Review
Behavioral Sciences
Gavan P. McNally
Summary: Progress has been made in understanding the behavioral and brain mechanisms for motivational systems, but less is known about competition between motivational states. Behavior during motivational competition exhibits bistability and metastability, revealing the operation of positive feedback mechanisms in behavioral selection. Different neuronal architectures rely on circuit-level inhibition for rapid and stable selection between competing tendencies, with the paraventricular thalamus (PVT) playing a critical role in resolving motivational competition.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Endocrinology & Metabolism
Qiying Ye, Jeremiah Nunez, Xiaobing Zhang
Summary: This study reveals that raphe-ZIR 5-HT projections dynamically regulate ZIR GABA neurons for feeding control. Photostimulation of 5-HT projections inhibits ZIR neurons while exciting PVT neurons, resulting in decreased motivated food consumption. However, acute food deprivation and high-fat high-sugar diet abolish the inhibitory regulation of raphe-ZIR 5-HT projections on feeding motivation and food intake.
MOLECULAR METABOLISM
(2022)
Article
Neurosciences
Nowrin Ahmed, Drew B. Headley, Denis Pare
Summary: The central medial (CMT) and paraventricular (PVT) thalamic nuclei project strongly to the basolateral amygdala (BL) and mainly contact principal BL neurons, exerting an excitatory influence. Limited feedforward inhibition counters their effects on principal cells, while indirect recruitment of interneurons via activation of principal cells generates feedback inhibition.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Anatomy & Morphology
Sa Li, Xinwen Dong, Gilbert J. Kirouac
Summary: Neurons in the paraventricular nucleus of the thalamus (PVT) respond to emotionally salient events and project densely to subcortical regions known to mediate adaptive behavioral responses, with recent tracing experiments revealing two intermixed populations of neurons that project to different subcortical regions. These neurons provide collateral innervation to a common set of forebrain regions, suggesting a potential broad regulatory role in influencing responses to physiological and psychological challenges.
BRAIN STRUCTURE & FUNCTION
(2021)
Article
Clinical Neurology
Xin-Ya Qin, Qing-Hong Shan, Hui Fang, Yu Wang, Peng Chen, Zhi-Qi Xiong, Dick F. Swaab, Jiang-Ning Zhou
Summary: The study observed an increased density of PSD-93-CRH co-localized neurons in the hypothalamic PVN of major depression patients, showing that PSD-93 regulates excitatory synaptic activity in CRH neurons leading to depression-like behaviors. PSD-93 overexpression heightened HPA axis activity, while PSD-93 knockdown alleviated depression phenotypes.
ACTA NEUROPATHOLOGICA
(2021)
Review
Behavioral Sciences
Gilbert J. Kirouac
Summary: This review discusses the anatomical connections of the paraventricular nucleus of the thalamus (PVT) in the brain anxiety network and its role in promoting anxiety-related behaviors. Experimental findings show that the PVT receives signals from the cortex and hypothalamus, and modulates defensive responses by projecting to different brain regions. The PVT also plays a key role in social avoidance in rats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Neurosciences
Qiying Ye, Jeremiah Nunez, Xiaobing Zhang
Summary: OTR-expressing PVT neurons play a significant role in regulating feeding behavior through modulation of glutamatergic synaptic transmission in the posterior basolateral amygdala (pBLA), nucleus accumbens core (NAcC), and local PVT neurons.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Di Zhao, Cuilan Liu, Minghu Cui, Jing Liu, Fantao Meng, Haifeng Lian, Dan Wang, Fengai Hu, Dunjiang Liu, Chen Li
Summary: This study reveals that PVT plays a key role in MDD, and the PVT-CeA projection regulates depression-related behaviors in a sex-dependent manner.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Neurosciences
Danielle N. Jones, Joseph M. Erwin, Chet C. Sherwood, Patrick R. Hof, Mary Ann Raghanti
Summary: The study compared neural cell density and serotonergic innervation in the amygdala among four macaque species. The results showed that pigtailed macaques had higher serotonergic innervation while Japanese macaques had higher neuron and glia densities.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Siara Kate Rouzer, Marvin R. Diaz
Summary: The study showed that age and sex have a dynamic influence on GABAergic neuronal activity in the central amygdala, and the CRFR1 agonist Stressin-1 has gender-specific effects on adult and adolescent rats. Furthermore, the CRF1R antagonist NBI 35965 only increased mIPSC frequency in the CeM of adult male rats.
