Article
Cell Biology
Shaohua Huang, Liping Ma, Biyang Lan, Ning Liu, Wenwei Nong, Zhihu Huang
Summary: Through bioinformatic analyses, key dysregulated genes associated with the development of gastric cancer were identified, showing potential prognostic value. High expression of LRFN4 and LOC100506388 was linked to a higher risk of gastric cancer, while tumor infiltration levels were associated with overall survival in patients.
Article
Oncology
Linbao Chen, Chao Wang, Yuning Wang, Tianyu Hong, Guangwen Zhang, Xingang Cui
Summary: In this study, a multigene joint signature for predicting prognosis in renal cancer patients was constructed by analyzing ferroptosis-associated genes in renal cancer. The results showed that SLC7A11, HMOX1, and MT1G were associated with renal cancer prognosis, and ferroptosis was highly associated with renal carcinogenesis progression.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Medicinal
Yuhao Ren, Shanshan Li, Ren Zhu, Chengying Wan, Dongmei Song, Jiawen Zhu, Guiping Cai, Sihui Long, Lingyi Kong, Wenying Yu
Summary: The study found that inhibiting histone deacetylases (HDACs) in breast cancer can activate the cancer-related STAT3, limiting the anti-proliferation effect of HDAC inhibitors in solid tumors. The synthesized dual-target inhibition activity derivatives exhibited potent ability to inhibit both STAT3 and HDAC.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Medicine, General & Internal
Leila Dorling, Sara Carvalho, Jamie Allen, Anna Gonzalez-Neira, Craig Luccarini, Cecilia Wahlstrom, Karen A. Pooley, Michael T. Parsons, Cristina Fortuno, Qin Wang, Manjeet K. Bolla, Joe Dennis, Renske Keeman, M. Rosario Alonso, Nuria Alvarez, Belen Herraez, Victoria Fernandez, Rocio Nunez-Torres, Ana Osorio, Jeanette Valcich, Minerva Li, Therese Torngren, Patricia A. Harrington, Caroline Baynes, Don M. Conroy, Brennan Decker, Laura Fachal, Nasim Mavaddat, Thomas Ahearn, Kristiina Aittomaki, Natalia N. Antonenkova, Norbert Arnold, Patrick Arveux, Margreet G. E. M. Ausems, Paivi Auvinen, Heiko Becher, Matthias W. Beckmann, Sabine Behrens, Marina Bermisheva, Katarzyna Bialkowska, Carl Blomqvist, Natalia V. Bogdanova, Nadja Bogdanova-Markov, Stig E. Bojesen, Bernardo Bonanni, Anne-Lise Borresen-Dale, Hiltrud Brauch, Michael Bremer, Ignacio Briceno, Thomas Bruning, Barbara Burwinkel, David A. Cameron, Nicola J. Camp, Archie Campbell, Angel Carracedo, Jose E. Castelao, Melissa H. Cessna, Stephen J. Chanock, Hans Christiansen, J. Margriet Collee, Emilie Cordina-Duverger, Sten Cornelissen, Kamila Czene, Thilo Doerk, Arif B. Ekici, Christoph Engel, Mikael Eriksson, Peter A. Fasching, Jonine Figueroa, Henrik Flyger, Asta Foersti, Marike Gabrielson, Manuela Gago-Dominguez, Vassilios Georgoulias, Fabian Gil, Graham G. Giles, Gord Glendon, Encarna B. Gomez Garcia, Grethe I. Grenaker Alnaes, Pascal Guenel, Andreas Hadjisavvas, Lothar Haeberle, Eric Hahnen, Per Hall, Ute Hamann, Elaine F. Harkness, Jaana M. Hartikainen, Mikael Hartman, Wei He, Bernadette A. M. Heemskerk-Gerritsen, Peter Hillemanns, Frans B. L. Hogervorst, Antoinette Hollestelle, Weang Kee Ho, Maartje J. Hooning, Anthony Howell, Keith Humphreys, Faiza Idris, Anna Jakubowska, Audrey Jung, Pooja Middha Kapoor, Michael J. Kerin, Elza Khusnutdinova, Sung-Won Kim, Yon-Dschun Ko, Veli-Matti Kosma, Vessela N. Kristensen, Kyriacos Kyriacou, Inge M. M. Lakeman, Jong Won Lee, Min Hyuk Lee, Jingmei Li, Annika Lindblom, Wing-Yee Lo, Maria A. Loizidou, Artitaya Lophatananon, Jan Lubinski, Robert J. MacInnis, Michael J. Madsen, Arto