledge of genome protection mechanisms.
Article
Biochemistry & Molecular Biology
Xin-ge Ke, Yi-yi Xiong, Bing Yu, Chong Yuan, Peng-yu Chen, Yan-fang Yang, He-zhen Wu
Summary: Mollugin has been found to exhibit anti-tumor activity by inducing DNA damage and cell cycle arrest in hepatocellular carcinoma.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Materials Science, Biomaterials
Luiza Steffens Reinhardt, Bor Shin Chee, Zhi Cao, Dinara Jaqueline Moura, Michael Nugent
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
(2020)
Article
Oncology
Gustavo A. Laporte, Natalia M. Leguisamo, Helena de Castro e Gloria, Daniel B. Azambuja, Antonio N. Kalil, Jenifer Saffi
JOURNAL OF SURGICAL ONCOLOGY
(2020)
Article
Neurosciences
Mariana Zancan, Dinara J. Moura, Ana Moira Moras, Luiza Steffens, Ana Carolina de Moura, Marcia Giovenardi, Alberto A. Rasia-Filho
BRAIN RESEARCH BULLETIN
(2020)
Article
Pharmacology & Pharmacy
Luiza Steffens, Ana Moira Moras, Pablo Ricardo Arantes, Kevin Masterson, Zhi Cao, Michael Nugent, Dinara Jaqueline Moura
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2020)
Article
Pharmacology & Pharmacy
Leticia Lazzarotto, Pricila Pfluger, Gabriela Gregory Regner, Fernanda Marcelia Santos, Debora Goncalves Aguirre, Veronica Bidinotto Brito, Dinara Jaqueline Moura, Nayane Mendes dos Santos, Jaqueline Nascimento Picada, Belisa Parmeggiani, Marina Rocha Frusciante, Guilhian Leipnitz, Patricia Pereira
Summary: This study evaluated the effects of lacosamide on biochemical and mitochondrial parameters after PTZ kindling in mice. Lacosamide showed positive effects on reducing free radicals, improving mitochondrial enzymatic activity, and protecting against oxidative stress and DNA damage induced by repeated PTZ administration.
FUNDAMENTAL & CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Marcela Silva dos Santos, Marcio Marcal Lobo, Simone Schneider Amaral, Nilo Zanatta, Cassiana Macagnan Viau, Jenifer Saffi
Summary: The study demonstrates that compound 9c induces cell cycle arrest in G2/M phase, increases levels of reactive oxygen species and DNA damage, and triggers DNA damage response by ATM and histone H2AX phosphorylation induction in PC-3 cells. Additionally, compound 9c leads to lipid peroxidation and mitochondrial depolarization, activating the intrinsic pathway and increasing cleaved caspase-9 and 3. Furthermore, 9c reduces vascular endothelial growth factor expression (VEGF) and inhibits topoisomerase I enzyme, indicating its potential as a new molecule for further investigation in prostate cancer management.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Polymer Science
Joice Maria Scheibel, Felipe Castro Menezes, Camila Leites Reginatto, Claudia de Brito da Silva, Dinara Jaqueline Moura, Fabiano Rodembusch, Roberta Bussamara, Daniel Eduardo Weibel, Rosane Michele Duarte Soares
Summary: The presence of GT modified the physical and chemical properties of the fibers, showing antibacterial activity against Escherichia coli strains, and did not present cytotoxicity.
JOURNAL OF APPLIED POLYMER SCIENCE
(2021)
Article
Medicine, Research & Experimental
Franciele Faccio Busatto, Victoria Pereira Viero, Bruna Thais Schaefer, Jenifer Saffi
Summary: The study found that all NER genes increased during treatment with DOX, but not after treatment with PCTX. MRE11 was consistently overexpressed at all evaluated time points. As cells were followed-up and regained their growth pattern, there was a resumption of NER genes overexpression profile.
Article
Developmental Biology
Romulo Batista Rodrigues, Mariana Uczay, Veronica Bidinotto Brito, Antonio Cesar Godoy, Dinara Jaqueline Moura, Carla Vogel, Ana Carina Nogueira Vasconcelos, Danilo Pedro Streit
Summary: The study found that zebrafish sperm experience oxidative stress and DNA damage during the freezing-thawing process, with greater oxidative stress and DNA damage caused by freezing and thawing.
Article
Oncology
Helena de Castro e Gloria, Laura Jesuino Nogueira, Patricia Bencke Grudzinski, Paola Victoria da Costa Ghignatti, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Jenifer Saffi
Summary: Our study demonstrated that Olaparib enhances the cytotoxicity of 5-FU in MMR-deficient CRC cells, while it reduces clonogenic survival and induces DNA damage in MMR-proficient CRC cells. Combined therapy with Olaparib could be a strategy to overcome 5-FU chemotherapeutic resistance in MMR-deficient CRC.
Article
Endocrinology & Metabolism
Jessica Lamberty Faverzani, Aline Steinmetz, Marion Deon, Desiree Padilha Marchetti, Gilian Guerreiro, Angela Sitta, Daniella de Moura Coelho, Franciele Fatima Lopes, Leopoldo Vinicius Martins Nascimento, Luiza Steffens, Jeferson Gustavo Henn, Matheus Bernardes Ferro, Veronica Bidinotto Brito, Moacir Wajner, Dinara Jaqueline Moura, Carmen Regla Vargas
Summary: The study revealed that phenylalanine and its metabolites can induce DNA damage in glial cells in phenylketonuria, with L-carnitine potentially serving as an adjuvant therapeutic agent.
METABOLIC BRAIN DISEASE
(2021)
Review
Oncology
Paula Pellenz Tomasini, Temenouga Nikolova Guecheva, Natalia Motta Leguisamo, Sarah Pericart, Anne-Cecile Brunac, Jean Sebastien Hoffmann, Jenifer Saffi
Summary: Colorectal cancer is a common cancer that currently relies on conventional chemotherapy for treatment, but targeting DNA repair and replication stress response may offer new therapeutic opportunities. Synthetic lethal mechanisms targeting DNA damage response pathways have not been systematically explored in CRC, presenting a potential area for further research and clinical trials.
Article
Cardiac & Cardiovascular Systems
Veronica Bidinotto Brito, Leopoldo Vinicius Martins Nascimento, Dinara Jaqueline Moura, Jenifer Saffi
Summary: Supplementation with resveratrol during pregnancy in rats can protect offspring cardiomyocytes against doxorubicin-induced toxicity, likely due to its antioxidant function and enhancement of DNA damage repair response.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2021)
Article
Cell Biology
Franciele Faccio Busatto, Sofiane Y. Mersaoui, Yilun Sun, Yves Pommier, Jean-Yves Masson, Jenifer Saffi
Summary: This study further defines the mechanism and type of lesions induced by TOP2 inhibitors when CSB is abrogated. CSB knockdown provokes the accumulation of DSBs induced by TOP2 inhibitors and stimulates the activity of TOP2.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Chemistry, Medicinal
Luiza Steffens Reinhardt, Jeferson Gustavo Henn, Ana Moira Moras, Nathalia Denise de Moura Sperotto, Matheus Bernardes Ferro, Zhi Cao, Adriana Vial Roehe, Adriana Ubirajara Silva Petry, Michael Nugent, Dinara Jaqueline Moura
Summary: This study developed wound dressings containing a hydroethanolic extract of Plantago australis Lam. based on its wound healing activity. The nanofiber and ointment containing the extract showed enhanced wound healing efficacy in in vitro and in vivo tests, showcasing the potential of these dressings to improve the treatment outcome.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2021)