Article
Agriculture, Dairy & Animal Science
Tomoko Harayama, Takamitsu Tsukahara, Kikuto Fukuta, Machi Oda, Ryo Inoue
Summary: This study measured immunocytes in piglets to investigate how their populations change during development and are affected by weaning. The results showed a decrease in myeloid cells and an increase in NK cells after birth, while killer T, helper T, and B cell populations increased around 2-3 weeks after birth. There were no significant differences in the populations of the evaluated cell types between suckling and weaned piglets for at least 14 days post weaning.
Article
Chemistry, Multidisciplinary
Shuai Liu, Xu Wang, Xueliang Yu, Qiang Cheng, Lindsay T. Johnson, Sumanta Chatterjee, Di Zhang, Sang M. Lee, Yehui Sun, Ting-Chih Lin, John L. Liu, Daniel J. Siegwart
Summary: The study introduces a rational design and combinatorial synthesis of zwitterionic phospholipidated polymers (ZPPs) for efficient mRNA delivery to spleen and lymph nodes, with potential for substantial immunotherapeutic applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Pharmacology & Pharmacy
Reyaj Mikrani, Ian K. Styles, Thu A. Hoang, Mohammad Abdallah, Danielle Senyschyn, Christopher J. H. Porter, Enyuan Cao, Natalie L. Trevaskis
Summary: Mesenteric lymph leakage associated with obesity diverts dietary lipids, drugs, and antigens away from their normal lymphatic trafficking pathways, contributing to detrimental changes in lipid metabolism and immunity.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Critical Care Medicine
Hua Liu, Jian-Feng Li, Li-Min Zhang, Huai-Huai Wang, Xu-Qing Wang, Gui-Qing Liu, Hui-Bo Du, Yu-Jie Jin, Li-Qiang Xing, Zi-Gang Zhao, Chun-Yu Niu
Summary: This study found that post-hemorrhagic shock mesenteric lymph (PHSML) has adverse effects on splenic dendritic cells (DCs), contributing to immune dysfunction in severe hemorrhagic shock. PHSML drainage attenuated cell death and enhanced the response of DCs to LPS stimulation, promoting cytokine production and surface marker expressions. These findings suggest that PHSML plays a crucial role in hemorrhagic shock-induced immunosuppression through impairing DC function and maturation.
Article
Food Science & Technology
Unni Cecilie Nygaard, Ashild Vege, Torleiv Rognum, Koni Grob, Christel Cartier, Jean-Pierre Cravedi, Jan Alexander
Summary: Humans are exposed to mineral oil saturated hydrocarbons (MOSH) from the diet. Female rats were exposed to different fractions of MOSH and showed increased liver and spleen weight, vacuolization, and granuloma formation. The effects varied depending on the MOSH fractions tested and were related to the accumulation of specific types of hydrocarbons. The accumulation of iso-alkanes and substituted cycloalkanes in rat tissues were similar to those in humans.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuya Umebayashi, Satoru Muro, Masanori Tokunaga, Toshifumi Saito, Yuya Sato, Toshiro Tanioka, Yusuke Kinugasa, Keiichi Akita
Summary: Through cadaveric studies, it was found that there are more posterior lymph nodes in the splenic hilum area and they are located in the deep intervascular area, which may be neglected during spleen-preserving splenic hilar lymph node dissection (SPSHLD). Surgeons should consider the possibility of residual posterior lymph nodes in SPSHLD.
WORLD JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Article
Multidisciplinary Sciences
Shuaihua Chen, Hao Huang, Xuyang Yang, Han Wang, Mingtian Wei, Haixian Zhang, Ziqiang Wang, Zhang Yi
Summary: This article presents TeachMe, a web-based teaching system for annotating abdominal lymph nodes. The system features an annotation-review workflow and a feedback mechanism, aiming to build an expert database and assist junior doctors in learning the interpretation skills for abdominal medical images.
