Molecular mechanisms for anti-aging by natural dietary compounds

mTOR's role in ageing: protein synthesis or autophagy?

(2016) Sarah L. Hands et al.   Aging-US

p53, ROS and senescence in the control of aging

(2016) Arnaud Vigneron et al.   Aging-US

Telomerase deficiency impairs glucose metabolism and insulin secretion

(2016) Doreen Kuhlow et al.   Aging-US

SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2

(2016) Matthew D. Hirschey et al.   Aging-US

METABOLIC SYNDROME IN THE ELDERLY: AN OVERVIEW OF THE EVIDENCE

(2014) K. Denys et al.   ACTA CLINICA BELGICA

Glycated Lysine Residues: A Marker for Non-Enzymatic Protein Glycation in Age-Related Diseases

(2013) Nadeem A. Ansari et al.   DISEASE MARKERS

The Okinawan Diet: Health Implications of a Low-Calorie, Nutrient-Dense, Antioxidant-Rich Dietary Pattern Low in Glycemic Load

(2013) D. Craig Willcox et al.   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Carnosic acid-rich rosemary (Rosmarinus officinalis L.) leaf extract limits weight gain and improves cholesterol levels and glycaemia in mice on a high-fat diet

(2011) Alvin Ibarra et al.   BRITISH JOURNAL OF NUTRITION

Nobiletin Attenuates VLDL Overproduction, Dyslipidemia, and Atherosclerosis in Mice With Diet-Induced Insulin Resistance

(2011) E. E. Mulvihill et al.   DIABETES

Epigallocatechin-3-O-gallate (EGCG) attenuates FFAs-induced peripheral insulin resistance through AMPK pathway and insulin signaling pathway in vivo

(2011) Yan Li et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Dietary d-limonene alleviates insulin resistance and oxidative stress–induced liver injury in high-fat diet and L-NAME-treated rats

(2011) Jesudoss Victor Antony Santiago et al.   EUROPEAN JOURNAL OF NUTRITION

[6]-Gingerol attenuates β-amyloid-induced oxidative cell death via fortifying cellular antioxidant defense system

(2011) Chan Lee et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective effect of curcumin (Curcuma longa) againstd-galactose-induced senescence in mice

(2011) Anil Kumar et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Genistein inhibits mitochondrial-targeted oxidative damage induced by beta-amyloid peptide 25–35 in PC12 cells

(2011) Yuan-Di Xi et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Genistein reverses free fatty acid-induced insulin resistance in HepG2 hepatocytes through targeting JNK

(2011) Hongwei Lei et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

A Lutein-Enriched Diet Prevents Cholesterol Accumulation and Decreases Oxidized LDL and Inflammatory Cytokines in the Aorta of Guinea Pigs

(2011) Jung Eun Kim et al.   JOURNAL OF NUTRITION

Naringin, the major grapefruit flavonoid, specifically affects atherosclerosis development in diet-induced hypercholesterolemia in mice

(2011) Audrey Chanet et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Cyanidin 3-glucoside attenuates obesity-associated insulin resistance and hepatic steatosis in high-fat diet-fed and db/db mice via the transcription factor FoxO1

(2011) Honghui Guo et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Glutathione Biosynthesis via Activation of the Nuclear Factor E2–Related Factor 2 (Nrf2) – Antioxidant-Response Element (ARE) Pathway Is Essential for Neuroprotective Effects of Sulforaphane and 6-(Methylsulfinyl) Hexyl Isothiocyanate

(2011) Keita Mizuno et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

(2011) Harpreet Kaur et al.   NEUROCHEMICAL RESEARCH

Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol

(2011) Angana G. Rajapakse et al.   PLoS One

Effect of resveratrol on cartilage protection and apoptosis inhibition in experimental osteoarthritis of rabbit

(2011) Jing Wang et al.   RHEUMATOLOGY INTERNATIONAL

Histone H4 Lysine 12 Acetylation Regulates Telomeric Heterochromatin Plasticity in Saccharomyces cerevisiae

(2011) Bo O. Zhou et al.   PLoS Genetics

Kaempferol modulates pro-inflammatory NF-κB activation by suppressing advanced glycation endproducts-induced NADPH oxidase

(2010) Ji Min Kim et al.   AGE

Ageing, neurodegeneration and Parkinson's disease

(2010) J. V. Hindle   AGE AND AGEING

Fat tissue, aging, and cellular senescence

(2010) Tamara Tchkonia et al.   AGING CELL

Role of autophagy in diabetes and mitochondria

(2010) Hye Seung Jung et al.   Annals of the New York Academy of Sciences

Epigallocatechin gallate-induced modulation of FoxO signaling in mammalian cells and C. elegans: FoxO stimulation is masked via PI3K/Akt activation by hydrogen peroxide formed in cell culture

