Article
Oncology
Xiong Du, Yanxin Li, Bin Lian, Xiangli Yin
Summary: This study investigated the influence of microRNA-128-3p (miR-128-3p) on gastric cancer (GC) cells by regulating Tuftelin1 (TUFT1). It was found that miR-128-3p expression was low and TUFT1 expression was high in GC tissues. miR-128-3p can inhibit GC cell activities by repressing TUFT1 expression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Xinhui Fang, Yangqiu Bai, Lida Zhang, Songze Ding
Summary: The study confirmed the upregulation of CDH3 in GC, which promoted cell proliferation and adhesion but reduced apoptosis levels. In contrast, the miR-665 inhibitor had the opposite effect. The findings indicated that miR-665 targeted CDH3 to suppress the progression of GC.
Article
Genetics & Heredity
Dan Hong, Aimin Zang, Zhiyu Wang, Lin Yang, Guanying Ren, Chong Zhang, Liwei Zhang, Wei Hou, Yaning Wei
Summary: MicroRNA-365 plays a crucial role in the regulation of tumorigenesis in gastric cancer (GC) by inhibiting PAX6.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2022)
Article
Medicine, General & Internal
Min Wei, Hongjuan Jin, ShuLi Yang, Zhuo Li, Xinlei Wang, LiXiang Li, Yan Jia, ManHua Cui
Summary: The research demonstrated that miRNA-101 is down-regulated in ovarian cancer cells and its over-expression can suppress the growth of ovarian cancer cells by inducing apoptosis and cell cycle arrest, potentially through regulating molecules like PTEN, PI3K, and AKT.
ARCHIVES OF MEDICAL SCIENCE
(2021)
Review
Cell Biology
Boya Peng, Poh Ying Theng, Minh T. N. Le
Summary: miR-125b, a key miRNA in cancer pathogenesis, is deregulated in various types of cancer and plays important roles in tumourigenesis and cancer progression. Its potential as a diagnostic and prognostic biomarker, as well as a therapeutic tool against cancer, is supported by emerging evidence on its essential functions.
CELL PROLIFERATION
(2021)
Article
Oncology
Yaying Chen, Miaomiao Pei, Jiaying Li, Zhi Wang, Side Liu, Li Xiang, Jieming Zhang, Linjie Hong, Jianjiao Lin, Weiyu Dai, Yizhi Xiao, Hongsong Hu, Weimei Tang, Guangnan Liu, Qiong Yang, Zhizhao Lin, Xiaoling Jiang, Yusi Wang, Xiaosheng Wu, Zheng Guo, Jide Wang
Summary: This study investigates the interplay between CCDC43 and FHL1 in gastric cancer cell growth and apoptosis. The results demonstrate that CCDC43 physically interacts with FHL1 and their expression levels are negatively correlated. Moreover, up-regulation of CCDC43 leads to a decrease in FHL1 levels, while knockdown of CCDC43 results in decreased stability of FHL1 protein. Importantly, co-expression of CCDC43 and FHL1 significantly inhibits the growth, metastasis, and invasion of gastric cancer cells, and knockdown of CCDC43 combined with overexpression of FHL1 inhibits cell proliferation and migration, and induces apoptosis in vitro and in vivo.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Lan Zhang, Fanglin Liu, Zhixing Meng, Qingyue Luo, Daojing Pan, Yihua Qian
Summary: The study revealed that HDAC3 and WNT2b were up-regulated in gastric cancer tissues and cells, while miR-376c-3p was reduced. Inhibiting HDAC3 or elevating miR-376c-3p could restrain malignant behaviors of GC cells. WNT2b plays a crucial role in GC cell growth under the regulation of miR-376c-3p.
Article
Biotechnology & Applied Microbiology
Zhiqing Cheng, Limei Gong, Qinghe Cai
Summary: This study found that LINC00978 is upregulated in HCC and is associated with poor prognosis. Silencing LINC00978 can inhibit the growth and metastasis of HCC cells. Mechanistically, LINC00978 functions as a sponge for miR-125b-5p and regulates the expression of SOX12, promoting liver cancer migration, invasion, and proliferation.
Article
Oncology
Lei He, Xiaohan Qian, Pingping Ge, Dong Fan, Xiang Ma, Qiong Wu, Jin Sun, Lihua Yang, Jian Shen, Lijian Xu
Summary: NOL6 knockdown inhibits cell proliferation and induces cell apoptosis of gastric cancer, suggesting NOL6 may serve as a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xiaojie Wang, Yarui Dai, Yina Zhao, Meichuan Li, Jialu Zhang, Yunzhe Ci, Huan Wang, Xin Li
Summary: This study aimed to explore the influence of AnnexinA5 on human gastric cancer cells and its potential as an auxiliary treatment for gastric cancer. The findings indicated that when the ANXA5 gene was knocked down, cell proliferation and metastasis were promoted, while cell apoptosis was suppressed; conversely, when AnnexinA5 protein was added to gastric cancer cells, cell proliferation and metastasis were inhibited, while cell apoptosis and necrosis was promoted.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lee Lee Wong, Azizah Binti Fadzil, Qiying Chen, Miriam T. Rademaker, Christopher J. Charles, Arthur Mark Richards, Peipei Wang
Summary: MiR-125b and its 3' isomiRs have therapeutic potential in the treatment of myocardial ischemic injury. The addition or deletion of nucleotide A in isomiRs has a protective effect against hypoxia, while other isomiRs have weaker effects. Understanding the metabolism and function of isomiRs will contribute to the design of better miRNA therapeutic drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Xu Liu, Qiaoyu Zheng, Qiongfang Yu, Yan Hu, Yanmin Cheng, Zhaozhao Shao, Li Chen, Wenjie Ding, Dian Gao
Summary: The study demonstrates that Apatinib inhibits the proliferation of GC cells by promoting apoptosis and autophagy, altering cell cycle distribution, and inhibiting invasion and migration capacities of GC cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Weixin Li, Lixia Mu, Yuxiao Zou, Weifei Wang, Haifeng Zhao, Xuli Wu, Sentai Liao
Summary: The study found that the hydrolysates from silkworm pupa proteins could inhibit the proliferation of MGC-803 gastric cancer cells, possibly by activating apoptosis.
Article
Biochemistry & Molecular Biology
Ming Song, Jun Liu, Xin Zheng, Xin Zhou, Zehui Feng, Wei Hu
Summary: The study found that the expression of CEMIP was significantly elevated while miR-148a-3p level was downregulated in gastric cancer tissues and cell lines. miR-148a-3p suppressed the development of gastric cancer by inhibiting the expression of CEMIP.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Tian Li, Dong Guo, Xiaoyan Xu, Peng Liu, Ping Wang, Yongcun Zhu, Lin Lin, Yemin Qu, Feng Liu, Yanliu Chu, Xiaozhong Gao
Summary: MicroRNA-153 (miR-153), a novel tumor-related miRNA, is aberrantly expressed in gastric cancer (GC). The study showed that miR-153 expression is significantly decreased in GC cells, tissues, and serum samples. Transfection with miR-153 mimics inhibits GC cell proliferation and migration, while promoting apoptosis. The serum expression levels of miR-153 are lower in patients with larger tumor size, poor differentiation, lymph node metastasis, and advanced tumor stage. These findings suggest that miR-153 may serve as a potential tumor biomarker and therapeutic target in GC.
