Article
Agricultural Engineering
Dennise A. Carrillo-Lomeli, Diana Jasso de Rodriguez, Victor M. Moo-Huchin, Lorena Ramon-Canul, Raill Rodriguez-Garcia, Susana Gonzalez-Morales, Jose A. Villarreal-Quintanilla
Summary: This study evaluated the effects of ultrasound-assisted extraction of Flourensia microphylla extract on polyphenolic composition, antioxidant capacity, and antifungal activity. The results showed that ultrasound-assisted extraction increased the bioactivity of the extract and demonstrated inhibitory and fungicidal activity against phytopathogenic fungi.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Aline Machado Lucas, Americia F. M. L. Bento, Rubem Mario Figueiro Vargas, Thamiris Becker Scheffel, Liliana Rockenbach, Fernando Mendonca Diz, Angelica Regina Capellari, Fernanda B. Morrone, Eduardo Cassel
Summary: The methanolic fraction of Baccharis uncinella's supercritical extract demonstrated high antioxidant activity and antitumor effects against bladder cancer and glioblastoma cells, with lower toxicity to normal cells.
JOURNAL OF CO2 UTILIZATION
(2021)
Article
Chemistry, Applied
Hong Duan, Wei Wang, Yongxiang Li, Ghulam Jilany Khan, Yuan Chen, Tianci Shen, Nina Bao, Jing Hua, Zhenglian Xue, Kefeng Zhai, Zhaojun Wei
Summary: The study identified 18 compounds in the stem of Premna microphylla Turcz., with 6 compounds being identified for the first time within this genus and plant. These compounds highlight the strong therapeutic potential of Premna microphylla Turcz. stem extract against oxidation-related diseases.
Article
Biotechnology & Applied Microbiology
Hanghong Wang, Chenhuan Lai, Yuheng Tao, Mengyi Zhou, Ruilin Tang, Qiang Yong
Summary: This study evaluated the effects of galactomannan oligosaccharides (GMOS) derived from Gleditsia microphylla as a prebiotic on human intestinal bacteria. The results showed that GMOS effectively promoted the proliferation of intestinal bacteria, had a stabilizing effect on intestinal pH, and significantly affected the diversity of gut microbiota and metabolic functions. These findings provide a theoretical basis for the potential use of galactomannan oligosaccharides from Gleditsia microphylla as prebiotics for regulating human intestinal bacteria.
FERMENTATION-BASEL
(2023)
Article
Chemistry, Multidisciplinary
Bo Zhang, Meng Zhang, Min Lin, Xinzhe Dong, Xutao Ma, Yuanhong Xu, Jing Sun
Summary: This study reports the development of an innovative cationic copolypeptoid antimicrobial that exhibits a wide spectrum of antibacterial activity and low hemolytic properties. It effectively inhibits biofilm formation and eradicates bacteria embedded in mature biofilms. The antimicrobial also shows potent activity against drug-resistant bacteria without developing visible resistance after repeated usage.
Article
Microbiology
Paulo Castro, Rodolfo Parada, Carlos Corrial, Leonora Mendoza, Milena Cotoras
Summary: Two endophytic fungi, Epicoccum sp. and Pleosporales sp., were isolated from Chilean foothills and their extracts showed antifungal activity against Botrytis cinerea, suggesting their potential as alternatives to synthetic fungicides.
Article
Chemistry, Medicinal
Matheus L. Silva, Cyntia S. Oliveira, Wagner J. O. dos Santos, Vani X. Oliveira Junior, Guilherme M. Antar, Joao H. G. Lago, Giselle Cerchiaro
Summary: This study evaluates the cytotoxic activity of natural diterpenes isolated from Brazilian native plants. The results show that ent-kaurenoic acid has activity against aggressive adenocarcinoma cells and low toxicity against non-tumorigenic epithelial cells, indicating selectivity. The derivatives of ent-kaurenoic acid exhibit reduced toxicity and selectivity. In silico studies predict good bioavailability and ADME properties for these compounds. Therefore, ent-kaurenoic acid can be a promising candidate for the development of molecular prototypes for breast cancer treatment.
ARCHIV DER PHARMAZIE
(2022)
Review
Pharmacology & Pharmacy
Priscilla L. Nyembe, Thandokuhle Ntombela, Maya M. Makatini
Summary: Due to the broad-spectrum activity against bacteria, natural antimicrobial peptides (AMPs) and their synthetic analogs are potential therapies for multi-drug resistant pathogens. Oligo-N-substituted glycines (peptoids) are a promising alternative that overcomes the limitations of AMPs. Peptoid structures, with functional side chains attached to the backbone nitrogen, are more stable and less susceptible to degradation.