SCIENTIFIC REPORTS
(2022)
Review
Biochemical Research Methods
Gregory Bauwens, Aleksandra Gorska, Giorgia Purcaro
Summary: Mineral oil hydrocarbons (MOH) are analyzed using the online coupled liquid chromatography-gas chromatography with flame ionization detection (LC-GC-FID) method, which lacks sufficient separation performance and may result in coelution of interfering compounds. Comprehensive two-dimensional gas chromatography (GC x GC) has proven to be relevant in overcoming the weaknesses of the LC-GC method and meeting the analytical requirements. This paper highlights the contributions of GC x GC in understanding MOH, meeting the determination requirements, and overcoming analytical and toxicological challenges.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemical Research Methods
Gregory Bauwens, Sebastiano Panto, Giorgia Purcaro
Summary: The determination of mineral oil contamination levels in foods is a complex issue that requires methods like GC x GC for data interpretation and reliable integration of analytical results. The application of a new algorithm on an automated platform provides a novel solution for quantification and highlights the advantages of using an integrated platform.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Food Science & Technology
Raquel B. Gomez-Coca, Maria Del Carmen Perez-Camino, Wenceslao Moreda
Summary: The aim of this study was to determine the content of mineral oil hydrocarbons (MOH) in olive pomace oil and contribute to the monitoring required by EFSA. The study provided information on the concentrations and molecular mass profiles of MOH, as well as identified the structures that prove the harmless nature of the mineral oil aromatic hydrocarbon (MOAH) fraction. The results showed that the C25-C35 fraction is the main fraction to which humans are exposed through olive pomace oil, with concentrations dependent on the extraction process.
Article
Food Science & Technology
Dieter Schrenk, Margherita Bignami, Laurent Bodin, Jesus del Mazo, Bettina Grasl-Kraupp, Christer Hogstrand, Laurentius (Ron) Hoogenboom, Jean-Charles Leblanc, Carlo Stefano Nebbia, Elsa Nielsen, Evangelia Ntzani, Annette Petersen, Salomon Sand, Tanja Schwerdtle, Christiane Vleminckx, Heather Wallace, Jan Alexander, Christophe Goldbeck, Konrad Grob, Jose angel Gomez Ruiz, Olaf Mosbach-Schulz, Marco Binaglia, James Kevin Chipman
Summary: Mineral oil hydrocarbons (MOH) consist of saturated hydrocarbons (MOSH) and aromatic hydrocarbons (MOAH). The complex composition of MOH makes it impossible to fully characterize chemically. Accumulation of MOSH differs in various tissues among different species. Liver damage and inflammation are observed in F344 rats due to specific accumulation of wax components, while no such effects are seen in SD rats or humans. Based on dietary exposure assessments, the present dietary exposure to MOSH is not a concern for human health. However, the presence of genotoxic and carcinogenic MOAH with three or more aromatic rings raises possible concerns for human health. The highest dietary exposure to MOAH is found in the young population. Overall, this article highlights the importance of understanding the effects and risks associated with the different components of mineral oil hydrocarbons. Rating: 8/10.
Article
Agriculture, Dairy & Animal Science
Elettra Febo, Francesca Del Signore, Nicola Bernabo, Andrea Paolini, Francesco Simeoni, Andrea De Bonis, Martina Rosto, Sara Canal, Massimo Vignoli
Summary: This study evaluated the diagnostic performance of strain elastography (SE) in differentiating between benign and malignant lymph nodes in cats, using a multivariate approach that included SE results, B-mode ultrasound, and color Doppler findings. The results showed that by combining these different imaging techniques, it was possible to accurately distinguish between the three groups of lymph nodes.
Article
Biochemistry & Molecular Biology
Basak B. Ural, Daniel P. Caron, Pranay Dogra, Steven B. Wells, Peter A. Szabo, Tomer Granot, Takashi Senda, Maya M. L. Poon, Nora Lam, Puspa Thapa, Yoon Seung Lee, Masaru Kubota, Rei Matsumoto, Donna L. Farber
Summary: Carbon-containing particulates accumulate in lung-associated lymph nodes with age, leading to decreased macrophage function and disruption of lymphoid tissue structure, which may compromise respiratory immune responses.
Article
Engineering, Manufacturing
Romy Fengler, Ludwig Gruber
Summary: This article compares migration studies of mineral oil hydrocarbons (MOH) from real papers with previous studies on surrogates and food simulants. The results show that the migration behavior of MOH can be depicted by the use of respective surrogates, which helps to simplify the analytical tasks. The study also verifies the applicability of food simulants in contact with MOH.
