Folate-Based Radiotracers for PET Imaging—Update and Perspectives

Cyclotron produced 44gSc from natural calcium

(2012) G.W. Severin et al.   APPLIED RADIATION AND ISOTOPES

44Sc-DOTA-BN[2-14]NH2 in comparison to 68Ga-DOTA-BN[2-14]NH2 in pre-clinical investigation. Is 44Sc a potential radionuclide for PET?

(2012) E. Koumarianou et al.   APPLIED RADIATION AND ISOTOPES

[18F]Fluoro-Deoxy-Glucose Folate: A Novel PET Radiotracer with Improved in Vivo Properties for Folate Receptor Targeting

(2012) Cindy R. Fischer et al.   BIOCONJUGATE CHEMISTRY

Radiosynthesis and Preclinical Evaluation of 3′-Aza-2′-[18F]fluorofolic Acid: A Novel PET Radiotracer for Folate Receptor Targeting

(2012) Thomas Betzel et al.   BIOCONJUGATE CHEMISTRY

Can PET Imaging Facilitate Optimization of Cancer Therapies?

(2012) Gabriela Kramer-Marek et al.   CURRENT PHARMACEUTICAL DESIGN

Folate Based Radiopharmaceuticals for Imaging and Therapy of Cancer and Inflammation

(2012) Cristina Muller   CURRENT PHARMACEUTICAL DESIGN

A Unique Matched Quadruplet of Terbium Radioisotopes for PET and SPECT and for  - and  --Radionuclide Therapy: An In Vivo Proof-of-Concept Study with a New Receptor-Targeted Folate Derivative

(2012) C. Muller et al.   JOURNAL OF NUCLEAR MEDICINE

DOTA Conjugate with an Albumin-Binding Entity Enables the First Folic Acid-Targeted 177Lu-Radionuclide Tumor Therapy in Mice

(2012) C. Muller et al.   JOURNAL OF NUCLEAR MEDICINE

The Role of 68Ga-DOTATATE PET/CT in Suspected Neuroendocrine Tumors

(2012) A. R. Haug et al.   JOURNAL OF NUCLEAR MEDICINE

Multicenter Trial of EC145 in Advanced, Folate-Receptor Positive Adenocarcinoma of the Lung

(2012) Martin J. Edelman et al.   Journal of Thoracic Oncology

Imaging of Protein Synthesis: In Vitro and In Vivo Evaluation of 44Sc-DOTA-Puromycin

(2012) Sebastian Eigner et al.   MOLECULAR IMAGING AND BIOLOGY

Imaging Sites of Infection Using a 99mTc-Labeled Folate Conjugate Targeted to Folate Receptor Positive Macrophages

(2012) Walter A. Henne et al.   MOLECULAR PHARMACEUTICS

In Vivo Imaging of Folate Receptor Positive Tumor Xenografts Using Novel 68Ga-NODAGA-Folate Conjugates

(2012) Melpomeni Fani et al.   MOLECULAR PHARMACEUTICS

Novel synthesis and preclinical evaluation of folic acid derivatives labeled with 18F-[FDG] for PET imaging of folate receptor-positive tumors

(2012) I. Al Jammaz et al.   NUCLEAR MEDICINE AND BIOLOGY

Efficacy of an immunotoxin to folate receptor beta in the intra-articular treatment of antigen-induced arthritis

(2012) Taku Nagai et al.   ARTHRITIS RESEARCH & THERAPY

Imaging of activated macrophages in experimental osteoarthritis using folate-targeted animal single-photon-emission computed tomography/computed tomography

(2011) Tom M. Piscaer et al.   ARTHRITIS AND RHEUMATISM

The synthesis of pteroyl-lys conjugates and its application as Technetium-99m labeled radiotracer for folate receptor-positive tumor targeting

(2011) Hongjuan Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and activity of folate conjugated didemnin B for potential treatment of inflammatory diseases

(2011) Walter A. Henne et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Folate receptor-α expression in resectable hepatic colorectal cancer metastases: patterns and significance

(2011) Michael D'Angelica et al.   MODERN PATHOLOGY

Rapid synthesis and in vitro and in vivo evaluation of folic acid derivatives labeled with fluorine-18 for PET imaging of folate receptor-positive tumors

(2011) I. Al Jammaz et al.   NUCLEAR MEDICINE AND BIOLOGY

Tumor targeting using 67Ga-DOTA-Bz-folate — investigations of methods to improve the tissue distribution of radiofolates

(2011) Cristina Müller et al.   NUCLEAR MEDICINE AND BIOLOGY

The low-energy β− and electron emitter 161Tb as an alternative to 177Lu for targeted radionuclide therapy

(2011) Silvia Lehenberger et al.   NUCLEAR MEDICINE AND BIOLOGY

Synthesis of Precursors for ¹8F-Labeling of Folic Acid for PET Application

(2011) Viola Groehn et al.   SYNTHESIS-STUTTGART

A folate receptor beta-specific human monoclonal antibody recognizes activated macrophage of rheumatoid patients and mediates antibody-dependent cell-mediated cytotoxicity

(2011) Yang Feng et al.   ARTHRITIS RESEARCH & THERAPY

Treatment of experimental adjuvant arthritis with a novel folate receptor-targeted folic acid-aminopterin conjugate

