Article
Pharmacology & Pharmacy
Dan Tian, Qing Qin, Mingfei Li, Xiaoyu Li, Qing Xu, Qianzhou Lv
Summary: This study found significantly elevated levels of EphA2, VCAM-1, and Hcy in patients with arteriosclerosis, with EphA2 knockdown leading to impaired cell adhesion and migration. Furthermore, the interaction between PGRN and EphA2 signaling pathway may play a crucial role in Hcy-induced endothelial injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Clinical Neurology
Peng Chen, Dongsheng Lin, Chen Wang, Cuiwen Song, Wenjing Wang, Jinglian Qu, Zhibing Wu
Summary: The study found that emodin may alleviate neuropathic pain by inhibiting the expression of calcium signaling pathway-related proteins in patients with neuropathic pain.
JOURNAL OF PAIN RESEARCH
(2021)
Article
Biochemical Research Methods
Huichun Shi, Siyuan Liu, Zhimi Tan, Lin Yin, Liyan Zeng, Tiefu Liu, Shuye Zhang, Lijun Zhang
Summary: This study revealed the cellular mechanisms of EV71 infection and identified the glycolysis pathway as a key player. ENO1 was identified as a potential target against EV71, and DCA could act as an inhibitor.
Article
Agriculture, Dairy & Animal Science
Muhan Zhang, Daoying Wang, Xinglian Xu, Weimin Xu, Guanghong Zhou
Summary: The study identified 301 differentially expressed proteins in duck muscles related to lipid oxidation through iTRAQ analysis and confirmed by PRM. These proteins were found to be involved in lipid binding and metabolism, lipolysis, stress response, oxidative respiratory chain, and redox regulation, potentially impacting lipid oxidation in muscles.
Article
Cell Biology
Debasis Sahu, Subasa Chandra Bishwal, Md. Zubbair Malik, Sukanya Sahu, Sandeep Rai Kaushik, Shikha Sharma, Ekta Saini, Rakesh Arya, Archana Rastogi, Sandeep Sharma, Shanta Sen, R. K. Brojen Singh, Chuan-Ju Liu, Ranjan Kumar Nanda, Amulya Kumar Panda
Summary: This study explored the antiarthritic properties of Troxerutin (TXR) using an adjuvant-induced arthritic (AIA) rat model. Proteomics analysis identified important deregulated proteins in AIA and demonstrated the efficacy of TXR in reducing arthritis score. The study suggests that TXR could be a potential therapeutic agent for arthritis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yong Zhang, Jun Liu, Jingjin Yu, Huangwei Zhang, Zhimin Yang
Summary: This study identified that the dwarf phenotype of the seashore paspalum T51 mutant is closely related to abnormal synthesis of lignin and flavonoids in the phenylpropane pathway through transcriptomic and proteomic analysis. CCR and HCT may serve as key genes for the dwarfing of T51.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tongtong Wang, Ling Liu, Jun Deng, Yu Jiang, Xiao Yan, Wen Liu
Summary: This study aimed to investigate the role of quercetin in the development of hyperlipidemia (HLP) and its underlying mechanisms using gut microbiome and plasma metabolomics analysis. The results showed that quercetin could regulate dyslipidemia, improve liver function, and alter the composition of intestinal flora in HLP rats. These findings suggest that quercetin may reduce lipid levels and improve HLP through its effects on metabolism and intestinal flora.
Article
Biology
Wucheng Tao, Joel Lee, Xiumin Chen, Javier Diaz-Alonso, Jing Zhou, Samuel Pleasure, Roger A. Nicoll
Summary: The study found that Ca2+-calmodulin-dependent kinase II (CaMKII) contributes to synaptic transmission and is essential for the maintenance of long-term potentiation (LTP). Acute inhibition of CaMKII erases LTP, while transient inhibition enhances subsequent LTP, strongly supporting the role of CaMKII as a molecular storage device.
Article
Agronomy
Xin Zhang, Yan Feng, Aziz Khan, Najeeb Ullah, Zengqiang Li, Saira Zaheer, Ruiyang Zhou, Zhiyong Zhang
Summary: Proteome analysis of grafted cotton exposed to low-temperature stress provides insights into the molecular mechanisms of chilling tolerance in plants. This study found that under low-temperature stress, cotton seedlings exhibited enhanced responses in MAPK and calcium signaling pathways, intensified metabolism of carbohydrates, lipids, nucleotides, and amino acids, as well as activation of proteins involved in protein folding and degradation and the antioxidant system. Grafting onto a vigorous rootstock improved the ability of plants to resist chilling stress.
Article
Nutrition & Dietetics
Kexin Zhang, Yanyan Liu, Lingyun Liu, Baoling Bai, Lin Shi, Qin Zhang
Summary: This study analyzed plasma metabolomics characteristics to explore the potential mechanism of hypertension in children. The results showed that children with hypertension had obvious disorders of lipid metabolism, especially in the overweight hypertension group, which led to the occurrence of hypertension. Additionally, the concentration of NO production-related NG,NG-dimethyl-L-arginine was significantly increased, which may play an important role in H-type hypertension in children.
Article
Biochemical Research Methods
Weimin Ni, William Jagust, Daojing Wang
Summary: Direct analysis of amyloid proteins in human plasma can facilitate rapid screening for the earliest pathological signature of Alzheimer's disease. A developed microflow liquid chromatography-targeted mass spectrometry assay showed 90% accuracy in predicting brain amyloid using plasma A beta 42/A beta 40 values from 36 cognitively normal individuals, potentially contributing to early diagnosis of Alzheimer's disease.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Gang Luo, Lu Xiang, Lin Xiao
Summary: The study found that a low-iron diet helps improve atherosclerosis by reducing aortic lesions and inflammation in mice. At the protein level, a low-iron diet can alter the expression of proteins involved in atherosclerotic inflammation, vascular remodeling, and adhesion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Qing Zhang, Jing Wang, Liang Zhu, Shi-jie Jiang, Juan Liu, Lin-xiao Wang, Xi-hu Qin
Summary: Ligustrazine, extracted from traditional Chinese herb, shows promise in treating cerebrovascular diseases, particularly in attenuating AD-like pathologies induced by hyperhomocysteinemia.
CURRENT MEDICAL SCIENCE
(2021)
Article
Agriculture, Multidisciplinary
Xue Luo, Mo Li, Henan Zhang, Danli Yan, Shuaiqi Ji, Rina Wu, Yongfu Chen
Summary: Proteomics and bioinformatics analysis of three strains of Lactobacillus plantarum under salt stress revealed differential expression of proteins related to protein biosynthesis, nucleotide metabolism, and sugar metabolism. Specific differentially expressed proteins were found between the strains in response to high salt conditions.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Genetics & Heredity
Nana Liu, Jiayuan Xu, Huaigui Liu, Shijie Zhang, Miaoxin Li, Yao Zhou, Wen Qin, Mulin Jun Li, Chunshui Yu
Summary: The study identifies 24 genes associated with Alzheimer's disease (AD) in hippocampal tissue and shows these genes are related to AD-related biological processes. It also demonstrates that hippocampal volume mediates the effects of hippocampal gene expression of QPCTL and ERCC2 on AD. These findings contribute to a better understanding of the genetic and neural mechanisms of AD.
