α-Synuclein Elevation in Human Neurodegenerative Diseases: Experimental, Pathogenetic, and Therapeutic Implications
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Title
α-Synuclein Elevation in Human Neurodegenerative Diseases: Experimental, Pathogenetic, and Therapeutic Implications
Authors
Keywords
Parkinson’s disease, Risk factor, Synuclein, Therapeutics, Transgenic, Viral vector
Journal
MOLECULAR NEUROBIOLOGY
Volume 47, Issue 2, Pages 484-494
Publisher
Springer Nature
Online
2012-09-03
DOI
10.1007/s12035-012-8329-y
References
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Note: Only part of the references are listed.- Increased α-synuclein phosphorylation and nitration in the aging primate substantia nigra
- (2012) A L McCormack et al. Cell Death & Disease
- Head injury, alpha-synuclein Rep1, and Parkinson's disease
- (2011) Samuel M. Goldman et al. ANNALS OF NEUROLOGY
- GDNF fails to exert neuroprotection in a rat -synuclein model of Parkinson's disease
- (2011) M. Decressac et al. BRAIN
- Rotenone, Paraquat, and Parkinson’s Disease
- (2011) Caroline M. Tanner et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Phosphorylated α-synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
- (2011) Penelope G. Foulds et al. FASEB JOURNAL
- Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design
- (2011) J N Martin et al. GENE THERAPY
- Efficient and stable transduction of dopaminergic neurons in rat substantia nigra by rAAV 2/1, 2/2, 2/5, 2/6.2, 2/7, 2/8 and 2/9
- (2011) A Van der Perren et al. GENE THERAPY
- Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
- (2011) Ken Nakamura et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Alpha-synuclein in colonic submucosa in early untreated Parkinson's disease
- (2011) Kathleen M. Shannon et al. MOVEMENT DISORDERS
- Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling
- (2011) Sang Ryong Kim et al. NEUROBIOLOGY OF DISEASE
- Use of viral vectors to create animal models for Parkinson's disease
- (2011) Karin Löw et al. NEUROBIOLOGY OF DISEASE
- Progressive neurodegenerative and behavioural changes induced by AAV-mediated overexpression of α-synuclein in midbrain dopamine neurons
- (2011) M. Decressac et al. NEUROBIOLOGY OF DISEASE
- Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
- (2011) Michael J. Devine et al. Nature Communications
- Lewy pathology in the submandibular gland of individuals with incidental Lewy body disease and sporadic Parkinson’s disease
- (2010) Kelly Del Tredici et al. ACTA NEUROPATHOLOGICA
- DJ-1 and α-synuclein in human cerebrospinal fluid as biomarkers of Parkinson’s disease
- (2010) Zhen Hong et al. BRAIN
- Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
- (2010) Frits Kamp et al. EMBO JOURNAL
- Co-expression of C-terminal truncated alpha-synuclein enhances full-length alpha-synuclein-induced pathology
- (2010) Ayse Ulusoy et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Lysosomal Degradation of α-Synucleinin Vivo
- (2010) Sally K. Mak et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A brief history of levodopa
- (2010) Oleh Hornykiewicz JOURNAL OF NEUROLOGY
- In Vivo RNAi-Mediated α-Synuclein Silencing Induces Nigrostriatal Degeneration
- (2010) Oleg S Gorbatyuk et al. MOLECULAR THERAPY
- Evidence in favor of Braak staging of Parkinson's disease
- (2010) Dennis W. Dickson et al. MOVEMENT DISORDERS
- α-Synuclein Gene May Interact with Environmental Factors in Increasing Risk of Parkinson’s Disease
- (2010) Nicole M. Gatto et al. NEUROEPIDEMIOLOGY
- Detection of elevated levels of -synuclein oligomers in CSF from patients with Parkinson disease
- (2010) T. Tokuda et al. NEUROLOGY
- A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice
- (2010) Alexander Kurz et al. PLoS One
- Colonic Biopsies to Assess the Neuropathology of Parkinson's Disease and Its Relationship with Symptoms
- (2010) Thibaud Lebouvier et al. PLoS One
- α-Synuclein Suppression by Targeted Small Interfering RNA in the Primate Substantia Nigra
- (2010) Alison L. McCormack et al. PLoS One
- -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro
- (2010) J. Burre et al. SCIENCE
- Decreased α-synuclein expression in the aging mouse substantia nigra
- (2009) Sally K. Mak et al. EXPERIMENTAL NEUROLOGY
- α-Synuclein modulation of Ca2+signaling in human neuroblastoma (SH-SY5Y) cells
- (2009) Nishani T. Hettiarachchi et al. JOURNAL OF NEUROCHEMISTRY
- Pathologic Modifications of α-Synuclein in 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP)-Treated Squirrel Monkeys
- (2009) Alison L. McCormack et al. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
- Dynamic Changes in Presynaptic and Axonal Transport Proteins Combined with Striatal Neuroinflammation Precede Dopaminergic Neuronal Loss in a Rat Model of AAV -Synucleinopathy
- (2009) C. Y. Chung et al. JOURNAL OF NEUROSCIENCE
- Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease
- (2009) Wataru Satake et al. NATURE GENETICS
- Genome-wide association study reveals genetic risk underlying Parkinson's disease
- (2009) Javier Simón-Sánchez et al. NATURE GENETICS
- Genomic investigation of α-synuclein multiplication and parkinsonism
- (2008) Owen A. Ross et al. ANNALS OF NEUROLOGY
- The Therapeutical Potential of Alpha-Synuclein Antiaggregatory Agents for Dementia with Lewy Bodies
- (2008) Katrin Beyer et al. CURRENT MEDICINAL CHEMISTRY
- Olfactory deficits in mice overexpressing human wildtype -synuclein
- (2008) Sheila M. Fleming et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Neurodegeneration and Motor Dysfunction in a Conditional Model of Parkinson's Disease
- (2008) S. Nuber et al. JOURNAL OF NEUROSCIENCE
- In vivo silencing of alpha-synuclein using naked siRNA
- (2008) Jada Lewis et al. Molecular Neurodegeneration
- The phosphorylation state of Ser-129 in human -synuclein determines neurodegeneration in a rat model of Parkinson disease
- (2008) O. S. Gorbatyuk et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Genetic variability in the SNCA gene influences α-synuclein levels in the blood and brain
- (2007) Julia Fuchs et al. FASEB JOURNAL
- Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice
- (2006) Masaki Wakamatsu et al. NEUROBIOLOGY OF AGING
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