PACKAGING TECHNOLOGY AND SCIENCE
(2022)
Article
Multidisciplinary Sciences
Coralie M. Backlund, Rebecca L. Holden, Kelly D. Moynihan, Daniel Garafola, Charlotte Farquhar, Naveen K. Mehta, Laura Maiorino, Sydney Pham, J. Bryan Iorgulescu, David A. Reardon, Catherine J. Wu, Bradley L. Pentelute, Darrell J. Irvine
Summary: Covalent conjugation of antigens with cell-penetrating peptides enhances the potency of peptide vaccines by promoting antigen uptake by dendritic cells and accumulation in draining lymph nodes. This results in robust T cell priming and expansion.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Nicole Concin, Xavier Matias-Guiu, Ignace Vergote, David Cibula, Mansoor Raza Mirza, Simone Marnitz, Jonathan Ledermann, Tjalling Bosse, Cyrus Chargari, Anna Fagotti, Christina Fotopoulou, Antonio Gonzalez Martin, Sigurd Lax, Domenica Lorusso, Christian Marth, Philippe Morice, Remi A. Nout, Dearbhaile O'Donnell, Denis Querleu, Maria Rosaria Raspollini, Jalid Sehouli, Alina Sturdza, Alexandra Taylor, Anneke Westermann, Pauline Wimberger, Nicoletta Colombo, Francois Planchamp, Carien L. Creutzberg
Summary: The European consensus conference on endometrial carcinoma in 2014 aimed to produce multi-disciplinary evidence-based guidelines. Since then, the European Society of Gynaecological Oncology (ESGO), the European SocieTy for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) have decided to update the guidelines and cover new topics to improve care for women with endometrial carcinoma globally.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Hematology
Charles Herbaux, Christoph Kornauth, Stephanie Poulain, Stephen J. F. Chong, Mary C. Collins, Rebecca Valentin, Liam Hackett, Olivier Tournilhac, Francois Lemonnier, Jehan Dupuis, Adrien Daniel, Cecile Tomowiak, Kamel Laribi, Loic Renaud, Damien Roos-Weil, Cedric Rossi, Eric Van den Neste, Cecile Leyronnas, Fatiha Merabet, Jean Valere Malfuson, Mourad Tiab, Loic Ysebaert, Samuel Ng, Franck Morschhauser, Philipp B. Staber, Matthew S. Davids
Summary: Novel agent classes like JAK/STAT and T-cell receptor pathway inhibitors, as well as HDAC inhibitors, have shown preclinical activity in T-PLL. BH3 profiling revealed that primary T-PLL cells mainly depend on BCL-2 and MCL-1 proteins for survival. The combination therapy of venetoclax and ruxolitinib demonstrated significant efficacy in refractory T-PLL patients, especially in those with JAK3 mutations.
Letter
Hematology
Christoph Kornauth, Charles Herbaux, Bernd Boidol, Chantal Guillemette, Patrick Caron, Marius E. Mayerhoefer, Stephanie Poulain, Olivier Tournilhac, Tea Pemovska, Stephen J. F. Chong, Emiel van der Kouwe, Lukas Kazianka, Georg Hopfinger, Daniel Heintel, Roland Jaeger, Markus Raderer, Ulrich Jager, Ingrid Simonitsch-Klupp, Wolfgang R. Sperr, Stefan Kubicek, Matthew S. Davids, Philipp B. Staber
Article
Oncology
Joanna Baum, Elena Ioana Braicu, Oliver Hunsicker, Ignace Vergote, Nicole Concin, Els Van Nieuwenhuysen, Aarne Feldheiser, Patriciu Achimas-Cadariu, Silvia Darb-Esfahani, Astrid Berger, Bogdan Fetica, Sven Mahner, Andrea Papadia, Linn Woelber, Maria Luisa Gasparri, Adriaan Vanderstichele, Pierluigi Benedetti Panici, Michael D. Mueller, Ilary Ruscito, Hannah Woopen, Jalid Sehouli
Summary: This study aimed to identify characteristics of long-term survivors with high-grade serous ovarian cancer and found that platinum sensitivity, recurrence, ascites, and BRCA1 gene mutation were significant factors affecting long-term survival. Intraoperatively, long-term survivors also had less tumor involvement of the upper abdomen.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Pathology
Nicole Concin, Carien L. Creutzberg, Ignace Vergote, David Cibula, Mansoor Raza Mirza, Simone Marnitz, Jonathan A. Ledermann, Tjalling Bosse, Cyrus Chargari, Anna Fagotti, Christina Fotopoulou, Antonio Gonzalez-Martin, Sigurd F. Lax, Domenica Lorusso, Christian Marth, Philippe Morice, Remi A. Nout, Dearbhaile E. O'Donnell, Denis Querleu, Maria Rosaria Raspollini, Jalid Sehouli, Alina E. Sturdza, Alexandra Taylor, Anneke M. Westermann, Pauline Wimberger, Nicoletta Colombo, Francois Planchamp, Xavier Matias-Guiu
Summary: A European consensus conference on endometrial carcinoma was held in 2014 to produce multidisciplinary evidence-based guidelines. Given the large body of literature on the management of endometrial carcinoma published since 2014, the guidelines were updated by ESGO/ESTRO/ESP. The guidelines cover various aspects of endometrial carcinoma care and are evidence-based.
