Multiple e-Pharmacophore Modeling Combined with High-Throughput Virtual Screening and Docking to Identify Potential Inhibitors of β-Secretase(BACE1)

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Identification of BACE2 as an avid ß-amyloid-degrading protease

(2012) Samer O Abdul-Hay et al.   Molecular Neurodegeneration

The Membrane-Bound Aspartyl Protease BACE1: Molecular and Functional Properties in Alzheimer’s Disease and Beyond

(2012) Bastian Dislich et al.   Frontiers in Physiology

Flexibility of the flap in the active site of BACE1 as revealed by crystal structures and molecular dynamics simulations

(2011) Yechun Xu et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Developing β-secretase inhibitors for treatment of Alzheimer’s disease

(2011) Arun K. Ghosh et al.   JOURNAL OF NEUROCHEMISTRY

Identification and biology of β-secretase

(2011) Patty C. Kandalepas et al.   JOURNAL OF NEUROCHEMISTRY

The β-secretase enzyme BACE1 as a therapeutic target for Alzheimer's disease

(2011) Robert Vassar et al.   Alzheimers Research & Therapy

Multiple Pharmacophore Models Combined with Molecular Docking: A Reliable Way for Efficiently Identifying Novel PDE4 Inhibitors with High Structural Diversity

(2010) Zhi Chen et al.   Journal of Chemical Information and Modeling

Novel Method for Generating Structure-Based Pharmacophores Using Energetic Analysis

(2009) Noeris K. Salam et al.   Journal of Chemical Information and Modeling

BACE1 and BACE2 enzymatic activities in Alzheimer’s disease

(2009) Rachel R. Ahmed et al.   JOURNAL OF NEUROCHEMISTRY

The  -Secretase Enzyme BACE in Health and Alzheimer's Disease: Regulation, Cell Biology, Function, and Therapeutic Potential

(2009) R. Vassar et al.   JOURNAL OF NEUROSCIENCE

Beta-Secretase: Structure, Function, and Evolution

(2008) Chitra Venugopal et al.   CNS & Neurological Disorders-Drug Targets

Memapsin 2 (Beta-Secretase) Inhibitors: Drug Development

(2008) Arun Ghosh et al.   Current Alzheimer Research

β-Secretase as a therapeutic target for Alzheimer’s disease

(2008) Arun K. Ghosh et al.   Neurotherapeutics