(2010) André Bartholome et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Specific Dietary Polyphenols Attenuate Atherosclerosis in Apolipoprotein E–Knockout Mice by Alleviating Inflammation and Endothelial Dysfunction

(2010) Wai Mun Loke et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

(2010) Katarzyna Zygmunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice

(2010) Young-Sil Lee et al.   BIOCHEMICAL PHARMACOLOGY

Luteolin inhibits inflammatory response and improves insulin sensitivity in the endothelium

(2010) Zhu Deqiu et al.   BIOCHIMIE

Anti-aging Effects of Cyanidin under a Stress-Induced Premature Senescence Cellular System

(2010) Mi Jin Choi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

RETRACTED: SIRT1 Suppresses β-Amyloid Production by Activating the α-Secretase Gene ADAM10

(2010) Gizem Donmez et al.   CELL

FoxO1 Is a Positive Regulator of Bone Formation by Favoring Protein Synthesis and Resistance to Oxidative Stress in Osteoblasts

(2010) Marie-Therese Rached et al.   Cell Metabolism

The role of insulin/IGF-like signaling in C. elegans longevity and aging

(2010) R. Kaletsky et al.   Disease Models & Mechanisms

Genistein Induces Pancreatic β-Cell Proliferation through Activation of Multiple Signaling Pathways and Prevents Insulin-Deficient Diabetes in Mice

(2010) Zhuo Fu et al.   ENDOCRINOLOGY

Protein oxidation and aggregation in UVA-irradiated Escherichia coli cells as signs of accelerated cellular senescence

(2010) Franziska Bosshard et al.   ENVIRONMENTAL MICROBIOLOGY

Modulation of age-related NF-κB activation by dietary zingerone via MAPK pathway

(2010) Mi Kyung Kim et al.   EXPERIMENTAL GERONTOLOGY

Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice

(2010) Ting Wang et al.   HEPATOLOGY RESEARCH

AMP-activated Protein Kinase Signaling Activation by Resveratrol Modulates Amyloid-β Peptide Metabolism

(2010) Valérie Vingtdeux et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

(2010) Olaf Brouwers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 contributes to telomere maintenance and augments global homologous recombination

(2010) Jose A. Palacios et al.   JOURNAL OF CELL BIOLOGY

Sulforaphane protects human chondrocytes against cell death induced by various stimuli

(2010) Annalisa Facchini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Baicalein Significantly Protects Human Retinal Pigment Epithelium Cells Against H2O2-Induced Oxidative Stress by Scavenging Reactive Oxygen Species and Downregulating the Expression of Matrix Metalloproteinase-9 and Vascular Endothelial Growth Factor

(2010) Jorn-Hon Liu et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Quercetin activates AMP-activated protein kinase by reducing PP2C expression protecting old mouse brain against high cholesterol-induced neurotoxicity

(2010) Jun Lu et al.   JOURNAL OF PATHOLOGY

Protective Effects of Resveratrol Against Senescence-Associated Changes in Cultured Human Fibroblasts

(2010) Lisa Giovannelli et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The Aging Stress Response

(2010) Marcia C. Haigis et al.   MOLECULAR CELL

Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

(2010) Katrin Düvel et al.   MOLECULAR CELL

Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress

(2010) Shomit Sengupta et al.   MOLECULAR CELL

Effects of plant-derived polyphenols on TNF-α and nitric oxide production induced by advanced glycation endproducts

(2010) Dave Chandler et al.   MOLECULAR NUTRITION & FOOD RESEARCH

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

(2010) Matthew D. Hirschey et al.   NATURE

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genistein ameliorates learning and memory deficits in amyloid β(1–40) rat model of Alzheimer’s disease

(2010) Maryam Bagheri et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

n-3 long-chain fatty acids and regulation of glucose transport in two models of rat brain endothelial cells

(2010) Fabien Pifferi et al.   NEUROCHEMISTRY INTERNATIONAL

Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system

(2010) Rajat Sandhir et al.   NEUROCHEMISTRY INTERNATIONAL

Silibinin: A novel inhibitor of Aβ aggregation

(2010) Fei Yin et al.   NEUROCHEMISTRY INTERNATIONAL

β-Carotene accumulation in 3T3-L1 adipocytes inhibits the elevation of reactive oxygen species and the suppression of genes related to insulin sensitivity induced by tumor necrosis factor-α