Mannermaa, Mehdi Manoochehri, Siranoush Manoukian, Sara Margolin, Maria Elena Martinez, Tabea Maurer, Dimitrios Mavroudis, Catriona McLean, Alfons Meindl, Arjen R. Mensenkamp, Kyriaki Michailidou, Nicola Miller, Nur Aishah Mohd Taib, Kenneth Muir, Anna Marie Mulligan, Heli Nevanlinna, William G. Newman, Borge G. Nordestgaard, Pei-Sze Ng, Jan C. Oosterwijk, Sue K. Park, Tjoung-Won Park-Simon, Jose I. A. Perez, Paolo Peterlongo, David J. Porteous, Karolina Prajzendanc, Darya Prokofyeva, Paolo Radice, Muhammad U. Rashid, Valerie Rhenius, Matti A. Rookus, Thomas Rudiger, Emmanouil Saloustros, Elinor J. Sawyer, Rita K. Schmutzler, Andreas Schneeweiss, Peter Schurmann, Mitul Shah, Christof Sohn, Melissa C. Southey, Harald Surowy, Maija Suvanto, Somchai Thanasitthichai, Ian Tomlinson, Diana Torres, Therese Truong, Maria Tzardi, Yana Valova, Christi J. van Asperen, Rob M. Van Dam, Ans M. W. van den Ouweland, Lizet E. van der Kolk, Elke M. van Veen, Camilla Wendt, Justin A. Williams, Xiaohong R. Yang, Sook-Yee Yoon, M. Pilar Zamora, D. Gareth Evans, Miguel de la Hoya, Jacques Simard, Antonis C. Antoniou, Ake Borg, Irene L. Andrulis, Jenny Chang-Claude, Montserrat Garcia-Closas, Georgia Chenevix-Trench, Roger L. Milne, Paul D. P. Pharoah, Marjanka K. Schmidt, Amanda B. Spurdle, Maaike P. G. Vreeswijk, Javier Benitez, Alison M. Dunning, Anders Kvist, Soo H. Teo, Peter Devilee, Douglas F. Easton
Summary: This study sequenced samples from 60,466 women with breast cancer and 53,461 controls using a panel of 34 putative susceptibility genes, identifying associations between protein-truncating variants in certain genes and breast cancer risk. The results provide important information for genetic counseling and define genes that are most clinically useful for predicting breast cancer risk.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Mengjie Yang, Shuna Liu, Yue Xiong, Jingxin Zhao, Wenbin Deng
Summary: This study investigates the role of mitochondrial creatine kinase 1A (CKMT1A) in different types of cancer. The results show that CKMT1A is highly expressed in most tumors and its expression is significantly correlated with patient prognosis. Genetic alterations of CKMT1A are associated with poor overall survival in non-small cell lung cancer. CKMT1A expression is negatively correlated with cancer-associated fibroblast infiltration and CD8(+) T-cell infiltration in certain tumors. Enrichment analysis reveals the involvement of CKMT1A in glycolysis/gluconeogenesis and metabolic pathways.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
William D. Gwynne, Yujin Suk, Stefan Custers, Nicholas Mikolajewicz, Jeremy K. Chan, Zsolt Zador, Shawn C. Chafe, Kui Zhai, Laura Escudero, Cunjie Zhang, Olga Zaslaver, Chirayu Chokshi, Muhammad Vaseem Shaikh, David Bakhshinyan, Ian Burns, Iqra Chaudhry, Omri Nachmani, Daniel Mobilio, William T. Maich, Patricia Mero, Kevin R. Brown, Andrew T. Quaile, Chitra Venugopal, Jason Moffat, J. Rafael Montenegro-Burke, Sheila K. Singh
Summary: This research integrated data from genetic screening and metabolomic profiling to identify multiple cancer-selective metabolic vulnerabilities in MYC-driven medulloblastoma, providing potential therapeutic targets. The inhibition of DHODH, an enzyme involved in pyrimidine biosynthesis, leads to metabolic stress response, cell-cycle arrest, and apoptosis in tumor cells. A small-molecule DHODH inhibitor demonstrated strong therapeutic efficacy against patient-derived xenografts in vivo, offering a new treatment option for MYC-driven medulloblastoma.
