Article
Multidisciplinary Sciences
Maolin Mu, Wanxiang Niu, Fang Chu, Qingsheng Dong, Shanshan Hu, Chaoshi Niu
Summary: This study reveals the critical role of circSOBP in glioma by regulating cell proliferation, glycolysis, and immune response. The findings offer potential therapeutic avenues for targeting glioma metabolism and immunological reprogramming.
Review
Biochemical Research Methods
Yuxuan Xu, Zhenyu Shi, Li Bao
Summary: Protein post-translational modifications, particularly acylation, play vital roles in cellular processes and are involved in various physiological activities. Advancements in technologies such as antibodies and mass spectrometry allow for better understanding of protein acylation and its functional significance in future research.
MOLECULAR & CELLULAR PROTEOMICS
(2022)
Editorial Material
Cell Biology
Guoping Li, Saumya Das
Summary: Extracellular vesicles and their cargo play a role in intercellular communication, affecting tumor growth and inducing an immune-tolerant phenotype.
Article
Biochemistry & Molecular Biology
Zhi-Yan Sun, Chang-Lin Yang, Li-Jie Huang, Zong-Chao Mo, Ke-Nan Zhang, Wen-Hua Fan, Kuan-Yu Wang, Fan Wu, Ji-Guang Wang, Fan-Lin Meng, Zheng Zhao, Tao Jiang
Summary: circRNADisease v2.0 is an enhanced and reliable database that provides experimentally verified relationships between circular RNAs (circRNAs) and various diseases. The expansion of the database includes an increase in circRNA numbers, disease types, covered species, and the introduction of a new section collecting information on circRNA-associated factors and prognostic evidence in diseases.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell Biology
Kui Luo, Aiqun Liu, Hao Wu, Qiang Liu, Jin Dai, Yu Liu, Zhifei Wang
Summary: Circular RNA circKIF4A is upregulated in glioma and plays a vital role in promoting glioma progression by binding miR-335-5p and upregulating ALDOA expression. Knockdown of circKIF4A reduces glioma cell proliferation, invasion, and enhances sensitivity to temozolomide treatment.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Chenxi Ju, Mingxia Zhou, Dan Du, Chang Wang, Jieqiong Yao, Hongle Li, Yang Luo, Fucheng He, Jing He
Summary: This study found that circ_0042881 is highly expressed in breast cancer and is closely associated with clinical features. The study revealed that circ_0042881 promotes breast cancer progression by sponging miR-217, which activates the RAS protein and initiates downstream signaling pathways.
CELL DEATH & DISEASE
(2023)
Review
Pharmacology & Pharmacy
Yang Pan, Kathryn E. Kadash-Edmondson, Robert Wang, John Phillips, Song Liu, Antoni Ribas, Richard Aplenc, Owen N. Witte, Yi Xing
Summary: Recent advances in high-throughput technologies and rapid accumulation of multiomic cancer profiling data in public repositories have provided opportunities to systematically characterize RNA dysregulation in cancer and identify antigen targets for immunotherapy. However, important conceptual and technological challenges exist due to the complexity of cancer transcriptomes and proteomes.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2021)
Article
Allergy
Thimo Ruethers, Aya C. Taki, Shaymaviswanathan Karnaneedi, Shuai Nie, Tanja Kalic, Danyi Dai, Sakda Daduang, Michael Leeming, Nicholas A. Williamson, Heimo Breiteneder, Sam S. Mehr, Sandip D. Kamath, Dianne E. Campbell, Andreas L. Lopata
Summary: This study investigated the allergen repertoire of two highly farmed fish species, demonstrating IgE-binding to fish tropomyosins and TPIs for the first time in a large patient cohort. Tropomyosins, along with parvalbumins, should be considered for improved fish allergy diagnostics.
Article
Multidisciplinary Sciences
Danye Zhu, Shanmin Yuan, Cong Chen
Summary: This study revealed that the combination of Hedyotis diffusa and Scutellaria barbata could inhibit the proliferation, migration, and invasion of colorectal cancer cells by modulating the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Junwei Tang, Chuan Zhang, Yuanjian Huang, Lu Wang, Ziwei Xu, Dongsheng Zhang, Yue Zhang, Wen Peng, Yifei Feng, Yueming Sun
Summary: Colorectal cancer is a common type of cancer worldwide, with increasing incidence and mortality rates in China. The study found that elevated levels of circ-LNLM in tumor tissues of LNLM1 patients were associated with liver metastasis and vascular invasion, suggesting it could potentially serve as a diagnostic and prognostic biomarker for LNLM1 patients.
CELL DEATH & DISEASE
(2021)
Review
Pharmacology & Pharmacy
Namrashee V. Mehta, Mariam S. Degani
Summary: Covalent warheads, previously neglected for safety concerns, have gained attention due to their advantages over noncovalent drugs. The approval of several covalent inhibitors in the past decade has accelerated research in this area. Strategies are being developed to improve the potency and mitigate toxicity of covalent warheads.
DRUG DISCOVERY TODAY
(2023)
Article
Chemistry, Multidisciplinary
Jia-Xin Chen, Shu He, Yan-Jun Wang, Xiong-Kang Gan, Ya-Qing Zhou, Lei Hua, Can Hou, Sheng Zhang, Han-Xiao Zhou, En-Zhi Jia
Summary: This study aimed to investigate mRNA expression profiling in CAD patients and identified BTRC and UBE2D2 genes as potential diagnostic biomarkers with significant diagnostic values. The study highlights the potential of these genes as novel diagnostic biomarkers and therapeutic targets for CAD.
