Article
Urology & Nephrology
Georg R. Herrnstadt, Christoph B. Niehus, Torben Ramcke, Julia Hagenstein, Laura-Isabell Ehnold, Anna Nosko, Matthias T. Warkotsch, Frederic C. Feindt, Simon Melderis, Hans-Joachim Paust, Varshi Sivayoganathan, Saskia-Larissa Jauch-Speer, Milagros N. Wong, Daniela Indenbirken, Christian F. Krebs, Tobias B. Huber, Ulf Panzer, Victor G. Puelles, Malte A. Kluger, Oliver M. Steinmetz
Summary: Previous studies have identified a unique Treg population, known as RORyt+ Tregs, which possess enhanced immunosuppressive capacity and therapeutic potential. However, they are also capable of secreting pro-inflammatory IL-17A. This study investigated the absence of RORyt+ Tregs in glomerulonephritis (GN) and found that their absence significantly aggravated kidney injury, demonstrating their overall kidney-protective properties. Analyses showed that RORyt+ Tregs were broadly immunosuppressive, and their absence had a negative impact on GN.
KIDNEY INTERNATIONAL
(2023)
Article
Dermatology
L. Wang, M. Yang, X. Wang, B. Cheng, Q. Ju, D. Z. Eichenfield, B. K. Sun
Summary: The study showed that glucocorticoids can increase CCL20 expression in human keratinocytes and murine skin by directly binding to the enhancer region of CCL20. This mechanism may contribute to the inflammation observed in steroid-exacerbated skin conditions.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Kamila Baran, Jacek Kordiak, Slawomir Jablonski, Ewa Brzezianska-Lasota
Summary: This study evaluated the expression levels of CCR6/CCL20 mRNA and non-coding RNAs (ncRNAs) such as miR-150 and linc00673 in NSCLC tissue. It was found that CCL20 mRNA was upregulated while CCR6 mRNA was downregulated in tumor tissue. In addition, the expression levels of miR-150 and linc00673 in serum extracellular vesicles showed associations with tumor staging and histopathological type.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Bomi Lee, Hong Namkoong, Yan Yang, Huang Huang, David Heller, Gregory L. Szot, Mark M. Davis, Sohail Z. Husain, Stephen J. Pandol, Melena D. Bellin, Aida Habtezion
Summary: Single-cell sequencing of pancreatic immune cells in human CP revealed distinct immune characteristics, with significantly enriched CCR6(+) CD4(+) T cells in hereditary CP. This study also showed a reduction in T-cell clonality in hereditary CP due to an increase in CD4(+) T cells. Furthermore, an upregulation of CCR6 ligand (CCL20) expression was observed among monocytes in hereditary CP.
Article
Oncology
Hiroshi Kano, Kouji Izumi, Kaoru Hiratsuka, Ren Toriumi, Ryunosuke Nakagawa, Shuhei Aoyama, Taiki Kamijima, Takafumi Shimada, Renato Naito, Suguru Kadomoto, Hiroaki Iwamoto, Hiroshi Yaegashi, Shohei Kawaguchi, Takahiro Nohara, Kazuyoshi Shigehara, Yoshifumi Kadono, Yohei Saito, Kyoko Nakagawa-Goto, Kazuaki Yoshioka, Hiroki Nakata, Wen-Jye Lin, Atsushi Mizokami
Summary: This study identified a regulation of the androgen receptor (AR)-controlled pathway that promotes migration potential in prostate cancer cells. The increase in migration potential was associated with upregulated CCL20 expression and enhanced AKT phosphorylation and Snail expression.
Article
Biochemistry & Molecular Biology
Tao Xie, Du-Jiang Fu, Zhi-Min Li, Dao-Jun Lv, Xian-Lu Song, Yu-Zhong Yu, Chong Wang, Kang-Jin Li, Baoqian Zhai, Jiacheng Wu, Ning-Han Feng, Shan-Chao Zhao
Summary: This study reveals that circSMARCC1 upregulates the secretion of chemokine CCL20 by sponging miR-1322, which mediates the interaction between tumor cells and TAMs, promoting the progression of PCa.
Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Gastroenterology & Hepatology
David N. Hanna, Paula Marincola Smith, Sergey V. Novitskiy, M. Kay Washington, Jinghuan Zi, Connie J. Weaver, Jalal A. Hamaamen, Keeli B. Lewis, Jing Zhu, Jing Yang, Qi Liu, R. Daniel Beauchamp, Anna L. Means
Summary: Loss of SMAD4 in colonic epithelial cells can increase CCL20 expression and recruitment of CCR6+ immune cells, leading to a greater susceptibility to colon cancer.
Review
Immunology
Heikrujam Thoihen Meitei, Nandadeep Jadhav, Girdhari Lal
Summary: CCR6 and CCL20 play crucial roles in cell migration and inflammatory conditions, with strong associations found between their expression and disease severity in various autoimmune disorders. Targeting the CCR6-CCL20 axis shows promise in controlling autoimmune diseases by preventing immune cell migration and reducing inflammation.
AUTOIMMUNITY REVIEWS
(2021)
Article
Oncology
Watchara Sakares, Wannaporn Wongkhattiya, Ponlawat Vichayachaipat, Chompunoot Chaiwut, Varalee Yodsurang, Pattiya Nutthachote
Summary: This study aimed to investigate the potential of chemokines as biomarkers for differential diagnosis between benign tumors and ovarian cancer. CCL20 was found to be a potential biomarker for diagnosing early-stage OC with endometriosis differentiation. Further studies are recommended to confirm the accuracy of CCL20 levels in a large patient sample.
FRONTIERS IN ONCOLOGY
(2022)
Article
Rheumatology
Zhenrui Shi, Emma Garcia-Melchor, Xuesong Wu, Anthony E. Getschman, Mimi Nguyen, Douglas J. Rowland, Machelle Wilson, Flavia Sunzini, Moeed Akbar, Mindy Huynh, Timothy Law, Smriti K. Raychaudhuri, Siba P. Raychaudhuri, Brian F. Volkman, Neal L. Millar, Sam T. Hwang
Summary: The study reveals the pathogenic role of the CCR6/CCL20 axis in enthesitis associated with psoriatic arthritis and psoriasis. Targeting CCL20 expression can alleviate inflammation, presenting a potential novel therapeutic approach for patients with PsO and PsA.
ARTHRITIS & RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mitsuru Jimbo, Mayumi Otake, Haruna Amano, Ko Yasumoto, Shugo Watabe, Daisuke Okada, Hiroshi Kumagai
Summary: In this study, Akane1 and Akane3 from Scleronephthya gracillima were successfully overexpressed in Escherichia coli and their fluorescence spectra were found to have multiple peaks. It was observed that the matured Akanes under ambient light had two fragments, and Akane3 was modified in the N-terminal region. Additionally, both Akane1 and Akane3 showed photoconversion, but the fluorescent intensity of Akane1 decreased significantly compared to that of Akane3.
JOURNAL OF BIOCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Michelle Fennen, Toni Weinhage, Vanessa Kracke, Johanna Intemann, Georg Varga, Corinna Wehmeyer, Dirk Foell, Adelheid Korb-Pap, Thomas Pap, Berno Dankbar
Summary: The study demonstrated the involvement of myostatin in regulating joint inflammation by recruiting Th17 cells to inflammatory sites. Blockade of the CCL20-CCR6 axis by inhibiting myostatin could be a promising treatment option for chronic inflammatory diseases such as arthritis.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Eun Jeong Won, Hui-Ju Kim, Yu Jeong Lee, Moon-Ju Kim, Hae-In Lee, Hyun Hee Jang, Seong Hoon Kim, Ji-Hyoun Kang, Ki-Jeong Park, Seung Cheol Shim, Sungsin Jo, Tae-Hwan Kim, Tae-Jong Kim
Summary: This study aims to examine the effectiveness of CCL20 inhibition in treating inflammation in AS. The results show that CCL20 affects the migration of Th17 cells and that the CCL20 inhibitor can reduce joint inflammation in AS patients. Therefore, targeting CCL20 inhibition could be a novel therapeutic approach for AS treatment.
