Molecular Basis of Etiological Implications in Alzheimer’s Disease: Focus on Neuroinflammation

A New Function of Human HtrA2 as an Amyloid-β Oligomerization Inhibitor

(2017) Joel Kooistra et al.   JOURNAL OF ALZHEIMERS DISEASE

Development of a novel method for quantification of sterols and oxysterols by UPLC-ESI-HRMS: application to a neuroinflammation rat model

(2012) Sophie Ayciriex et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells, C6

(2012) Rituraj Niranjan et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Neuroinflammation

(2012) Heinz Wiendl   CURRENT OPINION IN NEUROLOGY

Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease

(2012) Paula Agostinho et al.   CURRENT PHARMACEUTICAL DESIGN

Immunopathogenesis of Neurodegenerative Diseases: Current Therapeutic Models of Neuroprotection with Special Reference to Natural Products

(2012) T. Magrone et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting intracellular and extracellular alpha-synuclein as a therapeutic strategy in Parkinson's disease and other synucleinopathies

(2012) Kostas Vekrellis et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Neurosteroid-mediated regulation of brain innate immunity in HIV/AIDS: DHEA-S suppresses neurovirulence

(2012) Ferdinand G. Maingat et al.   FASEB JOURNAL

Melatonin attenuated mediators of neuroinflammation and alpha-7 nicotinic acetylcholine receptor mRNA expression in lipopolysaccharide (LPS) stimulated rat astrocytoma cells, C6

(2012) Rituraj Niranjan et al.   FREE RADICAL RESEARCH

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease

(2012) Sang-Ho Choi et al.   JOURNAL OF NEUROCHEMISTRY

Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

(2012) Maria Teresa Ferretti et al.   Journal of Neuroinflammation

Lipopolysaccharide-induced neuroinflammation leads to the accumulation of ubiquitinated proteins and increases susceptibility to neurodegeneration induced by proteasome inhibition in rat hippocampus

(2012) Cristina Pintado et al.   Journal of Neuroinflammation

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease

(2012) Tomomi Kiyota et al.   NEUROBIOLOGY OF AGING

Neuroinflammation and Common Mechanism in Alzheimer’s Disease and Prion Amyloidosis: Amyloid-Associated Proteins, Neuroinflammation and Neurofibrillary Degeneration

(2012) Annemieke J.M. Rozemuller et al.   Neurodegenerative Diseases

The Role of S100a9 in the Pathogenesis of Alzheimer’s Disease: The Therapeutic Effects of S100a9 Knockdown or Knockout

(2012) Keun-A Chang et al.   Neurodegenerative Diseases

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibition of 26S Protease Regulatory Subunit 7 (MSS1) Suppresses Neuroinflammation

(2012) Wei Bi et al.   PLoS One

Role of genes linked to sporadic Alzheimer's disease risk in the production of  -amyloid peptides

(2012) J. Bali et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Guggulipid and Nimesulide Differentially Regulated Inflammatory Genes mRNA Expressions via Inhibition of NF-kB and CHOP Activation in LPS-Stimulated Rat Astrocytoma Cells, C6

(2011) Rituraj Niranjan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Dietary supplementation with α-tocopherol reduces neuroinflammation and neuronal degeneration in the rat brain after kainic acid-induced status epilepticus

(2011) Michele Betti et al.   FREE RADICAL RESEARCH

Neuroinflammation in Alzheimer's disease wanes with age

(2011) Jeroen JM Hoozemans et al.   Journal of Neuroinflammation

Alzheimer’s disease: pathological mechanisms and the beneficial role of melatonin

(2011) Sergio A. Rosales-Corral et al.   JOURNAL OF PINEAL RESEARCH

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

WNT5A Signaling Contributes to Aβ-Induced Neuroinflammation and Neurotoxicity

(2011) Bei Li et al.   PLoS One

Inflammation and Alzheimer’s disease

(2010) Young-Jung Lee et al.   ARCHIVES OF PHARMACAL RESEARCH

Abeta-induced BACE-1 cleaves N-terminal sequence of mPGES-2

(2010) Takeshi Kihara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interleukin-6 receptor gene polymorphisms were associated with sporadic Alzheimer's disease in Chinese Han

(2010) Min Wang et al.   BRAIN RESEARCH

Amyloid-β Protein Oligomer at Low Nanomolar Concentrations Activates Microglia and Induces Microglial Neurotoxicity

(2010) Izumi Maezawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-inflammatory effects of pioglitazone on iron-induced oxidative injury in the nigrostriatal dopaminergic system

(2010) H. C. Yu et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

(2010) M. M. Lipinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

The role of proteomics in dementia and Alzheimer’s disease

(2009) Maria Zellner et al.   ACTA NEUROPATHOLOGICA

Neuroinflammatory changes increase the impact of stressors on neuronal function

(2009) Alessia Piazza et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The relation between inflammation and neurodegeneration in multiple sclerosis brains

(2009) Josa M. Frischer et al.   BRAIN

Decreased neuronal CD200 expression in IL-4-deficient mice results in increased neuroinflammation in response to lipopolysaccharide

