ZIPping to Pain Relief: The Role (or Not) of PKMζ in Chronicc Pain

BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State

(2013) Ohannes K Melemedjian et al.   Molecular Pain

Prkcz null mice show normal learning and memory

(2013) Anna M. Lee et al.   NATURE

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

(2013) Lenora J. Volk et al.   NATURE

Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Itsin VitroProfile

(2012) Alyssa X. Wu-Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Generation of a Pain Memory in the Primary Afferent Nociceptor Triggered by PKC  Activation of CPEB

(2012) O. Bogen et al.   JOURNAL OF NEUROSCIENCE

LTP requires a reserve pool of glutamate receptors independent of subunit type

(2012) Adam J. Granger et al.   NATURE

Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy

(2012) Bruno Thomas Fievet et al.   NATURE CELL BIOLOGY

Intra-amygdala infusion of the protein kinase Mzeta inhibitor ZIP disrupts foreground context fear memory

(2012) Janine L. Kwapis et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Matching biochemical and functional efficacies confirm ZIP as a potent competitive inhibitor of PKMζ in neurons

(2012) Yudong Yao et al.   NEUROPHARMACOLOGY

Contribution of PKMζ-dependent and independent amplification to components of experimental neuropathic pain

(2012) Tamara King et al.   PAIN

Activation of PKCzeta and PKMzeta in the Nucleus Accumbens Core Is Necessary for the Retrieval, Consolidation and Reconsolidation of Drug Memory

(2012) Jose A. Crespo et al.   PLoS One

Erasure of a Spinal Memory Trace of Pain by a Brief, High-Dose Opioid Administration

(2012) R. Drdla-Schutting et al.   SCIENCE

Postsynaptic signaling during plasticity of dendritic spines

(2012) Hideji Murakoshi et al.   TRENDS IN NEUROSCIENCES

Memory maintenance by PKMζ — an evolutionary perspective

(2012) Todd Sacktor   Molecular Brain

Overexpression of PKMζ Alters Morphology and Function of Dendritic Spines in Cultured Cortical Neurons

(2011) Shiri Ron et al.   CEREBRAL CORTEX

Structural plasticity of dendritic spines

(2011) Miquel Bosch et al.   CURRENT OPINION IN NEUROBIOLOGY

Memory erasure by very high concentrations of ZIP may not be due to PKM-zeta

(2011) John Lisman   HIPPOCAMPUS

Erasing injury-related cortical synaptic potentiation as a new treatment for chronic pain

(2011) Xiang-Yao Li et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Nerve growth factor enhances the excitability of rat sensory neurons through activation of the atypical protein kinase C isoform, PKMζ

(2011) Y. H. Zhang et al.   JOURNAL OF NEUROPHYSIOLOGY

TrkB and Protein Kinase M   Regulate Synaptic Localization of PSD-95 in Developing Cortex

(2011) A. Yoshii et al.   JOURNAL OF NEUROSCIENCE

Spinal Protein Kinase M   Underlies the Maintenance Mechanism of Persistent Nociceptive Sensitization

(2011) M. N. Asiedu et al.   JOURNAL OF NEUROSCIENCE

Role of Extracellular Signal-Regulated Kinase in Synaptic Transmission and Plasticity of a Nociceptive Input on Capsular Central Amygdaloid Neurons in Normal and Acid-Induced Muscle Pain Mice

(2011) S.-J. Cheng et al.   JOURNAL OF NEUROSCIENCE

Inhibition of PKM  in Nucleus Accumbens Core Abolishes Long-Term Drug Reward Memory

(2011) Y.-q. Li et al.   JOURNAL OF NEUROSCIENCE

Intra-amygdala ZIP injections impair the memory of learned active avoidance responses and attenuate conditioned taste-aversion acquisition in rats

(2011) F. Gamiz et al.   LEARNING & MEMORY

PKMξ is Essential for Spinal Plasticity Underlying the Maintenance of Persistent Pain

(2011) Andre Laferrière et al.   Molecular Pain

Long-Term Potentiation in Spinal Nociceptive Pathways as a Novel Target for Pain Therapy

