Review
Cell Biology
Minxi Fang, Tao Tang, Mengsheng Qiu, Xiaofeng Xu
Summary: Remyelination is a crucial repair process in the central nervous system, but it often fails in demyelinating diseases. The Hedgehog signaling pathway is a key regulatory target for myelin regeneration, although its exact mechanisms are still not fully understood.
Article
Cell Biology
Haritha L. Desu, Placido Illiano, James S. Choi, Maureen C. Ascona, Han Gao, Jae K. Lee, Roberta Brambilla
Summary: The study reveals that neuroinflammation in multiple sclerosis leads to a shift in oligodendrocyte precursor cells (OPCs) towards an immunomodulatory phenotype, reducing their remyelination capacity and impairing their repair function. Furthermore, enhancing TNFR2 activation could be an effective strategy to restore OPC reparative capacity.
Review
Biology
Nadjet Gacem, Brahim Nait-Oumesmar
Summary: Myelination by oligodendrocytes is crucial for central nervous system development and function, with multiple sclerosis being a common neurodegenerative disease characterized by inflammation and demyelination. Current treatments for MS target the immune component of the disease, but there is ongoing research on pharmacological compounds that could enhance remyelination.
Article
Medicine, Research & Experimental
Laura Ghezzi, Bryan Bollman, Luca De Feo, Laura Piccio, Bruce D. Trapp, Robert E. Schmidt, Anne H. Cross
Summary: Multiple sclerosis (MS) is a CNS demyelinating disease that often leads to unsuccessful remyelination and neuronal/axonal damage. While oligodendroglial cells are responsible for myelin production, remyelination by Schwann cells (SchC) has been observed in spinal cord demyelination. This study investigated the extent of SchC remyelination in the brain and spinal cords of autopsied MS specimens.
LABORATORY INVESTIGATION
(2023)
Article
Pharmacology & Pharmacy
Yaqin Sun, Jing Ji, Zheng Zha, Hui Zhao, Bing Xue, Liangyun Jin, Lei Wang
Summary: Catalpol has the potential to promote remyelination by enhancing OPC differentiation through modulation of the NOTCH1 pathway, providing new insight into the treatment of multiple sclerosis.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xinda Zhao, Claire Jacob
Summary: All licensed medications for multiple sclerosis (MS) target the immune system, but most drug candidates in human clinical trials have modest or no effects on disease amelioration and remyelination enhancement. Remyelination is a complex process involving multiple cell types, and the interplay between them may differ in humans and rodent models. Successful remyelination requires the regulation of each cell type in a highly organized spatio-temporal manner, making it challenging for drug candidates targeting a single pathway or cell population. Therefore, considering the effects on all CNS cell populations and the optimal time of administration is crucial when exploring new drug candidates for MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Martine El-Etr, Yvette Akwa, Marion Rame, Michael Schumacher, Regine Sitruk-Ware
Summary: The study demonstrated that NES promotes oligodendrocyte progenitor cell proliferation and differentiation into mature OL by regulating the expression of transcription factors Olig2, Myt1, and Sox17, ultimately contributing to remyelination in a demyelination mouse model.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Review
Genetics & Heredity
Midhuna Devanand, V. N. Saiprabha, Krishnadas Madhu
Summary: Multiple sclerosis is an autoimmune neurodegenerative disease that leads to progressive disabilities due to CNS axon degeneration caused by demyelination. Therapies targeting diverse signaling pathways involved in neuroprotection and remyelination have the potential to overcome the challenges in developing treatments for multiple sclerosis.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Neurosciences
Qi Shao, Ming Zhao, Wenwen Pei, Yingyan Pu, Mingdong Liu, Weili Liu, Zhongwang Yu, Kefu Chen, Hong Liu, Benqiang Deng, Li Cao
Summary: The study found that pinocembrin can promote OPC differentiation and remyelination, and has a therapeutic effect on demyelinating diseases by increasing the phosphorylation level of mTOR.
