Review
Clinical Neurology
Samuel David, Fari Ryan, Priya Jhelum, Antje Kroner
Summary: Iron accumulation in the CNS is common in neurological disorders and can contribute to neuropathology through the generation of free radicals. Ferroptosis, a form of cell death induced by iron, has been shown to occur under conditions of deficient antioxidant defense. Iron chelation has limited success in treating neurological diseases, leading to increased interest in ferroptosis as a potential therapeutic target.
Article
Nanoscience & Nanotechnology
Xueyan Hu, Xinyue Wang, Qiqi Liu, Jin Wu, Haoqi Zhang, Anila Khalique, Zhiyuan Sun, Rui Chen, Jing Wei, Hongbo Li, Deling Kong, Jie Zhuang, Xiyun Yan, Xinglu Huang
Summary: The fully synthetic cell system, integrating biomimetic nanozymes into giant unilamellar vesicles, successfully mimics intracellular oxidative stress pathways and induces tumor cell death by sensing and responding to external chemical signals.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Agricultural Engineering
Muhammad Ahmad, Ejaz Ahmad Waraich, Usman Zulfiqar, Aman Ullah, Muhammad Farooq
Summary: This study demonstrated that the application of thiourea can improve heat tolerance in camelina, increase seed yield, and protect plants from oxidative damage. Additionally, thiourea application was more effective at the reproductive stage, and genotype 618 showed higher tolerance to heat stress compared to genotype 611.
INDUSTRIAL CROPS AND PRODUCTS
(2021)
Article
Cell Biology
Giulia Leanza, Caterina Conte, Francesca Cannata, Camilla Isgro, Alessandra Piccoli, Rocky Strollo, Carlo Cosimo Quattrocchi, Rocco Papalia, Vincenzo Denaro, Mauro Maccarrone, Nicola Napoli, Anna Maria Sardanelli
Summary: In this study, the oxidative stress states were compared between postmenopausal women with and without obesity. The results showed that women with obesity had doubled levels of oxidative stress markers compared to women of normal weight. The severity of oxidative stress was correlated with body mass index, visceral fat mass, and trunk fat percentage, but not with fasting glucose levels. These findings suggest that obesity and visceral fat increase oxidative stress in postmenopausal women, potentially increasing the risks of cardiometabolic and cancer diseases.
Article
Biochemistry & Molecular Biology
Jan Stepniak, Aleksandra Rynkowska, Malgorzata Karbownik-Lewinska
Summary: Iron is essential for many organs but its overload can be toxic. Excessive iron absorption and deposition can lead to diseases like hemochromatosis. This study found that the thyroid is less sensitive to oxidative effects caused by Fenton reaction substrates and melatonin has the same protective effects in different tissues.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Yuta Matsuoka, Masatomo Takahashi, Yuki Sugiura, Yoshihiro Izumi, Kazuhiro Nishiyama, Motohiro Nishida, Makoto Suematsu, Takeshi Bamba, Ken-ichi Yamada
Summary: This study constructed a library of 465 oxPCs using mass spectrometry and found that doubly oxygenated polyunsaturated fatty acid (PUFA)-PCs are generated in the early phase of acetaminophen-induced acute liver failure.
NATURE COMMUNICATIONS
(2021)
Article
Environmental Sciences
Xiaole Wang, Jingwen Zhang, Chengbo Lu, Yu Liu, Xiao Yang, Kaixuan Hou, Zhongkun Du, Bing Li, Albert Juhasz, Lusheng Zhu
Summary: This study evaluated the toxicity of environmentally relevant concentrations of pyroxsulam to zebrafish embryos and adults, providing valuable data for assessing its effects on aquatic ecosystems.
ENVIRONMENTAL POLLUTION
(2023)
Article
Biochemistry & Molecular Biology
Zitong Meng, Yuxiao Liao, Zhao Peng, Xiaolei Zhou, Huanhuan Zhou, Andreas K. Nuessler, Liegang Liu, Wei Yang
Summary: This study investigated the effects of rat BMSC-secreted exos on DON-induced liver damage. It was found that BMSC-exos can alleviate liver pathological changes, reduce liver function indicators and inflammatory factors, and alter oxylipin metabolism.
