Article
Fisheries
Tulio Teruo Yoshinaga, Jose Roberto Kfoury Junior, Arno Juliano Butzge, Rennan Lopes Olio, Francisco Javier Hernandez-Blazquez, Ana Claudia Oliveira Carreira, Cristina de Oliveira Massoco Salles Gomes, Pedro Kastein Faria da Cunha Bianchi, Yara Aiko Tabata, Ricardo Shohei Hattori
Summary: Germ cell transplantation and testis graft can be promising biotechnologies for reproducing commercial or endangered species, but immune system rejection may limit their success. Tacrolimus and cyclosporine were shown to inhibit immune responses in rainbow trout, suggesting they could be effective immunosuppressants for these procedures. Combining tacrolimus with other drugs may enhance immunosuppressive effects in host organisms, similar to strategies used in human organ transplantation.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Review
Pediatrics
Esther Bernaldo-de-Quiros, Marjorie Pion, Marta Martinez-Bonet, Rafael Correa-Rocha
Summary: Regulatory T cells (Treg) play a crucial role in regulating immune responses after kidney transplantation. Utilizing the thymus removed during surgery as a source of therapeutic Treg cells could be an innovative strategy to prevent rejection in pediatric kidney transplants.
FRONTIERS IN PEDIATRICS
(2022)
Article
Ophthalmology
Raquel Esteves Marques, Ines Leal, Paulo Silva Guerra, Rafael Correia Barao, Ana Miguel Quintas, Walter Rodrigues
Summary: Supplementing topical cyclosporine A to topical corticosteroids shows efficacy in preventing and treating corneal graft rejection post penetrating keratoplasty. The use of CsA 2% is particularly effective in high-risk patients. Further studies are required to confirm these findings.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Review
Immunology
Angus Hann, Ye H. Oo, M. Thamara P. R. Perera
Summary: The liver possesses unique immunological characteristics but is susceptible to immune mediated injury. Regulatory T cells play a crucial role in preventing tissue damage, and therapies aiming to increase their function have shown efficacy in autoimmune diseases and organ transplantations. Research on the hepatic microenvironment and the role of Tregs in liver diseases is crucial for maintaining immunological balance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Hajer Alsawad, Fatema M. Aljufairi, Abdulhameed H. Mahmood
Summary: Bilateral corneal graft rejection can occur even after successful PK, emphasizing the importance of prompt management for successful reversal of acute rejection episodes. In steroid responders, cyclosporine-A 1% can be considered as a long-term steroid-sparing agent for maintenance therapy.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Immunology
Hoa Le Mai, Nicolas Degauque, Marine Lorent, Marie Rimbert, Karine Renaudin, Richard Danger, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Sabine Le Bot, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: This study found that kidney allograft rejection is associated with an imbalance between immune cells with effector/memory functions and those with regulatory properties, manifested as a decrease in the percentage of circulating B cells and an increase in the ratio of CD28-CD8+ T cells to Tregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Ramzi Abboud, Sena Kim, Karl Staser, Reyka G. Jayasinghe, Sora Lim, Parmeshwar Amatya, C. Corbin Frye, Benjamin Kopecky, Julie Ritchey, Feng Gao, Kory Lavine, Daniel Kreisel, John F. DiPersio, Jaebok Choi
Summary: The combination of JAK inhibitor baricitinib and CsA can prevent rejection in preclinical models of fully major histocompatibility mismatched skin and heart transplantation, supporting the study of JAK inhibitors in human solid organ transplantation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yohan Park, Hanbi Lee, Sang Hun Eum, Hyung Duk Kim, Eun Jeong Ko, Chul Woo Yang, Byung Ha Chung
Summary: This study revealed that intrapatient variability (IPV) of tacrolimus (TAC) trough levels post-kidney transplantation significantly impacts allograft outcomes, emphasizing the importance of maintaining low TAC-IPV even with high mean TAC levels for improving transplant outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Yunhui Li, Bin Liang