(2010) Hiroyuki Kameji et al.   NUTRITION

Curcumin improves insulin resistance in skeletal muscle of rats

(2010) L.-X. Na et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Inhibiting NF-κB activation and ROS production are involved in the mechanism of silibinin's protection against D-galactose-induced senescence

(2010) Qiong Wang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Epigallocatechin gallate inhibits beta amyloid oligomerization in Caenorhabditis elegans and affects the daf-2/insulin-like signaling pathway

(2010) S. Abbas et al.   PHYTOMEDICINE

Reduction of lipid accumulation in HepG2 Cells by luteolin is associated with activation of AMPK and Mitigation of oxidative stress

(2010) Jin-Feng Liu et al.   PHYTOTHERAPY RESEARCH

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Transcriptional Regulation of Human and Rat Hepatic Lipid Metabolism by the Grapefruit Flavonoid Naringenin: Role of PPARα, PPARγ and LXRα

(2010) Jonathan Goldwasser et al.   PLoS One

Curcumin Extends Life Span, Improves Health Span, and Modulates the Expression of Age-Associated Aging Genes in Drosophila melanogaster

(2010) Kyu-Sun Lee et al.   REJUVENATION RESEARCH

Extending Healthy Life Span--From Yeast to Humans

(2010) L. Fontana et al.   SCIENCE

Pterostilbene, a natural dimethylated analog of resveratrol, inhibits rat aortic vascular smooth muscle cell proliferation by blocking Akt-dependent pathway

(2010) Eun-Seok Park et al.   VASCULAR PHARMACOLOGY

Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

(2010) E Morselli et al.   Cell Death & Disease

Quercetin increases brain and muscle mitochondrial biogenesis and exercise tolerance

(2009) J. Mark Davis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

AMP-activated Protein Kinase and FoxO Transcription Factors in Dietary Restriction-induced Longevity

(2009) Eric L. Greer et al.   Annals of the New York Academy of Sciences

Association of telomere length with type 2 diabetes, oxidative stress and UCP2 gene variation

(2009) Klelia D. Salpea et al.   ATHEROSCLEROSIS

Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway

(2009) Takatoshi Murase et al.   BIOCHEMICAL PHARMACOLOGY

N-3 polyunsaturated fatty acids suppress insulin-induced SREBP-1c transcription via reduced trans-activating capacity of LXRα

(2009) George Howell et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Protective Effects of Lycopene against H2O2-Induced Oxidative Injury and Apoptosis in Human Endothelial Cells

(2009) XiangYu Tang et al.   CARDIOVASCULAR DRUGS AND THERAPY

SIRT6 Links Histone H3 Lysine 9 Deacetylation to NF-κB-Dependent Gene Expression and Organismal Life Span

(2009) Tiara L.A. Kawahara et al.   CELL

Autophagy in Atherosclerosis

(2009) Wim Martinet et al.   CIRCULATION RESEARCH

NAD+, Sirtuins, and Cardiovascular Disease

(2009) Nica Borradaile et al.   CURRENT PHARMACEUTICAL DESIGN

Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver

(2009) H Quesada et al.   INTERNATIONAL JOURNAL OF OBESITY

Epigallocatechin Gallate (EGCG) and Rutin Suppress the Glucotoxicity through Activating IRS2 and AMPK Signaling in Rat Pancreatic β Cells

(2009) Erica P. Cai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neuroprotective Effect of Baicalein on Hydrogen Peroxide-Mediated Oxidative Stress and Mitochondrial Dysfunction in PC12 Cells

(2009) Shehua Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

All-trans Retinoic Acid Lowers Serum Retinol-Binding Protein 4 Concentrations and Increases Insulin Sensitivity in Diabetic Mice

(2009) Daniel-Constantin Manolescu et al.   JOURNAL OF NUTRITION

Curcumin Inhibits Adipogenesis in 3T3-L1 Adipocytes and Angiogenesis and Obesity in C57/BL Mice

(2009) Asma Ejaz et al.   JOURNAL OF NUTRITION

Dietary flavonoid apigenin inhibits high glucose and tumor necrosis factor α-induced adhesion molecule expression in human endothelial cells

(2009) Kazuo Yamagata et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Daidzein and the daidzein metabolite, equol, enhance adipocyte differentiation and PPARγ transcriptional activity

(2009) Kae Won Cho et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Resveratrol Protects Mitochondria against Oxidative Stress through AMP-Activated Protein Kinase-Mediated Glycogen Synthase Kinase-3  Inhibition Downstream of Poly(ADP-ribose)polymerase-LKB1 Pathway