Article
Multidisciplinary Sciences
Wei Tan, Ye Yuan, Hao Huang, Junhao Ma, Yadong Li, Yuanqing Gou, Hao Wu, Zili Hu
Summary: In this study, a prognostic autophagy-related (PAR) lncRNA signature was constructed to predict disease outcome in muscle-invasive bladder cancer (MIBC). The signature showed strong predictive ability and potential mechanisms in MIBC, and provided valuable prognostic tools for individualized drug therapies.
SCIENTIFIC REPORTS
(2022)
Article
Nanoscience & Nanotechnology
Changrong Shi, Qianyu Zhang, Yuying Yao, Fantian Zeng, Chao Du, Sureya Nijiati, Xuejun Wen, Xinyi Zhang, Hongzhang Yang, Haoting Chen, Zhide Guo, Xianzhong Zhang, Jinhao Gao, Weisheng Guo, Xiaoyuan Chen, Zijian Zhou
Summary: This study designs T-cell-targeting fusogenic liposomes to regulate and quantify the activity of T cells by exploiting their surface redox status. The T-cell-targeting fusogenic liposomes neutralize reactive oxygen species to protect T cells and allow magnetic resonance imaging quantification of T cell activity. In multiple mouse models, the T-cell-targeting fusogenic liposomes efficiently inhibit tumors and predict radiotherapy outcomes. This study provides insights into measuring the in situ activity of T cells and may contribute to cancer treatment.
NATURE NANOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jingjing Dai, Abdusemer Reyimu, Ao Sun, Zaxi Duoji, Wubi Zhou, Song Liang, Suxia Hu, Weijie Dai, Xiaoguang Xu
Summary: A multigene prognostic risk scoring system was constructed using bioinformatics analysis for esophageal cancer (EC) patients. The model, based on gene expression profiles and clinical data, effectively predicted prognosis and had independent prognostic value.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Zhimin Chen, Caiming Chen, Fengbin Chen, Ruilong Lan, Guo Lin, Yanfang Xu
Summary: This study investigates the pathogenesis of renal injury caused by COVID-19 and identifies key genes and signaling pathways associated with the progression of renal injury. These genes are mainly distributed in immune cells and are involved in extensive immune inflammation and cell death-related pathways. Furthermore, a protein-protein interaction analysis identifies 15 hub genes associated with renal injury. Additionally, a Nomogram model is constructed to predict severe COVID-19.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemical Research Methods
Chakit Arora, Dilraj Kaur, Gajendra P. S. Raghava
Summary: This study aimed to develop universal or multi-cancer prognostic models, identifying specific prognostic biomarker genes as well as the best model consisting of 11 genes, validated across multiple independent cancer cohorts. Cluster analysis based on shared survival related apoptosis genes contributed to the development of cross-cancer prognostic models.