Article
Anesthesiology
Zheng Xu, Yu Zhou, Qingchen Guo, Di Wang, Yi-Hong Gao, Wei -Nan Zhao, Hui-Mei Tang, Jun-Xia Yang, Xiaolu Yu, Hai -Lei Ding, Jun -Li Cao
Summary: PVNCRF neurons in the paraventricular nucleus of the hypothalamus play a role in isoflurane anesthesia and its modulation by acute stress. Inhibition of PVNCRF neurons can facilitate emergence from anesthesia, while activation of these neurons delays emergence.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Neurosciences
Yingqi Wang, Yan Pan, Zhangyin Cai, Chao Lei, Xinli Guo, Dongyang Cui, Yu Yuan, Bin Lai, Ping Zheng
Summary: This study discovered that the CeL is crucial for the conditioned context-induced retrieval of morphine-withdrawal memory, and inputs from PVT and LC contribute to the activation of CeL during this process.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Zhao-Fu Sheng, Hua Zhang, Jeffery G. Phaup, PeiRu Zheng, XunLei Kang, Zhenguo Liu, Hui-Ming Chang, Edward T. H. Yeh, Alan Kim Johnson, Hui-Lin Pan, De-Pei Li
Summary: Chronic stress is a known risk factor for the development of hypertension. In this study, it was found that the corticotropin-releasing hormone (CRH) neurons in the central nucleus of the amygdala (CeA) are involved in the autonomic responses to chronic stress. Suppressing CeA-CRH neurons can alleviate chronic stress-induced hypertension and decrease elevated sympathetic outflow. Additionally, chronic stress leads to decreased levels of Kv7.2 and Kv7.3 channels in the CeA, which contribute to the hyperactivity of CeA-CRH neurons.
CARDIOVASCULAR RESEARCH
(2023)
Article
Neurosciences
Jun-Nan Li, Kevin Chen, Patrick L. Sheets
Summary: The central nucleus of the amygdala (CeA) network is composed of a heterogeneous population of inhibitory GABAergic neurons distributed across distinct subregions. The study reveals that there are phenotypic differences between CRH+ neurons in the lateral (CeL) and medial (CeM) subdivisions of the CeA.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Jobe L. Ritchie, Jennifer L. Walters, Justine M. C. Galliou, Robert J. Christian, Shuyi Qi, Marina Savenkova, Christopher K. Ibarra, Shayna R. Grogan, Rita A. Fuchs
Summary: The study found that CRFR1 signaling in the brain region BLA is crucial for regulating the strength of cocaine memories in rats, with potential sex differences in its effects.
