Article
Biology
Yali Shan, Shiping Shen, Jing Long, Zhengshan Tang, Cichun Wu, Xin Ni
Summary: The study reveals that there is an increase in inflammatory response, particularly from macrophages, during term and preterm labor. This inflammation plays a critical role in the initiation of parturition.
Article
Immunology
Lina Chen, Lele Wang, Yihong Luo, Qian Huang, Kaiyuan Ji, Junjie Bao, Huishu Liu
Summary: This study utilized RNA sequencing and mass spectrometry to uncover that inflammation and hypoxia play a role in differentially expressed proteins and mRNA in the myometrium during labor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Obstetrics & Gynecology
Oksana Shynlova, Lubna Nadeem, Anna Dorogin, Sam Mesiano, Stephen J. Lye
Summary: This study demonstrates that the selective progesterone receptor modulator, promegestone, can effectively prevent term labor and bacterial endotoxin-induced preterm birth in mice.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Anesthesiology
Asha Tyagi, Aparna Mohan, Yuvraj Singh, Ankit Luthra, Devansh Garg, Rajeev Kumar Malhotra
Summary: Patients with preeclampsia require a higher dose of oxytocin to achieve satisfactory uterine contraction during cesarean delivery, especially in those receiving preoperative magnesium therapy, compared to normotensive patients.
ANESTHESIA AND ANALGESIA
(2022)
Article
Obstetrics & Gynecology
Jason Phung, Carol Wang, Jocelyn Reeders, Tamas Zakar, Jonathan W. Paul, Sonika Tyagi, Craig E. Pennell, Roger Smith
Summary: This study aimed to comprehensively determine the protein-coding transcriptomic differences between preterm nonlaboring and preterm laboring myometria with and without chorioamnionitis. The results showed that myometria from preterm patients in labor without chorioamnionitis and preterm patients not in labor were transcriptionally similar, while the presence of chorioamnionitis was associated with marked gene changes. Comprehensive bioinformatic analysis indicated that preterm labor with or without chorioamnionitis was associated with innate immune activation.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Multidisciplinary Sciences
Mary C. Peavey, San-Pin Wu, Rong Li, Jian Liu, Olivia M. Emery, Tianyuan Wang, Lecong Zhou, Margeaux Wetendorf, Chandra Yallampalli, William E. Gibbons, John P. Lydon, Francesco J. DeMayo
Summary: The study revealed that overexpression of progesterone receptor PGR-B leads to relaxation of uterine muscles, prolonged gestational length, and increased incidence of labor dystocia, while overexpression of PGR-A increases uterine muscle contraction without affecting gestational length.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Reproductive Biology
Nardhy Gomez-Lopez, Roberto Romero, Jose Galaz, Gaurav Bhatti, Bogdan Done, Derek Miller, Corina Ghita, Kenichiro Motomura, Marcelo Farias-Jofre, Eunjung Jung, Roger Pique-Regi, Sonia S. Hassan, Tinnakorn Chaiworapongsa, Adi L. Tarca
Summary: By analyzing the transcriptomic data, it was found that women undergoing term labor exhibit labor-specific gene expression changes in their peripheral blood, which correlate with gene changes in the chorioamniotic membranes, myometrium, and cervix, partially overlapping with changes observed in asymptomatic women prior to preterm birth, potentially serving as a tool for assessing labor status and identifying preterm birth risk.
BIOLOGY OF REPRODUCTION
(2022)
Article
Pharmacology & Pharmacy
Chaolu Chen, Shuaiying Zhu, Long Bai, Meihua Sui, Danqing Chen
Summary: This study analyzed the myometrial transcriptome during parturition and found that the onset of labor was associated with an inflammatory response. Hub genes, including FPR1, were identified as being associated with the onset of labor, with FPR1 playing a novel role as a modulator of myometrial contraction.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Endocrinology & Metabolism
Melissa L. Kozakiewicz, Chad A. Grotegut, Allyn C. Howlett
Summary: The endocannabinoid system plays a crucial role in early pregnancy success, embryo development, and parturition, influencing uterine activation and maternal-fetal interaction, regulating pregnancy maintenance and timing of labor.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Jason Phung, Carol A. Wang, Jocelyn Reeders, Eng-Cheng Chan, Carlos Riveros, Tamas Zakar, Jonathan W. Paul, Craig E. Pennell, Roger Smith
Summary: The study found that gene expression patterns in preterm uterine contractions are different from term labor, suggesting preterm labor may have different initiation processes compared to term labor.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Multidisciplinary Sciences
Bridget M. Arman, Natalie K. Binder, Natasha de Alwis, Sally Beard, Danielle A. Debruin, Alan Hayes, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino, Natalie J. Hannan
