Article
Medicine, Research & Experimental
Yiren Zhang, Xuejun Wen, Yanjie Wang, Xia Yang, Yingxi Chen, Xinying Zeng, Yesen Li, Jinxiong Huang, Zhide Guo, Xianzhong Zhang
Summary: Noninvasive single-photon emission computed tomography (SPECT) imaging with folate receptor (FR) targeting can be used to assess the inflammation and therapeutic effect of systemic sclerosis (SSc). The method has high radiochemical yield and purity, and shows a high consistency with pathological changes.
MOLECULAR PHARMACEUTICS
(2023)
Review
Immunology
Yan Lin Fu, Rene E. Harrison
Summary: Phagocytosis is a crucial process for the uptake of large particulate matter by specialized cells in the body, enabled by cell surface receptors. Professional phagocytes, including macrophages, neutrophils and dendritic cells, play a key role in innate immunity through engaging target cells for destruction and recycling in phagosomes. Macrophages, in particular, produce a variety of cytokines that modulate the inflammatory response to microbes.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xu Zhou, Dandan Huang, Runkong Wang, Mingquan Wu, Liyang Zhu, Wei Peng, He Tu, Xuangeng Deng, He Zhu, Zhong Zhang, Xinming Wang, Xi Cao
Summary: The use of folic acid-modified liposomes containing triptolide has been shown to be effective in treating rheumatoid arthritis by targeting M1 macrophages and repolarizing macrophages from M1 to M2 subtypes, achieving precise inflammation therapy.
Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Gabriela E. Garcia, Yingjuan J. Lu, Luan D. Truong, Carlos A. Roncal-Jimenez, Makoto Miyazaki, Shinobu Miyazaki-Anzai, Gabriel Cara-Fuentes, Ana Andres-Hernando, Miguel Lanaspa, Richard J. Johnson, Christopher P. Leamon
Summary: Targeting activated macrophages expressing FR beta with folate-linked drugs can be a selective approach for treating inflammatory diseases. The novel folic acid-aminopterin conjugate EC2319 showed significant kidney protection in anti-GBM glomerulonephritis through FR beta-mediated mechanisms, reducing macrophage infiltration and pro-inflammatory cytokine expression.
Article
Medicine, General & Internal
Xinghan Liu, Qi Jiang, Sunan Shen, Yayi Hou
Summary: This study found that local inflammation inhibits tumor growth, while systemic inflammation promotes tumor growth. The infiltration of different types of immune cells, such as M1 and M2 macrophages, into the tumor microenvironment may contribute to these different outcomes.
CHINESE MEDICAL JOURNAL
(2022)
Review
Immunology
Maarten M. Steinz, Aiarpi Ezdoglian, Fatemeh Khodadust, Carla F. M. Molthoff, Madduri Srinivasarao, Philip S. Low, Gerben J. C. Zwezerijnen, Maqsood Yaqub, Wissam Beaino, Albert D. Windhorst, Sander W. Tas, Gerrit Jansen, Conny J. van der Laken
Summary: Non-invasive imaging modalities, particularly macrophage imaging with folate-based PET tracers, hold great promise in diagnostic and therapy response monitoring of autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haein Lee, Eunha Kim, Seyun Kim
Summary: In response to LPS stimulation, the levels of IPMK in macrophages decrease due to the binding of miR-181c to the 3'UTR of IPMK mRNA, which leads to the suppression of TLR4 signaling and inflammation. Deletion of the miR-181c-binding site prevents the downregulation of IPMK levels and reduces the activation of TRAF6 and the expression of proinflammatory cytokines.