Article
Polymer Science
A. Chiloeches, A. Funes, R. Cuervo-Rodriguez, F. Lopez-Fabal, M. Fernandez-Garcia, C. Echeverria, A. Munoz-Bonilla
Summary: This study reported the synthesis of clickable polymers derived from biobased itaconic acid, which were used to prepare novel cationic polymers with antibacterial properties and low hemotoxicity via click chemistry. The modified polymers exhibited potent antibacterial activity against Gram-positive bacteria and low hemolysis, showing excellent selectivity for Gram-positive bacteria over human red blood cells.
Article
Biochemistry & Molecular Biology
Xiaoli Ma, Hongwei Chen, Sisi Zhu, Pengfei Tu, Yong Jiang
Summary: In this study, seventeen new carbazole alkaloid derivatives were isolated from the leaves and stems of Murraya microphylla, including trimeric and dimeric carbazole racemates. The structures of the new compounds were elucidated using HRESIMS and NMR data analysis, and the optically pure isomers were obtained through chiral HPLC separation.
Article
Multidisciplinary Sciences
Eunice Barbosa, Yasmim M. Assumpcao, Izabel M. Teixeira, Renata F. A. Pereira, Victor P. Ribeiro, Jairo K. Bastos, Clarissa Cardoso, Maira H. T. Liberal, Bruno A. Penna, Leandro M. Rocha
Summary: This study evaluated the antibacterial and antibiofilm properties of Green Propolis and Baccharis dracunculifolia against Staphylococcus pseudintermedius and compared their chemical similarities. The results suggest that the Baccharis dracunculifolia extract could be an alternative to the Green Propolis extract in the treatment of canine pyoderma caused by Staphylococcus pseudintermedius.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
Article
Fisheries
Xiaowan Ma, Yuan Jin, Ying Qiao, Shengping Zhong, Yongze Xing, Xuyang Chen
Summary: Two antimicrobial peptides derived from histone 1 (LcH1-1 and LcH1-2) were described in this study, and they showed a broad antimicrobial spectrum. The results suggested that LcH1 may play a role in the immune response of L. crocea against Cryptocaryon irritans infection, and LcH1-derived antimicrobial peptides may be a potential strategy for controlling parasitic and bacterial diseases.
Article
Chemistry, Multidisciplinary
Corrado Di Nicola, Fabio Marchetti, Alessia Tombesi, Sonila Xhafa, Patrizio Campitelli, Marco Moroni, Simona Galli, Riccardo Pettinari, Claudio Pettinari
Summary: Novel copper(ii) coordination polymers were synthesized and their thermal behavior and structural features were investigated. The nanoparticles showed potential antibacterial activity through a contact kill mechanism involving ROS production.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Tong Zhang, Wei An, Jiawei Sun, Fei Duan, Zeyu Shao, Fan Zhang, Ting Jiang, Xuliang Deng, Cyrille Boyer, Weiping Gao
Summary: Microbial resistance to antibiotics is a major challenge in global healthcare. A study found that a photoinduced cationic polymer conjugated with lysozyme can effectively overcome bacterial resistance and improve therapeutic efficacy in a rat periodontitis model. This discovery provides an efficient strategy to enhance antimicrobial activities and overcome antimicrobial resistance.
Article
Biochemistry & Molecular Biology
Jenna M. Greve, J. A. Cowan
Summary: Antibiotic resistance calls for innovative strategies and treatments. The tested antimicrobial peptides in this study exhibited broad-spectrum synergy and the ability to interact with various bacterial membranes. In most cases, the presence of the ATCUN motif enhanced the activity of the combined peptides. Additionally, the multifaceted peptide CP10A was found to have both cell membrane and intracellular activity, acting as a chameleon to enhance the activity of other peptides when needed. The results highlight the importance of diverse modes of action and the value of the metal-binding domain in enhancing the activity of antimicrobial peptides in combination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chukwuemeka R. Nwokocha, Isheba Warren, Javier Palacios, Mario Simirgiotis, Magdalene Nwokocha, Sharon Harrison, Rory Thompson, Adrian Paredes, Jorge Borquez, Astrid Lavado, Fredi Cifuentes
Article
Biochemistry & Molecular Biology
Mari Carmen Ruiz-Dominguez, Carolina Espinosa, Adrian Paredes, Jenifer Palma, Carolina Jaime, Carlos Vilchez, Pedro Cerezal
Article
Biochemistry & Molecular Biology
Fredi Cifuentes, Javier Palacios, Chukwuemeka R. Nwokocha, Jorge Borquez, Mario J. Simirgiotis, Ignacio Norambuena, Mario Chiong, Adrian Paredes
Article
Biochemistry & Molecular Biology
Fredi Cifuentes, Javier Palacios, Jorge Borquez, Adrian Paredes, Claudio Parra, Alejandra Bravo, Mario J. Simirgiotis
Article
Endocrinology & Metabolism
Paulina Ormazabal, Mariana Cifuentes, Rosaria Vari, Beatrice Scazzocchio, Roberta Masella, Igor Pacheco, Wladimir Vega, Adrian Paredes, Glauco Morales
ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS
(2020)
Article
Biochemistry & Molecular Biology
Ruth E. Barrientos, Mario J. Simirgiotis, Javier Palacios, Adrian Paredes, Jorge Borquez, Alejandra Bravo, Fredi Cifuentes
Article
Biochemistry & Molecular Biology
Jorge Touma, Myriam Navarro, Betsabet Sepulveda, Alequis Pavon, Gino Corsini, Katia Fernandez, Claudia Quezada, Angelo Torres, Maria Jose Larrazabal-Fuentes, Adrian Paredes, Ivan Neira, Matias Ferrando, Flavia Bruna, Alejandro Venegas, Jessica Bravo
Article
Endocrinology & Metabolism
Sofia Sanhueza, Nicolas Tobar, Mariana Cifuentes, Daniela Quenti, Rosaria Vari, Beatrice Scazzocchio, Roberta Masella, Karin Herrera, Adrian Paredes, Glauco Morales, Paulina Ormazabal
Summary: The study suggests that HEL can prevent liver steatosis and inflammation by reducing activation of proinflammatory pathways and inhibiting lipid accumulation in HepG2 hepatocytes and Drosophila larvae exposed to OA/PA and HFD.