Article
Biochemistry & Molecular Biology
Marcelo P. Barros, Jaime Zacarias-Garcia, Florencia Rey, Lorenzo Zacarias, Maria J. Rodrigo
Summary: This study investigated the scavenging and quenching capacities of four different carotenoid extracts from citrus fruits, as well as the effect of ascorbic acid (ASC) on these activities. The results showed that all citrus extracts had balanced antioxidant properties, with the 'Nadorcott' mandarin extract slightly prevailing over the others.
Article
Biochemistry & Molecular Biology
Jie Niu, Xin Wan, Gui-Yuan Yu, Shan Jiang, Ruo-Nan Yi, Yan-Ping Wu, Shu-Hua Ouyang, Lei Liang, Hiroshi Kurihara, Wan-Yang Sun, Xiao-Feng Zhu, Rong-Hua Zhang, Yun-Feng Cao, Jian-Bo He, Wen-Jun Duan, Yi-Fang Li, Rong-Rong He
Summary: The study demonstrates that maternal stress may lead to abnormal embryo bone development through oxidative stress damage, specifically by inducing ferroptosis-related signals in chondrocytes with alkoxyl radicals. This process causes accumulation of oxidized phospholipids in chondrocytes and dampens chondrogenesis through adduct formation with the SOX9 transcription factor.
Review
Biochemistry & Molecular Biology
Manuel Aureliano, Ana Luisa De Sousa-Coelho, Connor C. Dolan, Deborah A. Roess, Debbie C. Crans
Summary: Lipid peroxidation (LPO), induced by exposure to vanadium salts and compounds, is a process that affects human health. The LPO reaction involves the oxidation of alkene bonds in polyunsaturated fatty acids, resulting in the formation of radical and reactive oxygen species (ROS). Vanadium species have both direct and indirect effects on ROS formation, making the study of LPO arising from increased ROS challenging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ji Eun Lim, Srideshikan Sargur Madabushi, Paresh Vishwasrao, Joo Y. Song, Amr M. H. Abdelhamid, Hemendra Ghimire, V. L. Vanishree, Jatinder K. Lamba, Savita Dandapani, Amandeep Salhotra, Mengistu Lemecha, Antonio Pierini, Daohong Zhao, Guy Storme, Shernan Holtan, Cynthia Aristei, Dorthe Schaue, Monzr Al Malki, Susanta K. Hui
Summary: Total marrow irradiation (TMI) is an emerging radiation conditioning regimen that can overcome the limitations of total body irradiation (TBI) by reducing normal tissue damage and preserving repair capacity. Studies have shown that dose escalation using TMI significantly improves survival rates in relapsed/refractory AML patients. Preclinical experiments on mice demonstrated that TMI does not affect donor engraftment, but reduces normal tissue damage and enhances repair processes, suggesting the potential for dose escalation in elderly patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Environmental Sciences
Ryan S. Babadi, Anne M. Riederer, Paul D. Sampson, Sheela Sathyanarayana, Terrance J. Kavanagh, Jennifer E. Krenz, Syam S. Andra, Seunghee Kim-Schulze, Karen L. Jansen, Elizabeth Torres, Adriana Perez, Lisa R. Younglove, Maria I. Tchong-French, Catherine J. Karr
Summary: Studies show a positive relationship between phthalate exposure and oxidative stress in children with asthma, indicating a potential adverse impact on asthma morbidity. Further research is needed to confirm these findings and better understand the role of phthalates in childhood asthma.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
Valeria Marasco, Manrico Sebastiano, David Costantini, Gianni Pola, Leonida Fusani
Summary: The emergence of the migratory phenotype in birds is associated with changes in oxidative status, including higher levels of TBARS in the liver, lower levels of SOD in red blood cells and liver, and higher levels of GPx in the pectoral muscle. Despite higher food intake in migratory birds, there is no link between food intake and markers of oxidative status. The increase in body mass is positively correlated with muscle GPx activity during pre-migratory fattening, suggesting strategic displacement of oxidative costs to safeguard muscles for successful migration.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2021)
