Making the Brain Glow: In Vivo Bioluminescence Imaging to Study Neurodegeneration

Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau

(2012) Ann Van der Jeugd et al.   ACTA NEUROPATHOLOGICA

Degradation of tau protein by autophagy and proteasomal pathways: Figure 1

(2012) Yipeng Wang et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Deep Tissue Optical and Optoacoustic Molecular Imaging Technologies for Pre-Clinical Research and Drug Discovery

(2012) Daniel Razansky et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer’s Disease: Novel PET/SPECT Imaging Probes for Diagnosis of Alzheimer’s Disease

(2012) Masahiro Ono et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Microglial activation in the injured and healthy brain: What are we really talking about? Practical and theoretical issues associated with the measurement of changes in microglial morphology

(2012) S.B. Beynon et al.   NEUROSCIENCE

Inhibition of Firefly Luciferase by General Anesthetics: Effect on In Vitro and In Vivo Bioluminescence Imaging

(2012) Marleen Keyaerts et al.   PLoS One

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments

(2011) Vivek Swarup et al.   BRAIN

Mitochondrial DNA toxicity compromises mitochondrial dynamics and induces hippocampal antioxidant defenses

(2011) Knut H. Lauritzen et al.   DNA REPAIR

Dynamic Optical Imaging of Metabolic and NADPH Oxidase-Derived Superoxide in Live Mouse Brain Using Fluorescence Lifetime Unmixing

(2011) David J Hall et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Clinical amyloid imaging in Alzheimer's disease

(2011) Karl Herholz et al.   LANCET NEUROLOGY

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

(2011) Saul A. Villeda et al.   NATURE

Bioluminescence imaging of the brain response to acute inflammation in living C/EBP reporter mice

(2011) Luis Lopez de Heredia et al.   NEUROSCIENCE LETTERS

Bioluminescence resonance energy transfer (BRET) imaging of protein-protein interactions within deep tissues of living subjects

(2011) A. Dragulescu-Andrasi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioluminescence imaging of A  deposition in bigenic mouse models of Alzheimer's disease

(2011) J. C. Watts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GFAP in health and disease

(2011) J. Middeldorp et al.   PROGRESS IN NEUROBIOLOGY

Staging Alzheimer's disease progression with multimodality neuroimaging

(2011) Michael Ewers et al.   PROGRESS IN NEUROBIOLOGY

Regulation of neural process growth, elaboration and structural plasticity by NF-κB

(2011) Humberto Gutierrez et al.   TRENDS IN NEUROSCIENCES

A Significant Improvement of the Efficacy of Radical Oxidant Probes by the Kinetic Isotope Effect

(2010) Kousik Kundu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Bioluminescence imaging of reporter mice for studies of infection and inflammation

(2010) Kathryn E. Luker et al.   ANTIVIRAL RESEARCH

Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin

(2010) J Hickson et al.   CELL DEATH AND DIFFERENTIATION

Clinical Potential of Intravenous Neural Stem Cell Delivery for Treatment of Neuroinflammatory Disease in Mice?

(2010) Kristien P. Reekmans et al.   CELL TRANSPLANTATION

Mitochondrial DNA Toxicity in Forebrain Neurons Causes Apoptosis, Neurodegeneration, and Impaired Behavior

(2010) K. H. Lauritzen et al.   MOLECULAR AND CELLULAR BIOLOGY

Lipopolysaccharide-QD Micelles Induce Marked Induction of TLR2 and Lipid Droplet Accumulation in Olfactory Bulb Microglia

(2010) Mélanie Lalancette-Hébert et al.   MOLECULAR PHARMACEUTICS

APP Transgenic Mice: Their Use and Limitations

(2010) Claudia Balducci et al.   NEUROMOLECULAR MEDICINE

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

The ketogenic diet reverses gene expression patterns and reduces reactive oxygen species levels when used as an adjuvant therapy for glioma

(2010) Phillip Stafford et al.   Nutrition & Metabolism

Molecular Optical Imaging with Radioactive Probes

(2010) Hongguang Liu et al.   PLoS One

Analysis of proteome dynamics in the mouse brain

(2010) J. C. Price et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioluminescence in the Ocean: Origins of Biological, Chemical, and Ecological Diversity

