Evaluation of the Antioxidant and Neuroprotectant Activities of New Asymmetrical 1,3-Diketones

The Mechanisms of Action of Curcumin in Alzheimer’s Disease

(2017) Mengxi Tang et al.   JOURNAL OF ALZHEIMERS DISEASE

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Curcumin for neuropsychiatric disorders: a review of in vitro, animal and human studies

(2017) Adrian L Lopresti   JOURNAL OF PSYCHOPHARMACOLOGY

The SH-SY5Y cell line in Parkinson’s disease research: a systematic review

(2017) Helena Xicoy et al.   Molecular Neurodegeneration

α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies

(2017) Yvette C Wong et al.   NATURE MEDICINE

Dual role of cellular prion protein in normal host and Alzheimer’s disease

(2017) Takashi ONODERA   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Tau Oligomers: Cytotoxicity, Propagation, and Mitochondrial Damage

(2017) Scott S. Shafiei et al.   Frontiers in Aging Neuroscience

Propagation of Tau aggregates

(2017) Michel Goedert et al.   Molecular Brain

Mitochondria and Antioxidant Targeted Therapeutic Strategies for Alzheimer's Disease

(2017) Magali Dumont et al.   JOURNAL OF ALZHEIMERS DISEASE

An updated review of Parkinson's disease genetics and clinicopathological correlations

(2016) M. Ferreira et al.   ACTA NEUROLOGICA SCANDINAVICA

Improving Drug Design: An Update on Recent Applications of Efficiency Metrics, Strategies for Replacing Problematic Elements, and Compounds in Nontraditional Drug Space

(2016) Nicholas A. Meanwell   CHEMICAL RESEARCH IN TOXICOLOGY

Molecular Basis of Familial and Sporadic Alzheimer's Disease

(2016) Jolanta Dorszewska et al.   Current Alzheimer Research

Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia

(2016) Jennifer Y.Y. Szeto et al.   Current Neuropharmacology

Oral bioavailability of curcumin: problems and advancements

(2016) Weidong Liu et al.   JOURNAL OF DRUG TARGETING

Therapies for Parkinson’s diseases: alternatives to current pharmacological interventions

(2016) Song Li et al.   JOURNAL OF NEURAL TRANSMISSION

Altered Proteins in the Aging Brain

(2016) Adila Elobeid et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Polyphenols in dementia: From molecular basis to clinical trials

(2016) Silvia Molino et al.   LIFE SCIENCES

Ageing, neurodegeneration and brain rejuvenation

(2016) Tony Wyss-Coray   NATURE

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

The efficacy and safety of coenzyme Q10 in Parkinson’s disease: a meta-analysis of randomized controlled trials

(2016) Zhen-Guo Zhu et al.   NEUROLOGICAL SCIENCES

Current pharmacotherapy and putative disease-modifying therapy for Alzheimer’s disease

(2016) Akanksha Kulshreshtha et al.   NEUROLOGICAL SCIENCES

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

(2016) Shanmugam Manoharan et al.   Oxidative Medicine and Cellular Longevity

Genes associated with Alzheimer's disease: an overview and current status

(2016) Mohan Giri et al.   Clinical Interventions in Aging

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

The genetics of Parkinson's disease

(2015) Stephen Mullin et al.   BRITISH MEDICAL BULLETIN

Clinical development of curcumin in neurodegenerative disease

(2015) Shuxin Hu et al.   Expert Review of Neurotherapeutics

Degradation of Curcumin: From Mechanism to Biological Implications

(2015) Claus Schneider et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structure–Activity Relationship and Pharmacokinetic Studies of 1,5-Diheteroarylpenta-1,4-dien-3-ones: A Class of Promising Curcumin-Based Anticancer Agents

(2015) Rubing Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthetic Curcumin Analogs as Inhibitors of β -Amyloid Peptide Aggregation: Potential Therapeutic and Diagnostic Agents for Alzheimer's Disease

(2015) Syed Abbas Bukhari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Mitochondria-Targeted Protective Compounds in Parkinson’s and Alzheimer’s Diseases

(2015) Carlos Fernández-Moriano et al.   Oxidative Medicine and Cellular Longevity

Alzheimer's and Parkinson's diseases: The prion concept in relation to assembled A , tau, and  -synuclein

(2015) M. Goedert   SCIENCE

The structure of β-diketones related to curcumin determined by X-ray crystallography, NMR (solution and solid state) and theoretical calculations

