Article
Environmental Sciences
Sobia Shahzad, Mumtaz Hussain, Hassan Munir, Muhammad Arfan
Summary: This study analyzed the proximate composition and phytochemical heterogeneity of locally adapted sisal plants in different seasons and locations in Punjab, Pakistan. The results showed that the seasonal and locational differences significantly influenced the phytochemical contents of sisal.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Chemistry, Applied
Claudia Cecilio Daher, Stella Maria Andrade Gomes Barreto, Gabriel Azevedo de Brito Damasceno, Artur de Santana Oliveira, Pedro Ivo Palacio Leite, Fernanda Priscila Santos Reginaldo, Cassiano Carlos Escudeiro, Elissa Arantes Ostrosky, Raquel Brandt Giordani, Marcio Ferrari
Summary: The study aimed to extract a polyphenol-enriched extract from sisal residue using ultrasound, characterize it chemically, evaluate its antioxidant activity, and develop safe and stable photoprotective formulations for cosmetic applications. The extraction process showed promising results in terms of yield and antioxidant properties, and the developed formulations incorporating the extract demonstrated increased sun protection factor and protection against UVA and visible/blue light.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Immunology
Daniel J. Browne, Ashton M. Kelly, Jamie L. Brady, Denise L. Doolan
Summary: This study developed a high-throughput screening assay using reverse transcription-quantitative PCR (RT-qPCR) to quantify surrogate markers of immunity. The assay has low cell consumption and reagent cost, making it suitable for measuring immune effector function with limited PBMCs. It also has single-cell analytical sensitivity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Shanmuga Sundaram Mahalingam, Sangeetha Jayaraman, Adhvika Arunkumar, Holly M. Dudley, Donald D. Anthony, Carey L. Shive, Jeffrey M. Jacobson, Pushpa Pandiyan
Summary: Individuals aged >61 show intrinsic changes in T cell responses during SARS-CoV-2 infection, including reduced cytokine production capacity and increased PD-1(+) cells. These findings may provide insights into dysregulated immune responses in COVID-19 in the elderly.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Madhuparna Nandi, Mitterrand Muamba Moyo, Sakina Orkhis, Jeanne Masunga Faida Mobulakani, Marc-Andre Limoges, Fjolla Rexhepi, Marian Mayhue, Anny Armas Cayarga, Gisela Cofino Marrero, Subburaj Ilangumaran, Alfredo Menendez, Sheela Ramanathan
Summary: Interleukin-15 (IL-15) regulates immune cell activity by forming a trimeric complex with IL-15Rα, but can also signal through the IL-15Rβγ(c) dimer. IL-15 deficiency results in the inability to control bacterial infections, while mice lacking IL-15Rα are able to effectively clear pathogens.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Wei-Jia Luo, Sung-Liang Yu, Chia-Ching Chang, Min-Hui Chien, Ya-Ling Chang, Keng-Mao Liao, Pei-Chun Lin, Kuei-Pin Chung, Ya-Hui Chuang, Jeremy J. W. Chen, Pan-Chyr Yang, Kang-Yi Su
Summary: HLJ1 knockout mice show reduced organ injury and mortality in lipopolysaccharide-induced endotoxic shock. HLJ1 deletion affects IFN-gamma-related gene signatures in distinct immune cell clusters. HLJ1 deficiency leads to reduced IL-12 levels, dampened IFN-gamma production in natural killer cells, and improved survival rate. HLJ1 converts misfolded IL-12p35 homodimers to monomers, maintaining bioactive IL-12p70 heterodimerization and secretion.
Article
Virology
Marcel Gluchowski, Xiaoqiong Yu, Bernard Abrenica, Samantha Yao, Joshua Kimani, Renee N. Douville, Terry Blake Ball, Ruey-Chyi Su
Summary: In a group of Kenyan female sex workers who remain seronegative despite repeated exposure to HIV-1, a unique profile of proinflammatory and proapoptotic ISGs with robust but transient responses to exogenous IFN was identified. The HESN cells also showed increased expression of negative regulators of ISG induction, potentially contributing to a strict regulation of ISG expression and decreased HIV susceptibility. The distinct ISG profile in HESN cells may be a correlate of protection against HIV infection.