INTERNATIONAL JOURNAL OF OBESITY
(2021)
Article
Biochemistry & Molecular Biology
Javier Palacios, Adrian Paredes, Marcelo A. Catalan, Chukwuemeka R. Nwokocha, Fredi Cifuentes
Summary: Senecio nutans Sch. Bip. and its constituents have antihypertensive effects and cause vasorelaxation by regulating calcium influx and release.
Article
Biochemistry & Molecular Biology
Ruth E. Barrientos, Elena Ibanez, Adrian Puerta, Jose M. Padron, Adrian Paredes, Fredi Cifuentes, Javier Romero-Parra, Javier Palacios, Jorge Borquez, Mario J. Simirgiotis
Summary: This preliminary study investigated the phenolic composition, antioxidant activity, relaxation effects, enzyme inhibition potential, and antiproliferative activity of Gypothamnium pinifolium Phil. from Chile. The results showed that G. pinifolium is a valuable source of secondary metabolites with potential activity against noncommunicable diseases.
Article
Food Science & Technology
Lucia Cuesta Ramos, Javier Palacios, Ruth E. Barrientos, Jessica Gomez, Juan Manuel Castagnini, Francisco J. Barba, Alejandro Tapia, Adrian Paredes, Fredi Cifuentes, Mario J. Simirgiotis
Summary: This study investigated the proximal analysis, phenolic fingerprinting, antioxidant activity, and enzymatic inhibition and relaxation effects of Azara dentata Ruiz & Pav. in rat aorta. The fruits of this plant exhibited high mineral and heavy metal contents, as well as significant amounts of anthocyanins, flavonoids, phenolic acids, and coumarins. The ethanolic extracts showed strong antioxidant activity and inhibited important enzymes, while also inducing relaxation in rat aorta through the release of endothelial nitric oxide.
Article
Cell Biology
Gabriela Yuri, Sofia Sanhueza, Adrian Paredes, Glauco Morales, Mariana Cifuentes, Paulina Ormazabal
Summary: Elevated fatty acid levels in obesity can cause liver inflammation, fibrosis, and NAFLD. Impaired communication between hepatocytes and adipose tissue leads to adipose lipolysis and fibrosis, negatively impacting metabolic function. The plant extract HEL can counteract fibrotic marker expression and lipolysis caused by obesity, suggesting a preventive approach against hepatic fibrosis and liver-adipose crosstalk.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Food Science & Technology
Ruth E. Barrientos, Javier Romero-Parra, Fredi Cifuentes, Javier Palacios, Nestor Jaime Romero-Jola, Adrian Paredes, Gabriel Vargas-Arana, Mario J. Simirgiotis
Summary: In this study, the chemical and biological analysis of canelo fruits from Chile was reported for the first time. The fruits were found to be rich in secondary metabolites and could inhibit enzymes associated with neurodegenerative diseases, potentially inducing a hypotensive effect in rat aorta.
Article
Food Science & Technology
Jenifer Palma, Ana Mercado, Adrian Paredes, Catherine Lizama, Gissel Pohl, Maria J. Larrazabal
QUALITY ASSURANCE AND SAFETY OF CROPS & FOODS
(2020)
Article
Biochemistry & Molecular Biology
Roberto O. Ybanez-Julca, Daniel Asuncion-Alvarez, Ivan M. Quispe-Diaz, Javier Palacios, Jorge Borquez, Mario J. Simirgiotis, Shagufta Perveen, Chukwuemeka R. Nwokocha, Fredi Cifuentes, Adrian Paredes
