Article
Multidisciplinary Sciences
Richa Singh, Walia Zahra, Saumitra Sen Singh, Hareram Birla, Aaina Singh Rathore, Priyanka Kumari Keshri, Hagera Dilnashin, Shekhar Singh, Surya Pratap Singh
Summary: Major pathological features of Parkinson's disease (PD) include oxidative stress, alpha-synuclein aggregation, mitochondrial dysfunction, apoptosis of dopaminergic neurons, and downregulation of neurotrophic factors. Trophic factor-based neuroprotective medicines have been of interest for treating PD symptoms. Rotenone inhibits mitochondrial complex I, leading to ROS overproduction and alpha-synuclein aggregation. BDNF and TrkB interaction triggers neuronal cell development and differentiation through Akt and GSK-3 beta. The homeostasis of these signaling cascades is compromised in PD. Oleuropein (OLE) from olive leaves shows antioxidative properties and was found to be neuroprotective in a PD mouse model. OLE improved motor impairment, upregulated CREB regulation, phosphorylated Akt and GSK-3 beta, reduced mitochondrial dysfunction, and downregulated proapoptotic markers. OLE may be used as a therapeutic agent for PD by regulating BDNF/CREB/Akt signaling pathway.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Zune Jansen van Rensburg, Shameemah Abrahams, Soraya Bardien, Colin Kenyon
Summary: Parkinson's disease is a movement disorder caused by severe loss of dopaminergic neurons in the substantia nigra. The disease pathology involves a toxic loop of reactive oxygen species, iron, alpha-synuclein, and neuromelanin, ultimately leading to neuronal death. Targeting the increase in ROS and iron levels may be a potential therapeutic approach to disrupt this toxic cycle and complement existing PD treatments.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Qingyu Ren, Xin Jiang, Shanshan Zhang, Xin Gao, Yam Nath Paudel, Pengyu Zhang, Rongchun Wang, Kechun Liu, Meng Jin
Summary: In this study, it was found that YIAEDAER peptide extracted from Neptunea arthritica cumingii has potential therapeutic effects on MPTP-induced PD-like condition by modulating multiple genes related to autophagy and oxidative stress.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Plant Sciences
Fahim Muhammad, Yan Liu, Yongtao Zhou, Hui Yang, Hongyu Li
Summary: This study highlights the neuroprotective and antioxidative properties of newly discovered Traditional Chinese Medicine (TCM) and proposes potential treatment approaches against Parkinson's disease (PD) for future researchers. Targeting reactive oxygen species (ROS) through anti-radical activities may be an effective therapeutic strategy for preventing or slowing down the progression of PD.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Neha Sharma, Navneet Khurana, Arunachalam Muthuraman, Puneet Utreja
Summary: In this study, it was found that vanillic acid has anti-Parkinson's effects in rats induced with rotenone, reducing muscle rigidity and motor defects while lowering oxidative stress levels and providing neuroprotection for neurons.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anna T. Bergsma, Hui Ting Li, Jitske Eliveld, Marian L. C. Bulthuis, Annemieke Hoek, Harry van Goor, Arno R. Bourgonje, Astrid E. P. Cantineau
Summary: This study investigates the impact of oxidative stress on male infertility by comparing levels of free thiols and malondialdehyde (MDA) in seminal fluid and serum of infertile patients. The researchers find a positive correlation between seminal plasma-free thiol levels and sperm concentration and motility, as well as a positive correlation between MDA levels in seminal plasma and sperm concentration.
