期刊
MOLECULAR MEDICINE REPORTS
卷 10, 期 6, 页码 3169-3176出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/mmr.2014.2630
关键词
Sox2; paclitaxel; drug resistance; prostate cancer; phosphoinositide 3-kinase/Akt pathway
资金
- National Youth Natural Science Foundation of China [81101942]
- Natural Science Foundation of Education Department, Heilongjiang, China [12531300]
Prostate cancer is the most commonly diagnosed type of cancer and the second leading cause of cancer-associated mortality in males. The efficacy of prostate cancer chemotherapy is frequently impaired by drug resistance; however, the underlying mechanisms of this resistance remain elusive. Sex determining region Y-box 2 (Sox2) is of vital importance in the regulation of stem cell proliferation and carcinogenesis. In the present study, using MTT, clone formation, cell cycle and apoptosis assays, over-expression of Sox2 was demonstrated to enhance the paclitaxel (Pac) resistance of the PC-3 prostate cancer cell line, promoting cell proliferation and exhibiting an anti-apoptotic effect. Western blot analysis revealed that the phosphoinositide 3-kinase/Akt signaling pathway was activated in cells overexpressing Sox2, and by targeting cyclin E and survivin, Sox2 promoted G1/S phase transition and prevented apoptosis under Pac treatment. The present study provided an understanding of Pac resistance in prostate cancer and may indicate novel therapeutic methods for chemoresistant prostate cancer.
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