Article
Radiology, Nuclear Medicine & Medical Imaging
Xuejun Wen, Changrong Shi, Liu Yang, Xinying Zeng, Xiaoru Lin, Jinxiong Huang, Yesen Li, Rongqiang Zhuang, Haibo Zhu, Zhide Guo, Xianzhong Zhang
Summary: A novel FR-beta-targeted radiotracer was developed and shown to have potential for noninvasive detection of atherosclerosis and non-alcoholic fatty liver. Cell uptake studies and animal experiments demonstrated the high affinity and signal specificity of the tracer, suggesting its utility for imaging macrophages in advanced plaques.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Immunology
Zhukai Cong, Cui Yang, Zhaojin Zeng, Changyi Wu, Feng Zhao, Ziyuan Shen, Han Xiao, Xi Zhu
Summary: In this study, it was found that alpha 1-AR activation could alleviate lung injuries and inflammation and improve alveolar capillary barrier integrity in the lipopolysaccharide-induced ARDS mouse model without influencing cardiovascular hemodynamics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Guangxin Luan, Fan Pan, Lina Bu, Kaixuan Wu, Aizhong Wang, Xiaotao Xu
Summary: Butorphanol can promote macrophage polarization from a proinflammatory to an anti-inflammatory phenotype by inhibiting NF-kappa B, MAPKs, and the TRIF-mediated IFN signaling pathway, thus alleviating lung inflammation and injury.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jose Garrido-Mesa, Bethan Lynne Thomas, John Dodd, Carl Spana, Mauro Perretti, Trinidad Montero-Melendez
Summary: This study demonstrated the therapeutic effects of MC1 agonist PL8177 in inflammatory conditions, including arthritis, showing both anti-inflammatory and pro-resolving activities. PL8177 activates MC1 to reduce clinical symptoms, swelling, and overall disease severity in a mouse model of inflammatory arthritis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Dandong Fang, Yu Li, Bo He, Daqian Gu, Mingming Zhang, Jingwen Guo, Hongmei Ren, Xinyue Li, Ziyue Zhang, Ming Tang, Xingbing Li, Donghai Yang, Chunmei Xu, Yijie Hu, Hongyong Wang, Pedro A. Jose, Yu Han, Chunyu Zeng
Summary: Gastrin/CCKBR plays a protective role in sepsis-induced myocardial dysfunction and may serve as a potential therapeutic target for SMD.
ACTA PHARMACEUTICA SINICA B
(2023)
Review
Biochemistry & Molecular Biology
Ji Hye Han, Wook Kim
Summary: The review highlights the role of peripheral CB1R in metabolic inflammation and its involvement in various metabolic disorders such as insulin resistance. It also discusses the therapeutic potential of second- and third-generation peripherally restricted CB1R antagonists for treating obesity-induced metabolic inflammation without causing central CB1R-mediated neurobehavioral effects.
Article
Immunology
Huiyao Ge, Yiwen Mao, Weiwei Chen, Zhuo Li, Yanxia Yu, Sihan Luo, Daiyue Wang, Yuanming Bai, Wencheng Fan, Yirui Wang, Qi Zhen, Liangdan Sun
Summary: This study investigated the relationship between stress and psoriasis. It was found that stress aggravated skin inflammation and increased the number of macrophages and glucocorticoid receptor expression. Additionally, blocking the glucocorticoid receptor signaling improved skin inflammation and reduced macrophage polarization.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemical Research Methods
Hanwen Zhang, Ananda Kumar Kanduluru, Pooja Desai, Afruja Ahad, Sean Carlin, Nidhi Tandon, Wolfgang A. Weber, Philip S. Low
BIOCONJUGATE CHEMISTRY
(2018)
Article
Biochemical Research Methods
Loganathan Rangasamy, Venkatesh Chelvam, Ananda Kumar Kanduluru, Madduri Srinivasarao, N. Achini Bandara, Fei You, Esteban A. Orellana, Andrea L. Kasinski, Philip S. Low
BIOCONJUGATE CHEMISTRY
(2018)
Article
Biochemical Research Methods
Jyoti Roy, Miranda Kaake, Madduri Sriniyasarao, Philip S. Low
BIOCONJUGATE CHEMISTRY
(2018)
Article
Medicine, Research & Experimental