Summary: Spontaneous preterm birth is a major problem causing perinatal mortality and morbidity. Nifedipine, a calcium channel blocker, is used to delay threatened preterm birth, but its efficacy and mechanisms of action are unclear. Our study shows that while nifedipine effectively prevents contractions in vitro and ex vivo, it does not modulate inflammation. These findings suggest that nifedipine's limited clinical efficacy may be due to its inability to target inflammatory pathways in the myometrium.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Tsuyoshi Murata, Hirotaka Isogami, Karin Imaizumi, Toma Fukuda, Hyo Kyozuka, Shun Yasuda, Akiko Yamaguchi, Akiko Sato, Yuka Ogata, Kosei Shinoki, Mitsuaki Hosoya, Seiji Yasumura, Koichi Hashimoto, Hidekazu Nishigori, Keiya Fujimori
Summary: We conducted a study using a nationwide birth cohort to assess the relationship between gestational age at threatened preterm birth (TPTB) diagnosis and the incidence of preterm birth (PTB). We analyzed data from 94,236 women with singleton deliveries enrolled in the Japan Environment and Children's Study. The results showed that the association between gestational age at TPTB diagnosis and PTB incidence varied based on maternal parity and PTB before 37 or 34 weeks. Further studies with detailed clinical data and a unified TPTB diagnosis protocol are needed to clarify this association.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Ying Zha, Haiyi Liu, Xingguang Lin, Long Yu, Peng Gao, Yuqi Li, Min Wu, Xun Gong, Xinyi Bian, Qi Kang, Pan Zhi, Xiaohe Dang, Jingyu Wang, Ling Feng, Fuyuan Qiao, Yafei Huang, Wanjiang Zeng
Summary: This study explores the immune features in the decidua during term and preterm labor, finding that an imbalance between M1 and M2 macrophages is associated with breakdown of maternal-fetal immune tolerance in preterm birth, while aberrant Th1/Th2 profile plays a role in immune disorder during term labor. Additionally, the Th17/Treg deviation is more significant in the decidua basalis than in the decidua parietalis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Andrea M. Weckman, Robyn E. Elphinstone, John M. Ssenkusu, Vanessa Tran, Kathleen Zhong, Mwayiwawo Madanitsa, Carole Khairallah, Linda Kalilani-Phiri, Victor Mwapasa, Andrea L. Conroy, Feiko O. Ter Kuile, Chloe R. McDonald, Kevin C. Kain
Summary: Preterm birth is a leading cause of death in children under five. Sequential disruptions to inflammatory and angiogenic pathways during pregnancy increase the risk of placental insufficiency and preterm labor. Study findings suggest a potential causal link between early inflammation, subsequent angiogenic dysregulation, and preterm birth, highlighting the importance of interventions before 24 weeks gestation.
Article
Microbiology
Marvin Williams, Alyssa B. Jones, Amanda L. Maxedon, Jennifer E. Tabakh, Cindy B. McCloskey, David E. Bard, Daniel P. Heruth, Susana Chavez-Bueno
Summary: This study investigated the colonization rate of E. coli strains in the cervix of fifty pregnant women with preterm labor, revealing that a minority of women were colonized with E. coli and the colonizing strains were not representative of those causing invasive disease in newborns. Further larger studies are needed to explore the molecular characteristics of E. coli strains colonizing pregnant women that may increase the risk of neonatal septicemia.
Article
Obstetrics & Gynecology
Fergus P. McCarthy, Adedamola Adetoba, Carolyn Gill, Kate Bramham, Maria Bertolaccini, Graham J. Burton, Guillermina Girardi, Paul T. Seed, Lucilla Poston, Lucy C. Chappell
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2016)
Review
Immunology
Maria Laura Bertolaccini, Gregorio Contento, Ross Lennen, Giovanni Sanna, Philip J. Blower, Michelle T. Ma, Kavitha Sunassee, Guillermina Girardi
JOURNAL OF AUTOIMMUNITY
(2016)
Article
Medicine, Research & Experimental
Eleftheria Lefkou, Apostolos Mamopoulos, Themistoklis Dagklis, Christos Vosnakis, David Rousso, Guillermina Girardi
JOURNAL OF CLINICAL INVESTIGATION
(2016)
Article
Obstetrics & Gynecology
Rozalia Pataky, Forbes A. Howie, Guillermina Girardi, James P. Boardman
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2017)
Article
Immunology
Guillermina Girardi
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Pathology
Juan M. Gonzalez, Claus-Werner Franzke, Fengyuan Yang, Roberto Romero, Guillermina Girardi
AMERICAN JOURNAL OF PATHOLOGY
(2011)
Article
Biochemistry & Molecular Biology
Silvia M. A. Pedroni, Juan M. Gonzalez, Jean Wade, Maurits A. Jansen, Andrea Serio, Ian Marshall, Ross J. Lennen, Guillermina Girardi
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2014)
Letter
Peripheral Vascular Disease
Eleftheria Lefkou, Apostolos Mamopoulos, Nikolaos Fragakis
Article
Immunology
Juan M. Gonzalez, Roberto Romero, Guillermina Girardi
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2013)
Article
Immunology
Guillermina Girardi
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2014)
Article
Biochemistry & Molecular Biology
G. Girardi, J. Fraser, R. Lennen, R. Vontell, M. Jansen, G. Hutchison
MOLECULAR PSYCHIATRY
(2015)
Article
Multidisciplinary Sciences
Silvia M. A. Pedroni, Sophie Turban, Tiina Kipari, Donald R. Dunbar, Kerry McInnes, Philippa T. K. Saunders, Nicholas M. Morton, Jane E. Norman