Article
Biochemistry & Molecular Biology
Feng Wang, Jiayi Zhang, Houyi Tang, Yi Pang, Xiaoxue Ke, Wen Peng, Shitong Chen, Muhammad Nadeem Abbas, Zhen Dong, Zhaobo Cui, Hongjuan Cui
Summary: The overexpression of CARM1 in gastric cancer correlates with poor prognosis. CARM1 interacts with Nup54 to promote its nuclear importation and cooperates with TFEB to activate Notch2 transcription, affecting gastric cancer cell proliferation and tumor formation. Methylation of N2ICD by CARM1 enhances its binding with MAML1, contributing to gastric cancer progression.
Article
Immunology
Ange Zhang, Xiaoming Zou, Shifeng Yang, Hao Yang, Zhen Ma, Jiacheng Li
Summary: This study reveals that NETs can promote gastric cancer metastasis by activating COX-2 through TLR2, and COX-2 may become a potential target for gastric cancer immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Mengqian Yu, Jiani Yi, Qiongzi Qiu, Dongxia Yao, Jia Li, Juze Yang, Chunyi Mi, Liyuan Zhou, Bingjian Lu, Weiguo Lu, Kejing Ying, Wantao Chen, Enguo Chen, Honghe Zhang, Zhimin Lu, Yan Lu, Pengyuan Liu
Summary: A study found that a tRF called CAT1 is upregulated in various cancers and is associated with poor prognosis. In cancer cells, CAT1 binds to RBPMS and prevents the degradation of NOTCH2, promoting proliferation and metastasis in lung cancer cells. Additionally, plasma levels of CAT1 are significantly increased in patients with lung cancer.
Article
Gastroenterology & Hepatology
Xiwu Rao, Xuan Liu, Ningning Liu, Yi Zhang, Zhaozhou Zhang, Lihong Zhou, Gang Han, Rong Cen, Nuolin Shi, Huirong Zhu, Hangjun Gong, Chen Huang, Qing Ji, Qi Li
Summary: This study identified that lncRNA NEAT1 may act as a promoter of tumorigenesis in H. pylori gastric cancer by sponging miR-30a (miR-30a-3p and miR-30a-5p) to regulate the COX-2/BCL9 pathway.
Article
Oncology
Da-Cen Lin, Si-Yi Zheng, Zhi-Guang Zhang, Jian-Hua Luo, Zhuang-Li Zhu, Li Li, Lu-Shan Chen, Xinjian Lin, James S. K. Sham, Mo-Jun Lin, Rui-Xiang Zhou
Summary: The study reveals that TRPC3 is overexpressed in gastric cancer and correlates with malignant progression and poor prognosis. TRPC3 enhances Ca2+ entry and promotes NFATc2 nuclear translocation, contributing to cell proliferation and apoptosis regulation. TRPC3 may serve as a potential therapeutic target for gastric cancer intervention.
Review
Cell Biology
Hui Sun, Xu Wang, Xin Wang, Midie Xu, Weiqi Sheng
Summary: Despite progress in cancer treatment, gastric cancer (GC) still has a poor prognosis. Recent research has shown that the malignant behavior of cancer is not only caused by tumor cells, but also mediated by the activity of cancer stroma and regulated by molecular networks in the tumor microenvironment (TME). Cancer-associated fibroblasts (CAFs) are abundant in the stroma and play a significant role in the malignant development of GC. CAFs can modulate the biological properties of tumor cells through various mechanisms, affecting the initiation and progression of GC. However, there is heterogeneity in the cellular origins, phenotypes, and functions of CAFs in the TME of GC, and the molecular mechanisms are not well understood.