Isaac S. Marks, Spencer S. Gardeen, Sarah J. Kurdziel, Sonia T. Nicolaou, J. Evan Woods, Sumith A. Kularatne, Philip S. Low
MOLECULAR PHARMACEUTICS
(2018)
Article
Nanoscience & Nanotechnology
Scott Poh, Venkatesh Chelvam, Wilfredo Ayala-Lopez, Karson S. Putt, Philip S. Low
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2018)
Article
Chemistry, Multidisciplinary
Jeffery J. Nielsen, Stewart A. Low, Neal T. Ramseier, Rahul Hadap, Nicholas A. Young, Mingding Wang, Philip S. Low
Summary: The study aimed to improve bone fracture management by continuously applying bone anabolic agents to the fracture surface. Short oligopeptides of acidic amino acids were found to significantly increase localization of peptide payload to bone fractures, offering a promising strategy for enhancing fracture healing.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Biochemistry & Molecular Biology
Ioannis Tsamesidis, Karine Reybier, Giuseppe Marchetti, Maria Carmina Pau, Patrizia Virdis, Claudio Fozza, Francoise Nepveu, Philip S. Low, Francesco Michelangelo Turrini, Antonella Pantaleo
Article
Biochemical Research Methods
Xin Liu, Weichuan Luo, Boning Zhang, Yong Gu Lee, Imrul Shahriar, Madduri Srinivasarao, Philip S. Low
Summary: In this study, a modified influenza virus neuraminidase inhibitor, zanamivir, was utilized for diagnostic, imaging, and therapeutic purposes in influenza virus infections. Different conjugates like the zanamivir-conjugated rhodamine dye and zanamivir99 mTc radioimaging conjugate were designed for visual monitoring of virus-infected cells. Moreover, targeted cytotoxic drugs and CAR T cells were developed specifically for viral neuraminidase-expressing cells, showing potential for improved treatment of influenza virus infections.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sakkarapalayam M. Mahalingam, Karson S. Putt, Madduri Srinivasarao, Philip S. Low
Summary: The inadvertent severing of a ureter during colorectal surgeries is a common issue, leading to the development of new near-infrared dyes to help surgeons identify ureter location. The new PEGylated UreterGlow derivatives show promising optical and biodistribution characteristics, making them good candidates for translation into the clinic.
Article
Chemistry, Multidisciplinary
John Victor Napoleon, Boning Zhang, Qian Luo, Madduri Srinivasarao, Philip S. Low
Summary: Administering a CAR-targeted TLR7 agonist can reverse CAR T cell exhaustion and successfully treat solid tumors.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Qian Luo, John Napoleon, Xin Liu, Boning Zhang, Suilan Zheng, Philip S. Low
Summary: This study describes a strategy to reverse CAR T-cell exhaustion by using a universal anti-fluorescein CAR that engages multiple cancer cell clones and acts as a drug-internalizing receptor. By attaching a Toll-like receptor 7 agonist to the anti-fluorescein CAR, they downregulate exhaustion markers and reactivate exhausted CAR-T cells, leading to regression of solid tumors.
MOLECULAR CANCER RESEARCH
(2022)
Article
Engineering, Biomedical
Yun Chang, Gyuhyung Jin, Weichuan Luo, Qian Luo, Juhyung Jung, Sydney N. Hummel, Sandra Torregrosa-Allen, Bennett D. Elzey, Philip S. Low, Xiaojun Lance Lian, Xiaoping Bao
Summary: Adoptive CAR-engineered NK cells have potential for cancer treatment, but limited immunological memory and donor cell availability hinder their applications. We evaluated different CAR constructs to enhance NK cell proliferation and anti-tumor cytotoxicity. We genetically engineered hPSCs with optimized CARs and differentiated them into dual CAR-NK cells. The memory-like hPSC-NK cells showed enhanced anti-tumor activity through antigen-dependent activation of signaling pathways. Our modular hPSC CAR-NK engineering platform is a realistic strategy for off-the-shelf CAR-NK cells with immunological memory-like phenotype for targeted immunotherapy.
