G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca2+ Accumulation

Clinical Phenotype of G206D Mutation in the Presenilin 1 Gene in Pathologically Confirmed Familial Alzheimer's Disease

(2018) Ya-Ying Wu et al.   JOURNAL OF ALZHEIMERS DISEASE

Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

(2015) MaryKate McBrayer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

Presenilin-1 Regulates the Expression of p62 to Govern p62-dependent Tau Degradation

(2013) Ying-Tsen Tung et al.   MOLECULAR NEUROBIOLOGY

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons

(2013) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilins and Calcium Signaling--Systems Biology to the Rescue

(2013) I. Bezprozvanny   Science Signaling

Regulators of Calcium Homeostasis Identified by Inference of Kinetic Model Parameters from Live Single Cells Perturbed by siRNA

(2013) S. Bandara et al.   Science Signaling

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function

(2012) Kara M Neely Kayala et al.   BRAIN RESEARCH

The mechanism of γ-Secretase dysfunction in familial Alzheimer disease

(2012) Lucía Chávez-Gutiérrez et al.   EMBO JOURNAL

Familial Alzheimer Disease Presenilin-1 Mutations Alter the Active Site Conformation of γ-secretase

(2012) De-Ming Chau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lack of Evidence for Presenilins as Endoplasmic Reticulum Ca2+Leak Channels

(2012) Dustin Shilling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilins: A novel link between intracellular calcium signaling and lysosomal function?: Figure 1.

(2012) Ilya Bezprozvanny   JOURNAL OF CELL BIOLOGY

Lysosomal calcium homeostasis defects, not proton pump defects, cause endo-lysosomal dysfunction in PSEN-deficient cells

(2012) Katrijn Coen et al.   JOURNAL OF CELL BIOLOGY

Polar Transmembrane-based Amino Acids in Presenilin 1 Are Involved in Endoplasmic Reticulum Localization, Pen2 Protein Binding, and γ-Secretase Complex Stabilization

(2011) Matthias Fassler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Temporal control of nuclear envelope assembly by phosphorylation of lamin B receptor

(2011) Li-Chuan Tseng et al.   MOLECULAR BIOLOGY OF THE CELL

Clarifying lysosomal storage diseases

(2011) Mark L. Schultz et al.   TRENDS IN NEUROSCIENCES

Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

The Evolutionarily Conserved Interaction Between LC3 and p62 Selectively Mediates Autophagy-Dependent Degradation of Mutant Huntingtin

(2010) Ying-Tsen Tung et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synaptic and Endosomal Localization of Active γ-Secretase in Rat Brain

(2010) Susanne Frykman et al.   PLoS One

A Presenilin-1 Mutation Renders Neurons Vulnerable to Isoflurane Toxicity

(2009) Ge Liang et al.   ANESTHESIA AND ANALGESIA

Lysosome biogenesis and lysosomal membrane proteins: trafficking meets function

(2009) Paul Saftig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Masking of Transmembrane-Based Retention Signals Controls ER Export of γ-Secretase

(2009) Matthias Fassler et al.   TRAFFIC

Sequence analyses of presenilin mutations linked to familial Alzheimer’s disease

(2008) Sun Don Kim et al.   CELL STRESS & CHAPERONES

SERCA pump activity is physiologically regulated by presenilin and regulates amyloid β production

(2008) Kim N. Green et al.   JOURNAL OF CELL BIOLOGY

Identification of PSEN1 and APP Gene Mutations in Korean Patients with Early-Onset Alzheimer's Disease

(2008) Hyun-Kyung Park et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Tumor Necrosis Factor-α–elicited Stimulation of γ-Secretase Is Mediated by c-Jun N-terminal Kinase-dependent Phosphorylation of Presenilin and Nicastrin

(2008) Lan-Hsin Kuo et al.   MOLECULAR BIOLOGY OF THE CELL

Mutant Presenilin 1 Increases the Levels of Alzheimer Amyloid β-Peptide Aβ42 in Late Compartments of the Constitutive Secretory Pathway

(2003) Suzana S. Petanceska et al.   JOURNAL OF NEUROCHEMISTRY