Review
Biochemistry & Molecular Biology
Shasha Yin, Liu Liu, Wenjian Gan
Summary: The mechanistic target of rapamycin (mTOR) regulates cell growth, proliferation, and metabolism by integrating various environmental inputs, controlling processes like nucleotide, protein, and lipid synthesis, autophagy, and apoptosis. Dysregulation of mTOR pathway is linked to diseases like cancers, metabolic disorders, and neurodegenerative diseases, often caused by genetic alterations or post-translational modifications. Research on PTMs-mediated regulation of mTOR signaling and targeting mTOR pathway and PTM-related enzymes for disease treatment has advanced significantly in recent years.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Yanxiang Meng, Jarrod J. Sandow, Peter E. Czabotar, James M. Murphy
Summary: This article discusses the role of phosphorylation, ubiquitylation, GlcNAcylation, proteolytic cleavage, and disulfide bonding in regulating necroptotic signaling, with a focus on RIPK1, RIPK3, and MLKL. Understanding of these post-translational modifications can be valuable in efforts to therapeutically modulate necroptosis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biotechnology & Applied Microbiology
Abhisha Sawant Dessai, Poonam Kalhotra, Aaron T. Novickis, Subhamoy Dasgupta
Summary: Metabolic reprogramming is a characteristic of cancer development and metastasis, which involves the modulation of multiple metabolic pathways to support cancer cell growth. The activity of rate-limiting enzymes in these pathways is specifically regulated through transcriptional, translational, and post translational modifications to maintain enhanced activity.
CANCER GENE THERAPY
(2023)
Review
Oncology
Ana Gonzalez-Garcia, Antonio Garrido, Ana C. Carrera
Summary: Genetic alterations in the PI3-kinase/PTEN pathway are common in cancer cells. Current efforts to treat PTEN-dependent tumors mainly focus on PI3-kinase inhibition, but modulating PTEN post-translational modifications could provide alternative therapeutic strategies.
Review
Cell Biology
Chunhua Yang, Mengna Wei, Yanpu Zhao, Zhanyi Yang, Mengyao Song, Jia Mi, Xiaoyong Yang, Geng Tian
Summary: Post-translational modifications (PTMs) in pancreatic beta cells play crucial roles in insulin secretion and have significant implications for diabetes mellitus development. This article summarizes the major PTMs occurring in beta cells and their impact on insulin secretion, providing valuable insights into the understanding of insulin secretion mechanisms and potential therapeutic targets for diabetes from the perspective of protein PTMs.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Juan Facundo Chrestia, Ornella Turani, Noelia Rodriguez Araujo, Guillermina Hernando, Maria del Carmen Esandi, Cecilia Bouzat
Summary: Nicotinic acetylcholine receptors (nAChRs) are widely distributed in the central and peripheral nervous system and play crucial roles in vital physiological processes. Post-translational modifications (PTMs) have been shown to regulate different aspects of nAChR life cycle, but our knowledge in this field is still limited and many important aspects remain unknown.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yunhua Peng, Huadong Liu, Jiankang Liu, Jiangang Long
Summary: Mitochondria play a crucial role in the initiation and development of tumor cells, with metabolic proteins serving as key mediators in tumorigenesis. Understanding mitochondria-related post-translational modifications is important for the future of cancer treatment.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Plant Sciences
Manuel Balparda, Maroua Bouzid, Maria del Pilar Martinez, Ke Zheng, Markus Schwarzlaender, Veronica G. Maurino
Summary: The flexibility of plant growth, development and stress responses is controlled by signaling cascades and genetic programs, while metabolism executes these programs through selective delivery of building blocks and energy. Photosynthetic carbon fixation is essential for plant metabolism, which is influenced by environmental fluctuations. The regulation of carbon assimilation metabolism requires versatility and rapidity to maintain efficiency. Post-translational modifications (PTMs) have a significant impact on carbon assimilation metabolism, altering protein characteristics and function. The exploitation of PTMs has the potential to control metabolic flux, influence crop yields, modify metabolite composition, optimize stress tolerance, and regulate growth and developmental programs.
Review
Cell Biology
Clotilde C. N. Renaud, Nicolas Bidere
Summary: Centriolar satellites are small granules that revolve around the centrosome, and recent research has uncovered their complex nature and diverse roles in cellular processes beyond centrosome and primary cilia formation. Post-translational modifications like phosphorylation and ubiquitination play a crucial role in shaping the composition and functions of these structures.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sofia-Iris Bibli, Ingrid Fleming
Summary: This article discusses the impact of changes in oxidative balance on cellular physiology and adaptation, with a focus on the sensitivity of endothelial cells to reactive oxygen species and the role of oxidative modifications in regulating protein function. Persulfidation, a newly identified reversible oxidation modification, plays a crucial role in maintaining cellular redox homeostasis.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Review
Virology
Celia Chamontin, Guillaume Bossis, Sebastien Nisole, Nathalie J. Arhel, Ghizlane Maarifi
Summary: Intrinsic immunity is mediated by host cellular proteins called restriction factors which interfere with viral replication and are tightly regulated by interferons. Post-translational modifications play a crucial role in determining the antiviral activity of restriction factors, with viruses evolving mechanisms to counteract these modifications. Understanding the role of PTMs in restriction factors is essential for comprehending antiviral defense mechanisms and immune response regulations during infection.
Review
Biochemistry & Molecular Biology
Ashley J. Ovens, John W. Scott, Christopher G. Langendorf, Bruce E. Kemp, Jonathan S. Oakhill, William J. Smiles
Summary: AMP-activated protein kinase (AMPK) plays a crucial role in adaptive responses to exercise, and its post-translational modifications extensively influence its activity, subcellular localization, nutrient interactions, and protein stability. Areas for further research include novel regulatory modifications of AMPK and improving characterization of these modifications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Han Xue, Qingfeng Zhang, Panqin Wang, Bijin Cao, Chongchong Jia, Ben Cheng, Yuhua Shi, Wei-Feng Guo, Zhenlong Wang, Ze-Xian Liu, Han Cheng
Summary: The paper introduces an integrative database of quantitative PTMs in plants named qPTMplants, which includes experimentally identified PTM events for 123,551 proteins at 429,821 nonredundant sites under 583 conditions for 43 plant species from 293 published studies. This database is expected to be a valuable resource for further research on PTMs in plants.
NUCLEIC ACIDS RESEARCH
(2022)
Review
Oncology
Le Yu, Ian J. Davis, Pengda Liu
Summary: Ewing sarcoma is a malignant pediatric bone cancer characterized by unique gene fusions, with EWSR1-FLI1 being the most prevalent. The understanding of regulatory mechanisms and potential therapeutic approaches for targeting EWSR1-FLI1 in Ewing sarcoma is still insufficient. This review provides a summary of up-to-date knowledge on the subject, aiming to identify knowledge gaps and propose new therapeutic directions.
Review
Biochemistry & Molecular Biology
Bo Dong, Yadi Wu
Summary: SNAI1, a zinc finger transcription factor, plays a crucial role in cancer metastasis by regulating transcriptional, translational, and post-translational levels. Epigenetic regulation and post-translational modifications are key mechanisms for the regulation of SNAI1 in cancer metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