BIOACTIVE MATERIALS
(2023)
Article
Immunology
Huynh Dinh Chien, Antonella Pantaleo, Kristina R. Kesely, Panae Noomuna, Karson S. Putt, Tran Anh Tuan, Philip S. Low, Francesco M. Turrini
Summary: The coadministration of imatinib with standard of care (SOC) in uncomplicated P. falciparum malaria patients led to a faster decline in parasite density and fever, without any delayed parasite clearance. The improvements were most significant in patients with the highest parasite density, where serious complications and death are most common.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Xin Liu, Boning Zhang, Yingcai Wang, Hanan S. Haymour, Fenghua Zhang, Le-cun Xu, Madduri Srinivasarao, Philip S. Low
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Sakkarapalayam M. Mahalingam, Josue D. Ordaz, Philip S. Low
Article
Chemistry, Medicinal
Shibin Zhao, Julian Maceren, Mia Chung, Samantha Stone, Raphael Geiben, Melissa L. Boby, Bradley S. Sherborne, Derek S. Tan
Summary: Antibiotic resistance is a major threat to public health, with Gram-negative bacteria presenting unique challenges due to their low permeability and efflux pumps. Limited understanding of the chemical rules for overcoming these barriers hinders antibacterial drug discovery. Efforts to address this issue, such as screening compound libraries and using cheminformatic analysis, have led to the design of sulfamidoadenosines with diverse substituents, showing potential utility in accumulation in Escherichia coli.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Jichun Li, Qing Li, Shuai Xia, Jiahuang Tu, Longbo Zheng, Qian Wang, Shibo Jiang, Chao Wang
Summary: This study successfully developed a short peptide mimetic as a MERS-CoV fusion inhibitor by reproducing the key recognition features of the HR2 helix. The resulting 23-mer lipopeptide showed comparable inhibitory effect to the 36-mer HR2 peptide HR2P-M2. This has important implications for developing short peptide-based antiviral agents to treat MERS-CoV infection.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Krista Jaunsleine, Linda Supe, Jana Spura, Sten van Beek, Anna Sandstrom, Jessica Olsen, Carina Halleskog, Tore Bengtsson, Ilga Mutule, Benjamin Pelcman
Summary: Beta(2)-adrenergic receptor agonists can stimulate glucose uptake by skeletal muscle cells and are therefore potential treatments for type 2 diabetes. The chirality of compounds has a significant impact on the activity of these agonists. This study found that certain synthesized compounds showed higher glucose uptake activity. These findings provide important information for the design of novel beta(2)AR agonists for T2D treatment.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Xin Xu, Jia Chen, Guan Wang, Xiaojuan Zhang, Qiang Li, Xiaobo Zhou, Fengying Guo, Min Li
Summary: The study focuses on EZH2, a promising therapeutic target for various types of cancers. Researchers designed and synthesized a series of novel derivatives aiming to enhance the EZH2 inhibition activity. Among them, compound 28 displayed potent EZH2 inhibition activity and showed high anti-proliferative effects in lymphoma cell lines and xenograft mouse models. The study suggests that compound 28 has potential as a therapeutic candidate for EZH2-associated cancers.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Wei Zhang, Wei Liu, Ya-Dong Zhao, Li-Zi Xing, Ji Xu, Rui-Jun Li, Yun-Xiao Zhang
Summary: This study developed a series of aromatic amide derivatives based on Rhein and investigated their inhibitory activity against alpha-Syn aggregation. Two of these compounds showed promising potential in treating Parkinson's disease by stabilizing alpha-Syn's conformation and disassembling alpha-Syn oligomers and fibrils.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
Article
Chemistry, Medicinal
Mani Sharma, S. S. S. S. Sudha Ambadipudi, Neeraj Kumar Chouhan, V. Lakshma Nayak, Srihari Pabbaraja, Sai Balaji Andugulapati, Ramakrishna Sistla
Summary: Therapeutically active lipids in drug delivery systems can enhance the safety and efficacy of treatment. The liposome formulation created using synthesized biologically active lipids showed additive anti-cancer effects and reduced tumorigenic potential.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2024)