(2010) E. A. Widder   SCIENCE

In Vivo Bioluminescent Imaging (BLI): Noninvasive Visualization and Interrogation of Biological Processes in Living Animals

(2010) Dan M. Close et al.   SENSORS

Tracking Early Autoimmune Disease by Bioluminescent Imaging of NF-κB Activation Reveals Pathology in Multiple Organ Systems

(2009) Michael Zangani et al.   AMERICAN JOURNAL OF PATHOLOGY

Rational design of novel red-shifted BRET pairs: Platforms for real-time single-chain protease biosensors

(2009) Seth T. Gammon et al.   BIOTECHNOLOGY PROGRESS

Live imaging of Toll-like receptor 2 response in cerebral ischaemia reveals a role of olfactory bulb microglia as modulators of inflammation

(2009) M. Lalancette-Hébert et al.   BRAIN

Proteasome Inhibition Blocks Ligand-Induced Dynamic Processing and Internalization of Epidermal Growth Factor Receptor via Altered Receptor Ubiquitination and Phosphorylation

(2009) A. H. Kesarwala et al.   CANCER RESEARCH

Biosensing and imaging based on bioluminescence resonance energy transfer

(2009) Zuyong Xia et al.   CURRENT OPINION IN BIOTECHNOLOGY

Guided by the light: visualizing biomolecular processes in living animals with bioluminescence

(2009) Jennifer A Prescher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Live imaging of amyotrophic lateral sclerosis pathogenesis: Disease onset is characterized by marked induction of GFAP in Schwann cells

(2009) A. Florence Keller et al.   GLIA

Dual transgenic reporter mice as a tool for monitoring expression of glial fibrillary acidic protein

(2009) Woosung Cho et al.   JOURNAL OF NEUROCHEMISTRY

In vivobioluminescence tomography with a blocking-off finite-difference SP3 method and MRI/CT coregistration

(2009) Alexander D. Klose et al.   MEDICAL PHYSICS

Bioluminescence imaging of myeloperoxidase activity in vivo

(2009) Shimon Gross et al.   NATURE MEDICINE

Optical imaging of Cerenkov light generation from positron-emitting radiotracers

(2009) R Robertson et al.   PHYSICS IN MEDICINE AND BIOLOGY

Real-Time Imaging of HIF-1α Stabilization and Degradation

(2009) Ekaterina Moroz et al.   PLoS One

Measuring prions by bioluminescence imaging

(2009) G. Tamguney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion Diseases: From Protein to Cell Pathology

(2008) Gabor G. Kovacs et al.   AMERICAN JOURNAL OF PATHOLOGY

Applications of bioluminescence imaging to antiviral research and therapy: Multiple luciferase enzymes and quantitation

(2008) Kathryn E. Luker et al.   ANTIVIRAL RESEARCH

Functional imaging of interleukin 1 beta expression in inflammatory process using bioluminescence imaging in transgenic mice

(2008) Limei Li et al.   BMC IMMUNOLOGY

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Noninvasive Imaging of Apoptosis and Its Application in Cancer Therapeutics

(2008) J. M. Coppola et al.   CLINICAL CANCER RESEARCH

Uptake kinetics and biodistribution of 14C-d-luciferin—a radiolabeled substrate for the firefly luciferase catalyzed bioluminescence reaction: impact on bioluminescence based reporter gene imaging

(2008) Frank Berger et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Firefly bioluminescence: A mechanistic approach of luciferase catalyzed reactions

(2008) Simone M. Marques et al.   IUBMB LIFE

Bioluminescence in vivo imaging of autoimmune encephalomyelitis predicts disease

(2008) Jian Luo et al.   Journal of Neuroinflammation

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE

Noninvasive and Quantitative Monitoring of Adult Neuronal Stem Cell Migration in Mouse Brain Using Bioluminescence Imaging

(2008) Veerle Reumers et al.   STEM CELLS

Live Imaging of Neuroinflammation Reveals Sex and Estrogen Effects on Astrocyte Response to Ischemic Injury

(2008) Pierre Cordeau et al.   STROKE

BRET-Based Method For Detection of Specific RNA Species

(2007) Zachary F. Walls et al.   BIOCONJUGATE CHEMISTRY

Knock-out and transgenic mouse models of tauopathies

(2007) Franziska Denk et al.   NEUROBIOLOGY OF AGING