(2011) Yingjuan Lu et al.   ARTHRITIS RESEARCH & THERAPY

Development of new folate-based PET radiotracers: preclinical evaluation of 68Ga-DOTA-folate conjugates

(2010) Melpomeni Fani et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Macrocyclic complexes of scandium radionuclides as precursors for diagnostic and therapeutic radiopharmaceuticals

(2010) A. Majkowska-Pilip et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

A New 18F-Labeled Folic Acid Derivative with Improved Properties for the PET Imaging of Folate Receptor-Positive Tumors

(2010) T. L. Ross et al.   JOURNAL OF NUCLEAR MEDICINE

68Ga-DOTATATE PET/CT for the Early Prediction of Response to Somatostatin Receptor-Mediated Radionuclide Therapy in Patients with Well-Differentiated Neuroendocrine Tumors

(2010) A. R. Haug et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging of Atherosclerosis in Apoliprotein E Knockout Mice: Targeting of a Folate-Conjugated Radiopharmaceutical to Activated Macrophages

(2010) W. Ayala-Lopez et al.   JOURNAL OF NUCLEAR MEDICINE

Folic Acid Conjugates for Nuclear Imaging of Folate Receptor-Positive Cancer

(2010) C. Muller et al.   JOURNAL OF NUCLEAR MEDICINE

Effects of the Antifolates Pemetrexed and CB3717 on the Tissue Distribution of99mTc-EC20 in Xenografted and Syngeneic Tumor-Bearing Mice†

(2010) Cristina Müller et al.   MOLECULAR PHARMACEUTICS

Labeling and Glycosylation of Peptides Using Click Chemistry: A General Approach to 18F-Glycopeptides as Effective Imaging Probes for Positron Emission Tomography

(2009) Simone Maschauer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A “Click Chemistry” Approach to the Efficient Synthesis of Multiple Imaging Probes Derived from a Single Precursor

(2009) Thomas L. Mindt et al.   BIOCONJUGATE CHEMISTRY

A series of 2-O-trifluoromethylsulfonyl-d-mannopyranosides as precursors for concomitant 18F-labeling and glycosylation by click chemistry

(2009) Simone Maschauer et al.   CARBOHYDRATE RESEARCH

Folate-targeted therapeutic and imaging agents for cancer

(2009) Philip Stewart Low et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Evaluation of a novel radiofolate in tumour-bearing mice: promising prospects for folate-based radionuclide therapy

(2009) Cristina Müller et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Cell line cross-contamination: KB is not an oral squamous cell carcinoma cell line

(2009) Lu Jiang et al.   EUROPEAN JOURNAL OF ORAL SCIENCES

Folate-Targeted Hapten Immunotherapy of Adjuvant-Induced Arthritis: Comparison of Hapten Potencies

(2009) Young-Su Yi et al.   MOLECULAR PHARMACEUTICS

Properties Influencing the Relative Binding Affinity of Pteroate Derivatives and Drug Conjugates Thereof to the Folate Receptor

(2009) Christopher P. Leamon et al.   PHARMACEUTICAL RESEARCH

Positron Emission Tomography/Computed Tomography: The Current  Technology and Applications

(2009) Erik Mittra et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

A Portable Albumin Binder from a DNA-Encoded Chemical Library

(2008) Christoph E. Dumelin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of11C,18F,15O, and13N Radiolabels for Positron Emission Tomography

(2008) Philip W. Miller et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Expression Status of Folate Receptor α Is Significantly Correlated with Prognosis in Non-Small-Cell Lung Cancers

(2008) Shotaro Iwakiri et al.   ANNALS OF SURGICAL ONCOLOGY

“Click-to-Chelate”: In Vitro and In Vivo Comparison of a99mTc(CO)3-Labeled N(τ)-Histidine Folate Derivative with Its Isostructural, Clicked 1,2,3-Triazole Analogue

(2008) Thomas L. Mindt et al.   BIOCONJUGATE CHEMISTRY

Fluorine-18 Click Radiosynthesis and Preclinical Evaluation of a New18F-Labeled Folic Acid Derivative

(2008) Tobias L. Ross et al.   BIOCONJUGATE CHEMISTRY

A functional folate receptor is induced during macrophage activation and can be used to target drugs to activated macrophages

(2008) W. Xia et al.   BLOOD

68Ga-PET: a powerful generator-based alternative to cyclotron-based PET radiopharmaceuticals

(2008) Melpomeni Fani et al.   Contrast Media & Molecular Imaging

Rationale for folate receptor alpha targeted therapy in “high risk” endometrial carcinomas

(2008) Monica Brown Jones et al.   INTERNATIONAL JOURNAL OF CANCER

SPECT Study of Folate Receptor-Positive Malignant and Normal Tissues in Mice Using a Novel 99mTc-Radiofolate

(2008) C. Muller et al.   JOURNAL OF NUCLEAR MEDICINE

Pemetrexed Improves Tumor Selectivity of 111In-DTPA-Folate in Mice with Folate Receptor-Positive Ovarian Cancer

(2008) C. Muller et al.   JOURNAL OF NUCLEAR MEDICINE

Exploratory Study of 99mTc-EC20 Imaging for Identifying Patients with Folate Receptor-Positive Solid Tumors

(2008) R. E. Fisher et al.   JOURNAL OF NUCLEAR MEDICINE

Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases

(2007) Philip S. Low et al.   ACCOUNTS OF CHEMICAL RESEARCH