An efficient multistep ligand-based virtual screening approach for GPR40 agonists

Free Fatty Acid Receptor 1: A New Drug Target for Type 2 Diabetes?

(2012) Mourad Ferdaoussi et al.   Canadian Journal of Diabetes

Ligand-Based Virtual Screening Approach Using a New Scoring Function

(2012) Adel Hamza et al.   Journal of Chemical Information and Modeling

Discovery of Phenylpropanoic Acid Derivatives Containing Polar Functionalities as Potent and Orally Bioavailable G Protein-Coupled Receptor 40 Agonists for the Treatment of Type 2 Diabetes

(2012) Satoshi Mikami et al.   JOURNAL OF MEDICINAL CHEMISTRY

Identification of Fused-Ring Alkanoic Acids with Improved Pharmacokinetic Profiles that Act as G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonists

(2012) Nobuyuki Negoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonists: Mesylpropoxy Appendage Lowers Lipophilicity and Improves ADME Properties

(2012) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Optimization of (2,3-Dihydro-1-benzofuran-3-yl)acetic Acids: Discovery of a Non-Free Fatty Acid-Like, Highly Bioavailable G Protein-Coupled Receptor 40/Free Fatty Acid Receptor 1 Agonist as a Glucose-Dependent Insulinotropic Agent

(2012) Nobuyuki Negoro et al.   JOURNAL OF MEDICINAL CHEMISTRY

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

(2012) Michael M. Mysinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists

(2011) Shawn P. Walsh et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel mGluR1 antagonists: A multistep virtual screening approach based on an SVM model and a pharmacophore hypothesis significantly increases the hit rate and enrichment factor

(2011) Guo-Bo Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

AMG 837: A potent, orally bioavailable GPR40 agonist

(2011) Jonathan B. Houze et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Improving VEGFR-2 Docking-Based Screening by Pharmacophore Postfiltering and Similarity Search Postprocessing

(2011) Jesús M. Planesas et al.   Journal of Chemical Information and Modeling

Identification of a Potent and Selective Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist with Favorable Physicochemical and in Vitro ADME Properties

(2011) Elisabeth Christiansen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Activity of Potent and Orally Available G Protein-Coupled Receptor 40 Agonists

(2011) Shinobu Sasaki et al.   JOURNAL OF MEDICINAL CHEMISTRY

Insight into analysis of interactions of GW9508 to wild-type and H86F and H137F GPR40: A combined QM/MM study and pharmacophore modeling

(2011) Shao-Yong Lu et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Pharmacophore modeling and applications in drug discovery: challenges and recent advances

(2010) Sheng-Yong Yang   DRUG DISCOVERY TODAY

Extended-Connectivity Fingerprints

(2010) David Rogers et al.   Journal of Chemical Information and Modeling

Structure-Based Discovery of Novel Chemotypes for Adenosine A2AReceptor Antagonists

(2010) Vsevolod Katritch et al.   JOURNAL OF MEDICINAL CHEMISTRY

G-protein coupled receptors mediating long chain fatty acid signalling in the pancreatic beta-cell

(2009) Noel G. Morgan et al.   BIOCHEMICAL PHARMACOLOGY

Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists

(2009) Changyou Zhou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Combining Machine Learning and Pharmacophore-Based Interaction Fingerprint for in Silico Screening

(2009) Tomohiro Sato et al.   Journal of Chemical Information and Modeling

Homology Model-Based Virtual Screening for GPCR Ligands Using Docking and Target-Biased Scoring

(2008) Tanja Weil et al.   Journal of Chemical Information and Modeling

Discovery of Novel Agonists and Antagonists of the Free Fatty Acid Receptor 1 (FFAR1) Using Virtual Screening

(2008) Irina G. Tikhonova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Novel CB2Receptor Ligands by a Pharmacophore-Based Virtual Screening Workflow

(2008) Patrick Markt et al.   JOURNAL OF MEDICINAL CHEMISTRY