CELL DEATH & DISEASE
(2022)
Review
Health Care Sciences & Services
Kenly Wuputra, Chia-Chen Ku, Jia-Bin Pan, Chung-Jung Liu, Yi-Chang Liu, Shigeo Saito, Kohsuke Kato, Ying-Chu Lin, Kung-Kai Kuo, Te-Fu Chan, Inn-Wen Chong, Chang-Shen Lin, Deng-Chyang Wu, Kazunari K. Yokoyama
Summary: Stomach cancer has a high mortality, partly due to the lack of suitable biomarkers for early detection of cancer progression. Therefore, identifying critical biomarkers associated with gastric cancer is crucial for improving clinical diagnoses and treatment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Cell Biology
Xiaolin Lin, Ting Han, Qing Xia, Jiujie Cui, Meng Zhuo, Yiyi Liang, Wenyu Su, Lisha Wang, Liwei Wang, Zebing Liu, Xiuying Xiao
Summary: CHPF is upregulated in gastric cancer tissues and correlates with tumor infiltration, advanced tumor stage, and shorter patient survival. It may promote gastric cancer development by regulating cell proliferation, colony formation, cell apoptosis, and cell migration, with knockdown inducing opposite effects. Additionally, CHPF may regulate E2F1 through affecting UBE2T-mediated E2F1 ubiquitination.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Jiayi Zang, Lin Xiao, Xin Shi, Sinan Liu, Yan Wang, Baolan Sun, Shaoqing Ju, Ming Cui, Rongrong Jing
Summary: Circular RNA plays a significant role in gastric cancer by regulating the expression of key molecules such as DEK and c-Myc, accelerating cancer development and metastasis, and affecting immune infiltration of CD8+ T cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Marek Majewski, Kamil Torres, Paulina Mertowska, Sebastian Mertowski, Izabela Korona-Glowniak, Jan Korulczyk, Witold Zgodzinski, Ewelina Grywalska
Summary: Gastric cancer is a common type of cancer worldwide. Toll-like receptors (TLRs) expressed on immune cells play a role in the pathogenesis of gastric cancer. This study found that patients with gastric cancer had a higher percentage of immune cells expressing TLR2 compared to the control group. Additionally, there was a significant association between TLR2 expression and the stage of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Zhonghua Ma, Xiangyu Gao, You Shuai, Xiaolong Wu, Yan Yan, Xiaofang Xing, Jiafu Ji
Summary: Linc01503 is significantly upregulated in GC and closely associated with patient survival. The transcription factor EGR1 activates linc01503 transcription. Knockdown of linc01503 leads to apoptosis activation and G1/G0 phase arrest in GC. Linc01503 interacts with histone modification enzymes EZH2 and LSD1 to silence DUSP5/CDKN1A expression in GC, mediating cell cycle progression and tumorigenesis.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Yan Lv, Yin Wang, Yu Song, Shu-Sheng Wang, Kai-wen Cheng, Zhi-qing Zhang, Jin Yao, Li-na Zhou, Zhuo-yan Ling, Cong Cao
Summary: PINK1-AS promotes G alpha i1-driven gastric cancer progression by sponging miR-200a, while miR-200a directly silences G alpha i1 to induce anti-gastric cancer activity.
Article
Biochemistry & Molecular Biology
Kurara Takagane, Michinobu Umakoshi, Go Itoh, Sei Kuriyama, Akiteru Goto, Masamitsu Tanaka
Summary: In this study, researchers found that SKAP2 plays a role in regulating inflammation and tumorigenesis by modulating the TLR4-NF-kappa B pathway and TLR4-IFN β pathway.
Article
Pharmacology & Pharmacy
Shilpa Sharma, Harshit Kalra, Ravi Shankar Akundi
Summary: The inflammatory protein COX-2 and extracellular ATP play crucial roles in tumor cell metastasis, with ATP acting on P2 receptors to regulate cell migration and invasion, leading to increased COX-2 expression.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Zhengyuan Yan, Kanghui Liu, Peng Xu, Zhengwei Chen, Pengpeng Zhang, Shengbin Pei, Quan Cheng, Shansong Huang, Bowen Li, Jialun Lv, Zekuan Xu, Hao Xu, Li Yang, Diancai Zhang
Summary: Mounting evidence suggests that ATP-citrate lyase (ACLY) plays a significant role in gastric cancer progression and peritoneal metastasis by promoting cell proliferation, migration, and angiogenesis as well as epithelial-mesenchymal transition. The expression of ACLY is regulated by HIF-1A under hypoxic conditions.
Article
Biochemistry & Molecular Biology
Ching-Ling Lin, Ming-Lin Tsai, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Li-Chi Huang, Chia-Hwa Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Ziyang Hao, Tong Wu, Xiaolong Cui, Pingping Zhu, Caiping Tan, Xiaoyang Dou, Kai-Wen Hsu, Yueh-Te Lin, Pei-Hua Peng, Li-Sheng Zhang, Yawei Gao, Lulu Hu, Hui-Lung Sun, Allen Zhu, Jianzhao Liu, Kou-Juey Wu, Chuan He
Article
Oncology
I-Han Wang, Tzu-Ting Huang, Ji-Lin Chen, Li-Wei Chu, Yueh-Hsin Ping, Kai-Wen Hsu, Kuo-Hung Huang, Wen-Liang Fang, Hsin-Chen Lee, Chian-Feng Chen, Chen-Chung Liao, Rong-Hong Hsieh, Tien-Shun Yeh
Article
Oncology
Shu-Huey Chen, Yao-Yu Hsieh, Huey-En Tzeng, Chun-Yu Lin, Kai-Wen Hsu, Yun-Shan Chiang, Su-Mei Lin, Ming-Jang Su, Wen-Shyang Hsieh, Chia-Hwa Lee
Article
Oncology
Pei-Hua Peng, Joseph Chieh-Yu Lai, Kai-Wen Hsu, Kou-Juey Wu
Article
Multidisciplinary Sciences
Lung-Hung Tsai, Kai-Wen Hsu, Cheng-Ming Chiang, Hsiu-Ju Yang, Yu-Huei Liu, Shun-Fa Yang, Pei-Hua Peng, Wei-Chung Cheng, Heng-Hsiung Wu
SCIENTIFIC REPORTS
(2020)
Article
Plant Sciences
Han-Tsang Wu, Joseph Lin, Yi-En Liu, Hsiao-Fan Chen, Kai-Wen Hsu, Shu-Hsuan Lin, Kai-Yen Peng, Kuo-Juei Lin, Chang-Chi Hsieh, Dar-Ren Chen
Summary: The study showed that luteolin effectively inhibited the proliferation and metastasis of androgen receptor-positive TNBC, reversing the epithelial-mesenchymal transition and downregulating MMP9 expression. The combination of luteolin and AKT/mTOR inhibitors synergistically suppressed the proliferation and metastasis of androgen receptor-positive TNBC cells.
Article
Multidisciplinary Sciences
Yumei Qi, Yo-Liang Lai, Pei-Chun Shen, Fang-Hsin Chen, Li-Jie Lin, Heng-Hsiung Wu, Pei-Hua Peng, Kai-Wen Hsu, Wei-Chung Cheng
SCIENTIFIC REPORTS
(2020)
Article
Medicine, Research & Experimental
Shu-Hsuan Liu, Kai-Wen Hsu, Yo-Liang Lai, Yu-Feng Lin, Fang-Hsin Chen, Pei-Hwa Peng, Li-Jie Lin, Heng-Hsiung Wu, Chia-Yang Li, Shu-Chi Wang, Min-Zu Wu, Yuh-Pyng Sher, Wei-Chung Cheng
Summary: The study found that both individual miRNA mimics and the combination of the three miRNA mimics were effective in inhibiting tumor growth and progression, with the combination being more effective than the single miRNA mimics. In lung cancer animal models, the combined miRNA mimics provided significant therapeutic effects in terms of reduced tumor volume and metastasis nodules.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Review
Biochemistry & Molecular Biology
Pei-Hua Peng, Kai-Wen Hsu, Joseph Chieh-Yu Lai, Kou-Juey Wu
Summary: Long noncoding RNAs (lncRNAs) are noncoding RNAs with length greater than 200 nt, which have been extensively studied for their biological roles and mechanisms. Hypoxia is a proven microenvironmental factor that promotes solid tumor metastasis, with epithelial-mesenchymal transition (EMT) being one of the major mechanisms induced by hypoxia. Many lncRNAs induced by hypoxia have been shown to interact with protein/protein complex and chromatin/epigenetic factors, contributing to metastasis.
BIOMEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Ching-Ling Lin, Ming-Lin Tsai, Yu-Hsin Chen, Wei-Ni Liu, Chun-Yu Lin, Kai-Wen Hsu, Chien-Yu Huang, Yu-Jia Chang, Po-Li Wei, Shu-Huey Chen, Li-Chi Huang, Chia-Hwa Lee
Summary: Thyroid cancer can be classified into well-differentiated and poorly differentiated types, with the latter being more aggressive. The study found that the PDGF/PDGFR signaling pathway plays a crucial role in thyroid cancer development, and targeting PDGFRA through gene editing and drug therapy could effectively reduce the aggressiveness of advanced thyroid cancers.
BIOMOLECULES & THERAPEUTICS
(2021)
Article
Oncology
I-Hung Shao, Pei-Hua Peng, Heng-Hsiung Wu, Ji-Lin Chen, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Han-Tsang Wu, Kou-Juey Wu, See-Tong Pang, Kai-Wen Hsu
Summary: In this study, a hypoxia-induced long non-coding RNA (lncRNA) RP11-367G18.1 was identified to be overexpressed in clear cell renal cell carcinoma (ccRCC) tissues. RP11-367G18.1 interacted with histone acetyltransferase p300 and regulated lysine 16 acetylation on histone 4 (H4K16Ac), thereby promoting ccRCC metastasis and growth. RP11-367G18.1 was associated with poor prognosis and may serve as a therapeutic target for ccRCC.
Article
Oncology
Pei-Hua Peng, Joseph Chieh-Yu Lai, Jeng-Shou Chang, Kai-Wen Hsu, Kou-Juey Wu
Summary: The study identified that lncRNA RP11-367G18.1 regulates the occurrence of EMT and the formation of metastatic tumors under hypoxic conditions by activating the H4K16Ac histone mark.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Han-Tsang Wu, Yi-En Liu, Kai-Wen Hsu, Yu-Fen Wang, Ya-Chi Chan, Yeh Chen, Dar-Ren Chen
AMERICAN JOURNAL OF CHINESE MEDICINE
(2020)
Review
Oncology
Pei-Hua Peng, Kai-Wen Hsu, Kou-Juey Wu
Summary: LLPS is a mechanism used to explain the formation of organelles and membraneless condensates, facilitating multiple biological processes. Dysfunction of LLPS may lead to disease formation, and it plays a role in regulating normal cellular physiology and contributing to tumorigenesis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)