Article
Biochemistry & Molecular Biology
Mahmoud A. Desouky, Mina Y. George, Haidy E. Michel, Doaa A. Elsherbiny
Summary: This study found that roflumilast, a phosphodiesterase-4 inhibitor, has a neuroprotective effect in a rat model of Parkinson's disease. It reduces motor impairment, brain lesions, and loss of dopaminergic neurons, and decreases the accumulation of misfolded α-synuclein. Roflumilast enhances proteasome activity, inhibits endoplasmic reticulum stress and oxidative stress, and shows significant anti-apoptotic activity. This study suggests that roflumilast can be repurposed as a novel neuroprotective drug to restore protein homeostasis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Biochemistry & Molecular Biology
Alessandra Mingione, Francesca Pivari, Nicoletta Plotegher, Michele Dei Cas, Aida Zulueta, Tommaso Bocci, Marco Trinchera, Elisabetta Albi, Vittorio Maglione, Anna Caretti, Luigi Bubacco, Rita Paroni, Daniele Bottai, Riccardo Ghidoni, Paola Signorelli
Summary: Parkinson's disease is associated with alpha-synuclein aggregation and lipid-protein inclusion formation, leading to impaired autophagy, protein aggregation, and inflammation. Myr treatment may help improve these conditions by reducing intracellular aggregates and inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Tapan Behl, Piyush Madaan, Aayush Sehgal, Sukhbir Singh, Md Khalid Anwer, Hafiz A. Makeen, Mohammed Albratty, Syam Mohan, Simona Bungau
Summary: This article discusses the etiology, oxidative stress, autophagy, programmed cell death, and other important roles in the pathogenesis of Parkinson's disease, emphasizing the crucial role of iron and copper in the development of Parkinson's disease. Metal chelators may have the potential to reduce oxidative stress levels by scavenging metal ions, thereby preventing or slowing down the progression of Parkinson's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Mingming Guo, Bowen Li, Guoqing Feng, Xin Su, Xue Wang, Xiaoxuan Han, Manyi Yang, Lipeng Bai, Xiaodong Zhu, Haojun Fan, Bin Zheng
Summary: This study introduces a Co-doped Prussian blue (PB/Co) nanozyme that can scavenge existing ROS and induce mitophagy to eliminate damaged mitochondria. By encapsulating PB/Co nanozyme in two cationic liposomes and developing a non-invasive inhalable nanospray ((PB/Co)@DD), the brain entry efficiency of PB/Co nanozyme is further enhanced. The research shows that (PB/Co)@DD nanospray can induce mitophagy to eliminate ROS production source and restore motor function in PD mice models.
MATERIALS & DESIGN
(2023)
Review
Pharmacology & Pharmacy
Yumin Wang, Shuang Wu, Qiang Li, Weihong Lang, Wenjing Li, Xiaodong Jiang, Zhirong Wan, Jichao Chen, Hongquan Wang
Summary: This review summarizes the recent updates and knowledge of the molecular mechanisms underlying the neuroprotective effects of epigallocatechin 3-gallate (EGCG) derived from green tea extract in Parkinson's disease (PD). The review highlights the pleiotropic effects of EGCG, including anti-apoptotic, anti-oxidative stress, anti-inflammatory, modulation of dopamine production, and inhibition of alpha-synuclein aggregation, which make it a promising neuroprotective compound for the treatment of PD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wen-li Dong, Jia-hong Zhong, Yun-qing Chen, Jin-feng Xie, Yun-yun Qin, Jiang-ping Xu, Ning-bo Cai, Meng-fan Li, Lu Liu, Hai-tao Wang
Summary: The research demonstrates that ROF can significantly attenuate cell apoptosis and reduce the level of alpha-syn in ROT-treated cells. Furthermore, ROF enhances lysosomal function through increasing NAD(+)/NADH and the expression of sirtuin 1 (SIRT1).
