Assessing Gene-Gene Interactions in Pharmacogenomics

A Support Vector Machine Approach to Assess Drug Efficacy of Interferon-α and Ribavirin Combination Therapy

(2012) Eugene Lin et al.   Molecular Diagnosis & Therapy

Pharmacogenetics of Major Depression

(2012) Magnus Lekman et al.   Molecular Diagnosis & Therapy

Effect of the Common -866G/A Polymorphism of the Uncoupling Protein 2 Gene on Weight Loss and Body Composition under Sibutramine Therapy in an Obese Taiwanese Population

(2012) Tun-Jen Hsiao et al.   Molecular Diagnosis & Therapy

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

(2011) M. Isabel Lucena et al.   GASTROENTEROLOGY

Prioritizing GWAS Results: A Review of Statistical Methods and Recommendations for Their Application

(2010) Rita M. Cantor et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Pharmacogenetics of Depression: Enter the GWAS

(2010) Anil K. Malhotra   AMERICAN JOURNAL OF PSYCHIATRY

Genome-Wide Pharmacogenetics of Antidepressant Response in the GENDEP Project

(2010) Rudolf Uher et al.   AMERICAN JOURNAL OF PSYCHIATRY

Survival dimensionality reduction (SDR): development and clinical application of an innovative approach to detect epistasis in presence of right-censored data

(2010) Lorenzo Beretta et al.   BMC BIOINFORMATICS

Evidence for depletion of CASP5 Ala90Thr heterozygous genotype in aged subjects

(2010) Yulia M. Ulybina et al.   EXPERIMENTAL GERONTOLOGY

Genetic Variation in IL28B Is Associated With Chronic Hepatitis C and Treatment Failure: A Genome-Wide Association Study

(2010) Andri Rauch et al.   GASTROENTEROLOGY

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists

(2010) Andrew D Johnson et al.   NATURE GENETICS

Genome-wide association studies in diverse populations

(2010) Noah A. Rosenberg et al.   NATURE REVIEWS GENETICS

Uncovering the roles of rare variants in common disease through whole-genome sequencing

(2010) Elizabeth T. Cirulli et al.   NATURE REVIEWS GENETICS

Research highlights from the latest articles in 5-HTTLPR pharmacogenomics

(2010) Hsien-Yuan Lane et al.   Personalized Medicine

GSNO reductase and β2-adrenergic receptor gene–gene interaction: bronchodilator responsiveness to albuterol

(2010) Shweta Choudhry et al.   Pharmacogenetics and Genomics

Gene–gene interactions of the INSIG1 and INSIG2 in metabolic syndrome in schizophrenic patients treated with atypical antipsychotics

(2010) Y-J Liou et al.   PHARMACOGENOMICS JOURNAL

Gene-Gene Interactions Lead to Higher Risk for Development of Type 2 Diabetes in an Ashkenazi Jewish Population

(2010) Rosalind J. Neuman et al.   PLoS One

Candidate genes versus genome-wide associations: which are better for detecting genetic susceptibility to infectious disease?

(2010) W. Amos et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Genome-wide association studies of antidepressant outcome: A brief review

(2010) Gonzalo Laje et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

A Novel Adaptive Method for the Analysis of Next-Generation Sequencing Data to Detect Complex Trait Associations with Rare Variants Due to Gene Main Effects and Interactions

(2010) Dajiang J. Liu et al.   PLoS Genetics

The Interaction of Reward Genes With Environmental Factors in Contribution to Alcoholism in Mexican Americans

(2009) Yanlei Du et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Massively Parallel Sequencing: The Next Big Thing in Genetic Medicine

(2009) Tracy Tucker et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Epistasis and Its Implications for Personal Genetics

(2009) Jason H. Moore et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A Genomewide Association Study Points to Multiple Loci That Predict Antidepressant Drug Treatment Outcome in Depression

(2009) Marcus Ising et al.   ARCHIVES OF GENERAL PSYCHIATRY

Predictive rule inference for epistatic interaction detection in genome-wide association studies

(2009) Xiang Wan et al.   BIOINFORMATICS

A Genomewide Association Study of Citalopram Response in Major Depressive Disorder

(2009) Holly A. Garriock et al.   BIOLOGICAL PSYCHIATRY

A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function

(2009) N. Soranzo et al.   BLOOD

Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses

(2009) Waranyu Wongseree et al.   BMC BIOINFORMATICS

A random forest approach to the detection of epistatic interactions in case-control studies

(2009) Rui Jiang et al.   BMC BIOINFORMATICS

An Open Access Database of Genome-wide Association Results

(2009) Andrew D Johnson et al.   BMC Medical Genetics

Neurobiological mechanisms in major depressive disorder

(2009) M. aan het Rot et al.   CANADIAN MEDICAL ASSOCIATION JOURNAL

Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer

(2009) Yulia M. Ulybina et al.   CANCER LETTERS

Genetic Risk Profiling and Prediction of Disease Course in Crohn's Disease Patients

(2009) Liesbet Henckaerts et al.   Clinical Gastroenterology and Hepatology

Using biological networks to search for interacting loci in genome-wide association studies

(2009) Mathieu Emily et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment

(2009) Chi-Un Pae et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Using genome-wide pathway analysis to unravel the etiology of complex diseases

(2009) Clara C. Elbers et al.   GENETIC EPIDEMIOLOGY

An evaluation of statistical approaches to rare variant analysis in genetic association studies