Article
Hematology
E. van der Kouwe, G. Heller, A. Czibere, J. A. Pulikkan, C. Agreiter, L. H. Castilla, R. Delwel, A. Di Ruscio, A. K. Ebralidze, M. Forte, F. Grebien, E. Heyes, L. Kazianka, J. Klinger, C. Kornauth, T. Le, K. Lind, I. A. M. Barbosa, T. Pemovska, A. Pichler, A-S Schmolke, C. M. Schweicker, H. Sill, W. R. Sperr, A. Spittler, S. Surapally, B. Q. Trinh, P. Valent, K. Vanura, R. S. Welner, J. Zuber, D. G. Tenen, P. B. Staber
Summary: The study reveals that downregulation of PU.1 in the blood system is an active process induced by an antisense promoter driven by RUNX transcription factors, resulting in myeloid differentiation blockade. Patients with CBF-AML show an elevated antisense/sense transcript ratio and promoter accessibility compared to normal karyotype AML or healthy CD34(+) cells. Additionally, competitive interaction between an enhancer and the proximal or antisense promoter acts as a binary switch for myeloid or T-cell development.
Article
Oncology
Jakob Nedomansky, Werner Haslik, Ursula Pluschnig, Christoph Kornauth, Christine Deutschmann, Stefan Hacker, Guenther G. Steger, Rupert Bartsch, Robert M. Mader
Summary: Analyzing removed tissue from patients undergoing surgical intervention for extravasation of anthracyclines revealed individual variations in tissue sensitivity, with surgical intervention post-demarcation leading to healing within approximately 2 weeks. Despite high variability in tissue concentrations post-extravasation surgery, preventive measures remain crucial in preventing tissue necrosis.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Letter
Oncology
Nicole Concin, Xavier Matias-Guiu, Carien L. Creutzberg
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Letter
Oncology
Dirk Timmerman, David Cibula, Francois Planchamp, Tom Bourne, Chiara Landolfo, Antonia Carla Testa, Andreas du Bois, Luis Chiva, Nicole Concin, Daniela Fisherova, Wouter Froyman, Birthe Lemley, Annika Loft, Liliana Mereu, Philippe Morice, Denis Querleu, Ignace Vergote, Vincent Vandecaveye, Giovanni Scambia, Christina Fotopoulou
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Article
Oncology
Christoph Kornauth, Tea Pemovska, Gregory Vladimer, Gunther Bayer, Michael Bergmann, Sandra Eder, Ruth Eichner, Martin Erl, Harald Esterbauer, Ruth Exner, Verena Felsleitner-Hauer, Maurizio Forte, Alexander Gaiger, Klaus Geissler, Hildegard T. Greinix, Wolfgang Gstoettner, Marcus Hacker, Bernd Lorenz Hartmann, Alexander W. Hauswirth, Tim Heinemann, Daniel Heintel, Mir Alireza Hoda, Georg Hopfinger, Ulrich Jaeger, Lukas Kazianka, Lukas Kenner, Barbara Kiesewetter, Nikolaus Krall, Gerhard Krajnik, Stefan Kubicek, Trang Le, Simone Lubowitzki, Marius E. Mayerhoefer, Elisabeth Menschel, Olaf Merkel, Katsuhiro Miura, Leonhard Muellauer, Peter Neumeister, Thomas Noesslinger, Katharina Ocko, Leopold Oehler, Michael Panny, Alexander Pichler, Edit Porpaczy, Gerald W. Prager, Markus Raderer, Robin Ristl, Reinhard Ruckser, Julius Salamon, Ana-Iris Schiefer, Ann-Sofie Schmolke, Ilse Schwarzinger, Edgar Selzer, Christian Sillaber, Cathrin Skrabs, Wolfgang R. Sperr, Ismet Srndic, Renate Thalhammer, Peter Valent, Emiel van der Kouwe, Katrina Vanura, Stefan Vogt, Cora Waldstein, Dominik Wolf, Christoph C. Zielinski, Niklas Zojer, Ingrid Simonitsch-Klupp, Giulio Superti-Furga, Berend Snijder, Philipp B. Staber
Summary: Personalized medicine using functional assays can be clinically feasible and effective in providing treatment guidance for patients with aggressive hematologic cancers, resulting in enhanced progression-free survival and exceptional responses lasting longer than expected for some patients.
