4.7 Article

Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice

Journal

MOLECULAR NUTRITION & FOOD RESEARCH
Volume 55, Issue 7, Pages 1118-1121

Publisher

WILEY
DOI: 10.1002/mnfr.201100095

Keywords

beta-Glucan; Energy intake; Neuropeptide Y; Obesity; Satiety

Funding

  1. ARC, Australia

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This study tested the effects of (1 -> 3),(1 -> 4) beta-D-glucan from oats, on activation of the guthypothalamic (PYY3-36-NPY) axis, satiety, and weight loss in diet-induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of beta-glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y-Y3-36 (PYY3-36) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (-13%, p<0.05) and body weight gain was lower with increasing beta-glucan over 6 wk with acute suppression of energy intake over 4 h. The highest beta-glucan diet significantly increased plasma PYY3-36, with suppression of Arc NPY mRNA.

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