Article
Biochemistry & Molecular Biology
Yina Qiao, Ting Jin, Shengdong Guan, Shaojie Cheng, Siyang Wen, Huan Zeng, Maojia Zhao, Liping Yang, Xueying Wan, Yuxiang Qiu, Qiao Li, Manran Liu, Yixuan Hou
Summary: The study reveals that Lnc-408 is upregulated in BC cells and enhances invasion and metastasis by regulating LIMK1 expression. Lnc-408 acts as a sponge for miR-654-5p to promote BC invasion through the Lnc-408/miR-654-5p/LIMK1 axis.
Article
Biochemistry & Molecular Biology
Hesam Montazeri, Mairene Coto-Llerena, Gaia Bianco, Ehsan Zangene, Stephanie Taha-Mehlitz, Viola Paradiso, Sumana Srivatsa, Antoine de Weck, Guglielmo Roma, Manuela Lanzafame, Martin Bolli, Niko Beerenwinkel, Markus von Fluee, Luigi M. Terracciano, Salvatore Piscuoglio, Charlotte K. Y. Ng
Summary: Systematic perturbation screens provide resources for identifying cancer driver genes, requiring specialized computational tools for processing data from perturbation of many genes in few cell lines. APSiC is a statistical framework developed for identifying novel cancer genes and effectors in perturbation screens, demonstrated through analysis of the DRIVE project. The analysis of DRIVE using APSiC is available as a web portal, providing a valuable resource for discovery of cancer genes.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Oncology
Md Faqrul Hasan, Kavya Ganapathy, Jiao Sun, Ayman Khatib, Thomas Andl, Julia N. Soulakova, Domenico Coppola, Wei Zhang, Ratna Chakrabarti
Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Lili Yu, Yajing Zhou, Lijuan Wang, Xuan Zhou, Jing Sun, Jiarui Xiao, Xiaolin Xu, Susanna C. Larsson, Shuai Yuan, Xue Li
Summary: This study used Mendelian randomization analysis to explore the association between GDF-15 levels and gallstone disease. The results suggest that GDF-15 may be a potential therapeutic target for gallstone disease, and the inverse association between GDF-15 levels and diabetic complications validates its therapeutic effects.
FRONTIERS IN GENETICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Neerav Goyal, Max Hennessy, Erik Lehman, Wenxue Lin, Antonio Agudo, Wolfgang Ahrens, Stefania Boccia, Paul Brennan, Hermann Brenner, Gabriella Cadoni, Cristina Canova, Chu Chen, David Conway, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Valeria Edefonti, Eleonora Fabianova, Leticia Fernandez, Silvia Franceschi, Werner Garavello, Maura Gillison, Richard B. Hayes, Claire Healy, Rolando Herrero, Ivana Holcatova, Jossy L. Kanda, Karl Kelsey, Bo T. Hansen, Rosalina Koifman, Pagona Lagiou, Carlo La Vecchia, Fabio Levi, Guojun Li, Jolanta Lissowska, Rossana Mendoza Lopez, Daniele Luce, Gary Macfarlane, Dana Mates, Keitaro Matsuo, Michael McClean, Ana Menezes, Gwenn Menvielle, Hal Morgenstern, Kirsten Moysich, Eva Negri, Andrew F. Olshan, Tamas Pandics, Jerry Polesel, Mark Purdue, Loredana Radoi, Heribert Ramroth, Lorenzo Richiardi, Stimson Schantz, Stephen M. Schwartz, Diego Serraino, Oxana Shangina, Elaine Smith, Erich M. Sturgis, Beata Swiatkowska, Peter Thomson, Thomas L. Vaughan, Marta Vilensky, Deborah M. Winn, Victor Wunsch-Filho, Guo-Pei Yu, Jose P. Zevallos, Zuo-Feng Zhang, Tongzhang Zheng, Ariana Znaor, Paolo Boffetta, Mia Hashibe, Yuan-Chin A. Lee, Joshua E. Muscat
Summary: This study analyzed the relationship between cigarette smoking, alcohol consumption, and head and neck cancer risk factors in less developed and more developed countries. The results showed that the duration of smoking and alcohol consumption had different effects on the risk of specific cancer sites depending on the country's level of development. These findings suggest that the degree of industrialization and economic development affects the relationship between smoking, alcohol, and head and neck cancer.