(2009) S. M. Shin et al.   MOLECULAR PHARMACOLOGY

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Omacor(R), n-3 polyunsaturated fatty acid, attenuated albuminuria and renal dysfunction with decrease of SREBP-1 expression and triglyceride amount in the kidney of type II diabetic animals

(2009) H. J. Chin et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity–related proteins in the hippocampus

(2009) Q. Li et al.   NEUROSCIENCE

Lutein and docosahexaenoic acid prevent cortex lipid peroxidation in streptozotocin-induced diabetic rat cerebral cortex

(2009) E. Arnal et al.   NEUROSCIENCE

Collagen cross-links as a determinant of bone quality: a possible explanation for bone fragility in aging, osteoporosis, and diabetes mellitus

(2009) M. Saito et al.   OSTEOPOROSIS INTERNATIONAL

Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone condition

(2009) Z.F. Zhang et al.   PHYTOMEDICINE

Kaempferol protects HIT-T15 pancreatic beta cells from 2-deoxy-D-ribose-induced oxidative damage

(2009) Yun Jung Lee et al.   PHYTOTHERAPY RESEARCH

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells

(2008) Hao-yu YUAN et al.   ACTA PHARMACOLOGICA SINICA

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL

Dietary Eicosapentaenoic Acid and Docosahexaenoic Acid Are More Effective than Alpha-Linolenic Acid in Improving Insulin Sensitivity in Rats

(2008) Gaby Andersen et al.   ANNALS OF NUTRITION AND METABOLISM

Neuroprotective effects of chronic hesperetin administration in mice

(2008) Eun Jeong Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Resveratrol inhibits the mTOR mitogenic signaling evoked by oxidized LDL in smooth muscle cells

(2008) Paula M. Brito et al.   ATHEROSCLEROSIS

SIRT1 longevity factor suppresses NF-κB -driven immune responses: regulation of aging via NF-κB acetylation?

(2008) Antero Salminen et al.   BIOESSAYS

Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H2O2-Induced Cellular Senescence

(2008) Young A Lee et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Resveratrol reduces endothelial progenitor cells senescence through augmentation of telomerase activity by Akt-dependent mechanisms

(2008) L Xia et al.   BRITISH JOURNAL OF PHARMACOLOGY

Potent Induction of Total Cellular and Mitochondrial Antioxidants and Phase 2 Enzymes by Cruciferous Sulforaphane in Rat Aortic Smooth Muscle Cells: Cytoprotection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   Cardiovascular Toxicology

Effect of a Proanthocyanidin-Rich Extract from Longan Flower on Markers of Metabolic Syndrome in Fructose-Fed Rats

(2008) Hui-Yun Tsai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Retinoic Acid Leads to Cytoskeletal Rearrangement through AMPK-Rac1 and Stimulates Glucose Uptake through AMPK-p38 MAPK in Skeletal Muscle Cells

(2008) Yun Mi Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signaling networks in aging

(2008) Eric L. Greer et al.   JOURNAL OF CELL SCIENCE

Age-related differences in insulin-like growth factor-1 receptor signaling regulates Akt/FOXO3a and ERK/Fos pathways in vascular smooth muscle cells

(2008) Muyao Li et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Isoflavones Promote Mitochondrial Biogenesis

(2008) K. A. Rasbach et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Grape seed polyphenols and curcumin reduce genomic instability events in a transgenic mouse model for Alzheimer's disease

(2008) Philip Thomas et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a high-fat diet in rabbits

(2008) Min-Yu Hu et al.   NUTRITION

Telomeres and Aging

(2008) Geraldine Aubert et al.   PHYSIOLOGICAL REVIEWS

All-trans retinoic acid induces nerve regeneration and increases serum and nerve contents of neural growth factor in experimental diabetic neuropathy

(2008) Norma Hernández-Pedro et al.   Translational Research

Defects in telomere maintenance molecules impair osteoblast differentiation and promote osteoporosis

(2007) Robert J. Pignolo et al.   AGING CELL

Insulin-Like Signaling, Nutrient Homeostasis, and Life Span

(2007) Akiko Taguchi et al.   Annual Review of Physiology

Cyanidin 3-glucoside protects 3T3-L1 adipocytes against H2O2- or TNF-α-induced insulin resistance by inhibiting c-Jun NH2-terminal kinase activation

(2007) Honghui Guo et al.   BIOCHEMICAL PHARMACOLOGY

Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin

(2007) Andreas Kampkötter et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY