Cholera toxin adjuvant promotes a balanced Th1/Th2/Th17 response independently of IL-12 and IL-17 by acting on Gsα in CD11b+ DCs
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Title
Cholera toxin adjuvant promotes a balanced Th1/Th2/Th17 response independently of IL-12 and IL-17 by acting on Gsα in CD11b+ DCs
Authors
Keywords
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Journal
Mucosal Immunology
Volume 8, Issue 4, Pages 815-827
Publisher
Springer Nature
Online
2014-11-26
DOI
10.1038/mi.2014.111
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- Cholera toxin activates nonconventional adjuvant pathways that induce protective CD8 T-cell responses after epicutaneous vaccination
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- Intradermal immunization in the ear with cholera toxin and its non-toxic β subunit promotes efficient Th1 and Th17 differentiation dependent on migrating DCs
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- Gene expression profiling identifies STAT3 as a novel pathway for immunomodulation by cholera toxin adjuvant
- (2010) A Sjöblom-Hallén et al. Mucosal Immunology
- Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax
- (2010) S. K. Datta et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Cholera toxin inhibits IL-12 production and CD8α+dendritic cell differentiation by cAMP-mediated inhibition of IRF8 function
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- CCR7-CCL19/CCL21-Regulated Dendritic Cells Are Responsible for Effectiveness of Sublingual Vaccination
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- CD11chigh Dendritic Cells Are Essential for Activation of CD4+ T Cells and Generation of Specific Antibodies following Mucosal Immunization
- (2009) L. Fahlen-Yrlid et al. JOURNAL OF IMMUNOLOGY
- IL-21 ensures TGF-β1-induced IgA isotype expression in mouse Peyer's patches
- (2009) Goo-Young Seo et al. JOURNAL OF LEUKOCYTE BIOLOGY
- Intranasal Delivery of Cholera Toxin Induces Th17-Dominated T-Cell Response to Bystander Antigens
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- Dendritic cells in colonic patches and iliac lymph nodes are essential in mucosal IgA induction following intrarectal administrationvia CCR7 interaction
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- Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity
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