Summary: This study analyzed the levels of circulating dd-cfDNA in different types of graft rejection and evaluated its diagnostic potential in predicting graft rejection after lung transplantation. The results showed that circulating dd-cfDNA levels were significantly higher in graft rejection, ACR, and AMR compared to non-rejection. Circulating dd-cfDNA could be used as a non-invasive biomarker to distinguish patients with graft rejection from normal stable controls.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Songcun Wang, Mengdie Li, Fengrun Sun, Chunqin Chen, Jiangfeng Ye, Dajin Li, Jinfeng Qian, Meirong Du
Summary: A successful pregnancy requires maternal immune system acceptance of fetus expressing paternal antigens, with immune abnormalities potentially leading to recurrent spontaneous abortion. Imbalances in Th17/Treg cells are associated with RSA, and immunotherapies like cyclosporine A and progesterone can help regulate these imbalances.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Zijian Zhang, Yan Qin, Yicun Wang, Shuai Li, Xiaopeng Hu
Summary: This study predicted the differential expression of monocytes associated with rejection by analyzing the transcriptome data of peripheral blood mononuclear cells. A novel gene, ISG15, was found to be associated with rejection and showed a critical role in promoting T cell proliferation. The results of this study have important implications for non-invasive diagnosis and potential therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Juanita Perez-Escobar, Jose Victor Jimenez, Erika Faride Rodriguez-Aguilar, Maximiliano Servin-Rojas, Jesus Ruiz-Manriquez, Luisa Safar-Boueri, Eduardo Carrillo-Maravilla, Miquel Navasa, Ignacio Garcia-Juarez
Summary: The use of immunosuppressive medications in solid organ transplantation is associated with complications, while the development of graft rejection leads to increased mortality and dysfunction. Liver transplant recipients can achieve immunotolerance by withdrawing from immunosuppression without graft injury. Spontaneous immunotolerance rates are low, but clinical, serologic, and tissue biomarkers can help select patients for safe withdrawal of immunosuppression. Pharmacological interventions for inducing immunotolerance are being developed.
ANNALS OF HEPATOLOGY
(2023)
Article
Immunology
Meng Dou, Chenguang Ding, Bingxuan Zheng, Ge Deng, Kun Zhu, Cuixiang Xu, Wujun Xue, Xiaoming Ding, Jin Zheng, Puxun Tian
Summary: This study identified feature immune-related genes associated with graft rejection and developed a prognostic model that showed good sensitivity and specificity in predicting 1- and 3-year kidney graft survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Yulian Wang, Lisi Huang, Tian Huang, Suxia Geng, Xiaomei Chen, Xin Huang, Peilong Lai, Xin Du, Jianyu Weng
Summary: This study explores the role of gut bacteria in a mice model of chronic sclerodermatous graft-versus-host disease (Scl-GVHD). The findings suggest that dysbiosis of gut bacteria may regulate the differentiation ratio of Treg and Th1 cells, which is associated with Scl-cGVHD.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Dennis Eurich, Stephan Schlickeiser, Ramin Raul Ossami Saidy, Deniz Uluk, Florian Rossner, Maximilian Postel, Wenzel Schoening, Robert Oellinger, Georg Lurje, Johann Pratschke, Petra Reinke, Natalie Gruen
Summary: This study presents a simple scoring system based on clinical parameters to estimate the probability of tolerance in liver transplant patients. The scoring system showed good predictive performance in assessing the clinical probability of tolerance or the dispensability of immunosuppressive drugs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Parasitology
Victor H. Salazar-Castanon, Imelda Juarez-Avelar, Martha Legorreta-Herrera, Tzipe Govezensky, Miriam Rodriguez-Sosa
PARASITOLOGY RESEARCH
(2018)
Article
Toxicology
G. Vazquez-Gomez, L. Rocha-Zavaleta, M. Rodriguez-Sosa, P. Petrosyan, J. Rubio-Lightbourn
TOXICOLOGY LETTERS
(2018)
Article
Oncology
Jonadab E. Olguin, Itzel Medina-Andrade, Emmanuel Molina, Armando Vazquez, Thalia Pacheco-Fernandez, Rafael Saavedra, Carlos Perez-Plasencia, Yolanda I. Chirino, Felipe Vaca-Paniagua, Luis E. Arias-Romero, Emma B. Gutierrez-Cirlos, Sonia A. Leon-Cabrera, Miriam Rodriguez-Sosa, Luis I. Terrazas
Article
Multidisciplinary Sciences
C. E. Matisz, B. Faz-Lopez, E. Thomson, A. Al Rajabi, F. Lopes, L. I. Terrazas, A. Wang, K. A. Sharkey, D. M. McKay
SCIENTIFIC REPORTS
(2017)
Article
Toxicology
Juan Carlos Rodriguez-Escamilla, Estefany Medina-Reyes, Carolina Rodriguez-lbarra, Alejandro Deciga-Alcaraz, Jose O. Flores-Flores, Adriana Ganem-Rondero, Miriam Rodriguez-Sosa, Luis Terrazas, Norma L. Delgado-Buenrostro, Yolanda Chirino
JOURNAL OF APPLIED TOXICOLOGY
(2019)
Article
Cell Biology
Tonathiu Rodriguez, Thalia Pacheco-Fernandez, Alicia Vazquez-Mendoza, Oscar Nieto-Yanez, Imelda Juarez-Avelar, Jose L. Reyes, Luis I. Terrazas, Miriam Rodriguez-Sosa
Article
Biochemistry & Molecular Biology
Monica G. Mendoza-Rodriguez, C. Angel Sanchez-Barrera, Blanca E. Callejas, Veronica Garcia-Castillo, Diana L. Beristain-Terrazas, Norma L. Delgado-Buenrostro, Yolanda I. Chirino, Sonia A. Leon-Cabrera, Miriam Rodriguez-Sosa, Emma Bertha Gutierrez-Cirlos, Carlos Perez-Plasencia, Felipe Vaca-Paniagua, Marco Antonio Meraz-Rios, Luis I. Terrazas
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Oncology
Jonadab E. Olguin, Itzel Medina-Andrade, Tonathiu Rodriguez, Miriam Rodriguez-Sosa, Luis I. Terrazas
Review
Biochemistry & Molecular Biology
Oscar Illescas, Thalia Pacheco-Fernandez, Juan P. Laclette, Tonathiu Rodriguez, Miriam Rodriguez-Sosa
Article
Biochemistry & Molecular Biology
Itzel Medina-Andrade, Jonadab E. Olguin, Stephanie Guerrero-Garcia, Jossael A. Espinosa, Elizabeth Garduno-Javier, Victoria Hernandez-Gomez, Felipe Vaca-Paniagua, Miriam Rodriguez-Sosa, Luis I. Terrazas
Summary: Inflammation has been closely linked to the risk of developing colon cancer, and the IL-4 receptor-mediated pathway may have a role in the development of colon tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Dunia M. Medina-Buelvas, Miriam Rodriguez-Sosa, Libia Vega
Summary: Macrophages play a key role in the immune response against Trypanosoma cruzi infection, with differences in the development of M1 and M2 subtypes in different mouse models.
Article
Chemistry, Multidisciplinary
Sonia E. Hernandez Navia, Jose L. Figueroa-Hernandez, Jose S. Rodriguez-Zavala, Miriam Rodriguez-Sosa, Mariano Martinez-Vazquez
Summary: Mexico has a tradition of using medicinal plants to combat diabetes. The ethyl acetate extract from Ibervillea lindheimeri roots contains compounds that can reduce blood glucose levels in mice with chemically induced diabetes. These compounds may act by promoting the activation of insulin-related receptors.
JOURNAL OF CHEMISTRY
(2022)
Article
Microbiology
Bertha Espinoza, Ignacio Martinez, Maria Luisa Martinez-Velasco, Miriam Rodriguez-Sosa, Augusto Gonzalez-Canto, Alicia Vazquez-Mendoza, Luis I. Terrazas
Summary: This study identifies a 49-kDa molecule (MASP49) that is mainly expressed on the surfaces of amastigotes and trypomastigotes in Trypanosoma cruzi. Blockade of MASP49 reduces parasite entry into cells, indicating its role in the infection process. MASP49 can also bind to macrophages and cardiomyocytes and undergo glycosylation. These findings suggest that MASP49 may be a virulence factor in T. cruzi and further investigation of its role in infection is needed.
Article
Dentistry, Oral Surgery & Medicine
Betsaida J. Ortiz-Sanchez, Imelda Juarez-Avelar, Antonio Andrade-Meza, Monica Gabriela Mendoza-Rodriguez, Yolanda I. Chirino, Eric Monroy-Perez, Gloria Luz Paniagua-Contreras, Miriam Rodriguez-Sosa
Summary: Our study suggests that MIF plays an important role in the exacerbation of periodontitis during pregnancy and that MIF is partially responsible for the inflammation associated with the severity of periodontitis during pregnancy.
JOURNAL OF PERIODONTAL RESEARCH
(2023)
Article
Biology
Israel Cotzomi-Ortega, Arely Rosas-Cruz, Dalia Ramirez-Ramirez, Julio Reyes-Leyva, Miriam Rodriguez-Sosa, Patricia Aguilar-Alonso, Paola Maycotte