NEUROSCIENCE BULLETIN
(2021)
Review
Biochemistry & Molecular Biology
Ilias Kalafatakis, Domna Karagogeos
Summary: This review summarizes the regulation of myelination by oligodendrocytes under physiological and pathological conditions, as well as the role of microglia in myelin generation, regeneration, and repair. The beneficial and detrimental roles of microglia in remyelination are discussed, along with the cellular and molecular components involved. Recent findings related to preclinical models using human stem cells for studying microglia in human pathologies and the impact of the microbiome on glial cell functions are also presented.
Article
Biochemical Research Methods
Fatmagul Ilayda Aydinli, Sezgin Er, Bilal Ersen Kerman
Summary: In this study, we established an in vitro co-culture method to investigate the role of macrophages in the survival and maturation of oligodendrocytes. Our results showed that M1 macrophages decreased the number of mature oligodendrocytes and phagocytosed myelin, while non-activated and M2 macrophages contributed to an increase in the number of mature oligodendrocytes in the co-culture platform.
JOURNAL OF NEUROSCIENCE METHODS
(2022)
Article
Neurosciences
Yuanyuan Wang, Roxanne V. Kyauk, Yun-An A. Shen, Luke Xie, Mike Reichelt, Han Lin, Zhiyu Jiang, Hai Ngu, Kimberle Shen, Jacob J. Greene, Morgan Sheng, Tracy J. Yuen
Summary: Disability in multiple sclerosis (MS) is partially caused by the failure of remyelination and progressive neurodegeneration. The role of microglia, especially triggering receptor expressed on myeloid cells 2 (TREM2), in remyelination is significant. In this study, using a mouse model of focal demyelination, we found that TREM2 knockout mice had persistent demyelination and subsequent neurodegeneration lasting more than 6 weeks. Furthermore, TREM2 knockout microglia showed defects in migration and phagocytosis of myelin debris.
Article
Neurosciences
Cui Liu, Song Han, Jiayin Zheng, Hongyu Wang, Shujuan Li, Junfa Li
Summary: Ischemic stroke leads to white matter injury and neurobehavioral dysfunction, and there is a lack of effective therapies to inhibit demyelination or promote remyelination. EphA4 promotes the proliferation of oligodendrocyte precursor cells but reduces the numbers of mature oligodendrocytes and the levels of myelin-associated proteins. EphA4 regulates white matter remyelination after ischemic stroke through the Ephexin-1/RhoA/ROCK signaling pathway. EphA4 may provide a novel therapeutic target in the clinical practice of ischemic stroke.
Review
Clinical Neurology
Jessica R. Allanach, John W. Farrell, Miceline Mesidor, Soheila Karimi-Abdolrezaee
Summary: This study systematically reviewed recent advances in neuroprotective and regenerative therapies for MS, finding that small molecules and antibody therapies are the most common strategies for promoting remyelination. However, further research is needed to address current barriers in implementing experimental treatments in clinical settings.