(2009) Andrew P. Morris et al.   GENETIC EPIDEMIOLOGY

Gene-Gene Interactions Among Genetic Variants from Obesity Candidate Genes for Nonobese and Obese Populations in Type 2 Diabetes

(2009) Eugene Lin et al.   Genetic Testing and Molecular Biomarkers

Association of three-gene interaction among MTHFR, ALOX5AP and NOTCH3 with thrombotic stroke: a multicenter case–control study

(2009) Junhao Liu et al.   HUMAN GENETICS

Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival

(2009) Lydia Quaye et al.   HUMAN MOLECULAR GENETICS

A comparison of classification methods for predicting Chronic Fatigue Syndrome based on genetic data

(2009) Lung-Cheng Huang et al.   Journal of Translational Medicine

Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance

(2009) Dongliang Ge et al.   NATURE

IL28B is associated with response to chronic hepatitis C interferon-α and ribavirin therapy

(2009) Vijayaprakash Suppiah et al.   NATURE GENETICS

Genome-wide association of IL28B with response to pegylated interferon-α and ribavirin therapy for chronic hepatitis C

(2009) Yasuhito Tanaka et al.   NATURE GENETICS

Detecting gene–gene interactions that underlie human diseases

(2009) Heather J Cordell   NATURE REVIEWS GENETICS

Association and interaction analyses of genetic variants in ADIPOQ, ENPP1, GHSR, PPAR  and TCF7L2 genes for diabetic nephropathy in a Taiwanese population with type 2 diabetes

(2009) L. S.-H. Wu et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Polymorphisms in GRIK4, HTR2A and FKBP5 Show Interactive Effects in Predicting Remission to Antidepressant Treatment

(2009) Sonja Horstmann et al.   NEUROPSYCHOPHARMACOLOGY

Common Genetic Variation and Human Traits

(2009) David B. Goldstein   NEW ENGLAND JOURNAL OF MEDICINE

Genetic ancestry modifies pharmacogenetic gene–gene interaction for asthma

(2009) Harriet Corvol et al.   Pharmacogenetics and Genomics

Weight loss and body fat reduction under sibutramine therapy in obesity with the C825T polymorphism in the GNB3 gene

(2009) Dun-Jen Hsiao et al.   Pharmacogenetics and Genomics

Genetic predictors of response to antidepressants in the GENDEP project

(2009) Rudolf Uher et al.   PHARMACOGENOMICS JOURNAL

Pharmacogenomics of antidepressant drugs

(2009) Sonja Horstmann et al.   PHARMACOLOGY & THERAPEUTICS

An Analysis of Growth, Differentiation and Apoptosis Genes with Risk of Renal Cancer

(2009) Linda M. Dong et al.   PLoS One

The Role of Genomic Data in the Discovery, Annotation and Evolutionary Interpretation of the Interferon-Lambda Family

(2009) Brian A. Fox et al.   PLoS One

Genome-Wide Association Study of Young-Onset Hypertension in the Han Chinese Population of Taiwan

(2009) Hsin-Chou Yang et al.   PLoS One

Interaction of serotonin-related genes affects short-term antidepressant response in major depressive disorder

(2009) Eugene Lin et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Gene–Gene Interactions of the Brain-Derived Neurotrophic-Factor and Neurotrophic Tyrosine Kinase Receptor 2 Genes in Geriatric Depression

(2009) Eugene Lin et al.   REJUVENATION RESEARCH

Epistatic Module Detection for Case-Control Studies: A Bayesian Model with a Gibbs Sampling Strategy

(2009) Wanwan Tang et al.   PLoS Genetics

Study of genegene interactions for endophenotypic quantitative traits in Chinese asthmatic children

(2008) I. H. S. Chan et al.   ALLERGY

Shifting Paradigm of Association Studies: Value of Rare Single-Nucleotide Polymorphisms

(2008) Ivan P. Gorlov et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Gene-Gene Interactions Among CHRNA4, CHRNB2, BDNF, and NTRK2 in Nicotine Dependence

(2008) Ming D. Li et al.   BIOLOGICAL PSYCHIATRY

A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis

(2008) Javier Gayán et al.   BMC GENOMICS

Sibutramine: current status as an anti-obesity drug and its future perspectives

(2008) Bikash Sharma et al.   EXPERT OPINION ON PHARMACOTHERAPY

A Controlled Pharmacogenetic Trial of Sibutramine on Weight Loss and Body Composition in Obese or Overweight Adults

(2008) April B.M. Grudell et al.   GASTROENTEROLOGY

Human interferon-λ3 is a potent member of the type III interferon family

(2008) C Dellgren et al.   GENES AND IMMUNITY

The complete genome of an individual by massively parallel DNA sequencing

(2008) David A. Wheeler et al.   NATURE

Common and rare variants in multifactorial susceptibility to common diseases

(2008) Walter Bodmer et al.   NATURE GENETICS

Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems

(2008) Patrick C. Phillips   NATURE REVIEWS GENETICS

Interaction of genes from influx-metabolism-efflux pathway and their influence on methotrexate efficacy in rheumatoid arthritis patients among Indians

(2008) Shruti Sharma et al.   Pharmacogenetics and Genomics

Pharmacogenomics with antidepressants in the STAR*D study

(2008) Eugene Lin et al.   PHARMACOGENOMICS

A Bayesian approach to gene–gene and gene–environment interactions in chronic fatigue syndrome

(2008) Eugene Lin et al.   PHARMACOGENOMICS

C2 and CFB Genes in Age-Related Maculopathy and Joint Action with CFH and LOC387715 Genes

(2008) Johanna Jakobsdottir et al.   PLoS One