Article
Oncology
Hamideh Rashidian, Maryam Hadji, Mahin Gholipour, Ahmad Naghibzadeh-Tahami, Maryam Marzban, Elham Mohebbi, Roya Safari-Faramani, Mahdieh Bakhshi, Monireh Sadat Seyyedsalehi, Bayan Hosseini, Reza Alizadeh-Navaei, Habib Emami, Ali Akbar Haghdoost, Abbas Rezaianzadeh, Abdolvahab Moradi, Alireza Ansari-Moghaddam, Azim Nejatizadeh, Soodabeh ShahidSales, Alireza Rezvani, Mohammad Hasan Larizadeh, Farid Najafi, Hossein Poustchi, Mohammad Ali Mohagheghi, Paul Brennan, Elisabete Weiderpass, Joachim Schuz, Eero Pukkala, Neal D. Freedman, Paolo Boffetta, Reza Malekzadeh, Arash Etemadi, Afarin Rahimi-Movaghar, Farin Kamangar, Kazem Zendehdel
Summary: Opium use is strongly associated with an increased risk of lung cancer, particularly small cell carcinoma. Regular opium users have a 3.6-fold higher risk of developing lung cancer compared to non-users, with a dose-response relationship observed. Female opium users have a higher risk than male users. The risk is further increased for individuals who use both opium and tobacco.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Oncology
Thomas Behrens, Calvin Ge, Roel Vermeulen, Benjamin Kendzia, Ann Olsson, Joachim Schuez, Hans Kromhout, Beate Pesch, Susan Peters, Luetzen Portengen, Per Gustavsson, Dario Mirabelli, Pascal Guenel, Daniele Luce, Dario Consonni, Neil E. Caporaso, Maria Teresa Landi, John K. Field, Stefan Karrasch, Heinz-Erich Wichmann, Jack Siemiatycki, Marie-Elise Parent, Lorenzo Richiardi, Lorenzo Simonato, Karl-Heinz Joeckel, Wolfgang Ahrens, Hermann Pohlabeln, Guillermo Fernandez-Tardon, David Zaridze, John R. McLaughlin, Paul A. Demers, Beata Swiatkowska, Jolanta Lissowska, Tamas Pandics, Eleonora Fabianova, Dana Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Paolo Boffetta, Bas Bueno-de-Mesquita, Francesco Forastiere, Kurt Straif, Thomas Bruening
Summary: Limited evidence exists regarding the exposure-effect relationship between lung-cancer risk and hexavalent chromium (Cr(VI)) or nickel. This study found that occupational exposure to Cr(VI) and nickel was associated with lung-cancer risks, particularly in men. In men, the highest quartile of cumulative exposure to CR(VI) and nickel were both significantly associated with increased odds ratios for lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Nutrition & Dietetics
Giulia Collatuzzo, Eva Negri, Claudio Pelucchi, Rossella Bonzi, Federica Turati, Charles S. Rabkin, Linda M. Liao, Rashmi Sinha, Domenico Palli, Monica Ferraroni, Lizbeth Lopez-Carrillo, Nuno Lunet, Samantha Morais, Demetrius Albanes, Stephanie J. Weinstein, Dominick Parisi, David Zaridze, Dmitry Maximovitch, Trinidad Dierssen-Sotos, Jose Juan Jimenez-Moleon, Jesus Vioque, Manoli Garcia de la Hera, Maria Paula Curado, Emmanuel Dias-Neto, Raul Ulises Hernandez-Ramirez, Malaquias Lopez-Cervantes, Mary H. Ward, Shoichiro Tsugane, Akihisa Hidaka, Areti Lagiou, Pagona Lagiou, Zuo-Feng Zhang, Antonia Trichopoulou, Anna Karakatsani, Maria Constanza Camargo, Carlo La Vecchia, Paolo Boffetta
Summary: A meta-analysis of 16 studies found no significant association between yoghurt consumption and gastric cancer risk.