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Vandana Zaman, Kelsey P. Drasites, Ali Myatich, Ramsha Shams, Donald C. Shields, Denise Matzelle, Azizul Haque, Narendra L. Banik
Summary: In this study, the researchers found that the activation of calpain-1 and calpain-2 in a nigrostriatal pathway has different effects on glial activation and neuronal survival in the Parkinson's disease (PD) model. They also found that attenuating calpain-2 may be important in reducing the loss of substantia nigra (SN) neurons in PD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
G. Pagano, K. I. Taylor, J. Anzures-Cabrera, M. Marchesi, T. Simuni, K. Marek, R. B. Postuma, N. Pavese, F. Stocchi, J. -P. Azulay, B. Mollenhauer, L. Lopez-Manzanares, D. S. Russell, J. T. Boyd, A. P. Nicholas, M. R. Luquin, R. A. Hauser, T. Gasser, W. Poewe, B. Ricci, A. Boulay, A. Vogt, F. G. Boess, J. Dukart, G. D'Urso, R. Finch, S. Zanigni, A. Monnet, N. Pross, A. Hahn, H. Svoboda, M. Britschgi, F. Lipsmeier, E. Volkova-Volkmar, M. Lindemann, S. Dziadek, S. Holiga, D. Rukina, T. Kustermann, G. A. Kerchner, P. Fontoura, D. Umbricht, R. Doody, T. Nikolcheva, A. Bonni
Summary: The study found that prasinezumab had no meaningful effect on global or imaging measures of Parkinson's disease progression and was associated with infusion reactions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kozo Nakai, Daisuke Tsuruta
Summary: Oxygen in the atmosphere is vital for human life, but the metabolites ROS, produced in excess, can exacerbate skin aging and inflammation. Excessive exposure to air pollutants and other harmful substances can stimulate the production of ROS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Tingfu Du, Guoxiang Li, Haiyu Luo, Yue Pan, Qi Xu, Kaili Ma
Summary: The study found that the expression of SNCA is upregulated in major depressive disorder patients and depressive mice, and overexpression of SNCA can lead to depressive-like behaviors in mice under nonstressed conditions, while knockout of SNCA can reverse stress-induced depressive-like behaviors. The study speculates that SNCA may cause synaptic loss and neuronal cell death in the hippocampus possibly through complement-mediated microglial engulfment and inflammation, thus contributing to the pathogenesis of depressive disorder.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Jing Pu, Qin Yu, Zhifang Yin, Ying Zhang, Xueqi Li, Qiongzhou Yin, Hongbo Chen, Runxiang Long, Zhimei Zhao, Tangwei Mou, Heng Zhao, Shiyin Feng, Zhongping Xie, Lichun Wang, Zhanlong He, Yun Liao, Shengtao Fan, Ruiju Jiang, Jianfeng Wang, Lingli Zhang, Jing Li, Huiwen Zheng, Pingfang Cui, Guorun Jiang, Lei Guo, Mingjue Xu, Huijuan Yang, Shan Lu, Xuanyi Wang, Yang Gao, Xingli Xu, Linrui Cai, Jian Zhou, Li Yu, Zhuo Chen, Chao Hong, Dan Du, Hongling Zhao, Yan Li, Kaili Ma, Yunfei Ma, Donglan Liu, Shibao Yao, Changgui Li, Yanchun Che, Longding Liu, Qihan Li
Summary: The study demonstrated that the inactivated SARS-CoV-2 vaccine was safe and immunogenic in individuals aged 18-59. Seroconversion rates and antibody titers indicated a robust immune response induced by the vaccine. Transcriptome analysis revealed the genetic diversity of immune responses triggered by the vaccine.
Article
Biochemistry & Molecular Biology
Jin-Ling Yang, Jia-Hong Gao, Ting-Fu Du, Hong-Kun Yi, Kai-Li Ma
Summary: Research has shown that alpha-synuclein protein is widely expressed in different brain regions and primary organs of nonhuman primates. The areas with the highest expression of alpha-synuclein are also the regions affected during the progression of neurodegenerative diseases.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2021)
Article
Food Science & Technology
Zhangqiong Huang, Qinfang Jiang, Yixuan Wang, Jinling Yang, Tingfu Du, Hongkun Yi, Cong Li, Yun Li, Zhengcun Wu, Shengtao Fan, Yun Liao, Ying Zhang, Lichun Wang, Guorun Jiang, Donghong Tang, Yousong Ye, Chenyun Wang, Zheli Li, Zhisai Li, Caixing Zhang, Kaili Ma, Qihan Li
Summary: The study aimed to evaluate the toxicity and severity of an inactivated SARS-CoV-2 vaccine in Sprague Dawley rats after multiple injections. Results showed no evident toxic reactions, stimulation of neutralizing antibodies, and overall safety of the vaccine in the rats.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Qi-wen Han, Qian-hang Shao, Xiao-tong Wang, Kai-li Ma, Nai-hong Chen, Yu-he Yuan
Summary: Neuroinflammation is closely associated with neurodegenerative diseases, and microglial cell activation leads to inflammatory response and release of neurotoxic molecules that accelerate neuronal death and degeneration. Both CB2 receptors and Nurr1 are present in microglial cells, and they regulate common molecular factors such as NF-kappa B. Activation of CB2 receptors increases nuclear Nurr1 protein, and Nurr1 overexpression increases CB2 receptor mRNA level. The CB2 receptor activation leads to increased levels of p-ERK, p-AKT, and p-GSK-3 beta. The interplay between β-arrestin2/ERK1/2 and PI3K/AKT/GSK-3 beta pathways contributes to the upregulation of nuclear Nurr1. CB2 receptor activation weakens the phagocytic function of microglial cells, and Nurr1 activation also inhibits phagocytosis. This study provides insights into the role of CB2 receptors and Nurr1 in phagocytosis and potential treatment strategies for neurodegenerative diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Biotechnology & Applied Microbiology
Zhengcun Wu, Chengxing Xia, Chao Zhang, Donghong Tang, Feineng Liu, Yitian Ou, Jiahong Gao, Hongkun Yi, Delin Yang, Kaili Ma
Summary: This study reveals that alpha-synuclein is significantly downregulated in bladder cancer and can inhibit the proliferation of bladder cancer cells through activation of the p53/p21 signaling pathway. These findings provide insights into the potential application of alpha-synuclein in the treatment of bladder cancer.