(2015) Carla I. Nieto et al.   STRUCTURAL CHEMISTRY

Clinical development of curcumin in neurodegenerative disease

(2015) Shuxin Hu et al.   Expert Review of Neurotherapeutics

A review on mitochondrial restorative mechanism of antioxidants in Alzheimer’s disease and other neurological conditions

(2015) Anil Kumar et al.   Frontiers in Pharmacology

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Do Epigenetic Pathways Initiate Late Onset Alzheimer Disease (LOAD): Towards a New Paradigm

(2014) Syed Waseem Bihaqi et al.   Current Alzheimer Research

Curcumin Alters the Salt Bridge-containing Turn Region in Amyloid β(1–42) Aggregates

(2014) Venus Singh Mithu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

(2014) Kavirayani Priyadarsini   MOLECULES

Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

(2014) Jana Hroudová et al.   Biomed Research International

On the origin of Alzheimer's disease. Trials and tribulations of the amyloid hypothesis

(2013) Michael A. Castello et al.   AGEING RESEARCH REVIEWS

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

(2013) Wing-Hin Lee et al.   Current Neuropharmacology

Structures of Hemi-Curcuminoids in the Solid State and in Solution

(2013) Pilar Cornago et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Targeting dysregulation of brain iron homeostasis in Parkinson's disease by iron chelators

(2013) Orly Weinreb et al.   FREE RADICAL BIOLOGY AND MEDICINE

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

Mitochondrial Energy Metabolism and Redox Signaling in Brain Aging and Neurodegeneration

(2012) Fei Yin et al.   ANTIOXIDANTS & REDOX SIGNALING

Curcumin uptake and metabolism

(2012) Manfred Metzler et al.   BIOFACTORS

Natural products as a rich source of tau-targeting drugs for Alzheimer’s disease

(2012) Laurent Calcul et al.   Future Medicinal Chemistry

Curcumin Prevents Aggregation in α-Synuclein by Increasing Reconfiguration Rate

(2012) Basir Ahmad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Antioxidant Therapies for Neurodegenerative Diseases: Mechanisms, Current Trends, and Perspectives

(2012) Daniel Pens Gelain et al.   Oxidative Medicine and Cellular Longevity

Mechanism of Oxidative Stress in Neurodegeneration

(2012) Sonia Gandhi et al.   Oxidative Medicine and Cellular Longevity

Cellular model of Alzheimer's disease — Relevance to therapeutic testing

(2011) Gurdeep Marwarha et al.   EXPERIMENTAL NEUROLOGY

Antioxidant protection: A promising therapeutic intervention in neurodegenerative disease

(2011) Nilanjan Ghosh et al.   FREE RADICAL RESEARCH

Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties

(2010) Travis T. Wager et al.   ACS Chemical Neuroscience

New small molecules for the treatment of Parkinson's disease

(2010) Thomas Müller   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Curcumin Decreases Amyloid-β Peptide Levels by Attenuating the Maturation of Amyloid-β Precursor Protein

(2010) Can Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The relevance of iron in the pathogenesis of Parkinson’s disease

(2010) Jeswinder Sian-Hülsmann et al.   JOURNAL OF NEUROCHEMISTRY

Synergistic Interactions between A , Tau, and  -Synuclein: Acceleration of Neuropathology and Cognitive Decline

(2010) L. K. Clinton et al.   JOURNAL OF NEUROSCIENCE

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Oxidative Stress Partially Contributes to Iron-Induced Alpha-Synuclein Aggregation in SK-N-SH Cells

(2010) Wenjing Li et al.   NEUROTOXICITY RESEARCH

Comparison of Nephelometric, UV-Spectroscopic, and HPLC Methods for High-Throughput Determination of Aqueous Drug Solubility in Microtiter Plates

(2009) Bettina Hoelke et al.   ANALYTICAL CHEMISTRY

Mitochondria, calcium and cell death: A deadly triad in neurodegeneration

(2009) Fulvio Celsi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Abnormal mitochondrial dynamics and neurodegenerative diseases

(2009) Bo Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Synthesis and biological evaluation of curcuminoid pyrazoles as new therapeutic agents in inflammatory bowel disease: Effect on matrix metalloproteinases

(2009) R.M. Claramunt et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Brain iron deficiency and excess; cognitive impairment and neurodegenration with involvement of striatum and hippocampus

(2009) Moussa B. H. Youdim   NEUROTOXICITY RESEARCH

Antioxidant and Iron-Binding Properties of Curcumin, Capsaicin, andS-Allylcysteine Reduce Oxidative Stress in Rat Brain Homogenate

(2008) Amichand Dairam et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis?

(2008) Hirokazu Fukui et al.   TRENDS IN NEUROSCIENCES