Suppressor of cytokine signaling 2 (SOCS2) associates with FLT3 and negatively regulates downstream signaling

Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling

(2013) Julhash U. Kazi et al.   PLoS One

SOCS1 cooperates with FLT3-ITD in the development of myeloproliferative disease by promoting the escape from external cytokine control

(2012) P. N. G. Reddy et al.   BLOOD

Adaptor protein Lnk binds to and inhibits normal and leukemic FLT3

(2012) D.-C. Lin et al.   BLOOD

Suppressor of Cytokine Signaling 6 (SOCS6) Negatively Regulates Flt3 Signal Transduction through Direct Binding to Phosphorylated Tyrosines 591 and 919 of Flt3

(2012) Julhash U. Kazi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia

(2012) Julhash U. Kazi et al.   Molecular Oncology

SOCS2-Induced Proteasome-Dependent TRAF6 Degradation: A Common Anti-Inflammatory Pathway for Control of Innate Immune Responses

(2012) Cortez McBerry et al.   PLoS One

STAT5A-Mediated SOCS2 Expression Regulates Jak2 and STAT3 Activity Following c-Src Inhibition in Head and Neck Squamous Carcinoma

(2011) B. Sen et al.   CLINICAL CANCER RESEARCH

The SOCS2 Ubiquitin Ligase Complex Regulates Growth Hormone Receptor Levels

(2011) Mattias Vesterlund et al.   PLoS One

Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase

(2010) Fahad Zadjali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anchoring of FLT3 in the endoplasmic reticulum alters signaling quality

(2009) D. Schmidt-Arras et al.   BLOOD

A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

(2009) Kristina Masson et al.   BRITISH JOURNAL OF HAEMATOLOGY

Oncogenic signaling from the hematopoietic growth factor receptors c-Kit and Flt3

(2009) Kristina Masson et al.   CELLULAR SIGNALLING

Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation

(2009) Elena Razumovskaya et al.   EXPERIMENTAL HEMATOLOGY

SOCS2: inhibitor of JAK2V617F-mediated signal transduction

(2008) H Quentmeier et al.   LEUKEMIA