CANCER GENE THERAPY
(2022)
Correction
Oncology
Xiuao Zhang, Zhengcun Wu, Kaili Ma
Article
Oncology
Zhengcun Wu, Chengxing Xia, Chao Zhang, Delin Yang, Kaili Ma
Summary: This study investigates the role of SNCA gene in bladder cancer (BLCA) and its potential as a prognostic diagnostic biomarker. The results show that SNCA is downregulated in BLCA tumor tissues and is negatively correlated with DNA methylation. High SNCA expression is associated with poor overall survival. SNCA is also found to play a role in immune cell infiltration, particularly with T cells. Therefore, SNCA may serve as a promising prognostic biomarker in BLCA patients.
Article
Oncology
Xiuao Zhang, Zhengcun Wu, Kaili Ma
Summary: The study revealed that in LUAD tissue, the expression level of SNCA was lower than in normal tissue, and high expression of SNCA was associated with a better prognosis. SNCA expression showed significant positive correlations with immune infiltrations and immune checkpoints, suggesting immune infiltration as a reason for the influence of SNCA on LUAD prognosis. Furthermore, SNCA inhibited the proliferation of A549 cells by suppressing the PI3K/AKT/mTOR pathway.
Article
Immunology
Zhangqiong Huang, Yun Li, Hongkun Yi, Zhengcun Wu, Cong Li, Tingfu Du, Jinling Yang, Yixuan Wang, Qinfang Jiang, Shengtao Fan, Yun Liao, Ying Zhang, Guorun Jiang, Kaili Ma, Qihan Li
Summary: This study demonstrates that intramuscular injection of inactivated SARS-CoV-2 vaccine in guinea pigs does not induce systemic allergic reactions and has a good safety profile.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhengcun Wu, Xiuao Zhang, Zhangqiong Huang, Kaili Ma
Summary: The study confirmed the direct interaction between SARS-CoV-2 proteins and the key protein alpha-Syn in Parkinson's disease. It was discovered that SARS-CoV-2 proteins can accelerate the aggregation of alpha-Syn, leading to the development of Parkinson's disease in the context of COVID-19.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Yue Pan, Qinglan Zong, Guoxiang Li, Zhengcun Wu, Tingfu Du, Zhangqiong Huang, Ying Zhang, Kaili Ma
Summary: Excessive nuclear translocation of alpha-syn in hippocampal neurons can lead to pathological accumulation, resulting in memory and motor impairments.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Yue Pan, Qinglan Zong, Guoxiang Li, Zhengcun Wu, Tingfu Du, Ying Zhang, Zhangqiong Huang, Kaili Ma
Summary: This study reveals the importance of excessive nuclear translocation of alpha-syn in the development of anxiety in Parkinson's disease, affecting the function of the hippocampus and amygdala and leading to anxiety-like behavior in mice.
NEUROSCIENCE LETTERS
(2023)
Article
Chemistry, Physical
Yingping Zheng, Dehua Yu, Ke Zhang, Wei Xu, Kaili Ma, Yuhang Wang, Yongbing Lou
Summary: By doping phosphorus into Fe-Co-Se, the electron density and mass transfer were successfully adjusted, leading to improved oxygen evolution reaction (OER) performance. This research provides another option for the design of transition metal OER catalysts and promotes the development of electrocatalytic oxygen production with higher efficiency and lower cost.