Letter
Clinical Neurology
Laura B. Jardim, Vanessa B. Leotti, Ursula Matte, Carmen R. Vargas
EUROPEAN JOURNAL OF NEUROLOGY
(2019)
Article
Biochemistry & Molecular Biology
Moacir Wajner, Angela Sitta, Aline Kayser, Marion Deon, Ana C. Groehs, Daniella M. Coelho, Carmen R. Vargas
GENETICS AND MOLECULAR BIOLOGY
(2019)
Article
Endocrinology & Metabolism
Bruna Donida, Marco Raabe, Barbara Tauffner, Marcelo A. de Farias, Andryele Z. Machado, Fernanda Timm, Rejane G. Kessler, Tatiane G. Hammerschmidt, Luiza S. Reinhardt, Veronica B. Brito, Rodrigo Portugal, Andressa Bernardi, Rudimar Frozza, Dinara J. Moura, Roberto Giugliani, Fernanda Poletto, Carmen R. Vargas
JOURNAL OF INHERITED METABOLIC DISEASE
(2020)
Article
Biochemistry & Molecular Biology
Thais S. Franceschi, Mayara S. P. Soares, Nathalia S. Pedra, Natalia P. Bona, Luiza Spohr, Fernanda C. Teixeira, Carlus A. T. do Couto, Roselia M. Spanevello, Marion Deon, Carmen R. Vargas, Elizandra Braganhol, Francieli M. Stefanello
Article
Pediatrics
Rahuany Velleda de Morais, Meriene Viquetti de Souza, Klerize Anecely de Souza Silva, Pablo Santiago, Marcelo Cunha Lorenzoni, Cecilia Fernandes Lorea, Claudio Galvao de Castro Junior, Adriano Nori Rodrigues Taniguchi, Fernanda Fetter Scherer, Mariana Bohns Michalowski, Liane Esteves Daudt
Summary: By analyzing data of children with acute myeloid leukemia treated in hospitals in southern Brazil, it was found that the prevalence of the M3 subtype was higher than reported in international literature, and the survival rates were lower compared to developed countries. This study suggests the need for further multicenter Brazilian studies with larger sample sizes to improve the treatment and prognosis in this population.
JORNAL DE PEDIATRIA
(2021)
Letter
Oncology
Claudio Galvao de Castro Jr., Lauro Jose Gregianin, Jan A. Burger
LEUKEMIA & LYMPHOMA
(2020)
Article
Endocrinology & Metabolism
Angela Sitta, Gilian Guerreiro, Daniella de Moura Coelho, Vitoria Volfart da Rocha, Bianca Gomes dos Reis, Carmen Sousa, Laura Vilarinho, Moacir Wajner, Carmen Regla Vargas
Summary: Glutaric aciduria type 1 (GA-1) is a rare but treatable inherited disease caused by deficiency of glutaryl-CoA dehydrogenase activity due to GCDH gene mutations. Symptoms include neurological deterioration, seizures, and dystonia, with difficulties in diagnosis and treatment in countries like Brazil. Genetic analysis is crucial for confirming the diagnosis as the disease is mainly caused by GCDH gene mutations.
METABOLIC BRAIN DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Gilian Guerreiro, Jessica Faverzani, Alana Pimentel Moura, Vitoria Volfart, Bianca Gome dos Reis, Angela Sitta, Esteban Alberto Gonzalez, Gabriel de Lima Rosa, Adriana Simon Coitinho, Guilherme Baldo, Moacir Wajner, Carmen Regla Vargas
Summary: Glutaric acidemia type 1 (GA1) is characterized by neurological symptoms and metabolic blockage, with treatment involving protein/lysine restriction and L-carnitine supplementation. In a study with mice, L-carnitine showed significant protective effects on behavioral abnormalities and pro-inflammatory status in the striatum, suggesting its potential therapeutic benefits for GA1 patients.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Article
Endocrinology & Metabolism
Jessica Lamberty Faverzani, Aline Steinmetz, Marion Deon, Desiree Padilha Marchetti, Gilian Guerreiro, Angela Sitta, Daniella de Moura Coelho, Franciele Fatima Lopes, Leopoldo Vinicius Martins Nascimento, Luiza Steffens, Jeferson Gustavo Henn, Matheus Bernardes Ferro, Veronica Bidinotto Brito, Moacir Wajner, Dinara Jaqueline Moura, Carmen Regla Vargas
Summary: The study revealed that phenylalanine and its metabolites can induce DNA damage in glial cells in phenylketonuria, with L-carnitine potentially serving as an adjuvant therapeutic agent.