Article
Oncology
Giulia Collatuzzo, Federica Turati, Matteo Malvezzi, Eva Negri, Carlo La Vecchia, Paolo Boffetta
Summary: This study estimated the number of cancers attributable to occupational carcinogens in Italy. By using a counterfactual scenario of no exposure and considering latency, the study calculated the attributable fraction of cancer. The most prevalent occupational carcinogens were found to be UV radiation, diesel exhaust, wood dust, and silica dust. The study highlighted the substantial burden of occupational cancers in Italy and the importance of surveillance of carcinogens in the workplace.
Article
Oncology
Giulia Collatuzzo, Margherita Ferrante, Antonella Ippolito, Alessia Di Prima, Cristina Colarossi, Salvatore Scarpulla, Paolo Boffetta, Salvatore Sciacca
Summary: This study investigates cancer patterns in migrants in Southern Italy using data from the Eastern Sicily Cancer Registry. Migrants have a higher probability of developing cancer, particularly in migrant women. Cervical and lung cancer are more prevalent in migrants, while colorectal cancer is less common. Interventions should be implemented to improve the access of migrants to cancer prevention, early diagnosis, and care, with a focus on HPV vaccination, cervical cancer screening, and tobacco control.
Article
Oncology
Monireh Sadat Seyyedsalehi, Marta Rossi, Maryam Hadji, Hamideh Rashidian, Maryam Marzban, Maria Parpinel, Federica Fiori, Ahmad Naghibzadeh-Tahami, Yusuf A. Hannun, Chiara Luberto, Kazem Zendehdel, Paolo Boffetta
Summary: This study found that dietary betaine, choline, and choline-containing compounds are associated with the risk of colorectal cancer (CRC). Men who consume phosphocholine and sphingomyelin are more likely to develop CRC, while women who consume betaine have a decreased risk. Therefore, modifying the diet to increase betaine intake and managing the consumption of animal products can help reduce the risk of CRC.
Review
Oncology
Federica Teglia, Giulia Collatuzzo, Paolo Boffetta
Summary: This narrative review provides new insights and reports the current state of knowledge on occupational cancers among women, with a focus on three female working categories: beauticians and hairdressers, farmers, and healthcare workers. The inclusion of women in occupational cancer studies has become more urgent and feasible due to the changing workforce and increasing number of women employed. The review also discusses the difficulties in evaluating occupational causes of female gynecologic tumors and the potential gender differences in outcome responses.
Article
Immunology
Emanuele Sansone, Giulia Collatuzzo, Stefano Renzetti, Giorgia Ditano, Carlo Bonfanti, Emma Sala, Luigina Terlenghi, Alberto Matteelli, Mahsa Abedini, Shuffield Seyram Asafo, Paolo Boffetta, Giuseppe De Palma
Summary: Given their occupational risk profile, healthcare workers (HCWs) were prioritized for anti-SARS-CoV-2 vaccination. However, breakthrough infections remained common, especially with new SARS-CoV-2 variants of concern (VOCs) spreading rapidly in Italy. The level of anti-SARS-CoV-2 antibodies does not accurately predict protection from natural infection or vaccination, emphasizing the need for further research on susceptibility to SARS-CoV-2. This study aimed to characterize the risk profiles for SARS-CoV-2 infection in recently booster-dosed HCWs, finding that hybrid immunization (vaccine plus natural infection) elicited higher antibody levels. However, it did not always provide better protection against reinfection, highlighting the importance of the immunization profile as a virus-host interaction modifier. Despite high resistance to reinfection, there was a notable infection rate (5.6%) during the peri-booster period, reinforcing the importance of preventive measures.
