β-Arrestins as Potential Therapeutic Targets for Alzheimer’s Disease

β2Adrenergic Receptor, Protein Kinase A (PKA) and c-Jun N-terminal Kinase (JNK) Signaling Pathways Mediate Tau Pathology in Alzheimer Disease Models

(2013) Dayong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer's γ-secretase under arrestin

(2013) Michael S Wolfe   NATURE MEDICINE

Arrestin' Alzheimer disease progression? β-arrestin 2 is a potential therapeutic target

(2013) Heather Wood   Nature Reviews Neurology

β-Arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology

(2012) Xiaosong Liu et al.   CELL RESEARCH

Differential Effects between  -Secretase Inhibitors and Modulators on Cognitive Function in Amyloid Precursor Protein-Transgenic and Nontransgenic Mice

(2012) Y. Mitani et al.   JOURNAL OF NEUROSCIENCE

β-arrestin 2 regulates Aβ generation and γ-secretase activity in Alzheimer's disease

(2012) Amantha Thathiah et al.   NATURE MEDICINE

Cofilin under control of  -arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning

(2012) C. G. Pontrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular Mechanism of β-Arrestin-Biased Agonism at Seven-Transmembrane Receptors

(2011) Eric Reiter et al.   Annual Review of Pharmacology and Toxicology

Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing

(2011) Annelie Pamrén et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Arrestin-1 Protein Represses Adipogenesis and Inflammatory Responses through Its Interaction with Peroxisome Proliferator-activated Receptor-γ (PPARγ)

(2011) Le-nan Zhuang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid β Peptide-(1–42) Induces Internalization and Degradation of β2Adrenergic Receptors in Prefrontal Cortical Neurons

(2011) Dayong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deficient brain insulin signalling pathway in Alzheimer's disease and diabetes

(2011) Ying Liu et al.   JOURNAL OF PATHOLOGY

Resolving controversies on the path to Alzheimer's therapeutics

(2011) Dennis J Selkoe   NATURE MEDICINE

The role of G protein-coupled receptors in the pathology of Alzheimer's disease

(2011) Amantha Thathiah et al.   NATURE REVIEWS NEUROSCIENCE

Emerging paradigms of β-arrestin-dependent seven transmembrane receptor signaling

(2011) Arun K. Shukla et al.   TRENDS IN BIOCHEMICAL SCIENCES

β-arrestin-mediated receptor trafficking and signal transduction

(2011) Sudha K. Shenoy et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Concerted changes in transcripts in the prefrontal cortex precede neuropathology in Alzheimer's disease

(2010) Koen Bossers et al.   BRAIN

Blocking β2-adrenergic receptor attenuates acute stress-induced amyloid β peptides production

(2010) Nan-Nan Yu et al.   BRAIN RESEARCH

Roles of β-adrenergic receptors in Alzheimer's disease: Implications for novel therapeutics

(2010) Jin-Tai Yu et al.   BRAIN RESEARCH BULLETIN

A GPCR/secretase complex regulates β- and γ-secretase specificity for Aβ production and contributes to AD pathogenesis

(2010) Lin Teng et al.   CELL RESEARCH

Therapeutic potential of β-arrestin- and G protein-biased agonists

(2010) Erin J. Whalen et al.   TRENDS IN MOLECULAR MEDICINE

Both Hematopoietic-Derived and Non–Hematopoietic-Derived β-Arrestin–2 Regulates Murine Allergic Airway Disease

(2009) John W. Hollingsworth et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

An Engineered GM-CSF-CCL2 Fusokine Is a Potent Inhibitor of CCR2-Driven Inflammation As Demonstrated in a Murine Model of Inflammatory Arthritis

(2009) M. Rafei et al.   JOURNAL OF IMMUNOLOGY

 -Secretase Inhibition Reduces Spine Density In Vivo via an Amyloid Precursor Protein-Dependent Pathway

(2009) T. Bittner et al.   JOURNAL OF NEUROSCIENCE

Orphan receptor coupled to Aβ production

(2009) Monica Hoyos Flight   NATURE REVIEWS DRUG DISCOVERY

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

Regulation of amygdalar PKA by  -arrestin-2/phosphodiesterase-4 complex is critical for fear conditioning

(2009) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polymorphisms at the β2-adrenergic receptor gene influence Alzheimer's disease susceptibility

(2008) Jin-Tai Yu et al.   BRAIN RESEARCH

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Glucocorticoids regulate innate immunity in a model of multiple sclerosis: reciprocal interactions between the A1 adenosine receptor and β-arrestin-1 in monocytoid cells

(2007) Shigeki Tsutsui et al.   FASEB JOURNAL