METABOLIC BRAIN DISEASE
(2021)
Article
Endocrinology & Metabolism
Carlos Eduardo Diaz Jacques, Franciele Fatima Lopes, Edina Poletto, Luisa Natalia Pimentel Vera, Priscila Vianna, Luiza Steffens Reinhardt, Guilherme Baldo, Carmen Regla Vargas
Summary: This study investigated the pathophysiology of MPS II cells and found evidence of oxidative stress and DNA damage. Additionally, it demonstrated the protective effects of genistein and coenzyme Q10 against oxidative damage in vitro.
METABOLIC BRAIN DISEASE
(2023)
Article
Endocrinology & Metabolism
Tatiane Grazieli Hammerschmidt, Bruna Donida, Marco Raabe, Jessica Lamberty Faverzani, Franciele de Fatima Lopes, Andryele Z. Machado, Rejane G. Kessler, Luiza S. Reinhardt, Fernanda Poletto, Dinara J. Moura, Carmen R. Vargas
Summary: Niemann-Pick C disease (NPC) is a severe genetic disorder with no cure. Recent studies have found that beta-cyclodextrin (beta-CD) can reduce cholesterol accumulation in cells of NPC1 patients, and the combination with antioxidants can further improve the treatment effect.
METABOLIC BRAIN DISEASE
(2023)
Article
Chemistry, Medicinal
Caroline Guerra Marangon, Camila Schafer Rojas, Marina Zaneti Michelsen, Satchie Sakamoto, Carlos Eduardo Diaz Jacques, Gilsane Lino von Poser, Carmen Regla Vargas, Stela Maris Kuze Rates
Summary: This study aimed to investigate the effect of uliginosin B on hippocampal stress oxidative and inflammation markers, and the results showed that uliginosin B has an antidepressant-like effect and enhances the levels of glutathione reduced, MCP-1, and IL-10.
REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY
(2023)
Article
Medicine, General & Internal
Andrea Z. Pereira, Afonso Celso Vigorito, Alessandro de Moura Almeida, Alexandre de Almeida Candolo, Ana Carolina Leao Silva, Ana Elisa de Paula Brandao-Anjos, Bianca Laselva de Sa, Catarina Lobo Santos de Souza, Claudio Galvao de Castro Junior, Jose Salvador Rodrigues de Oliveira, Juliana Bernardo Barban, Elaine Maria Borges Mancilha, Juliana Todaro, Lilian Pinheiro Lopes, Maria Cristina Martins de Almeida Macedo, Morgani Rodrigues, Paulo Cesar Ribeiro, Roberto Luiz da Silva, Telma Sigolo Roberto, Thays de Cassia Ruiz Rodrigues, Vergilio Antonio Rensi Colturato, Eduardo Jose de Alencar Paton, George Mauricio Navarro Barros, Rosana Ducatti Souza Almeida, Maria Claudia Rodrigues Moreira, Mary Evelyn Flowers
EINSTEIN-SAO PAULO
(2020)
Review
Biochemistry & Molecular Biology
Taiane Alves Vieira, Franciele Barbosa Trapp, Carolina Fischinger Moura de Souza, Lavinia Schuler Faccini, Laura Bannach Jardim, Ida Vanessa Doederlein Schwartz, Mariluce Riegel, Carmen Regla Vargas, Maira Graeff Burin, Sandra Leistner-Segal, Patricia Ashton-Prolla, Roberto Giugliani
GENETICS AND MOLECULAR BIOLOGY
(2019)
Article
Multidisciplinary Sciences
Rafaela M. Alvariz, Isabel T. D. S. Moreira, Gabriela K. Cury, Carmen R. Vargas, Alethea G. Barschak
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2019)