APP Transgenic Mice: Their Use and Limitations

APP Transgenic Mouse Models and their Use in Drug Discovery to Evaluate Amyloid-β Lowering Therapeutics

(2012) Ishrut Hussain   CNS & Neurological Disorders-Drug Targets

The clinical use of structural MRI in Alzheimer disease

(2010) Giovanni B. Frisoni et al.   Nature Reviews Neurology

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synthetic amyloid-  oligomers impair long-term memory independently of cellular prion protein

(2010) C. Balducci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Independent Effects of Intra- and Extracellular Aβ on Learning-Related Gene Expression

(2009) Bettina M. Wegenast-Braun et al.   AMERICAN JOURNAL OF PATHOLOGY

Intraneuronal β-Amyloid Accumulation in the Amygdala Enhances Fear and Anxiety in Alzheimer's Disease Transgenic Mice

(2009) Judit España et al.   BIOLOGICAL PSYCHIATRY

Longitudinal regional brain volume changes quantified in normal aging and Alzheimer's APP×PS1 mice using MRI

(2009) Satheesh Maheswaran et al.   BRAIN RESEARCH

Mice expressing the Swedish APP mutation on a 129 genetic background demonstrate consistent behavioral deficits and pathological markers of Alzheimer's disease

(2009) Nathan R. Rustay et al.   BRAIN RESEARCH

NMDA receptor-dependent signaling pathways that underlie amyloid β-protein disruption of LTP in the hippocampus

(2009) Ghiam Yamin   JOURNAL OF NEUROSCIENCE RESEARCH

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Phosphorylation of Tau at S422 is enhanced by Aβ in TauPS2APP triple transgenic mice

(2009) Fiona Grueninger et al.   NEUROBIOLOGY OF DISEASE

Remote sites of structural atrophy predict later amyloid formation in a mouse model of Alzheimer's disease

(2009) Alexandra Badea et al.   NEUROIMAGE

APP transgenic mice: The effect of active and passive immunotherapy in cognitive tasks

(2009) Stephan Röskam et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid-  and tau synergistically impair the oxidative phosphorylation system in triple transgenic Alzheimer's disease mice

(2009) V. Rhein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active and Passive Immunotherapy for Neurodegenerative Disorders

(2008) David L. Brody et al.   Annual Review of Neuroscience

Immunotherapy and naturally occurring autoantibodies in neurodegenerative disorders

(2008) Frauke Neff et al.   AUTOIMMUNITY REVIEWS

Age-dependent phenotypic characteristics of a triple transgenic mouse model of Alzheimer disease.

(2008) Susanna Pietropaolo et al.   BEHAVIORAL NEUROSCIENCE

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Release of acetylcholinesterase (AChE) from β-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice

(2008) Margarita C. Dinamarca et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Therapeutic Potential of γ -Secretase Inhibitors and Modulators

(2008) Bruno Imbimbo   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease

(2008) Fabrizio Trinchese et al.   JOURNAL OF CLINICAL INVESTIGATION

Neuro-inflammation induced by lipopolysaccharide causes cognitive impairment through enhancement of beta-amyloid generation

(2008) Jae Lee et al.   Journal of Neuroinflammation

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Amyloid   Protein Dimer-Containing Human CSF Disrupts Synaptic Plasticity: Prevention by Systemic Passive Immunization

(2008) I. Klyubin et al.   JOURNAL OF NEUROSCIENCE

Memantine leads to behavioral improvement and amyloid reduction in Alzheimer's-disease-model transgenic mice shown as by micromagnetic resonance imaging

(2008) Henrieta Scholtzova et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Long-term effects of Aβ42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

(2008) Clive Holmes et al.   LANCET

Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s disease

(2008) Melanie Meyer-Luehmann et al.   NATURE

Cyclophilin D deficiency attenuates mitochondrial and neuronal perturbation and ameliorates learning and memory in Alzheimer's disease

(2008) Heng Du et al.   NATURE MEDICINE

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

(2008) S. Hauptmann et al.   NEUROBIOLOGY OF AGING

Longitudinal neuroanatomical changes determined by deformation-based morphometry in a mouse model of Alzheimer's disease

(2008) Jonathan C. Lau et al.   NEUROIMAGE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Reduced brain volumes in mice expressing APP-Austrian mutation but not in mice expressing APP-Swedish–Austrian mutations

(2008) Bianca Van Broeck et al.   NEUROSCIENCE LETTERS

Hippocampal hypometabolism predicts cognitive decline from normal aging

(2007) Lisa Mosconi et al.   NEUROBIOLOGY OF AGING

LTP maintenance and its protein synthesis-dependence

(2007) Wickliffe C. Abraham et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Intraneuronal amyloid β and reduced brain volume in a novel APP T714I mouse model for Alzheimer's disease

(2006) Bianca Van Broeck et al.   NEUROBIOLOGY OF AGING