(2011) Ruth Ruscheweyh et al.   Molecular Pain

Specific Involvement of Atypical PKCξ/PKMξ in Spinal Persistent Nociceptive Processing following Peripheral Inflammation in Rat

(2011) Fabien Marchand et al.   Molecular Pain

PKMζ Maintains Drug Reward and Aversion Memory in the Basolateral Amygdala and Extinction Memory in the Infralimbic Cortex

(2011) Ying-Ying He et al.   NEUROPSYCHOPHARMACOLOGY

Structural Modulation of Dendritic Spines during Synaptic Plasticity

(2011) Dale A. Fortin et al.   NEUROSCIENTIST

Metaplasticity governs compartmentalization of synaptic tagging and capture through brain-derived neurotrophic factor (BDNF) and protein kinase M  (PKM )

(2011) S. Sajikumar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enhancement of Consolidated Long-Term Memory by Overexpression of Protein Kinase M  in the Neocortex

(2011) R. Shema et al.   SCIENCE

Dendritic spines, synaptic plasticity and neuronal survival: activity shapes dendritic spines to enhance neuronal viability

(2010) Menahem Segal   EUROPEAN JOURNAL OF NEUROSCIENCE

Mapping the brain pathways of traumatic memory: Inactivation of protein kinase M zeta in different brain regions disrupts traumatic memory processes and attenuates traumatic stress responses in rats

(2010) Hagit Cohen et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Shared Mechanisms for Opioid Tolerance and a Transition to Chronic Pain

(2010) E. K. Joseph et al.   JOURNAL OF NEUROSCIENCE

IL-6- and NGF-Induced Rapid Control of Protein Synthesis and Nociceptive Plasticity via Convergent Signaling to the eIF4F Complex

(2010) O. K. Melemedjian et al.   JOURNAL OF NEUROSCIENCE

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

(2010) Paola Virginia Migues et al.   NATURE NEUROSCIENCE

How does PKMζ maintain long-term memory?

(2010) Todd C. Sacktor   NATURE REVIEWS NEUROSCIENCE

Central sensitization: Implications for the diagnosis and treatment of pain

(2010) Clifford J. Woolf   PAIN

PKMζ Inhibition Reverses Learning-Induced Increases in Hippocampal Synaptic Strength and Memory during Trace Eyeblink Conditioning

(2010) Noelia Madroñal et al.   PLoS One

Erasing Sensorimotor Memories via PKMζ Inhibition

(2010) Lee Michael von Kraus et al.   PLoS One

Alleviating Neuropathic Pain Hypersensitivity by Inhibiting PKM  in the Anterior Cingulate Cortex

(2010) X.-Y. Li et al.   SCIENCE

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Nociceptors: a phylogenetic view

(2009) Ewan St. John Smith et al.   JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Presynaptic and Postsynaptic Cortical Mechanisms of Chronic Pain

(2009) Giannina Descalzi et al.   MOLECULAR NEUROBIOLOGY

Roles of the AMPA Receptor Subunit GluA1 but Not GluA2 in Synaptic Potentiation and Activation of ERK in the Anterior Cingulate Cortex

(2009) Hiroki Toyoda et al.   Molecular Pain

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

PKM  Maintains Late Long-Term Potentiation by N-Ethylmaleimide-Sensitive Factor/GluR2-Dependent Trafficking of Postsynaptic AMPA Receptors

(2008) Y. Yao et al.   JOURNAL OF NEUROSCIENCE

Silent synapses and the emergence of a postsynaptic mechanism for LTP

(2008) Geoffrey A. Kerchner et al.   NATURE REVIEWS NEUROSCIENCE

Neurotrophic factors and structural plasticity in addiction

(2008) Scott J. Russo et al.   NEUROPHARMACOLOGY

Role of interleukin-6 in chronic muscle hyperalgesic priming

(2008) O.A. Dina et al.   NEUROSCIENCE

BDNF: A key regulator for protein synthesis-dependent LTP and long-term memory?

(2007) Yuan Lu et al.   NEUROBIOLOGY OF LEARNING AND MEMORY