Article
Endocrinology & Metabolism
Jing Xu, Whitney K. McGee, Cecily V. Bishop, Byung S. Park, Judy L. Cameron, Mary B. Zelinski, Richard L. Stouffer
Article
Neurosciences
W. J. Lipski, V. J. DeStefino, S. R. Stanslaski, A. R. Antony, D. J. Crammond, J. L. Cameron, R. M. Richardson
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Developmental Biology
Danielle M. de Campo, Judy L. Cameron, Joseph M. Miano, David A. Lewis, Karoly Mirnics, Julie L. Fudge
DEVELOPMENTAL PSYCHOBIOLOGY
(2017)
Article
Obstetrics & Gynecology
Cecily V. Bishop, Fuhua Xu, Jing Xu, Alison Y. Ting, Etienne Galbreath, Whitney K. Mcgee, Mary B. Zelinski, Jon D. Hennebold, Judy L. Cameron, Richard L. Stouffer
FERTILITY AND STERILITY
(2016)
Article
Neurosciences
Judy L. Cameron, Kathie L. Eagleson, Nathan A. Fox, Takao K. Hensch, Pat Levitt
JOURNAL OF NEUROSCIENCE
(2017)
Article
Geriatrics & Gerontology
Stephen F. Smagula, Helmet T. Karim, Anusha Rangarajan, Fernando Pasquini Santos, Sossena C. Wood, Tales Santini, John M. Jakicic, Charles F. Reynolds, Judy L. Cameron, Abbe N. Vallejo, Meryl A. Butters, Caterina Rosano, Tamer S. Ibrahim, Kirk I. Erickson, Howard J. Aizenstein
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2018)
Article
Endocrinology & Metabolism
W. K. McGee, C. V. Bishop, C. R. Pohl, R. J. Chang, J. C. Marshall, F. K. Pau, R. L. Stouffer, J. L. Cameron
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2014)
Article
Zoology
G. L. Fawcett, A. M. Dettmer, D. Kay, M. Raveendran, J. D. Higley, N. D. Ryan, J. L. Cameron, J. Rogers
INTERNATIONAL JOURNAL OF PRIMATOLOGY
(2014)
Article
Neurosciences
Gregory B. Stanton, Shawn J. Kohler, Jennifer Boklweski, Judy L. Cameron, William T. Greenough
JOURNAL OF COMPARATIVE NEUROLOGY
(2015)
Article
Endocrinology & Metabolism
C. L. Bethea, A. Kim, A. P. Reddy, A. Chin, S. C. Bethea, J. L. Cameron
JOURNAL OF NEUROENDOCRINOLOGY
(2014)
Article
Obstetrics & Gynecology
Cynthia L. Bethea, Judy L. Cameron
Summary: In a cynomolgus macaque model of functional hypothalamic amenorrhoea (FHA), increased levels of hypothalamic norepinephrine (NE), kisspeptin and gonadotropin-releasing hormone (GnRH) are observed in anovulatory monkeys during stress, but can be normalized through administration of the NE reuptake inhibitor (NRI) reboxetine (REB). Daily administration of REB restored ovulation in stress-sensitive animals and reduced markers of stress in the hypothalamus, suggesting a potential novel treatment approach for FHA.
HUMAN REPRODUCTION
(2021)
Article
Psychology, Clinical
Judy L. Cameron, Karlie Brasch, Damara Strong, Barbara Paul, Erin Cavanaugh, Shreya Thakur, Mia N. Watson, Tyra Jennings, Sunil U. Nayak, Scott M. Rawls
Summary: School-based drug prevention programs aim to educate students about the physiological and addictive effects of drugs. Using nicotine-induced behaviors in planarians, this program successfully increased students' knowledge about nicotine, with a particularly significant impact on 6th grade students.
ADDICTIVE BEHAVIORS
(2021)
Article
Education & Educational Research
Tricia Shelton, Corinne Benatowicz, Pat Healy, Neal D. Ryan, Judy L. Cameron
Summary: Adolescence is a crucial period for developing decision-making skills, and schools provide an ideal environment for teaching and practicing these skills. However, finding time for this instruction can be challenging for educators. We have created a flexible curriculum that actively engages students and improves their decision-making skills. Students using this curriculum show evidence of enhanced decision-making abilities.
MIND BRAIN AND EDUCATION
(2023)
Article
Education & Educational Research
David J. Kupfer, Anneliese N. Murphree, Paul A. Pilkonis, Judy L. Cameron, Rosary T. Giang, Nathan E. Dodds, Kasey A. Godard, David A. Lewis
ACADEMIC PSYCHIATRY
(2014)
Article
Clinical Neurology
Rena A. S. Robinson, Ishan C. Williams, Judy L. Cameron, Keisha Ward, Melissa Knox, Melita Terry, Lisa Tamres, Uchenna Mbawuike, Marita Garrett, Jennifer H. Lingler
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2020)