MULTIPLE SCLEROSIS JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Pauline E. M. van Schaik, Inge S. Zuhorn, Wia Baron
Summary: Multiple sclerosis is a neuroinflammatory and neurodegenerative disease with unknown etiology that can be characterized by demyelinated lesions. Remyelination is essential for axonal survival and functional recovery, but fibronectin inhibits this process. The blood-brain barrier poses a challenge for delivering therapeutic interventions to the lesions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Xiaoqing Wang, Xiaowen Yu, Chong Xie, Zijian Tan, Qi Tian, Desheng Zhu, Mingyuan Liu, Yangtai Guan
MOLECULAR NEUROBIOLOGY
(2016)
Article
Neurosciences
Ming Zhao, Dingya Sun, Yangtai Guan, Zhihong Wang, Daoqian Sang, Mingdong Liu, Yingyan Pu, Xue Fang, Dan Wang, Aijun Huang, Xiaoying Bi, Li Cao, Cheng He
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Shuai Wu, Yan Han, Qiang Hu, Xiaojie Zhang, Guangcheng Cui, Zezhi Li, Yangtai Guan
MOLECULAR NEUROBIOLOGY
(2017)
Article
Clinical Neurology
Chong Xie, Xiajun Zhou, Desheng Zhu, Wei Liu, Xiaoqing Wang, Hong Yang, Zezhi Li, Yong Hao, Guang-Xian Zhang, Yangtai Guan
NEUROLOGICAL SCIENCES
(2016)
Article
Immunology
De-Sheng Zhu, Lu Yu, Mei Li, Lu Han, Xin-Xin Huang, Xiao-Qing Wang, Xiao-Li Yang, Ying Zhu, Xia-Jun Zhou, Yang-Tai Guan
JOURNAL OF NEUROIMMUNOLOGY
(2017)
Article
Medicine, General & Internal
De-Sheng Zhu, Xiao-Li Yang, Hui-Hui Lv, Chen-Guang Bai, Pang-Pan Yang, Ze-Zhi Li, Yong Hao, Ying Zhang, Yang-Tai Guan
Article
Endocrinology & Metabolism
Zezhi Li, Zuowei Wang, Chen Zhang, Jun Chen, Yousong Su, Jia Huang, Zhenghui Yi, Chengmei Yuan, Wu Hong, Yong Wang, Zhiguo Wu, Yingyan Hu, Lan Cao, Daihui Peng, Yangtai Guan, Yimin Zou, Shunying Yu, Donghong Cui, Yiru Fang
PSYCHONEUROENDOCRINOLOGY
(2017)
Article
Behavioral Sciences
Hongying Chen, Yong Fan, Lei Zhao, Yong Hao, Xiajun Zhou, Yangtai Guan, Zezhi Li
BRAIN AND BEHAVIOR
(2017)
Article
Immunology
Chong Xie, Xing Li, Xiajun Zhou, Zezhi Li, Yuan Zhang, Li Zhao, Yong Hao, Guang-Xian Zhang, Yangtai Guan
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Clinical Neurology
Yi Dong, Kun Fang, Xin Wang, Shengdi Chen, Xueyuan Liu, Yuwu Zhao, Yangtai Guan, Dingfang Cai, Gang Li, Jianmin Liu, Jianren Liu, Jianhua Zhuang, Panshi Wang, Xin Chen, Haipeng Shen, David Z. Wang, Ying Xian, Wuwei Feng, Bruce C. V. Campbell, Mark Parsons, Qiang Dong
INTERNATIONAL JOURNAL OF STROKE
(2018)
Article
Clinical Neurology
Meichun Gao, Xiaoying Yao, Jie Ding, Ronghua Hong, Yifan Wu, Hua Huang, Lei Zhuang, Zezhi Li, Yonggang Wang, Ying Zhang, Yangtai Guan
JOURNAL OF CLINICAL NEUROSCIENCE
(2019)
Letter
Clinical Neurology
Zezhi Li, Yong Hao, Yan Han, Shuai Wu, Desheng Zhu, Mingyuan Liu, Qiang Dong, Xin Wang, Yangtai Guan
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2019)
Article
Clinical Neurology
Wenbin Wan, Lan Cao, Bill Kalionis, Padma Murthi, Shijin Xia, Yangtai Guan
FRONTIERS IN NEUROLOGY
(2019)
Article
Cell Biology
Yong Hao, Jie Ding, Ronghua Hong, Shuwei Bai, Ze Wang, Chengjun Mo, Qiang Hu, Zezhi Li, Yangtai Guan
Article
Neurosciences
Ying Zhang, Xiao-Ying Yao, Mei-Chun Gao, Jie Ding, Rong-Hua Hong, Hua Huang, Lei Zhuang, Yong-Gang Wang, Yong Hao, Yang-Tai Guan
CNS NEUROSCIENCE & THERAPEUTICS
(2018)