Article
Immunology
Yanchun Che, Xiaoqiang Liu, Yi Pu, Meijian Zhou, Zhimei Zhao, Ruiju Jiang, Zhifang Yin, Mingjue Xu, Qiongzhou Yin, Jianfeng Wang, Jing Pu, Heng Zhao, Ying Zhang, Lichun Wang, Ya Jiang, Jin Lei, Yan Zheng, Yun Liao, Runxiang Long, Li Yu, Pingfang Cui, Huijuan Yang, Yuehui Zhang, Jingyu Li, Weiwu Chen, Zhanlong He, Kaili Ma, Chao Hong, Dandan Li, Guorun Jiang, Donglan Liu, Xingli Xu, Shengtao Fan, Chen Cheng, Hongling Zhao, Jianbo Yang, Yan Li, Yanxiang Zou, Youshuai Zhu, Yaling Zhou, Yingqiu Guo, Ting Yang, Hongbo Chen, Zhongping Xie, Changgui Li, Qihan Li
Summary: This study evaluated an inactivated SARS-CoV-2 vaccine for immunogenicity and safety in adults aged 18-59 years. The results showed that vaccinated adults developed neutralizing antibodies as well as anti-S/N antibodies with a low rate of adverse reactions.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Song Xue, Feng Kong, Yiying Song, Jia Liu
Summary: This study used resting-state functional magnetic resonance imaging to explore the relationship between individual's spontaneous neural activity and social interaction anxiety in a nonclinical population. The results showed that social interaction anxiety was correlated with the fractional amplitude of low-frequency fluctuations in several brain regions, and that emotional intelligence partially mediated this relationship. This study provides evidence for the neural basis of social interaction anxiety in the normal population and highlights the role of emotional intelligence in this anxiety.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Katsuyuki Yamaguchi, Takuya Yazawa
Summary: This study provides morphometric data on the development of the human medullary arcuate nucleus (AN) by examining the brains of preterm and perinatal infants. The results show that AN morphology demonstrates asymmetry and individual variability during the fetal period. The volume and neuronal number of AN increase exponentially with age, while neuronal density decreases exponentially. The AN may undergo neuron death and neuroblasts production after mid-gestation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zhan Zhou, Weixin Dai, Tianxiao Liu, Min Shi, Yi Wei, Lifei Chen, Yubo Xie
Summary: Studies have shown that propofol-induced neurotoxicity is caused by disruption of mitochondrial fission and fusion, leading to an energy supply imbalance for developing neurons. Healthy mitochondria released by astrocytes can migrate to compromised neurons to mitigate propofol-induced neurotoxicity, but the exact mechanisms involved still need further clarification.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
An Chen, Song Hao, Yongpeng Han, Yang Fang, Yibei Miao
Summary: This study explores the efficacy of two forms of BCI attention training games and finds that physical games may be more effective than video games. The research also offers valuable insights for future game design from a neuroscience perspective.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lina Liu, Luran Liu, Yunting Lu, Tianyuan Zhang, Wenting Zhao
Summary: This study reveals that GDI1 serves as a potential diagnostic biomarker for AD and inhibition of GDI1 can attenuate Aβ-induced neurotoxicity. The findings offer new insights for the treatment of AD.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Zahra Gholami, Ava Soltani Hekmat, Ali Abbasi, Kazem Javanmardi
Summary: This study investigated the effects of alamandine on allodynia in a rat model and found the presence of MrgD receptors in the vlPAG and RVM regions. Microinjection of alamandine resulted in a significant increase in paw withdrawal threshold and could be blocked by an MrgD receptor antagonist. Upregulation of MrgD receptor expression following allodynia induction suggests a potential compensatory mechanism in response to pain.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Mingliang Xu, Lei Xia, Junjie Li, Yehong Du, Zhifang Dong
Summary: This study found that DHF effectively alleviates sevoflurane-induced cognitive impairment in developing mice by restoring the balance between tau O-GlcNAcylation and phosphorylation. Therefore, DHF has the potential to be a therapeutic agent for treating cognitive impairment associated with anesthetics, such as sevoflurane.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Tsubasa Mitsutake, Hisato Nakazono, Takanori Taniguchi, Hisayoshi Yoshizuka, Maiko Sakamoto