(2009) Anthony Lyons et al.   BRAIN BEHAVIOR AND IMMUNITY

Interaction between Interleukin-8 and Methylenetetrahydrofolate Reductase Genes Modulates Alzheimer’s Disease Risk

(2009) Keshen Li et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Somatostatin, tau, and β-amyloid within the anterior olfactory nucleus in Alzheimer disease

(2009) D. Saiz-Sanchez et al.   EXPERIMENTAL NEUROLOGY

An update on the efficacy of non-steroidal anti-inflammatory drugs in Alzheimer's disease

(2009) Bruno P Imbimbo   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Epigenetics, oxidative stress, and Alzheimer disease

(2009) Nasser H. Zawia et al.   FREE RADICAL BIOLOGY AND MEDICINE

Melatonin as a potential therapeutic agent in psychiatric illness

(2009) Maria D. Maldonado et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Mutant Presenilin 1 Increases the Expression and Activity of BACE1

(2009) Luca Giliberto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of guggulipid and nimesulide on production of inflammatory mediators and GFAP expression in LPS stimulated rat astrocytoma, cell line (C6)

(2009) Rituraj Niranjan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Elevated cerebrospinal fluid levels of prostaglandin E2 and 15-(S)-hydroxyeicosatetraenoic acid in multiple sclerosis

(2009) N. Mattsson et al.   JOURNAL OF INTERNAL MEDICINE

Statins Reduce the Neurofibrillary Tangle Burden in a Mouse Model of Tauopathy

(2009) Moran Boimel et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mitochondrial Cholesterol Loading Exacerbates Amyloid   Peptide-Induced Inflammation and Neurotoxicity

(2009) A. Fernandez et al.   JOURNAL OF NEUROSCIENCE

T RI Independently Activates Smad- and CD2AP-Dependent Pathways in Podocytes

(2009) S. Xavier et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents pre-plaque amyloid-associated neuropathology

(2009) Fiona E. McAlpine et al.   NEUROBIOLOGY OF DISEASE

Oxidative stress promotes JNK-dependent amyloidogenic processing of normally expressed human APP by differential modification of α-, β- and γ-secretase expression

(2009) Ricardo Quiroz-Baez et al.   NEUROCHEMISTRY INTERNATIONAL

Dietary supplementation with a combination of α-lipoic acid, acetyl-l-carnitine, glycerophosphocoline, docosahexaenoic acid, and phosphatidylserine reduces oxidative damage to murine brain and improves cognitive performance

(2009) James Suchy et al.   NUTRITION RESEARCH

Vitamin C reduces spatial learning deficits in middle-aged and very old APP/PSEN1 transgenic and wild-type mice

(2009) F.E. Harrison et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Apolipoprotein E ε4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia

(2009) Federica Agosta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammation in Alzheimer's disease: Amyloid-β oligomers trigger innate immunity defence via pattern recognition receptors

(2009) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study

(2008) Ruth Remington et al.   American Journal of Alzheimers Disease and Other Dementias

Mitochondrial dysfunction triggered by loss of HtrA2 results in the activation of a brain-specific transcriptional stress response

(2008) N Moisoi et al.   CELL DEATH AND DIFFERENTIATION

On the mechanism of inhibition of p27 degradation by 15-deoxy-Δ12,14-prostaglandin J 2 in lymphoblasts of Alzheimer’s disease patients

(2008) Ú. Muñoz et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Oxidative Stress Signaling in Alzheimers Disease

(2008) B. Su et al.   Current Alzheimer Research

Oxidative stress induces macroautophagy of amyloid β-protein and ensuing apoptosis

(2008) Lin Zheng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mutations inTREM2lead to pure early-onset dementia without bone cysts

(2008) Eliane Chouery et al.   HUMAN MUTATION

Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells

(2008) Alexandre F. Fernandes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ABCG1 influences the brain cholesterol biosynthetic pathway but does not affect amyloid precursor protein or apolipoprotein E metabolism in vivo

(2008) Braydon L. Burgess et al.   JOURNAL OF LIPID RESEARCH

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Lymphoid chemokines in chronic neuroinflammation

(2008) Francesca Aloisi et al.   JOURNAL OF NEUROIMMUNOLOGY

Progression of Amyloid Pathology to Alzheimer's Disease Pathology in an Amyloid Precursor Protein Transgenic Mouse Model by Removal of Nitric Oxide Synthase 2

(2008) D. M. Wilcock et al.   JOURNAL OF NEUROSCIENCE

Alzheimer’s disease and other dementing conditions

(2008) Gioacchino Tedeschi et al.   NEUROLOGICAL SCIENCES

Hematopoietic stem cell transplantation in patients with sporadic amyotrophic lateral sclerosis

(2008) S. H. Appel et al.   NEUROLOGY

The Toll→NFκB Signaling Pathway Mediates the Neuropathological Effects of the Human Alzheimer's Aβ42 Polypeptide in Drosophila

(2008) Lihua Tan et al.   PLoS One