Article
Immunology
Chenchen Ye, Xinxue Guo, Jiani Wu, Minhua Wang, Haiyan Ding, Xianzhi Ren
Summary: Activation and polarization of macrophages mediated by CCL20/CCR6 may promote adenoid epithelial inflammation in adenoid hypertrophy. The CCL20/CCR6 axis could be a critical therapeutic target for treatment.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Virology
Danica Ciric, Charles-Adrien Richard, Mohammed Moudjou, Jerome Chapuis, Pierre Sibille, Nathalie Daude, David Westaway, Miguel Adrover, Vincent Beringue, Davy Martin, Human Rezaei
JOURNAL OF VIROLOGY
(2015)
Article
Immunology
Thien-Phong Vu Manh, Jamila Elhmouzi-Younes, Celine Urien, Suzana Ruscanu, Luc Jouneau, Mickael Bourge, Marco Moroldo, Gilles Foucras, Henri Salmon, Helene Marty, Pascale Quere, Nicolas Bertho, Pierre Boudinot, Marc Dalod, Isabelle Schwartz-Cornil
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
Mohammed Moudjou, Jerome Chapuis, Meriem Mekrouti, Fabienne Reine, Laetitia Herzog, Pierre Sibille, Hubert Laude, Didier Vilette, Olivier Andreoletti, Human Rezaei, Michel Dron, Vincent Beringue
SCIENTIFIC REPORTS
(2016)
Article
Parasitology
Francoise I. Bussiere, Alisson Niepceron, Alix Sausset, Evelyne Esnault, Anne Silvestre, Robert A. Walker, Nicholas C. Smith, Pascale Quere, Fabrice Laurent
PARASITES & VECTORS
(2018)
Article
Virology
Adrien Lion, Mathilde Richard, Evelyne Esnault, Emmanuel Kut, Denis Soubieux, Vanaique Guillory, Melody Germond, Caroline Blondeau, Rodrigo Guabiraba, Kirsty R. Short, Daniel Marc, Pascale Quere, Sascha Trapp
Article
Virology
Sascha Trapp, Denis Soubieux, Alexandra Lidove, Evelyne Esnault, Adrien Lion, Vanaique Guillory, Alan Wacquiez, Emmanuel Kut, Pascale Quere, Thibaut Larcher, Mireille Ledevin, Virginie Nadan, Christelle Camus-Bouclainville, Daniel Marc
Article
Multidisciplinary Sciences
Anne-Kathrin Sauer, Chi-Hui Liang, Juergen Stech, Ben Peeters, Pascale Quere, Christel Schwegmann-Wessels, Chung-Yi Wu, Chi-Huey Wong, Georg Herrler
Article
Multidisciplinary Sciences
Coralie Chaise, Anne-Christine Lalmanach, Helene Marty, Sebastien Mathieu Soubies, Guillaume Croville, Josyane Loupias, Daniel Marc, Pascale Quere, Jean-Luc Guerin
Article
Multidisciplinary Sciences
Lea Meyer, Olivier Leymarie, Christophe Chevalier, Evelyne Esnault, Marco Moroldo, Bruno Da Costal, Sonia Georgeault, Philippe Roingeard', Bernard Delmasl, Pascale Quere, Ronan Le Goffic
Article
Veterinary Sciences
Adrien Lion, Evelyne Esnault, Emmanuel Kut, Vanaique Guillory, Laetitia Trapp-Fragnet, Sebastien M. Soubies, Nathalie Chanteloup, Alisson Niepceron, Rodrigo Guabiraba, Daniel Marc, Nicolas Eterradossi, Sascha Trapp, Pascale Quere
Article
Microbiology
Raissa L. Davis, Geunho Choi, Thijs Kuiken, Pascale Quere, Sascha Trapp, Kirsty R. Short, Mathilde Richard
Article
Immunology
Noelle Mol, Lianci Peng, Evelyne Esnault, Pascale Quere, Henk P. Haagsman, Edwin J. A. Veldhuizen
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY
(2019)
Article
Multidisciplinary Sciences
Iman Al-Dybiat, Mohammed Moudjou, Davy Martin, Fabienne Reine, Laetitia Herzog, Sandrine Truchet, Patricia Berthon, Hubert Laude, Human Rezaei, Olivier Andreoletti, Vincent Beringue, Pierre Sibille
SCIENTIFIC REPORTS
(2019)
Review
Microbiology
Angelique Igel-Egalon, Vincent Beringue, Human Rezaei, Pierre Sibille
Article
Veterinary Sciences
Damien Garrido, Nathalie K. Chanteloup, Angelina Trotereau, Adrien Lion, Geoffrey Bailleul, Evelyne Esnault, Sascha Trapp, Pascale Quere, Catherine Schouler, Rodrigo Guabiraba
FRONTIERS IN VETERINARY SCIENCE
(2017)