Summary: The posterior parietal cortex plays a crucial role in postural stability, and transcranial electrical stimulation of this region can modulate physical control responses. This study found that cathodal stimulation significantly decreased joint angular velocity in multiple directions, while there were no significant differences with transcranial random noise stimulation.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xishuai Yang, Wei Zhang, Xueli Chang, Zuopeng Li, Runquan Du, Junhong Guo
Summary: This study aims to evaluate the efficacy of low-dose rituximab (RTX) in patients with muscle-specific kinase antibody positive myasthenia gravis (MuSK-MG). The results showed that low-dose RTX treatment led to significant improvements in clinical symptoms and quality of life for patients with MuSK-MG.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Jian Zhang, Shunyuan Guo, Rong Tao, Fan Wang, Yihong Xie, Huizi Wang, Lan Ding, Yuejian Shen, Xiaoli Zhou, Junli Feng, Qing Shen
Summary: This study established an Alzheimer's disease (AD) model of zebrafish induced by AlCl3 and found that marine-derived plasmalogens (Pls) could alleviate cognitive impairments of AD zebrafish by reversing athletic impairment and altering the expression levels of genes related to oxidative stress, ferroptosis, synaptic dysfunction, and apoptosis.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Lu Li, Jiaqi Ren, Qi Fang, Liqiang Yu, Jintao Wang
Summary: ICU-AW is a common and severe neuromuscular complication in critically ill patients. Electrophysiological examination is essential for accurate diagnosis and early prediction of the disease. This study aimed to establish and validate an ICU-AW predictive model in SIRS patients, providing a practical tool for early clinical prediction.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Ahmad Alipour, Roghayeh Mohammadi
Summary: The present study aimed to investigate the separate and combined effects of anodal transcranial direct current stimulation (tDCS) over the primary motor cortex (M1) and left dorsolateral prefrontal cortex (F3) regions on pain relief in patients with type-2 diabetes suffering from neuropathic pain (NP). The results showed that tDCS had the potential to induce pain relief in patients with type-2 diabetes suffering from NP. The mean perceived pain intensity in the posttest was lower in the M1 stimulation group than in the F3 stimulation group. However, more trials with larger sample sizes are necessary to define clinically relevant effects.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Eduardo J. Fusse, Franciele F. Scarante, Maria A. Vicente, Mariana M. Marrubia, Flavia Turcato, Davi S. Scomparin, Melissa A. Ribeiro, Maria J. Figueiredo, Tamires A. V. Brigante, Francisco S. Guimaraes, Alline C. Campos
Summary: Repeated exposure to psychosocial stress alters the endocannabinoid system and affects brain regions associated with emotional distress. Enhancing the effects of endocannabinoids through pharmacological inhibition induces an anti-stress behavioral effect, possibly mediated by the mTOR signaling pathway.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Giulia Agostoni, Luca Bischetti, Federica Repaci, Margherita Bechi, Marco Spangaro, Irene Ceccato, Elena Cavallini, Luca Fiorentino, Francesca Martini, Jacopo Sapienza, Mariachiara Buonocore, Michele Francesco D'Incalci, Federica Cocchi, Carmelo Guglielmino, Roberto Cavallaro, Marta Bosia, Valentina Bambini
Summary: This study found a general impairment in humor comprehension in individuals with schizophrenia, with mental jokes being more difficult for both patients and controls. Humor comprehension was closely associated with the patients' overall pragmatic and linguistic profile, while the association with Theory of Mind (ToM) was minimal. Another notable finding was the increased appreciation of humor in individuals with schizophrenia, who rated jokes as funnier than controls did, regardless of whether they were correctly or incorrectly completed. The funniness ratings were not predicted by any measure, suggesting a dimension of humor untied to cognition or psychopathology.
NEUROSCIENCE LETTERS
(2024)
Article
Neurosciences
Xiuping Gong, Qi Li, Yang Liu
Summary: This study demonstrates that Sev targets CREBBP to inhibit ALG13 transcription, leading to hippocampal damage and cognitive impairment.
NEUROSCIENCE LETTERS
(2024)