Article
Cell Biology
Xiuchao Geng, Yuhao Zhang, Xiaomeng Lin, Zhaomu Zeng, Jun Hu, Liangchao Hao, Jianglong Xu, Xinjuan Wang, Hong Wang, Qiang Li
Summary: The delivery of circWDR62 through exosomes promotes TMZ-resistance and malignant progression in glioma by targeting the miR-370-3p/MGMT axis, providing a new therapeutic strategy. Exosomal circWDR62 in human serum may serve as a promising therapeutic target and prognostic marker for glioma therapy.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Ruijuan Guan, Suonan Angxiu, Ling Li, Zefeng Kang, Xin Yan
Summary: This study identified differentially expressed circRNAs (DEcircRNAs) in peripheral blood samples from patients with glaucoma through transcriptome sequencing, suggesting that DEcircRNAs are involved in the pathogenesis of glaucoma and may serve as potential biomarkers and therapeutic targets.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, Research & Experimental
Yueyong Li, Yingjun Zhang, Shuai Zhang, Deyou Huang, Baosheng Li, Gencheng Liang, Yingning Wu, Qiulan Jiang, Longhua Li, Cheng Lin, Zhonghen Wei, Lingzhang Meng
Summary: Our study revealed that circARNT2 is significantly upregulated in HCC patients and can modulate cisplatin resistance through the miR-155-5p/PDK1 pathway. This suggests that circARNT2 may serve as a promising therapeutic target for overcoming cisplatin resistance in HCC.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Surgery
Peter A. Than, Christopher R. Davis, Robert C. Rennert, Shane D. Morrison, Michael W. Findlay, Mark A. Kay, Geoffrey C. Gurtner
Summary: This study achieved systemic gene delivery by transfecting rat superficial inferior epigastric artery flaps, opening up new possibilities for treating protein deficiency disorders.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2022)
Article
Clinical Neurology
Meredith M. Course, Kathryn Gudsnuk, C. Dirk Keene, Thomas D. Bird, Suman Jayadev, Paul N. Valdmanis
Summary: Course et al. performed targeted long-read isoform-sequencing of PSEN1 and PSEN2 in individuals with sporadic Alzheimer's disease, familial Alzheimer's disease with PSEN1 and PSEN2 pathogenic variants, and controls. The study revealed unique aberrant splicing of PSEN2 in sporadic Alzheimer's disease, expanding our understanding of PSEN1 and PSEN2 variants in Alzheimer's disease and suggesting novel mechanisms of Alzheimer's disease pathogenesis.
Article
Medicine, Research & Experimental
Francesco Puzzo, Chuanling Zhang, Bethany Powell Gray, Feijie Zhang, Bruce A. Sullenger, Mark A. Kay
Summary: This study developed a new chemically modified AAV vector, N & epsilon;-AAVs, which allows post-production engineering through click chemistry. The functionalized N & epsilon;-AAVs showed increased transduction efficiency and demonstrated selective uptake in vivo, making them versatile gene therapy vectors for specific cell targeting.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Letter
Biochemical Research Methods
Andrew D. Holmes, Patricia P. Chan, Qi Chen, Pavel Ivanov, Laurence Drouard, Norbert Polacek, Mark A. Kay, Todd M. Lowe
Article
Multidisciplinary Sciences
Adriana Gonzalez-Sandoval, Katja Pekrun, Shinnosuke Tsuji, Feijie Zhang, King L. Hung, Howard Y. Chang, Mark A. Kay
Summary: The effectiveness of rAAV vectors varies between species, and a single amino acid change in the vector can alter its epigenomic state and transgene expression levels between species.
NATURE COMMUNICATIONS
(2023)
Review
Biochemistry & Molecular Biology
Saebyeol Lee, Jungeun Kim, Paul N. N. Valdmanis, Hak Kyun Kim
Summary: Transfer RNAs (tRNAs) play a crucial role in mRNA translation by delivering amino acids to polypeptide chains. tRNAs can be cleaved by ribonucleases, resulting in tRNA-derived small RNAs (tsRNAs) with various regulatory functions. tsRNAs have been shown to have both oncogenic and tumor suppressor functions, and their abnormal expression and modifications are associated with various diseases. In this review, the biogenesis, gene regulation mechanisms, and potential therapeutic roles of tsRNAs in cancer are discussed.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
Francesco Puzzo, Chuanling Zhang, Feijie Zhang, Mark A. Kay
Meeting Abstract
Biotechnology & Applied Microbiology
Francesco Puzzo, Feijie Zhang, Katja Pekrun, Mark A. Kay
Meeting Abstract
Biotechnology & Applied Microbiology
Calvin J. Stephens, Katja Pekrun, Jianpeng Xu, Shinnosuke Tsuji, Yuqing Jing, Francesco Puzzo, Feijie Zhang, Mark A. Kay
Meeting Abstract
Biotechnology & Applied Microbiology
Adriana Gonzalez-Sandoval, Shinnosuke Tsuji, King L. Hung, Feijie Zhang, Mark A. Kay
Meeting Abstract
Biotechnology & Applied Microbiology
Hagoon Jang, Kirk Chu, Feijie Zhang, Calvin Stephens, Mark A. Kay
Article
Biotechnology & Applied Microbiology
Michela Lisjak, Alessia De Caneva, Thibaut Marais, Elena Barbon, Maria Grazia Biferi, Fabiola Porro, Adi Barzel, Lorena Zentilin, Mark A. Kay, Federico Mingozzi, Andres F. Muro
Summary: In this study, an alternative gene targeting strategy using the CRISPR/SaCas9 platform was investigated for the treatment of hemophilia. The results showed that gene therapy in neonatal and adult mice achieved certain therapeutic efficacy, although further studies are needed to improve targeting efficiency for adult patients.
FRONTIERS IN GENOME EDITING
(2022)
