Article
Oncology
Yui Yamazaki, Hidenori Wake, Takashi Nishinaka, Omer Faruk Hatipoglu, Keyue Liu, Masahiro Watanabe, Takao Toyomura, Shuji Mori, Tadashi Yoshino, Masahiro Nishibori, Hideo Takahashi
Summary: The study suggests that scavenger receptors CD36, CD163, and LOX-1, along with the RAGE receptor, work together to mediate toxic AGE-induced facilitation of angiogenesis.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Sasikarn Looprasertkul, Amornpun Sereemaspun, Nakarin Kitkumthorn, Kanidta Sooklert, Tewarit Sarachana, Depicha Jindatip
Summary: The study revealed the effects of AuNPs on pericytes, showing inhibition of proliferation, decreased migration, and reduced PDGFR-β mRNA expression. Ultrastructural analysis showed the presence of AuNPs in late endosomes, autolysosomes, and damaged mitochondria in pericytes. In 3D capillary tube formation, AuNPs led to abnormal positioning of pericytes, resulting in incomplete tube formation.
Article
Agriculture, Multidisciplinary
Hee-Seop Lee, Hee-Jung Song, Yeonhwa Park, Dmitriy Smolensky, Seong-Ho Lee
Summary: Permethrin was found to have adverse effects on human endothelial cells, including inhibition of cell migration, tube formation, and viability, as well as increased production of reactive oxygen species. The repression of cell viability by permethrin is ROS-dependent and does not affect cell apoptosis, necrosis, or mitochondrial membrane potential.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Oncology
Baikun Li, Xingyu Dong, Jimin Zhu, Ting Zhu, Xiaoxiao Tao, Daiyin Peng, Qinglin Li
Summary: This study revealed that the crosstalk between lung cancer cells and platelets can influence the proliferation, migration, and tube formation of HUVECs, potentially playing a crucial role in tumor angiogenesis by affecting or mediating changes in the properties of vascular endothelial cells (VECs).
Article
Food Science & Technology
Ho-Jeong Bang, Mok-Ryeon Ahn
Summary: This study found that pinobanksin exhibits antiangiogenic effect by inducing endothelial cell apoptosis, and it can be developed as an antiangiogenic agent. The mechanism involves inactivation of the Raf/MEK/ERK pathway and activation of apoptotic signaling such as caspase cascades.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Oncology
Joman Javadi, Ghazal Heidari-Hamedani, Angelika Schmalzl, Tunde Szatmari, Muzaffer Metintas, Pontus Aspenstrom, Anders Hjerpe, Katalin Dobra
Summary: SDC-1 is a transmembrane proteoglycan that regulates the binding of growth factors and cytokines, impacting angiogenesis. Overexpression of SDC-1 inhibits proliferation, wound healing, and tube formation in endothelial cells in malignant mesothelioma. Silencing SDC-1 affects wound healing but not tube formation.
Article
Food Science & Technology
Ho-Jeong Bang, Eunju Yoon, Sun Wook Kim, Mok-Ryeon Ahn
Summary: Benzyl caffeate significantly inhibits angiogenesis by inducing apoptosis and anti-proliferative effects on endothelial cells, showing potential antiangiogenic effects.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biochemistry & Molecular Biology
Ersilia Nigro, Marta Mallardo, Rita Polito, Filippo Scialo, Andrea Bianco, Aurora Daniele
Summary: AdipoRon has significant effects on proliferation, migration, and tube formation of human endothelial cells, while leptin has minimal impact on these factors. Co-treatment with AdipoRon and leptin results in antagonistic effects, reducing tube structures and cell migration. AdipoRon administration leads to increased expression of specific genes associated with angiogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Taku Wakabayashi, Hisamichi Naito
Summary: Vascular endothelial cells (ECs) are crucial for new vessel formation and organ homeostasis. Advances in single cell RNA sequencing (scRNA-seq) have revealed the heterogeneity of ECs in mice and humans, identifying molecular signatures and specialized subtypes. scRNA-seq has also documented the gene expression profiles of tissue-resident ECs involved in angiogenesis, as well as the responses of ECs in various diseases. These findings have significant implications for potential therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Anatomy & Morphology
Zhenkun Li, Yanmeng Li, Qin Ouyang, Xiaojin Li, Jian Huang
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer incidence and mortality worldwide. This study found that overexpression of DNA damage repair gene GTF2H2 in HCC tissues reduced the expression of angiogenesis-related genes, inhibiting angiogenesis. Further experiments revealed that GTF2H2-enriched exosomes can inhibit HCC angiogenesis, suggesting their potential as a novel drug for treating liver cancer.
Article
Dentistry, Oral Surgery & Medicine
Hiroko Takeuchi-Igarashi, Toshiaki Tachibana, Etsuko Murakashi, Satoshi Kubota, Yukihiro Numabe
Summary: CCN2/CTGF was found to promote the proliferation and tubulogenesis of endothelial cells from the periodontal ligament, suggesting a potential role in the regeneration of damaged periodontal tissue by activating endothelial cells.
ARCHIVES OF ORAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Emira D'Amico, Tania Vanessa Pierfelice, Rosa Amoroso, Ivana Cacciatore, Camillo D'Arcangelo, Stefania Lepore, Simonetta D'Ercole, Natalia Di Pietro, Annalisa Di Rienzo, Morena Petrini, Adriano Piattelli, Alessia Ricci, Susi Zara, Antonio Di Stefano, Giovanna Iezzi, Barbara De Filippis
Summary: Recently, research has focused on finding new approaches to manage oral wound healing. The use of resveratrol (RSV) as a drug is limited due to its poor bioavailability. This study aimed to investigate a series of RSV derivatives (1a-j) with better pharmacokinetic profiles. Among them, derivatives 1d and 1h showed increased cell viability compared to RSV. Further studies demonstrated that both 1d and 1h exhibited positive effects on cell viability, proliferation, and gene expression in various cells involved in oral wound healing. Additionally, 1d and 1h showed promising physicochemical properties and stability, indicating their potential as RSV-based agents for oral tissue repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Hee-Seop Lee, Darshika Amarakoon, Cheng- Wei, Kyu Yong Choi, Dmitriy Smolensky, Seong-Ho Lee
Summary: The study found that polystyrene microplastics have a significant cytotoxic effect on human umbilical vein endothelial cells, impacting tube formation and angiogenic signaling pathways, ultimately leading to cell death.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Nathalie Tisch, Carmen Ruiz de Almodovar
Summary: The formation of new blood vessels involves proliferation of endothelial cells and vessel sprout elongation, along with vessel remodeling and regression to adapt vessel density. Recent studies focus on how vessel regression and cell death contribute to this process, challenging the simplistic view of cell death machinery as only promoting cellular demise. This review highlights the role of cell death signaling pathways, particularly apoptosis and necroptosis, in blood vessel formation during development and pathology.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael G. McCoy, Daniel Perez-Cremades, Nathan Belkin, Wenhui Peng, Bofang Zhang, Jingshu Chen, Madhur Sachan, A. K. M. Khyrul Wara, Rulin Zhuang, Henry S. Cheng, Mark W. Feinberg
Summary: This study demonstrates that a 4-miRNA cassette can reprogram vascular smooth muscle cells into endothelial cells, and these induced cells exhibit high similarity to native endothelial cells. Injected induced cells even restore blood flow faster than conventional endothelial cells in a mouse model, suggesting the potential of this approach for vascular disease therapy.