Article
Immunology
Kaveh Abdi, Karen Laky, Mehrnoosh Abshari, Elizabeth M. Hill, Larry Lantz, Nevil J. Singh, Eric O. Long
Summary: It has been found that NK cells produce IFN-gamma before the production of IL-12 by DCs in the early stage of immune response. Toll-like Receptor 4 (TLR4) on DCs and soluble factors produced by LPS-activated DCs play important roles in IFN-gamma production by NK cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Iris Kamer, Elizabeta Bab-Dinitz, Oranit Zadok, Efrat Ofek, Teodor Gottfried, Inbal Daniel-Meshulam, Goni Hout-Siloni, Alon Ben Nun, Iris Barshack, Amir Onn, Jair Bar
Summary: A lack of robust, accessible experimental models is a major obstacle in advancing cancer immunotherapy. This study aimed to develop an ex-vivo organ culture (EVOC) model for non-small cell lung cancer (NSCLC) immunotherapy, which reflected original tissue features and showed promising correlations with immune checkpoint inhibitor response. The study provides valuable insights into biomarkers for ICI-induced response in early stage NSCLC.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Allergy
Aurora Holgado, Zhuangzhuang Liu, Aigerim Aidarova, Christina Mueller, Mira Haegman, Yasmine Driege, Marja Kreike, Charlotte L. Scott, Inna S. Afonina, Rudi Beyaert
Summary: IL-33 plays a crucial role in allergic diseases, and A20 is involved in regulating IL-33 signaling. In the absence of A20 in macrophages, IL-33-induced lung immune responses are altered, with reduced type 2 immune response and increased production of IFN-gamma. This study reveals a novel role for A20 in regulating IL-33-induced STAT1 signaling in macrophages.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ella Larissa Ndoricyimpaye, Jacques Van Snick, Rutayisire Robert, Emmanuel Bikorimana, Onesphore Majyambere, Enatha Mukantwari, Thaddee Nshimiyimana, Valens Mbonigaba, Jean Paul Coutelier, Nadine Rujeni
Summary: To effectively treat and prevent severe COVID-19, it is important to identify early markers of disease severity in different populations. This study analysed cytokine kinetics in COVID-19 patients in Rwanda and found that severe cases had significantly higher levels of pro-inflammatory cytokines and gene expressions compared to mild cases on the first day of infection. IFN gamma was identified as a severity marker throughout the disease course, while TGF beta 1, IL-6, and IL-17 were markers of severity only at an early phase. Additionally, low IL-9 levels and a high IFN gamma/IL-9 ratio were observed in patients who later died, suggesting that this could be an important biomarker for predicting COVID-19 severity and post-COVID-19 syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Daniela Andrea Paira, Silene Silvera-Ruiz, Andrea Tissera, Rosa Isabel Molina, Jose Javier Olmedo, Virginia Elena Rivero, Ruben Dario Motrich
Summary: The study suggests that inflammatory cytokines IFN-γ, IL-17A, and IL-1β can individually impair human sperm motility and decrease viability, leading to increased apoptosis. On the other hand, IL-8 does not have a significant impact on sperm.
Article
Medicine, General & Internal
Xu Zhang, Xingyu Lu, Yixuan Yu, Kexin Tan, Huijuan Cui
Summary: Immune checkpoint inhibitors (ICIs) have revolutionized tumor immunotherapy. Changes in cytokines have been associated with ICIs-related adverse events (irAEs). This study aimed to identify biomarkers for irAEs by investigating the changes in interleukin-6 (IL-6) and interferon-gamma levels before and after irAEs in patients treated with ICIs.
Article
Dermatology
Yanghe Liu, Chen Zhang, Bing Li, Chen Yu, Xiaocui Bai, Chunying Xiao, Lei Wang, Erle Dang, Luting Yang, Gang Wang
Summary: IL-17A inhibits the suppressive function of Tregs by blocking TGF-beta release and promoting IFN-gamma production. Treatment with anti-IL-17A in psoriasis patients restores the suppressive function of Tregs.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2021)
Article
Immunology
Merve Uslu, Esra Albayrak, Fatih Kocabas
Summary: This study found that IL-2 and its receptor play a crucial role in immune response regulation. The small molecule Ro 26-4550 trifluoroacetate is able to competitively inhibit the interaction between IL-2 and its receptor, promoting the expansion and self-renewal ability of hematopoietic stem cells. Furthermore, Ro treatment induces an increase in CD25 expressing cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
