Journal
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
Volume 30, Issue 20, Pages 2413-2416Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14767058.2016.1251896
Keywords
Preterm infant; brain; neuroinflammation; complement system; C5a
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Funding
- Theirworld
- MRC Centre grant [MRC G1002033]
- MRC [MR/N022556/1, G1002033] Funding Source: UKRI
- Medical Research Council [MR/N022556/1, G1002033] Funding Source: researchfish
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Neuroinflammation contributes to developmental brain injury associated with preterm birth, but the mediators that drive it are incompletely understood. Previous studies have shown that complement C5a is present and injurious in the brains of foetal mice exposed to preterm labour. Here, we demonstrate that C5a is present in the cerebrospinal fluid of newborn human infants and that levels are elevated in those born preterm. The difference is not explained by systemic infection. Complement activation in the neonatal brain and its role as a potential therapeutic target in preterm brain injury warrant further study. Activation in the neonatal brain and its role as a potential therapeutic target for preterm brain injury warrants further study.
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