Article
Oncology
Daniela Berger, Karin Bauer, Christoph Kornauth, Susanne Gamperl, Gabriele Stefanzl, Dubravka Smiljkovic, Christian Sillaber, Peter Bettelheim, Paul Knoebl, Ana-Iris Schiefer, Georg Greiner, Renate Thalhammer, Gregor Hoermann, Ilse Schwarzinger, Philipp B. Staber, Wolfgang R. Sperr, Peter Valent
Summary: Secondary basophilic leukemia is a rare type of leukemia characterized by significant expansion of basophils during disease progression, with a generally poor prognosis. Monotherapy with azacitidine may not be sufficient to control the disease effectively, and combination therapy may offer potential for better outcomes. Future clinical studies are needed to determine the efficacy of drug combinations, such as venetoclax, in improving outcomes for these patients.
Article
Food Science & Technology
Laura Barp, Sabrina Moret, Giorgia Purcaro
Summary: Polycyclic aromatic hydrocarbons (PAHs) are common environmental and processing contaminants generated by organic matter combustion processes. The contamination of PAHs in vegetable oils can come from various sources, including environmental pollution, oil processing, and migration from food contact materials. A purification method using solid-phase extraction (SPE) and high performance liquid chromatography-fluorometric detector (HPLC-FLD) analysis was developed to isolate PAHs from the complex matrix of edible oil. Evaluation of the pomace oil supply chain revealed an increase in PAH contamination with storage time and a significant contribution of the pomace drying process to the total PAH content.
Article
Biochemistry & Molecular Biology
Ana Srbinovska, Paolo Lucci, Chiara Conchione, Laura Barp, Sabrina Moret
Summary: The potential of endogenous n-alkane profiling for assessing EVOO adulteration has been studied by few authors. A rapid and solvent-sparing offline SPE-GC-FID method was optimized and validated for determining endogenous n-alkanes in vegetable oils. Promising indices were found to reveal the addition of SFO in EVOO and AVO in EVOO.
Review
Food Science & Technology
Laura Barp, Ana Miklavcic Visnjevec, Sabrina Moret
Summary: Pressurized liquid extraction (PLE) is an advanced extraction technique aimed at saving time and reducing solvent in comparison to traditional extraction processes. It is commonly used for solid and semi-solid samples, employing solvent extraction at elevated temperatures and pressures. The use of specific pressure and temperature conditions changes the physicochemical properties of the extraction solvent, allowing deeper penetration into the matrix to be extracted. By combining extraction and clean-up steps, PLE becomes a versatile and selective technique. This review focuses on recent applications of PLE in the field of food contaminants.
Article
Multidisciplinary Sciences
Tea Pemovska, Johannes Bigenzahn, Ismet Srndic, Alexander Lercher, Andreas Bergthaler, Adrian Cesar-Razquin, Felix Kartnig, Christoph Kornauth, Peter Valent, Philipp B. Staber, Giulio Superti-Furga
Summary: Metabolic reprogramming plays a critical role in cancer development. The study demonstrates the use of a metabolic drug library to uncover metabolic vulnerabilities and gain functional insights into myeloid leukemia biology. High-throughput screening approaches are effective in identifying cancer-specific metabolic vulnerabilities and unraveling contextual biology.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)