Article
Environmental Sciences
Jongeun Rhee, Erikka Loftfield, Demetrius Albanes, Tracy M. Layne, Rachael Stolzenberg-Solomon, Linda M. Liao, Mary C. Playdon, Sonja I. Berndt, Joshua N. Sampson, Neal D. Freedman, Steven C. Moore, Mark P. Purdue
Summary: This study aimed to investigate the biological effects of PFOS and PFOA on the human body. Through metabolomic analysis, several metabolites associated with PFOS and PFOA were identified, with lipids and xenobiotics being the most common types. These findings provide insights into the potential hazards of PFOS and PFOA.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Nutrition & Dietetics
Hung N. Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E. Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E. Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C. Clemente, Jian-Min Yuan
Summary: The study found that colorectal advanced adenoma is associated with alterations in ileal juice bile acids. The concentrations of hyodeoxycholic acid (HCA) species in ileal juice were significantly higher in advanced adenoma patients compared to controls. The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls.
Article
Medicine, General & Internal
Luigi De Maria, Giuseppe Delvecchio, Stefania Sponselli, Francesco Cafaro, Antonio Caputi, Gianmarco Giannelli, Pasquale Stefanizzi, Francesco Paolo Bianchi, Angela Stufano, Silvio Tafuri, Piero Lovreglio, Paolo Boffetta, Luigi Vimercati
Summary: A observational study at the University Hospital of Bari found a significant prevalence of SARS-CoV-2 breakthrough infections (BIs) among healthcare workers (HCWs) during the first year of mandatory vaccination with BNT162b2 mRNA COVID-19 vaccine. However, there were no hospitalizations or deaths. The study extended the observation period and determined the incidence, characteristics, and clinical course of SARS-CoV-2 BIs among 6213 HCWs. The results showed that SARS-CoV-2 infections can occur despite vaccination, but the clinical course is favorable.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Jan Niklas Mink, Oybek Khalmurzaev, Alexey Pryalukhin, Carol Immanuel Geppert, Stefan Lohse, Kristof Bende, Joao Lobo, Rui Henrique, Hagen Loertzer, Joachim Steffens, Carmen Jeronimo, Heiko Wunderlich, Julia Heinzelbecker, Rainer M. Bohle, Michael Stoeckle, Vsevolod Matveev, Arndt Hartmann, Kerstin Junker
Summary: This study evaluated 297 penile cancer patients from Germany, Russia, and Portugal and found a significant association between lymph node metastasis and lymphovascular invasion with prognosis. The current TNM classification was not found to improve prognosis estimation. Revision of the TNM classification is suggested.
Article
Public, Environmental & Occupational Health
Aline F. Fares, Yao Li, Mei Jiang, M. Catherine Brown, Andrew C. L. Lam, Reenika Aggarwal, Sabine Schmid, Natasha B. Leighl, Frances A. Shepherd, Zhichao Wang, Nancy Diao, Angela S. Wenzlaff, Juntao Xie, Takashi Kohno, Neil E. Caporaso, Curtis Harris, Hongxia Ma, Matthew J. Barnett, Leticia Ferro Leal, G. Fernandez-Tardon, Manica Perez-Rios, Michael P. A. Davies, Fiona Taylor, Ben Schoettker, Paul Brennan, David Zaridze, Ivana Holcatova, Jolanta Lissowska, Beata Swiatkowska, Dana Mates, Milan Savic, Hermann Brenner, Angeline Andrew, Angela Cox, John K. Field, Alberto Ruano-Ravina, Sanjay S. Shete, Adonina Tardon, Ying Wang, Loic Le Marchand, Rui Manuel Reis, Matthew B. Schabath, Chu Chen, Hongbing Shen, Brid M. Ryan, Maria Teresa Landi, Kouya Shiraishi, Jie Zhang, Ann G. Schwartz, Ming S. Tsao, David C. Christiani, Ping Yang, Rayjean J. Hung, Wei Xu, Geoffrey Liu
Summary: This large-scale study conducted in multiple countries and regions worldwide found that the duration of smoking abstinence is associated with overall survival in patients with NSCLC, even when diagnosed at a later lung-cancer screening visit.
LANCET PUBLIC HEALTH
(2023)